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Joshua A. Boyce, M.D.

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Biography
1981
Dowd-Lester Award
1981
Charlotte Fahey Award
1995 - 2000
Physician-Scientist Award (K08)
2012
Alpha Omega Alpha (Alumini Member)
2012
AAAAI Special Recognition Award

Overview
The overall goal of my lab is to apply principals of pathophysiology of allergic diseases in humans to questions at the bench, and in turn to bring fundamental findings made at the bench back to the clinic. The dominant themes include how lipid mediators and their receptors function in a network to control the development and activation of mast cells, a central cell type in the effector phases of all allergic diseases. We defined the growth factor requirements for the development of human mast cells from their earliest progenitors, and identified a key role for interleukin (IL)-4 as an accessory mitogen. Human mast cells exposed to IL-4 become competent to generate leukotriene C4 (LTC4) the precursor of the powerful bronchoconstrictor LTD4 and the stable metabolite LTE4. This competence is due to the induced expression of LTC4 synthase, the requisite terminal enzyme involved in LTC4 synthesis. These observations explain why mucosal inflammation elicits a mast cell hyperplasia accompanied by strikingly increased regional concentrations of LTC4 LTD4 and LTE4. We discovered that the growth potentiating effect of IL-4 depended on the induction of LTC4S, and the transactivation of the c-kit tyrosine kinase by the type 1 receptor for cys-LTs (CysLT1R). We also demonstrated that CysLT1R on mast cells exists as a heterodimer with the type 2 receptor for cys-LTs (CysLT2R), and that the latter is a potent negative regulator of the former. Most recently, we discovered that LTE4 only a weak agonist of CysLT1R and CysLT2R, is the most potent member of this mediator class for causing chemokine generation by mast cells and potentiating pulmonary inflammation in mice. These actions are due to the purinergic receptor P2Y12, which we have shown to be the long-elusive third cys-LT receptor. We plan to translate these observations into the clinic, and will test the efficacy of a P2Y12 antagonist on clinical reactions to aspirin challenge in aspirin-intolerant asthmatic individuals as a major goal of a U19 funded by NIAID.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI136041 (BOYCE, JOSHUA A) Dec 4, 2017 - Nov 30, 2022
    NIH/NIAID
    Eicosanoid Networks in Aspirin Hypersensitivity
    Role: Principal Investigator
  2. R01HL136209 (PENN, RAYMOND B.) Feb 1, 2017 - Jan 31, 2021
    NIH/NHLBI
    Optimizing EP receptor subtype targeting for asthma therapy
    Role: Co-Principal Investigator
  3. R21AI115137 (BOYCE, JOSHUA A) Dec 5, 2014 - Nov 30, 2016
    NIH
    Characterization of a Novel Growth and Survival Factor for Human Mast Cells
    Role: Principal Investigator
  4. R01HL117945 (BOYCE, JOSHUA A) Jun 15, 2013 - Apr 30, 2017
    NIH/NHLBI
    Eicosanoid Networks in Aspirin Exacerbated Respiratory Disease
    Role: Principal Investigator
  5. U19AI095219 (BOYCE, JOSHUA A) Jul 15, 2011 - Jun 30, 2021
    NIH/NIAID
    Pathophysiologic and Therapeutic Mechanisms in Aspirin Exacerbated Respiratory Disease
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pan D, Buchheit KM, Samuchiwal SK, Liu T, Cirka H, Raff H, Boyce JA. COX-1 mediates IL-33-induced extracellular signal-regulated kinase activation in mast cells: Implications for aspirin sensitivity. J Allergy Clin Immunol. 2018 Jul 12. PMID: 30017554.
    View in: PubMed
  2. Laidlaw TM, Cahill KN, Cardet JC, Murphy K, Cui J, Dioneda B, Kothari P, Raby BA, Israel E, Boyce JA. A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2018 Jun 08. PMID: 29890239.
    View in: PubMed
  3. Samuchiwal SK, Boyce JA. Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology. J Allergy Clin Immunol. 2018 Apr; 141(4):1182-1190. PMID: 29477727.
    View in: PubMed
  4. Liu T, Barrett NA, Kanaoka Y, Yoshimoto E, Garofalo D, Cirka H, Feng C, Boyce JA. Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. J Immunol. 2018 Feb 01; 200(3):915-927. PMID: 29282304.
    View in: PubMed
  5. Yamaguchi M, Samuchiwal SK, Quehenberger O, Boyce JA, Balestrieri B. Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms. Mucosal Immunol. 2018 May; 11(3):615-626. PMID: 29346348.
    View in: PubMed
  6. Cahill KN, Boyce JA, Israel E. Novel Treatments for Airway Disease. N Engl J Med. 2017 08 10; 377(6):597. PMID: 28813135.
    View in: PubMed
  7. Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N Engl J Med. 2017 05 18; 376(20):1911-1920. PMID: 28514613.
    View in: PubMed
  8. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. J Acad Nutr Diet. 2017 May; 117(5):788-793. PMID: 28449793.
    View in: PubMed
  9. Samuchiwal SK, Balestrieri B, Raff H, Boyce JA. Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway. J Biol Chem. 2017 05 19; 292(20):8195-8206. PMID: 28341741.
    View in: PubMed
  10. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States. JAAPA. 2017 Mar; 30(3):1-5. PMID: 28151739.
    View in: PubMed
  11. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. Ann Allergy Asthma Immunol. 2017 02; 118(2):166-173.e7. PMID: 28065802.
    View in: PubMed
  12. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. J Pediatr Nurs. 2017 Jan - Feb; 32:91-98. PMID: 28137368.
    View in: PubMed
  13. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. Pediatr Dermatol. 2017 Jan; 34(1):e1-e21. PMID: 28054723.
    View in: PubMed
  14. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. Pediatr Dermatol. 2017 Jan; 34(1):5-12. PMID: 28054718.
    View in: PubMed
  15. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol. 2017 Jan; 139(1):29-44. PMID: 28065278.
    View in: PubMed
  16. Cahill KN, Boyce JA. Aspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease. J Allergy Clin Immunol. 2017 Mar; 139(3):764-766. PMID: 27771324.
    View in: PubMed
  17. Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NA. Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7. PMID: 27185938; PMCID: PMC4896673 [Available on 11/30/16].
  18. Laidlaw TM, Boyce JA. Aspirin-Exacerbated Respiratory Disease--New Prime Suspects. N Engl J Med. 2016 Feb 04; 374(5):484-8. PMID: 26840139.
    View in: PubMed
  19. Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. Am J Respir Cell Mol Biol. 2016 Jan; 54(1):34-40. PMID: 26051534; PMCID: PMC4742927 [Available on 01/01/17].
  20. Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 05; 137(5):1566-1576.e5. PMID: 26691435.
    View in: PubMed
  21. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029; PMCID: PMC4592820 [Available on 10/15/16].
  22. Kondeti V, Al-Azzam N, Duah E, Thodeti CK, Boyce JA, Paruchuri S. Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. J Allergy Clin Immunol. 2016 Jan; 137(1):289-298. PMID: 26255103.
    View in: PubMed
  23. Laidlaw TM, Boyce JA. Platelets in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jun; 135(6):1407-14; quiz 1415. PMID: 26051947; PMCID: PMC4559084.
  24. Liu T, Garofalo D, Feng C, Lai J, Katz H, Laidlaw TM, Boyce JA. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. J Immunol. 2015 Jun 01; 194(11):5061-8. PMID: 25904552; PMCID: PMC4433852.
  25. Boyce JA, Barrett NA. Cysteinyl leukotrienes: an innate system for epithelial control of airway smooth muscle proliferation? Am J Respir Crit Care Med. 2015 Mar 01; 191(5):496-7. PMID: 25723820; PMCID: PMC4384772.
  26. Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E. LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Springerplus. 2014; 3:661. PMID: 25485197; PMCID: PMC4236308.
  27. Cahill KN, Bensko JC, Boyce JA, Laidlaw TM. Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jan; 135(1):245-52. PMID: 25218285.
    View in: PubMed
  28. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors; emerging concepts. Allergy Asthma Immunol Res. 2014 Jul; 6(4):288-95. PMID: 24991451; PMCID: PMC4077954.
  29. Laidlaw TM, Cutler AJ, Kidder MS, Liu T, Cardet JC, Chhay H, Feng C, Boyce JA. Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2014 Jun; 133(6):1692-701.e3. PMID: 24486071.
    View in: PubMed
  30. Laidlaw TM, Cutler A, Kidder M, Chhay H, Cardet JC, Feng C, Liu T, Boyce JA. Prostaglandin E2 Resistance in Granulocytes from Patients with Aspirin Exacerbated Respiratory Disease. J. Allergy Clinical Immunology. 2014.
  31. Cummings HE, Liu T, Feng C, Laidlaw TM, Conley PB, Kanaoka Y, Boyce JA. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. J Immunol. 2013 Dec 15; 191(12):5807-10. PMID: 24244016; PMCID: PMC3869987.
  32. Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids Health Dis. 2013 Oct 02; 12:141. PMID: 24088297; PMCID: PMC3851449.
  33. Liu T, Laidlaw TM, Katz HR, Boyce JA. Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16987-92. PMID: 24085850; PMCID: PMC3801005.
  34. Kondeti V, Duah E, Al-Azzam N, Thodeti CK, Boyce JA, Paruchuri S. Differential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells. PLoS One. 2013; 8(8):e71536. PMID: 23977066; PMCID: PMC3744564.
  35. Fanning LB, Boyce JA. Lipid mediators and allergic diseases. Ann Allergy Asthma Immunol. 2013 Sep; 111(3):155-62. PMID: 23987187; PMCID: PMC4088989.
  36. Barrett NA, Boyce JA. Activation of group 2 innate lymphoid cells: a new role for cysteinyl leukotrienes. J Allergy Clin Immunol. 2013 Jul; 132(1):214-6. PMID: 23810099; PMCID: PMC4024825.
  37. Ohta S, Imamura M, Xing W, Boyce JA, Balestrieri B. Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol. 2013 Jun 15; 190(12):5927-38. PMID: 23650617; PMCID: PMC3939699.
  38. Boyce JA, Peebles RS. Regulation of Th9-type pulmonary immune responses: a new role for COX-2. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):785-6. PMID: 23586375; PMCID: PMC3707373.
  39. Bochner BS, Rothenberg ME, Boyce JA, Finkelman F. Advances in mechanisms of allergy and clinical immunology in 2012. J Allergy Clin Immunol. 2013 Mar; 131(3):661-7. PMID: 23352632.
    View in: PubMed
  40. Laidlaw TM, Boyce JA. Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am. 2013 May; 33(2):195-210. PMID: 23639708; PMCID: PMC3781366.
  41. Cardet JC, Boyce JA. Addition of mycophenolate mofetil to tacrolimus is associated with decreases in food-specific IgE levels in a pediatric patient with liver transplantation-associated food allergy. J Allergy Clin Immunol Pract. 2013 Jan; 1(1):104-6. PMID: 24229832; PMCID: PMC4341888.
  42. Laidlaw TM, Boyce JA. Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin Exp Allergy. 2012 Sep; 42(9):1313-20. PMID: 22925317; PMCID: PMC3773244.
  43. Liu T, Laidlaw TM, Feng C, Xing W, Shen S, Milne GL, Boyce JA. Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12692-7. PMID: 22802632; PMCID: PMC3411985.
  44. Adachi R, Krilis SA, Nigrovic PA, Hamilton MJ, Chung K, Thakurdas SM, Boyce JA, Anderson P, Stevens RL. Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. J Biol Chem. 2012 Jun 08; 287(24):20047-55. PMID: 22511759; PMCID: PMC3370188.
  45. Simarro M, Giannattasio G, Xing W, Lundequist EM, Stewart S, Stevens RL, Orduña A, Boyce JA, Anderson PJ. The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett. 2012 Aug 30; 146(1-2):8-14. PMID: 22525013; PMCID: PMC3407291.
  46. Boyce JA, Bochner B, Finkelman FD, Rothenberg ME. Advances in mechanisms of asthma, allergy, and immunology in 2011. J Allergy Clin Immunol. 2012 Feb; 129(2):335-41. PMID: 22284930.
    View in: PubMed
  47. Bunyavanich S, Boyce JA, Raby BA, Weiss ST. Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma. Clin Exp Allergy. 2012 Feb; 42(2):229-37. PMID: 22010907; PMCID: PMC3353543.
  48. Laidlaw TM, Kidder MS, Bhattacharyya N, Xing W, Shen S, Milne GL, Castells MC, Chhay H, Boyce JA. Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood. 2012 Apr 19; 119(16):3790-8. PMID: 22262771; PMCID: PMC3335383.
  49. Burks AW, Jones SM, Boyce JA, Sicherer SH, Wood RA, Assa'ad A, Sampson HA. NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population. Pediatrics. 2011 Nov; 128(5):955-65. PMID: 21987705; PMCID: PMC3208961.
  50. Cozzi E, Ackerman KG, Lundequist A, Drazen JM, Boyce JA, Beier DR. The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12787-92. PMID: 21768379; PMCID: PMC3150901.
  51. Giannattasio G, Ohta S, Boyce JR, Xing W, Balestrieri B, Boyce JA. The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation. J Immunol. 2011 Aug 01; 187(3):1486-95. PMID: 21724990; PMCID: PMC3140636.
  52. Lundequist A, Boyce JA. LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1ß release. PLoS One. 2011 Mar 28; 6(3):e18192. PMID: 21464938; PMCID: PMC3065470.
  53. Boyce JA, Assa'a A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel Report. Nutrition. 2011 Feb; 27(2):253-67. PMID: 21215925.
    View in: PubMed
  54. Laidlaw TM, Steinke JW, Tiñana AM, Feng C, Xing W, Lam BK, Paruchuri S, Boyce JA, Borish L. Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FceRI. J Allergy Clin Immunol. 2011 Mar; 127(3):815-22.e1-5. PMID: 21281958; PMCID: PMC3052637.
  55. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. Nutr Res. 2011 Jan; 31(1):61-75. PMID: 21310308.
    View in: PubMed
  56. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel report. J Am Acad Dermatol. 2011 Jan; 64(1):175-92. PMID: 21167411.
    View in: PubMed
  57. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ. Guidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-sponsored expert panel report. J Am Diet Assoc. 2011 Jan; 111(1):17-27. PMID: 21185960.
    View in: PubMed
  58. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010 Dec; 126(6 Suppl):S1-58. PMID: 21134576.
    View in: PubMed
  59. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol. 2010 Dec; 126(6):1105-18. PMID: 21134568.
    View in: PubMed
  60. Giannattasio G, Fujioka D, Xing W, Katz HR, Boyce JA, Balestrieri B. Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. J Immunol. 2010 Oct 01; 185(7):4430-8. PMID: 20817863; PMCID: PMC3003260.
  61. Simarro M, Giannattasio G, De la Fuente MA, Benarafa C, Subramanian KK, Ishizawar R, Balestrieri B, Andersson EM, Luo HR, Orduña A, Boyce J, Anderson P. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol. 2010 May 01; 184(9):5325-32. PMID: 20363972; PMCID: PMC2858774.
  62. Finkelman FD, Boyce JA, Vercelli D, Rothenberg ME. Key advances in mechanisms of asthma, allergy, and immunology in 2009. J Allergy Clin Immunol. 2010 Feb; 125(2):312-8. PMID: 20159240.
    View in: PubMed
  63. Lundequist A, Nallamshetty SN, Xing W, Feng C, Laidlaw TM, Uematsu S, Akira S, Boyce JA. Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J Immunol. 2010 Jan 01; 184(1):433-41. PMID: 20028661; PMCID: PMC3721536.
  64. Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, Kanaoka Y, Conley P, Boyce JA. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med. 2009 Oct 26; 206(11):2543-55. PMID: 19822647; PMCID: PMC2768854.
  65. Austen KF, Maekawa A, Kanaoka Y, Boyce JA. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol. 2009 Sep; 124(3):406-14; quiz 415-6. PMID: 19647860; PMCID: PMC2739263.
  66. Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol. 2009 Aug 01; 183(3):2016-26. PMID: 19587017; PMCID: PMC3755459.
  67. Boyce JA, Broide D, Matsumoto K, Bochner BS. Advances in mechanisms of asthma, allergy, and immunology in 2008. J Allergy Clin Immunol. 2009 Mar; 123(3):569-74. PMID: 19281904; PMCID: PMC2671063.
  68. Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JA. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol. 2009 Jan 15; 182(2):1129-37. PMID: 19124756; PMCID: PMC2615395.
  69. Boyce JA. Eicosanoids in asthma, allergic inflammation, and host defense. Curr Mol Med. 2008 Aug; 8(5):335-49. PMID: 18691060.
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  70. Paruchuri S, Jiang Y, Feng C, Francis SA, Plutzky J, Boyce JA. Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem. 2008 Jun 13; 283(24):16477-87. PMID: 18411276; PMCID: PMC2423236.
  71. Jiang Y, Borrelli LA, Kanaoka Y, Bacskai BJ, Boyce JA. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood. 2007 Nov 01; 110(9):3263-70. PMID: 17693579; PMCID: PMC2200919.
  72. Gonzalo JA, Qiu Y, Lora JM, Al-Garawi A, Villeval JL, Boyce JA, Martinez-A C, Marquez G, Goya I, Hamid Q, Fraser CC, Picarella D, Cote-Sierra J, Hodge MR, Gutierrez-Ramos JC, Kolbeck R, Coyle AJ. Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis. J Immunol. 2007 Aug 01; 179(3):1740-50. PMID: 17641040.
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  73. Boyce JA. Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation. Immunol Rev. 2007 Jun; 217:168-85. PMID: 17498059.
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  74. Jiang Y, Kanaoka Y, Feng C, Nocka K, Rao S, Boyce JA. Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. J Immunol. 2006 Sep 01; 177(5):2755-9. PMID: 16920908.
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  75. Boyce JA. Asthma 2005-2006: bench to bedside. J Allergy Clin Immunol. 2006 Sep; 118(3):582-6. PMID: 16950274.
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  76. Tournilhac O, Santos DD, Xu L, Kutok J, Tai YT, Le Gouill S, Catley L, Hunter Z, Branagan AR, Boyce JA, Munshi N, Anderson KC, Treon SP. Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. Ann Oncol. 2006 Aug; 17(8):1275-82. PMID: 16788002.
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  77. Gurish MF, Boyce JA. Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell. J Allergy Clin Immunol. 2006 Jun; 117(6):1285-91. PMID: 16750988.
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  78. Boyce JA. Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE. J Allergy Clin Immunol. 2006 Jun; 117(6):1415-8. PMID: 16751006.
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  79. Metcalfe DD, Boyce JA. Mast cell biology in evolution. J Allergy Clin Immunol. 2006 Jun; 117(6):1227-9. PMID: 16750978.
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  80. Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MF. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood. 2006 Sep 01; 108(5):1588-94. PMID: 16670268; PMCID: PMC1895513.
  81. Lin DA, Boyce JA. Lysophospholipids as mediators of immunity. Adv Immunol. 2006; 89:141-67. PMID: 16682274.
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  82. Feng C, Beller EM, Bagga S, Boyce JA. Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses. Blood. 2006 Apr 15; 107(8):3243-50. PMID: 16357326; PMCID: PMC1895755.
  83. Lin DA, Boyce JA. IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells. J Immunol. 2005 Oct 15; 175(8):5430-8. PMID: 16210650.
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  84. Boyce JA, Austen KF. No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med. 2005 Jun 20; 201(12):1869-73. PMID: 15967817; PMCID: PMC2212041.
  85. Boyce JA. Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implications. Chem Immunol Allergy. 2005; 87:59-79. PMID: 16107763.
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  86. Feng C, Mery AG, Beller EM, Favot C, Boyce JA. Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptor. J Immunol. 2004 Dec 15; 173(12):7539-47. PMID: 15585881.
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  87. Bagga S, Price KS, Lin DA, Friend DS, Austen KF, Boyce JA. Lysophosphatidic acid accelerates the development of human mast cells. Blood. 2004 Dec 15; 104(13):4080-7. PMID: 15319282.
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  88. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol. 2004 Aug 01; 173(3):1503-10. PMID: 15265876.
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  89. Boyce JA. The biology of the mast cell. Allergy Asthma Proc. 2004 Jan-Feb; 25(1):27-30. PMID: 15055558.
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  90. Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DK, Beck LA, Boyce JA, Filipovich AH, Villanueva JM, Sutton SA, Assa'ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol. 2004 Jan; 113(1):115-9. PMID: 14699394.
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  91. Lora JM, Al-Garawi A, Pickard MD, Price KS, Bagga S, Sicoli J, Hodge MR, Gutiérrez-Ramos JC, Briskin MJ, Boyce JA. FcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines. J Allergy Clin Immunol. 2003 Dec; 112(6):1119-26. PMID: 14657870.
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  92. Lin DA, Boyce JA. The idiopathic hypereosinophilic syndrome. Allergy Asthma Proc. 2003 Nov-Dec; 24(6):417-20. PMID: 14763243.
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  93. Mellor EA, Frank N, Soler D, Hodge MR, Lora JM, Austen KF, Boyce JA. Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11589-93. PMID: 13679572; PMCID: PMC208802.
  94. Boyce JA. The role of mast cells in asthma. Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep; 69(2-3):195-205. PMID: 12895603.
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  95. Price KS, Friend DS, Mellor EA, De Jesus N, Watts GF, Boyce JA. CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13. Am J Respir Cell Mol Biol. 2003 Apr; 28(4):420-7. PMID: 12654630.
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  96. Boyce JA. Mast cells: beyond IgE. J Allergy Clin Immunol. 2003 Jan; 111(1):24-32; quiz 33. PMID: 12532090.
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  97. Beller TC, Boyce JA. Prolonged anticonvulsant hypersensitivity syndrome related to lamotrigine in a patient with human immunodeficiency virus. Allergy Asthma Proc. 2002 Nov-Dec; 23(6):415-9. PMID: 12528608.
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  98. Wong GW, Foster PS, Yasuda S, Qi JC, Mahalingam S, Mellor EA, Katsoulotos G, Li L, Boyce JA, Krilis SA, Stevens RL. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. J Biol Chem. 2002 Nov 01; 277(44):41906-15. PMID: 12194977.
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  99. Gurish MF, Humbles A, Tao H, Finkelstein S, Boyce JA, Gerard C, Friend DS, Austen KF. CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. J Immunol. 2002 Jun 01; 168(11):5730-6. PMID: 12023373.
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  100. Boyce JA, Mellor EA, Perkins B, Lim YC, Luscinskas FW. Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood. 2002 Apr 15; 99(8):2890-6. PMID: 11929779.
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  101. Gurish MF, Boyce JA. Mast cell growth, differentiation, and death. Clin Rev Allergy Immunol. 2002 Apr; 22(2):107-18. PMID: 11975418.
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  102. Mellor EA, Austen KF, Boyce JA. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. J Exp Med. 2002 Mar 04; 195(5):583-92. PMID: 11877481; PMCID: PMC2193768.
  103. Bannert N, Farzan M, Friend DS, Ochi H, Price KS, Sodroski J, Boyce JA. Human Mast cell progenitors can be infected by macrophagetropic human immunodeficiency virus type 1 and retain virus with maturation in vitro. J Virol. 2001 Nov; 75(22):10808-14. PMID: 11602722; PMCID: PMC114662.
  104. Mellor EA, Maekawa A, Austen KF, Boyce JA. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):7964-9. PMID: 11438743; PMCID: PMC35451.
  105. Austen KF, Boyce JA. Mast cell lineage development and phenotypic regulation. Leuk Res. 2001 Jul; 25(7):511-8. PMID: 11377675.
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  106. Hou FF, Miyata T, Boyce J, Yuan Q, Chertow GM, Kay J, Schmidt AM, Owen WF. beta(2)-Microglobulin modified with advanced glycation end products delays monocyte apoptosis. Kidney Int. 2001 Mar; 59(3):990-1002. PMID: 11231354.
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  107. Silverman ES, De Sanctis GT, Boyce J, Maclean JA, Jiao A, Green FH, Grasemann H, Faunce D, Fitzmaurice G, Shi GP, Stein-Streilein J, Milbrandt J, Collins T, Drazen JM. The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):778-85. PMID: 11254538.
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  108. Hsieh FH, Lam BK, Penrose JF, Austen KF, Boyce JA. T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4. J Exp Med. 2001 Jan 01; 193(1):123-33. PMID: 11136826.
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  109. Ochi H, De Jesus NH, Hsieh FH, Austen KF, Boyce JA. IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10509-13. PMID: 10973484; PMCID: PMC27055.
  110. Hou FF, Boyce J, Zhang Y, Owen WF. Phenotypic and functional characteristics of macrophage-like cells differentiated in pro-inflammatory cytokine-containing cultures. Immunol Cell Biol. 2000 Jun; 78(3):205-13. PMID: 10849108.
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  111. Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, Boyce JA. T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med. 1999 Jul 19; 190(2):267-80. PMID: 10432289.
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  112. Yuan Q, Gurish MF, Friend DS, Austen KF, Boyce JA. Generation of a novel stem cell factor-dependent mast cell progenitor. J Immunol. 1998 Nov 15; 161(10):5143-6. PMID: 9820483.
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  113. Owen WF, Hou FF, Stuart RO, Kay J, Boyce J, Chertow GM, Schmidt AM. Beta 2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts. Kidney Int. 1998 May; 53(5):1365-73. PMID: 9573554.
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  114. Hou FF, Boyce J, Chertow GM, Kay J, Owen WF. Aminoguanidine inhibits advanced glycation end products formation on beta2-microglobulin. J Am Soc Nephrol. 1998 Feb; 9(2):277-83. PMID: 9527404.
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  115. Castells M, Boyce J. Transfer of peanut allergy by a liver allograft. N Engl J Med. 1998 Jan 15; 338(3):202-3. PMID: 9441233.
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  116. Boyce JA. The pathobiology of eosinophilic inflammation. Allergy Asthma Proc. 1997 Sep-Oct; 18(5):293-300. PMID: 9337423.
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  117. Yuan Q, Austen KF, Friend DS, Heidtman M, Boyce JA. Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1). J Exp Med. 1997 Jul 21; 186(2):313-23. PMID: 9221761; PMCID: PMC2198988.
  118. Hou FF, Chertow GM, Kay J, Boyce J, Lazarus JM, Braatz JA, Owen WF. Interaction between beta 2-microglobulin and advanced glycation end products in the development of dialysis related-amyloidosis. Kidney Int. 1997 May; 51(5):1514-9. PMID: 9150467.
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  119. Boyce JA, Lam BK, Penrose JF, Friend DS, Parsons S, Owen WF, Austen KF. Expression of LTC4 synthase during the development of eosinophils in vitro from cord blood progenitors. Blood. 1996 Dec 01; 88(11):4338-47. PMID: 8943871.
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  120. Penrose JF, Spector J, Baldasaro M, Xu K, Boyce J, Arm JP, Austen KF, Lam BK. Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. J Biol Chem. 1996 May 10; 271(19):11356-61. PMID: 8626689.
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  121. Boyce JA, Friend D, Gurish MF, Austen KF, Owen WF. Constitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2436-41. PMID: 8637892; PMCID: PMC39815.
  122. Boyce JA, Friend D, Matsumoto R, Austen KF, Owen WF. Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate. J Exp Med. 1995 Jul 01; 182(1):49-57. PMID: 7540656; PMCID: PMC2192091.
  123. Boyce JA, Bernhard JD. Total skin examination: patient reactions. J Am Acad Dermatol. 1986 Feb; 14(2 Pt 1):280. PMID: 3950126.
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