Harvard Catalyst Profiles

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Giorgio Basile, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shirakawa J, Togashi Y, Basile G, Okuyama T, Inoue R, Fernandez M, Kyohara M, De Jesus DF, Goto N, Zhang W, Tsuno T, Kin T, Pan H, Dreyfuss JM, Shapiro AMJ, Yi P, Terauchi Y, Kulkarni RN. E2F1 transcription factor mediates a link between fat and islets to promote ß cell proliferation in response to acute insulin resistance. Cell Rep. 2022 10 04; 41(1):111436. PMID: 36198264; PMCID: PMC9617565.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Dirice E, Basile G, Kahraman S, Diegisser D, Hu J, Kulkarni RN. Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance. JCI Insight. 2022 08 22; 7(16). PMID: 35819843; PMCID: PMC9462484.
    Citations:    Fields:    
  3. Kahraman S, Dirice E, Basile G, Diegisser D, Alam J, Johansson BB, Gupta MK, Hu J, Huang L, Soh CL, Huangfu D, Muthuswamy SK, Raeder H, Molven A, Kulkarni RN. Abnormal exocrine-endocrine cell cross-talk promotes ß-cell dysfunction and loss in MODY8. Nat Metab. 2022 01; 4(1):76-89. PMID: 35058633.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  4. Basile G, Kahraman S, Dirice E, Pan H, Dreyfuss JM, Kulkarni RN. Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets. Genome Med. 2021 08 10; 13(1):128. PMID: 34376240; PMCID: PMC8356387.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. De Jesus DF, Orime K, Kaminska D, Kimura T, Basile G, Wang CH, Haertle L, Riemens R, Brown NK, Hu J, Männistö V, Silva AM, Dirice E, Tseng YH, Haaf T, Pihlajamäki J, Kulkarni RN. Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice. J Clin Invest. 2020 05 01; 130(5):2391-2407. PMID: 32250344.
    Citations: 12     Fields:    Translation:Animals
  6. Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN, Terauchi Y. Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway. Diabetologia. 2020 03; 63(3):577-587. PMID: 31897526.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  7. Basile G, Kulkarni RN, Morgan NG. How, When, and Where Do Human ß-Cells Regenerate? Curr Diab Rep. 2019 06 27; 19(8):48. PMID: 31250214.
    Citations: 11     Fields:    Translation:HumansCells
  8. Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Increased ß-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nat Metab. 2019 05; 1(5):509-518. PMID: 31423480.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  9. Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RW, El Ouaamari A, Teo AKK, Bhatt S, Hu J, Kulkarni RN. Human duct cells contribute to ß cell compensation in insulin resistance. JCI Insight. 2019 04 18; 4(8). PMID: 30996131.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  10. El Ouaamari A, O-Sullivan I, Shirakawa J, Basile G, Zhang W, Roger S, Thomou T, Xu S, Qiang G, Liew CW, Kulkarni RN, Unterman TG. Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion. J Biol Chem. 2019 01 18; 294(3):1059-1069. PMID: 30459233.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.