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Giuseppe Pettinato, Ph.D.

Title
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Department
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Biography
University of Catania, CataniaPh.D.2008Andrological Science and Human Reproduction
University of Catania, CataniaMS2002Molecular Biology
University of Catania, CataniaBS2000Biology
1995 - 2000
Full Scolarship
2002 - 2007
Research Award for Ph.D. Studies
2015
Young Investigator Award
2015
Co-chair State-of-the-Art Workshop: Organ Engineering & Repair
2016
2016 nominee for the ADA Pathway to Stop Diabetes Awards
2017
Chair the CTRMS Workshop III & Oral session: iPS Derived Cells & Stem
2019
TTS-CTRMS Scientific Award
2021
CTRMS Scientific Congress Award
2021 - 2022
Visiting Professor at Department of Drug and Health Sciences (DSFS)

Overview
As a biologist and embryologist, my major research focus is to study the fundamental basis underlying cell biology, with a particular interest in the differentiation of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) by following the in vivo developmental cues that drive these cells to become liver and pancreatic organoids. These organoids can be used as a drug screening model in vitro, or in regenerative medicine to treat liver and pancreatic degenerative diseases through cell transplantation therapy. My current research is focusing on the development of HLA-Knockout hiPSCs liver and pancreatic organoids.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. A10086 (Giuseppe Pettinato)
    CSL Behring
    Role of Alpha-1 Antitrypsin in hepatocyte-clusters and hepatocyte-like clusters in the ex vivo survival.
    Role Description: The goal of this study is the formation of hepatospheres from HPH and hiPSCs and further evaluation of their functions in vitro and in vivo. We will also evaluate the effect of A1AT on ex-vivo survival and the function of HPH in the hepatospheres both in vitro and in vivo.
    Role: PI

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pettinato G, Perelman LT, Fisher RA. Development of a Scalable Three-Dimensional Culture of Human Induced Pluripotent Stem Cells-Derived Liver Organoids. Methods Mol Biol. 2022; 2455:131-147. PMID: 35212992.
    Citations:    Fields:    Translation:HumansCells
  2. Ietto G, Amico F, Pettinato G, Iori V, Carcano G. Laparoscopy in Emergency: Why Not? Advantages of Laparoscopy in Major Emergency: A Review. Life (Basel). 2021 Sep 03; 11(9). PMID: 34575066.
    Citations:    
  3. Pettinato G, Coughlan MF, Zhang X, Chen L, Khan U, Glyavina M, Sheil CJ, Upputuri PK, Zakharov YN, Vitkin E, D'Assoro AB, Fisher RA, Itzkan I, Zhang L, Qiu L, Perelman LT. Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids. Sci Adv. 2021 08; 7(34). PMID: 34407934.
    Citations: 1     Fields:    Translation:HumansCells
  4. Pettinato G, Lehoux S, Ramanathan R, Salem MM, He LX, Muse O, Flaumenhaft R, Thompson MT, Rouse EA, Cummings RD, Wen X, Fisher RA. Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells. Sci Rep. 2019 06 20; 9(1):8920. PMID: 31222080.
    Citations: 41     Fields:    Translation:HumansCells
  5. He LX, Zhang ZF, Zhao J, Li L, Xu T, Ren JW, Liu R, Chen QH, Wang JB, Salem MM, Pettinato G, Zhou JR, Li Y. Ginseng oligopeptides protect against irradiation-induced immune dysfunction and intestinal injury. Sci Rep. 2018 09 17; 8(1):13916. PMID: 30224720.
    Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Ohmine S, Salisbury JL, Ingle J, Pettinato G, Haddox CL, Haddad T, Galanis E, Ikeda Y, D'assoro AB. Aurora-A overexpression is linked to development of aggressive teratomas derived from human iPS cells. Oncol Rep. 2018 Apr; 39(4):1725-1730. PMID: 29393405.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. He LX, Ren JW, Liu R, Chen QH, Zhao J, Wu X, Zhang ZF, Wang JB, Pettinato G, Li Y. Ginseng (Panax ginseng Meyer) oligopeptides regulate innate and adaptive immune responses in mice via increased macrophage phagocytosis capacity, NK cell activity and Th cells secretion. Food Funct. 2017 Oct 01; 8(10):3523-3532. PMID: 28875201.
    Citations: 16     Fields:    Translation:AnimalsCells
  8. Giuseppe Pettinato, Melissa T. Thompson, Robert A. Fisher. Human embryoid bodies to hepatocyte-like clusters: Preparing for translation. Liver Research. 2017; 2017(1):88-95. View Publication.
  9. Pettinato G, Ramanathan R, Fisher RA, Mangino MJ, Zhang N, Wen X. Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/ß-catenin Pathway Inhibition. Sci Rep. 2016 09 12; 6:32888. PMID: 27616299.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  10. Pettinato G, Wen X, Zhang N. Engineering Strategies for the Formation of Embryoid Bodies from Human Pluripotent Stem Cells. Stem Cells Dev. 2015 Jul 15; 24(14):1595-609. PMID: 25900308.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  11. Ramanathan R, Pettinato G, Beeston JT, Lee DD, Wen X, Mangino MJ, Fisher RA. Transplantation of human stem cell-derived hepatocytes in an animal model of acute liver failure. Surgery. 2015 Aug; 158(2):349-59. PMID: 26032830.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Pettinato G, Wen X, Zhang N. Formation of well-defined embryoid bodies from dissociated human induced pluripotent stem cells using microfabricated cell-repellent microwell arrays. Sci Rep. 2014 Dec 10; 4:7402. PMID: 25492588.
    Citations: 42     Fields:    Translation:HumansCells
  13. Pettinato G, Vanden Berg-Foels WS, Zhang N, Wen X. ROCK inhibitor is not required for embryoid body formation from singularized human embryonic stem cells. PLoS One. 2014; 9(11):e100742. PMID: 25365581.
    Citations: 10     Fields:    Translation:HumansCells
  14. Burrello N, Salmeri M, Perdichizzi A, Bellanca S, Pettinato G, D'Agata R, Vicari E, Calogero AE. Candida albicans experimental infection: effects on human sperm motility, mitochondrial membrane potential and apoptosis. Reprod Biomed Online. 2009 Apr; 18(4):496-501. PMID: 19400990.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.