Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Harvard Catalyst Profiles is currently experiencing a partial system outage. Login/Edit modules are currently disabled.

Xi Chen, Ph.D.

Title
Institution
Department
Address
Profile Picture

Biography
Xiamen University, Xiamen, ChinaPh.D.06/2009Magnetic Resonance Physics
National Institute on Drug Abuse, Baltimore, MD03/2014Magnetic Resonance Spectroscopy
Dartmouth College, Lebanon, NH08/2015Animal Neuroimaging

Overview
As a Magnetic Resonance (MR) Physicist, I have substantial background in MRS/MRI technical development. In particular, I have developed cutting-edge in vivo MR spectroscopy techniques on both clinical and preclinical MRI scanners to assess neurotransmitters and cerebral metabolites. I also performed a series of studies exploring the relations between regional neurotransmitters and brain functional network. My work was published in mainstream neuroscience, psychiatry and MRI journals such as Journal of Neuroscience, Cerebral Cortex, Schizophrenia Bulletin, Schizophrenia Research and Magnetic Resonance in Medicine and I have given numerous oral presentations at international conferences such as International Society of Magnetic Resonance in Medicine (ISMRM). My research interest is to develop cutting-edge neuroimaging techniques to better understand neurobiological mechanisms, better diagnosis and monitoring disease progression and treatment response of psychotic disorders.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. BBRF Young Investigator Grant (Xi Chen) Jan 15, 2021 - Jan 14, 2023
    Brain & Behavior Research Foundation
    How neurotransmitter concentrations in default-mode network modulate brain functional activities and connectivities as psychosis progresses: a longitudinal study
    Role Description: By combining functional MRI (fMRI) and magnetic resonance spectroscopy (MRS) techniques, it has been shown that the neurotransmitter concentrations in default-mode network (DMN) modulate the brain functional activities and resting-state connectivities. It was observed that the relationship between DMN neurotransmitter concentrations and the activities of brain functional network breaks down in first-episode psychosis patients in an ongoing study. In the current proposed study, these psychosis participants will be followed up with the same fMRI/MRS scans after four years, in order to monitor how neurotransmitter concentrations, brain functions as well as their relationship change as the disease progresses and medication takes effect.
    Role: Principal Investigator
  2. Livingston Fellowship Award (Xi Chen) Jul 1, 2020 - Jun 30, 2021
    Harvard Medical School
    Observing glutamate and lactate dynamics in schizophrenia during working memory task
    Role Description: The brain neurotransmission and energy metabolism systems are implicated in the pathophysiology of schizophrenia. With functional magnetic resonance spectroscopy (fMRS) using the unique macromolecule suppression technique, glutamate and lactate dynamics can be simultaneously observed in the active brain area of schizophrenia patients during the working memory task with different loads. These fMRS measures more directly reflect behaviorally relevant neural activities and would help to better understand the underlying neurotransmission abnormalities and mitochondrial dysfunction of schizophrenia under cognitive stress.
    Role: Principal Investigator
  3. Pathways Research Award (Xi Chen) Apr 1, 2020 - Mar 31, 2022
    Alkermes, Inc
    In vivo observing brain lactate changes in first episode schizophrenia using 3 T magnetic resonance spectroscopy
    Role Description: The project is to obtain brain energy metabolite information of newly diagnosed schizophrenia using MRI to better understand the pathophysiology of the brain disorder as well as potentially develop biomarkers to address treatment effects and optimize outcomes.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Updating...
This operation might take several minutes to complete. Please do not close your browser.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Chen's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (110)
Explore
_
Co-Authors (19)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.