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Xi Chen, Ph.D.

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Biography
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Xiamen University, Xiamen, ChinaPh.D.06/2009Magnetic Resonance Physics
National Institute on Drug Abuse, Baltimore, MD03/2014Magnetic Resonance Spectroscopy
Dartmouth College, Lebanon, NH08/2015Animal Neuroimaging

Overview
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As a Magnetic Resonance (MR) Physicist, I have substantial background in MRS/MRI technical development. In particular, I have developed cutting-edge in vivo MR spectroscopy techniques on both clinical and preclinical MRI scanners to assess neurotransmitters and cerebral metabolites. I also performed a series of studies exploring the relations between regional neurotransmitters and brain functional network. My work was published in mainstream neuroscience, psychiatry and MRI journals such as Journal of Neuroscience, Cerebral Cortex, Schizophrenia Bulletin, Schizophrenia Research and Magnetic Resonance in Medicine and I have given numerous oral presentations at international conferences such as International Society of Magnetic Resonance in Medicine (ISMRM). My research interest is to develop cutting-edge neuroimaging techniques to better understand neurobiological mechanisms, better diagnosis and monitoring disease progression and treatment response of psychotic disorders.
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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. BBRF Young Investigator Grant (Xi Chen) Jan 15, 2021 - Jan 14, 2023
    Brain & Behavior Research Foundation
    How neurotransmitter concentrations in default-mode network modulate brain functional activities and connectivities as psychosis progresses: a longitudinal study
    Role Description: By combining functional MRI (fMRI) and magnetic resonance spectroscopy (MRS) techniques, it has been shown that the neurotransmitter concentrations in default-mode network (DMN) modulate the brain functional activities and resting-state connectivities. It was observed that the relationship between DMN neurotransmitter concentrations and the activities of brain functional network breaks down in first-episode psychosis patients in an ongoing study. In the current proposed study, these psychosis participants will be followed up with the same fMRI/MRS scans after four years, in order to monitor how neurotransmitter concentrations, brain functions as well as their relationship change as the disease progresses and medication takes effect.
    Role: Principal Investigator
  2. Livingston Fellowship Award (Xi Chen) Jul 1, 2020 - Jun 30, 2021
    Harvard Medical School
    Observing glutamate and lactate dynamics in schizophrenia during working memory task
    Role Description: The brain neurotransmission and energy metabolism systems are implicated in the pathophysiology of schizophrenia. With functional magnetic resonance spectroscopy (fMRS) using the unique macromolecule suppression technique, glutamate and lactate dynamics can be simultaneously observed in the active brain area of schizophrenia patients during the working memory task with different loads. These fMRS measures more directly reflect behaviorally relevant neural activities and would help to better understand the underlying neurotransmission abnormalities and mitochondrial dysfunction of schizophrenia under cognitive stress.
    Role: Principal Investigator
  3. Pathways Research Award (Xi Chen) Apr 1, 2020 - Mar 31, 2022
    Alkermes, Inc
    In vivo observing brain lactate changes in first episode schizophrenia using 3 T magnetic resonance spectroscopy
    Role Description: The project is to obtain brain energy metabolite information of newly diagnosed schizophrenia using MRI to better understand the pathophysiology of the brain disorder as well as potentially develop biomarkers to address treatment effects and optimize outcomes.
    Role: Principal Investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.