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Joshua A. Boyce, M.D.

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Biography
1981
Dowd-Lester Award
1981
Charlotte Fahey Award
1995 - 2000
Physician-Scientist Award (K08)
2012
Alpha Omega Alpha (Alumini Member)
2012
AAAAI Special Recognition Award

Overview
The overall goal of my lab is to apply principals of pathophysiology of allergic diseases in humans to questions at the bench, and in turn to bring fundamental findings made at the bench back to the clinic. The dominant themes include how lipid mediators and their receptors function in a network to control the development and activation of mast cells, a central cell type in the effector phases of all allergic diseases. We defined the growth factor requirements for the development of human mast cells from their earliest progenitors, and identified a key role for interleukin (IL)-4 as an accessory mitogen. Human mast cells exposed to IL-4 become competent to generate leukotriene C4 (LTC4) the precursor of the powerful bronchoconstrictor LTD4 and the stable metabolite LTE4. This competence is due to the induced expression of LTC4 synthase, the requisite terminal enzyme involved in LTC4 synthesis. These observations explain why mucosal inflammation elicits a mast cell hyperplasia accompanied by strikingly increased regional concentrations of LTC4 LTD4 and LTE4. We discovered that the growth potentiating effect of IL-4 depended on the induction of LTC4S, and the transactivation of the c-kit tyrosine kinase by the type 1 receptor for cys-LTs (CysLT1R). We also demonstrated that CysLT1R on mast cells exists as a heterodimer with the type 2 receptor for cys-LTs (CysLT2R), and that the latter is a potent negative regulator of the former. Most recently, we discovered that LTE4 only a weak agonist of CysLT1R and CysLT2R, is the most potent member of this mediator class for causing chemokine generation by mast cells and potentiating pulmonary inflammation in mice. These actions are due to the purinergic receptor P2Y12, which we have shown to be the long-elusive third cys-LT receptor. We plan to translate these observations into the clinic, and will test the efficacy of a P2Y12 antagonist on clinical reactions to aspirin challenge in aspirin-intolerant asthmatic individuals as a major goal of a U19 funded by NIAID.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI136041 (BOYCE, JOSHUA A) Dec 4, 2017 - Nov 30, 2022
    NIH
    Eicosanoid Networks in Aspirin Hypersensitivity
    Role: Principal Investigator
  2. R01HL136209 (PENN, RAYMOND B.) Feb 1, 2017 - Jan 31, 2021
    NIH
    Optimizing EP receptor subtype targeting for asthma therapy
    Role: Co-Principal Investigator
  3. R21AI115137 (BOYCE, JOSHUA A) Dec 5, 2014 - Nov 30, 2016
    NIH
    Characterization of a Novel Growth and Survival Factor for Human Mast Cells
    Role: Principal Investigator
  4. R01HL117945 (BOYCE, JOSHUA A) Jun 15, 2013 - Apr 30, 2017
    NIH
    Eicosanoid Networks in Aspirin Exacerbated Respiratory Disease
    Role: Principal Investigator
  5. U19AI095219 (BOYCE, JOSHUA A) Jul 15, 2011 - Apr 30, 2026
    NIH
    Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mullol J, Boyce J, Dahlén SE, Dahlén B, Picado C, Bobolea I. Eicosanoid dysregulation and type 2 inflammation in AERD. J Allergy Clin Immunol. 2021 Nov; 148(5):1157-1160. PMID: 34464635.
    Citations:    Fields:    
  2. Dwyer DF, Boyce JA. Reply. J Allergy Clin Immunol. 2021 09; 148(3):904. PMID: 34183166.
    Citations:    Fields:    
  3. Dwyer DF, Boyce JA. Neonatal mast cells and transplacental IgE transfer: A mechanism of disease inheritance or of passive infant barrier defense? J Allergy Clin Immunol. 2021 07; 148(1):76-77. PMID: 33872654.
    Citations:    Fields:    Translation:HumansCells
  4. Baek SH, Foer D, Cahill KN, Israel E, Maiorino E, Röhl A, Boyce JA, Weiss ST. Systems Approaches to Treatment Response to Imatinib in Severe Asthma: A Pilot Study. J Pers Med. 2021 Mar 25; 11(4). PMID: 33805900.
    Citations:    
  5. Dwyer DF, Ordovas-Montanes J, Allon SJ, Buchheit KM, Vukovic M, Derakhshan T, Feng C, Lai J, Hughes TK, Nyquist SK, Giannetti MP, Berger B, Bhattacharyya N, Roditi RE, Katz HR, Nawijn MC, Berg M, van den Berge M, Laidlaw TM, Shalek AK, Barrett NA, Boyce JA. Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Sci Immunol. 2021 Feb 26; 6(56). PMID: 33637594.
    Citations: 3     Fields:    
  6. Derakhshan T, Samuchiwal SK, Hallen N, Bankova LG, Boyce JA, Barrett NA, Austen KF, Dwyer DF. Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation. J Exp Med. 2021 01 04; 218(1). PMID: 32946563.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Liu T, Barrett NA, Nagai J, Lai J, Feng C, Boyce JA. Leukotriene D4 paradoxically limits LTC4-driven platelet activation and lung immunopathology. J Allergy Clin Immunol. 2021 07; 148(1):195-208.e5. PMID: 33285161.
    Citations: 2     Fields:    Translation:AnimalsCells
  8. Wang L, Foer D, Bates DW, Boyce JA, Zhou L. Risk factors for hospitalization, intensive care, and mortality among patients with asthma and COVID-19. J Allergy Clin Immunol. 2020 10; 146(4):808-812. PMID: 32735807.
    Citations: 16     Fields:    Translation:HumansCellsPHPublic Health
  9. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020 05 28; 181(5):1016-1035.e19. PMID: 32413319.
    Citations: 716     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  10. Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM. IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 06; 145(6):1574-1584. PMID: 32199912.
    Citations: 5     Fields:    Translation:HumansCells
  11. Nagai J, Balestrieri B, Fanning LB, Kyin T, Cirka H, Lin J, Idzko M, Zech A, Kim EY, Brennan PJ, Boyce JA. P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation. J Clin Invest. 2019 12 02; 129(12):5169-5186. PMID: 31638598.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Boyce JA. Mast cells can be commandeered for staphylococcal pathogenicity in patients with chronic rhinosinusitis with nasal polyposis. J Allergy Clin Immunol. 2020 01; 145(1):103-104. PMID: 31738995.
    Citations:    Fields:    Translation:HumansCells
  13. Boyce JA. Legends of allergy and immunology: K. Frank Austen. Allergy. 2020 04; 75(4):1001-1002. PMID: 31560800.
    Citations:    Fields:    
  14. Boyce JA. Aspirin sensitivity: Lessons in the regulation (and dysregulation) of mast cell function. J Allergy Clin Immunol. 2019 10; 144(4):875-881. PMID: 31587797.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Cahill KN, Cui J, Kothari P, Murphy K, Raby BA, Singer J, Israel E, Boyce JA, Laidlaw TM. Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-exacerbated Respiratory Disease. A Prospective Trial. Am J Respir Crit Care Med. 2019 09 15; 200(6):704-711. PMID: 30978291.
    Citations: 18     Fields:    Translation:Humans
  16. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 05; 12(3):679-690. PMID: 30664709.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  17. Cahill KN, Murphy K, Singer J, Israel E, Boyce JA, Laidlaw TM. Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 02; 143(2):799-803.e2. PMID: 30339852.
    Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
  18. Bankova LG, Boyce JA. A new spin on mast cells and cysteinyl leukotrienes: Leukotriene E4 activates mast cells in vivo. J Allergy Clin Immunol. 2018 10; 142(4):1056-1057. PMID: 30165055.
    Citations: 1     Fields:    Translation:HumansCells
  19. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 08; 560(7720):649-654. PMID: 30135581.
    Citations: 77     Fields:    Translation:HumansCells
  20. Pan D, Buchheit KM, Samuchiwal SK, Liu T, Cirka H, Raff H, Boyce JA. COX-1 mediates IL-33-induced extracellular signal-regulated kinase activation in mast cells: Implications for aspirin sensitivity. J Allergy Clin Immunol. 2019 03; 143(3):1047-1057.e8. PMID: 30017554.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Laidlaw TM, Cahill KN, Cardet JC, Murphy K, Cui J, Dioneda B, Kothari P, Raby BA, Israel E, Boyce JA. A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 01; 143(1):316-324.e7. PMID: 29890239.
    Citations: 11     Fields:    Translation:Humans
  22. Samuchiwal SK, Boyce JA. Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology. J Allergy Clin Immunol. 2018 04; 141(4):1182-1190. PMID: 29477727.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  23. Liu T, Barrett NA, Kanaoka Y, Yoshimoto E, Garofalo D, Cirka H, Feng C, Boyce JA. Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. J Immunol. 2018 02 01; 200(3):915-927. PMID: 29282304.
    Citations: 17     Fields:    Translation:AnimalsCells
  24. Yamaguchi M, Samuchiwal SK, Quehenberger O, Boyce JA, Balestrieri B. Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms. Mucosal Immunol. 2018 05; 11(3):615-626. PMID: 29346348.
    Citations: 12     Fields:    Translation:AnimalsCells
  25. Cahill KN, Boyce JA, Israel E. Novel Treatments for Airway Disease. N Engl J Med. 2017 08 10; 377(6):597. PMID: 28813135.
    Citations:    Fields:    
  26. Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N Engl J Med. 2017 05 18; 376(20):1911-1920. PMID: 28514613.
    Citations: 47     Fields:    Translation:HumansCells
  27. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. J Acad Nutr Diet. 2017 05; 117(5):788-793. PMID: 28449793.
    Citations: 6     Fields:    Translation:Humans
  28. Samuchiwal SK, Balestrieri B, Raff H, Boyce JA. Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway. J Biol Chem. 2017 05 19; 292(20):8195-8206. PMID: 28341741.
    Citations: 13     Fields:    Translation:AnimalsCells
  29. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States. JAAPA. 2017 Mar; 30(3):1-5. PMID: 28151739.
    Citations: 1     Fields:    Translation:HumansAnimals
  30. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. Ann Allergy Asthma Immunol. 2017 02; 118(2):166-173.e7. PMID: 28065802.
    Citations: 16     Fields:    Translation:Humans
  31. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. J Pediatr Nurs. 2017 Jan - Feb; 32:91-98. PMID: 28137368.
    Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
  32. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. Pediatr Dermatol. 2017 Jan; 34(1):e1-e21. PMID: 28054723.
    Citations: 3     Fields:    Translation:HumansAnimals
  33. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. Pediatr Dermatol. 2017 Jan; 34(1):5-12. PMID: 28054718.
    Citations: 4     Fields:    Translation:HumansAnimals
  34. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol. 2017 Jan; 139(1):29-44. PMID: 28065278.
    Citations: 71     Fields:    Translation:HumansAnimals
  35. Cahill KN, Boyce JA. Aspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease. J Allergy Clin Immunol. 2017 03; 139(3):764-766. PMID: 27771324.
    Citations: 7     Fields:    Translation:Humans
  36. Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NA. Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7. PMID: 27185938.
    Citations: 38     Fields:    Translation:AnimalsCells
  37. Laidlaw TM, Boyce JA. Aspirin-Exacerbated Respiratory Disease--New Prime Suspects. N Engl J Med. 2016 Feb 04; 374(5):484-8. PMID: 26840139.
    Citations: 39     Fields:    Translation:Humans
  38. Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. Am J Respir Cell Mol Biol. 2016 Jan; 54(1):34-40. PMID: 26051534.
    Citations: 21     Fields:    Translation:HumansCells
  39. Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 05; 137(5):1566-1576.e5. PMID: 26691435.
    Citations: 47     Fields:    Translation:HumansCells
  40. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029.
    Citations: 40     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  41. Kondeti V, Al-Azzam N, Duah E, Thodeti CK, Boyce JA, Paruchuri S. Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. J Allergy Clin Immunol. 2016 Jan; 137(1):289-298. PMID: 26255103.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  42. Laidlaw TM, Boyce JA. Platelets in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jun; 135(6):1407-14; quiz 1415. PMID: 26051947.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  43. Liu T, Garofalo D, Feng C, Lai J, Katz H, Laidlaw TM, Boyce JA. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. J Immunol. 2015 Jun 01; 194(11):5061-8. PMID: 25904552.
    Citations: 8     Fields:    Translation:AnimalsCells
  44. Boyce JA, Barrett NA. Cysteinyl leukotrienes: an innate system for epithelial control of airway smooth muscle proliferation? Am J Respir Crit Care Med. 2015 Mar 01; 191(5):496-7. PMID: 25723820.
    Citations: 2     Fields:    Translation:HumansAnimals
  45. Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E. LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Springerplus. 2014; 3:661. PMID: 25485197.
    Citations: 2     
  46. Cahill KN, Bensko JC, Boyce JA, Laidlaw TM. Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jan; 135(1):245-52. PMID: 25218285.
    Citations: 66     Fields:    Translation:HumansCells
  47. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors; emerging concepts. Allergy Asthma Immunol Res. 2014 Jul; 6(4):288-95. PMID: 24991451.
    Citations: 37     
  48. Laidlaw TM, Cutler AJ, Kidder MS, Liu T, Cardet JC, Chhay H, Feng C, Boyce JA. Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2014 Jun; 133(6):1692-701.e3. PMID: 24486071.
    Citations: 18     Fields:    Translation:HumansCells
  49. Laidlaw TM, Cutler A, Kidder M, Chhay H, Cardet JC, Feng C, Liu T, Boyce JA. Prostaglandin E2 Resistance in Granulocytes from Patients with Aspirin Exacerbated Respiratory Disease. J. Allergy Clinical Immunology. 2014.
  50. Cummings HE, Liu T, Feng C, Laidlaw TM, Conley PB, Kanaoka Y, Boyce JA. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. J Immunol. 2013 Dec 15; 191(12):5807-10. PMID: 24244016.
    Citations: 15     Fields:    Translation:AnimalsCells
  51. Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids Health Dis. 2013 Oct 02; 12:141. PMID: 24088297.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  52. Liu T, Laidlaw TM, Katz HR, Boyce JA. Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16987-92. PMID: 24085850.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  53. Kondeti V, Duah E, Al-Azzam N, Thodeti CK, Boyce JA, Paruchuri S. Differential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells. PLoS One. 2013; 8(8):e71536. PMID: 23977066.
    Citations: 8     Fields:    Translation:HumansCells
  54. Fanning LB, Boyce JA. Lipid mediators and allergic diseases. Ann Allergy Asthma Immunol. 2013 Sep; 111(3):155-62. PMID: 23987187.
    Citations: 24     Fields:    Translation:HumansAnimals
  55. Barrett NA, Boyce JA. Activation of group 2 innate lymphoid cells: a new role for cysteinyl leukotrienes. J Allergy Clin Immunol. 2013 Jul; 132(1):214-6. PMID: 23810099.
    Citations: 2     Fields:    Translation:AnimalsCells
  56. Ohta S, Imamura M, Xing W, Boyce JA, Balestrieri B. Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol. 2013 Jun 15; 190(12):5927-38. PMID: 23650617.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  57. Boyce JA, Peebles RS. Regulation of Th9-type pulmonary immune responses: a new role for COX-2. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):785-6. PMID: 23586375.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  58. Bochner BS, Rothenberg ME, Boyce JA, Finkelman F. Advances in mechanisms of allergy and clinical immunology in 2012. J Allergy Clin Immunol. 2013 Mar; 131(3):661-7. PMID: 23352632.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  59. Laidlaw TM, Boyce JA. Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am. 2013 May; 33(2):195-210. PMID: 23639708.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  60. Cardet JC, Boyce JA. Addition of mycophenolate mofetil to tacrolimus is associated with decreases in food-specific IgE levels in a pediatric patient with liver transplantation-associated food allergy. J Allergy Clin Immunol Pract. 2013 Jan; 1(1):104-6. PMID: 24229832.
    Citations: 3     Fields:    Translation:Humans
  61. Laidlaw TM, Boyce JA. Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin Exp Allergy. 2012 Sep; 42(9):1313-20. PMID: 22925317.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  62. Liu T, Laidlaw TM, Feng C, Xing W, Shen S, Milne GL, Boyce JA. Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12692-7. PMID: 22802632.
    Citations: 26     Fields:    Translation:AnimalsCells
  63. Adachi R, Krilis SA, Nigrovic PA, Hamilton MJ, Chung K, Thakurdas SM, Boyce JA, Anderson P, Stevens RL. Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. J Biol Chem. 2012 Jun 08; 287(24):20047-55. PMID: 22511759.
    Citations: 11     Fields:    Translation:AnimalsCells
  64. Simarro M, Giannattasio G, Xing W, Lundequist EM, Stewart S, Stevens RL, Orduña A, Boyce JA, Anderson PJ. The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett. 2012 Aug 30; 146(1-2):8-14. PMID: 22525013.
    Citations: 4     Fields:    Translation:AnimalsCells
  65. Boyce JA, Bochner B, Finkelman FD, Rothenberg ME. Advances in mechanisms of asthma, allergy, and immunology in 2011. J Allergy Clin Immunol. 2012 Feb; 129(2):335-41. PMID: 22284930.
    Citations: 15     Fields:    Translation:HumansAnimals
  66. Bunyavanich S, Boyce JA, Raby BA, Weiss ST. Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma. Clin Exp Allergy. 2012 Feb; 42(2):229-37. PMID: 22010907.
    Citations: 9     Fields:    Translation:HumansAnimalsCTClinical Trials
  67. Laidlaw TM, Kidder MS, Bhattacharyya N, Xing W, Shen S, Milne GL, Castells MC, Chhay H, Boyce JA. Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood. 2012 Apr 19; 119(16):3790-8. PMID: 22262771.
    Citations: 83     Fields:    Translation:HumansCells
  68. Burks AW, Jones SM, Boyce JA, Sicherer SH, Wood RA, Assa'ad A, Sampson HA. NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population. Pediatrics. 2011 Nov; 128(5):955-65. PMID: 21987705.
    Citations: 31     Fields:    Translation:Humans
  69. Cozzi E, Ackerman KG, Lundequist A, Drazen JM, Boyce JA, Beier DR. The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12787-92. PMID: 21768379.
    Citations: 9     Fields:    Translation:AnimalsCells
  70. Giannattasio G, Ohta S, Boyce JR, Xing W, Balestrieri B, Boyce JA. The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation. J Immunol. 2011 Aug 01; 187(3):1486-95. PMID: 21724990.
    Citations: 14     Fields:    Translation:AnimalsCells
  71. Lundequist A, Boyce JA. LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1ß release. PLoS One. 2011 Mar 28; 6(3):e18192. PMID: 21464938.
    Citations: 23     Fields:    Translation:HumansCells
  72. Boyce JA, Assa'a A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel Report. Nutrition. 2011 Feb; 27(2):253-67. PMID: 21215925.
    Citations: 17     Fields:    
  73. Laidlaw TM, Steinke JW, Tiñana AM, Feng C, Xing W, Lam BK, Paruchuri S, Boyce JA, Borish L. Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FceRI. J Allergy Clin Immunol. 2011 Mar; 127(3):815-22.e1-5. PMID: 21281958.
    Citations: 20     Fields:    Translation:HumansCells
  74. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. Nutr Res. 2011 Jan; 31(1):61-75. PMID: 21310308.
    Citations: 36     Fields:    Translation:Humans
  75. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel report. J Am Acad Dermatol. 2011 Jan; 64(1):175-92. PMID: 21167411.
    Citations: 13     Fields:    
  76. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ. Guidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-sponsored expert panel report. J Am Diet Assoc. 2011 Jan; 111(1):17-27. PMID: 21185960.
    Citations: 4     Fields:    Translation:Humans
  77. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010 Dec; 126(6 Suppl):S1-58. PMID: 21134576.
    Citations: 338     Fields:    Translation:Humans
  78. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol. 2010 12; 126(6):1105-18. PMID: 21134568.
    Citations: 154     Fields:    Translation:Humans
  79. Giannattasio G, Fujioka D, Xing W, Katz HR, Boyce JA, Balestrieri B. Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. J Immunol. 2010 Oct 01; 185(7):4430-8. PMID: 20817863.
    Citations: 20     Fields:    Translation:AnimalsCells
  80. Simarro M, Giannattasio G, De la Fuente MA, Benarafa C, Subramanian KK, Ishizawar R, Balestrieri B, Andersson EM, Luo HR, Orduña A, Boyce J, Anderson P. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol. 2010 May 01; 184(9):5325-32. PMID: 20363972.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  81. Finkelman FD, Boyce JA, Vercelli D, Rothenberg ME. Key advances in mechanisms of asthma, allergy, and immunology in 2009. J Allergy Clin Immunol. 2010 Feb; 125(2):312-8. PMID: 20159240.
    Citations: 13     Fields:    Translation:Humans
  82. Lundequist A, Nallamshetty SN, Xing W, Feng C, Laidlaw TM, Uematsu S, Akira S, Boyce JA. Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J Immunol. 2010 Jan 01; 184(1):433-41. PMID: 20028661.
    Citations: 32     Fields:    Translation:Animals
  83. Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, Kanaoka Y, Conley P, Boyce JA. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med. 2009 Oct 26; 206(11):2543-55. PMID: 19822647.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  84. Austen KF, Maekawa A, Kanaoka Y, Boyce JA. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol. 2009 Sep; 124(3):406-14; quiz 415-6. PMID: 19647860.
    Citations: 34     Fields:    Translation:HumansAnimals
  85. Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol. 2009 Aug 01; 183(3):2016-26. PMID: 19587017.
    Citations: 19     Fields:    Translation:AnimalsCells
  86. Boyce JA, Broide D, Matsumoto K, Bochner BS. Advances in mechanisms of asthma, allergy, and immunology in 2008. J Allergy Clin Immunol. 2009 Mar; 123(3):569-74. PMID: 19281904.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  87. Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JA. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol. 2009 Jan 15; 182(2):1129-37. PMID: 19124756.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  88. Boyce JA. Eicosanoids in asthma, allergic inflammation, and host defense. Curr Mol Med. 2008 Aug; 8(5):335-49. PMID: 18691060.
    Citations: 39     Fields:    Translation:Humans
  89. Paruchuri S, Jiang Y, Feng C, Francis SA, Plutzky J, Boyce JA. Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem. 2008 Jun 13; 283(24):16477-87. PMID: 18411276.
    Citations: 41     Fields:    Translation:HumansCells
  90. Jiang Y, Borrelli LA, Kanaoka Y, Bacskai BJ, Boyce JA. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood. 2007 Nov 01; 110(9):3263-70. PMID: 17693579.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  91. Gonzalo JA, Qiu Y, Lora JM, Al-Garawi A, Villeval JL, Boyce JA, Martinez-A C, Marquez G, Goya I, Hamid Q, Fraser CC, Picarella D, Cote-Sierra J, Hodge MR, Gutierrez-Ramos JC, Kolbeck R, Coyle AJ. Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis. J Immunol. 2007 Aug 01; 179(3):1740-50. PMID: 17641040.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  92. Boyce JA. Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation. Immunol Rev. 2007 Jun; 217:168-85. PMID: 17498059.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  93. Jiang Y, Kanaoka Y, Feng C, Nocka K, Rao S, Boyce JA. Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. J Immunol. 2006 Sep 01; 177(5):2755-9. PMID: 16920908.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  94. Boyce JA. Asthma 2005-2006: bench to bedside. J Allergy Clin Immunol. 2006 Sep; 118(3):582-6. PMID: 16950274.
    Citations: 1     Fields:    Translation:HumansAnimals
  95. Tournilhac O, Santos DD, Xu L, Kutok J, Tai YT, Le Gouill S, Catley L, Hunter Z, Branagan AR, Boyce JA, Munshi N, Anderson KC, Treon SP. Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. Ann Oncol. 2006 Aug; 17(8):1275-82. PMID: 16788002.
    Citations: 22     Fields:    Translation:HumansCells
  96. Gurish MF, Boyce JA. Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell. J Allergy Clin Immunol. 2006 Jun; 117(6):1285-91. PMID: 16750988.
    Citations: 50     Fields:    Translation:AnimalsCells
  97. Boyce JA. Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE. J Allergy Clin Immunol. 2006 Jun; 117(6):1415-8. PMID: 16751006.
    Citations: 29     Fields:    Translation:Humans
  98. Metcalfe DD, Boyce JA. Mast cell biology in evolution. J Allergy Clin Immunol. 2006 Jun; 117(6):1227-9. PMID: 16750978.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  99. Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MF. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood. 2006 Sep 01; 108(5):1588-94. PMID: 16670268.
    Citations: 55     Fields:    Translation:AnimalsCells
  100. Lin DA, Boyce JA. Lysophospholipids as mediators of immunity. Adv Immunol. 2006; 89:141-67. PMID: 16682274.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  101. Feng C, Beller EM, Bagga S, Boyce JA. Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses. Blood. 2006 Apr 15; 107(8):3243-50. PMID: 16357326.
    Citations: 52     Fields:    Translation:HumansCells
  102. Lin DA, Boyce JA. IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells. J Immunol. 2005 Oct 15; 175(8):5430-8. PMID: 16210650.
    Citations: 27     Fields:    Translation:HumansCells
  103. Boyce JA, Austen KF. No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med. 2005 Jun 20; 201(12):1869-73. PMID: 15967817.
    Citations: 28     Fields:    Translation:AnimalsCells
  104. Boyce JA. Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implications. Chem Immunol Allergy. 2005; 87:59-79. PMID: 16107763.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  105. Feng C, Mery AG, Beller EM, Favot C, Boyce JA. Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptor. J Immunol. 2004 Dec 15; 173(12):7539-47. PMID: 15585881.
    Citations: 26     Fields:    Translation:HumansCells
  106. Bagga S, Price KS, Lin DA, Friend DS, Austen KF, Boyce JA. Lysophosphatidic acid accelerates the development of human mast cells. Blood. 2004 Dec 15; 104(13):4080-7. PMID: 15319282.
    Citations: 22     Fields:    Translation:HumansCells
  107. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol. 2004 Aug 01; 173(3):1503-10. PMID: 15265876.
    Citations: 86     Fields:    Translation:HumansAnimals
  108. Boyce JA. The biology of the mast cell. Allergy Asthma Proc. 2004 Jan-Feb; 25(1):27-30. PMID: 15055558.
    Citations: 10     Fields:    Translation:HumansCells
  109. Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DK, Beck LA, Boyce JA, Filipovich AH, Villanueva JM, Sutton SA, Assa'ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol. 2004 Jan; 113(1):115-9. PMID: 14699394.
    Citations: 82     Fields:    Translation:HumansCellsCTClinical Trials
  110. Lora JM, Al-Garawi A, Pickard MD, Price KS, Bagga S, Sicoli J, Hodge MR, Gutiérrez-Ramos JC, Briskin MJ, Boyce JA. FcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines. J Allergy Clin Immunol. 2003 Dec; 112(6):1119-26. PMID: 14657870.
    Citations: 7     Fields:    Translation:HumansCells
  111. Lin DA, Boyce JA. The idiopathic hypereosinophilic syndrome. Allergy Asthma Proc. 2003 Nov-Dec; 24(6):417-20. PMID: 14763243.
    Citations:    Fields:    Translation:HumansCells
  112. Mellor EA, Frank N, Soler D, Hodge MR, Lora JM, Austen KF, Boyce JA. Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11589-93. PMID: 13679572.
    Citations: 43     Fields:    Translation:HumansCells
  113. Boyce JA. The role of mast cells in asthma. Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep; 69(2-3):195-205. PMID: 12895603.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  114. Price KS, Friend DS, Mellor EA, De Jesus N, Watts GF, Boyce JA. CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13. Am J Respir Cell Mol Biol. 2003 Apr; 28(4):420-7. PMID: 12654630.
    Citations: 11     Fields:    Translation:HumansCells
  115. Boyce JA. Mast cells: beyond IgE. J Allergy Clin Immunol. 2003 Jan; 111(1):24-32; quiz 33. PMID: 12532090.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  116. Beller TC, Boyce JA. Prolonged anticonvulsant hypersensitivity syndrome related to lamotrigine in a patient with human immunodeficiency virus. Allergy Asthma Proc. 2002 Nov-Dec; 23(6):415-9. PMID: 12528608.
    Citations: 1     Fields:    Translation:HumansCells
  117. Wong GW, Foster PS, Yasuda S, Qi JC, Mahalingam S, Mellor EA, Katsoulotos G, Li L, Boyce JA, Krilis SA, Stevens RL. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. J Biol Chem. 2002 Nov 01; 277(44):41906-15. PMID: 12194977.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  118. Gurish MF, Humbles A, Tao H, Finkelstein S, Boyce JA, Gerard C, Friend DS, Austen KF. CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. J Immunol. 2002 Jun 01; 168(11):5730-6. PMID: 12023373.
    Citations: 25     Fields:    Translation:AnimalsCells
  119. Boyce JA, Mellor EA, Perkins B, Lim YC, Luscinskas FW. Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood. 2002 Apr 15; 99(8):2890-6. PMID: 11929779.
    Citations: 19     Fields:    Translation:HumansCells
  120. Gurish MF, Boyce JA. Mast cell growth, differentiation, and death. Clin Rev Allergy Immunol. 2002 Apr; 22(2):107-18. PMID: 11975418.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  121. Mellor EA, Austen KF, Boyce JA. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. J Exp Med. 2002 Mar 04; 195(5):583-92. PMID: 11877481.
    Citations: 52     Fields:    Translation:Cells
  122. Bannert N, Farzan M, Friend DS, Ochi H, Price KS, Sodroski J, Boyce JA. Human Mast cell progenitors can be infected by macrophagetropic human immunodeficiency virus type 1 and retain virus with maturation in vitro. J Virol. 2001 Nov; 75(22):10808-14. PMID: 11602722.
    Citations: 19     Fields:    Translation:HumansCells
  123. Mellor EA, Maekawa A, Austen KF, Boyce JA. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):7964-9. PMID: 11438743.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  124. Austen KF, Boyce JA. Mast cell lineage development and phenotypic regulation. Leuk Res. 2001 Jul; 25(7):511-8. PMID: 11377675.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  125. Hou FF, Miyata T, Boyce J, Yuan Q, Chertow GM, Kay J, Schmidt AM, Owen WF. beta(2)-Microglobulin modified with advanced glycation end products delays monocyte apoptosis. Kidney Int. 2001 Mar; 59(3):990-1002. PMID: 11231354.
    Citations: 17     Fields:    Translation:HumansCells
  126. Silverman ES, De Sanctis GT, Boyce J, Maclean JA, Jiao A, Green FH, Grasemann H, Faunce D, Fitzmaurice G, Shi GP, Stein-Streilein J, Milbrandt J, Collins T, Drazen JM. The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):778-85. PMID: 11254538.
    Citations: 8     Fields:    Translation:Animals
  127. Hsieh FH, Lam BK, Penrose JF, Austen KF, Boyce JA. T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4. J Exp Med. 2001 Jan 01; 193(1):123-33. PMID: 11136826.
    Citations: 45     Fields:    Translation:HumansCells
  128. Ochi H, De Jesus NH, Hsieh FH, Austen KF, Boyce JA. IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10509-13. PMID: 10973484.
    Citations: 32     Fields:    Translation:HumansCells
  129. Hou FF, Boyce J, Zhang Y, Owen WF. Phenotypic and functional characteristics of macrophage-like cells differentiated in pro-inflammatory cytokine-containing cultures. Immunol Cell Biol. 2000 Jun; 78(3):205-13. PMID: 10849108.
    Citations: 5     Fields:    Translation:HumansCells
  130. Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, Boyce JA. T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med. 1999 Jul 19; 190(2):267-80. PMID: 10432289.
    Citations: 75     Fields:    Translation:HumansCells
  131. Yuan Q, Gurish MF, Friend DS, Austen KF, Boyce JA. Generation of a novel stem cell factor-dependent mast cell progenitor. J Immunol. 1998 Nov 15; 161(10):5143-6. PMID: 9820483.
    Citations: 13     Fields:    Translation:AnimalsCells
  132. Owen WF, Hou FF, Stuart RO, Kay J, Boyce J, Chertow GM, Schmidt AM. Beta 2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts. Kidney Int. 1998 May; 53(5):1365-73. PMID: 9573554.
    Citations: 12     Fields:    Translation:HumansCells
  133. Hou FF, Boyce J, Chertow GM, Kay J, Owen WF. Aminoguanidine inhibits advanced glycation end products formation on beta2-microglobulin. J Am Soc Nephrol. 1998 Feb; 9(2):277-83. PMID: 9527404.
    Citations: 5     Fields:    Translation:HumansCells
  134. Castells M, Boyce J. Transfer of peanut allergy by a liver allograft. N Engl J Med. 1998 Jan 15; 338(3):202-3. PMID: 9441233.
    Citations: 3     Fields:    Translation:HumansAnimals
  135. Boyce JA. The pathobiology of eosinophilic inflammation. Allergy Asthma Proc. 1997 Sep-Oct; 18(5):293-300. PMID: 9337423.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  136. Yuan Q, Austen KF, Friend DS, Heidtman M, Boyce JA. Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1). J Exp Med. 1997 Jul 21; 186(2):313-23. PMID: 9221761.
    Citations: 20     Fields:    Translation:HumansCells
  137. Hou FF, Chertow GM, Kay J, Boyce J, Lazarus JM, Braatz JA, Owen WF. Interaction between beta 2-microglobulin and advanced glycation end products in the development of dialysis related-amyloidosis. Kidney Int. 1997 May; 51(5):1514-9. PMID: 9150467.
    Citations: 9     Fields:    Translation:HumansCells
  138. Boyce JA, Lam BK, Penrose JF, Friend DS, Parsons S, Owen WF, Austen KF. Expression of LTC4 synthase during the development of eosinophils in vitro from cord blood progenitors. Blood. 1996 Dec 01; 88(11):4338-47. PMID: 8943871.
    Citations: 12     Fields:    Translation:HumansCells
  139. Penrose JF, Spector J, Baldasaro M, Xu K, Boyce J, Arm JP, Austen KF, Lam BK. Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. J Biol Chem. 1996 May 10; 271(19):11356-61. PMID: 8626689.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  140. Boyce JA, Friend D, Gurish MF, Austen KF, Owen WF. Constitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2436-41. PMID: 8637892.
    Citations: 1     Fields:    Translation:HumansCells
  141. Boyce JA, Friend D, Matsumoto R, Austen KF, Owen WF. Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate. J Exp Med. 1995 Jul 01; 182(1):49-57. PMID: 7540656.
    Citations: 26     Fields:    Translation:HumansCells
  142. Boyce JA, Bernhard JD. Total skin examination: patient reactions. J Am Acad Dermatol. 1986 Feb; 14(2 Pt 1):280. PMID: 3950126.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.