Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Thomas Scadden, M.D.

Co-Author

This page shows the publications co-authored by David Scadden and David Sykes.
Connection Strength

2.499
  1. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016 Sep 22; 167(1):171-186.e15.
    View in: PubMed
    Score: 0.704
  2. tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche. Cell Stem Cell. 2021 Sep 15.
    View in: PubMed
    Score: 0.249
  3. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. 2020 09 10; 136(11):1303-1316.
    View in: PubMed
    Score: 0.232
  4. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metab. 2020 09 01; 32(3):391-403.e6.
    View in: PubMed
    Score: 0.230
  5. Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells. J Clin Invest. 2017 Apr 03; 127(4):1405-1413.
    View in: PubMed
    Score: 0.182
  6. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol. 2016 07; 34(7):738-45.
    View in: PubMed
    Score: 0.173
  7. Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports. 2016 06 14; 6(6):985-992.
    View in: PubMed
    Score: 0.172
  8. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016 Apr 01; 126(4):1300-10.
    View in: PubMed
    Score: 0.169
  9. The hematopoietic stem cell niche. Front Biosci (Landmark Ed). 2012 Jan 01; 17:30-9.
    View in: PubMed
    Score: 0.127
  10. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Leukemia. 2019 10; 33(10):2403-2415.
    View in: PubMed
    Score: 0.052
  11. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26; 2(11).
    View in: PubMed
    Score: 0.046
  12. Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nat Med. 2017 01; 23(1):100-106.
    View in: PubMed
    Score: 0.045
  13. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Dec 08; 7(12):1112-1117.
    View in: PubMed
    Score: 0.044
  14. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 10; 10(5):755-770.
    View in: PubMed
    Score: 0.039
  15. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating ß-catenin. EMBO Mol Med. 2013 Mar; 5(3):430-40.
    View in: PubMed
    Score: 0.034
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.