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Junfeng Wang, Ph.D.

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Biography
Peking University, BeijingPhD07/2009Chemical Biology
Zhengzhou University, ZhengzhouMS07/2006Medicinal Chemistry

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K25AG061282 (WANG, JUNFENG) Apr 1, 2019 - Mar 31, 2024
    NIH
    Development of PET imaging probes for metabolic glutamate receptor 3 (mGLuR3)
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wahsner J, Désogère P, Abston E, Graham-O'Regan KA, Wang J, Rotile NJ, Schirmer MD, Santos Ferreira DD, Sui J, Fuchs BC, Lanuti M, Caravan P. 68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis. J Am Chem Soc. 2019 Apr 10; 141(14):5593-5596. PMID: 30908032.
    Citations:    
  2. Wei Q, Wang J, Akam EA, Yin D, Ge Z, Cheng T, Wang X, Brownell AL, Li R. Transition Metal-Free Intermolecular C(sp2)-H Direct Amination of Furanones via a Redox Pathway. J Org Chem. 2019 Feb 01; 84(3):1310-1319. PMID: 30607949.
    Citations:    Fields:    
  3. Ruonan Wang, Jingcai Wang, Qingxuan Tang, Xin Zhao, Junfeng Wang, Yuting Leng, Yangjie Wu, Junbiao Chang, Yusheng Wu, Zhaoda Zhang, Shiwei Wang. Copper(I)-Catalyzed Direct C-H Trifluoromethylation of Imidazoheterocycles with Togni’s Reagent. Tetrahedron Letters. 2019; 60(8):586-590.
  4. Wang J, Wang H, Ramsay IA, Erstad DJ, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation. J Med Chem. 2018 Oct 11; 61(19):8811-8824. PMID: 30204438.
    Citations:    Fields:    
  5. Wang P, Goodwill PW, Pandit P, Gaudet J, Ross A, Wang J, Yu E, Hensley DW, Doyle TC, Contag CH, Conolly S, Moore A. Magnetic particle imaging of islet transplantation in the liver and under the kidney capsule in mouse models. Quant Imaging Med Surg. 2018 Mar; 8(2):114-122. PMID: 29675353.
    Citations:    
  6. Yi Pang, Junfeng Wang. Fluorescent sensor for metal cation detection based on 2-(2?-hydroxyphenyl)benzazole containing a Schiff base moiety. 2018.
  7. J Wahsner, P Desogere, J Wang, N Rotile, D Erstad, B Fuchs, M Lanuti, Peter Caravan. Journal of Nuclear Medicine. 68Ga-NODAGA-indole, an allysine-reactive PET probe for molecular imaging of actively progressive pulmonary fibrogenesis. 2018; 1(59):260-260.
  8. Li B, Zhao W, Zhang X, Wang J, Luo X, Baker SD, Jordan CT, Dong Y. Design, synthesis and evaluation of anti-CD123 antibody drug conjugates. Bioorg Med Chem. 2016 11 15; 24(22):5855-5860. PMID: 27687970.
    Citations:    
  9. McDonald L, Wang J, Alexander N, Li H, Liu T, Pang Y. Origin of Water-Induced Fluorescence Turn-On from a Schiff Base Compound: AIE or H-Bonding Promoted ESIPT? J Phys Chem B. 2016 Feb 04; 120(4):766-72. PMID: 26761400.
    Citations:    
  10. Junfeng Wang†, Bin Li†, Weiyu Zhao†, Xinfu Zhang†, Xiao Luo†, Mark E. Corkins‡, Sara L. Cole§, Chao Wang?, Yi Xiao?, Xiaoman Bi?, Yi Pang?, Craig A. McElroy†, Amanda J. Bird‡, and Yizhou Dong*†. Two-Photon Near Infrared Fluorescent Turn-On Probe Toward Cysteine and Its Imaging Applications. ACS Sensors. 2016; 7(1):882-887.
  11. Kanokthorn Boonkitpatarakul†‡, Junfeng Wang†, Nakorn Niamnont?, Bin Liu†, Lucas Mcdonald†, Yi Pang*†, and Mongkol Sukwattanasinitt*§. Novel Turn-On Fluorescent Sensors with Mega Stokes Shifts for Dual Detection of Al3+ and Zn2+. ACS Sensors. 2016; 2(1):144-150.
  12. Yizhoug Dong, Junfeng Wang. Anti-CD123 Antibody Drug Conjugates and Uses Thereof. 2016.
  13. Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler KM, Tan X, Dunn AL, Kerlin BA, Dong Y. An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo. Nano Lett. 2015 Dec 09; 15(12):8099-107. PMID: 26529392.
    Citations:    
  14. Wang J, Lu Z, Wang J, Cui M, Yeung BZ, Cole DJ, Wientjes MG, Au JL. Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors. J Control Release. 2015 Oct 28; 216:103-10. PMID: 26272765.
    Citations:    
  15. Yi Pang, Junfeng Wang. NOVEL FLUORESCENT SENSOR FOR METAL CATION DETECTION BASED ON 2-(2'-HYDROXYPHENYL)BENZAZOLE CONTAINING A SCHIFF BASE MOIETY. 2015.
  16. Yi Pang, Junfeng Wang. Hydroxyphenylbenzazole compounds that are useful for the selective detection of zinc, aluminum, chromium, and iron cations in vitro and in vivo. 2015.
  17. Yi Pang, Junfeng Wang. NOVEL FLUORESCENT SENSOR FOR METAL CATION DETECTION BASED ON 2-(2'-HYDROXYPHENYL)BENZAZOLE CONTAINING A SCHIFF BASE MOIETY. 2015.
  18. Wang J, Li Y, Patel NG, Zhang G, Zhou D, Pang Y. A single molecular probe for multi-analyte (Cr³?, Al³? and Fe³?) detection in aqueous medium and its biological application. Chem Commun (Camb). 2014 Oct 21; 50(82):12258-61. PMID: 25178169.
    Citations:    
  19. Wang J, Liu X, Pang Y. A Benzothiazole-Based Sensor for Pyrophosphate (PPi) and ATP: Mechanistic Insight for Anion-Induced ESIPT Turn-On. J Mater Chem B. 2014 Oct 14; 2(38):6634-6638. PMID: 25530852.
    Citations:    
  20. Wang J, Liu B, Liu X, Panzner MJ, Wesdemiotis C, Pang Y. A binuclear Zn(II)-Zn(II) complex from a 2-hydroxybenzohydrazide-derived Schiff base for selective detection of pyrophosphate. Dalton Trans. 2014 Oct 07; 43(37):14142-6. PMID: 25135613.
    Citations:    
  21. Wang J, Chen W, Liu X, Wesdemiotis C, Pang Y. A Mononuclear Zinc Complex for Selective Detection of Diphosphate via Fluorescence ESIPT Turn-On. J Mater Chem B. 2014 Jun 07; 2(21):3349-3354. PMID: 24999430.
    Citations:    
  22. Yi Pang, Junfeng Wang. Class of near infrared molecular probes for biological applications. 2014.
  23. Liu B, Wang J, Zhang G, Bai R, Pang Y. Flavone-based ESIPT ratiometric chemodosimeter for detection of cysteine in living cells. ACS Appl Mater Interfaces. 2014 Mar 26; 6(6):4402-7. PMID: 24571859.
    Citations:    
  24. Wang J, Li Y, Duah E, Paruchuri S, Zhou D, Pang Y. A selective NIR-emitting zinc sensor by using Schiff base binding to turn-on excited-state intramolecular proton transfer. J Mater Chem B. 2014; 2(14):2008-2012. PMID: 25411638.
    Citations:    
  25. Bin Liu, Junfeng Wang, Yi Pang, Zemei Ge, Runtao Li. Unexpected synthesis of 1,3,5-triarly-1,5-diketones from aryl ketones via di-enamine mechanism. Tetrahedron. 2014; 48(70):9240-9244.
  26. Bin Liu, Qin Liu, Mickey Shah, Junfeng Wang, Ge Zhang, Yi Pang. Fluorescence monitor of hydrazine in vivo by selective deprotection of flavonoid. Sensors and Actuators B: Chemical. 2014; 31(202):194-200.
  27. Guangzhuo Rong, Yusheng Chen, Lei Wang, Joanne Li, Junfeng Wang, Matthew J. Panzer, Yi Pang. A benzoxazole sulfenamide accelerator: Synthesis, structure, property, and implication in rubber vulcanization mechanism. Journal of Applied Polymer Science . 2014; 6(131):39699.
  28. Wang J, Pang Y. A Simple Sensitive ESIPT On-Off Fluorescent Sensor for Selective Detection of Al3+ in Water. RSC Adv. 2013 Dec 18; 4(12):5845-5848. PMID: 24839545.
    Citations:    
  29. Wang J, Chu Q, Liu X, Wesdemiotis C, Pang Y. Large fluorescence response by alcohol from a bis(benzoxazole)-zinc(II) complex: the role of excited state intramolecular proton transfer. J Phys Chem B. 2013 Apr 18; 117(15):4127-33. PMID: 23514312.
    Citations:    
  30. Wang W, Wang J, Zhou S, Sun Q, Ge Z, Wang X, Li R. An efficient organocatalytic enantioselective Michael addition of aryl methyl ketones with 2-furanones: highly functionalized chiral 3,4-substituted lactones. Chem Commun (Camb). 2013 Feb 14; 49(13):1333-5. PMID: 23304701.
    Citations:    
  31. Junfeng Wang, Yi Pang. A versatile synthesis of bis [2-(2'-hydroxylphenyl) benzoxazole] derivatives as zinc sensors. RSC Advances. 2013; 26(3):10208-10212 .
  32. Yi Liu, Pengchao Gao, Junfeng Wang, Qi Sun*, Zemei Ge, Runtao Li. Primary 1, 2-diamine catalysis (v): Efficient asymmetric aldol reactions of isatins with cyclohexanone. Synlett. 2012; 7(23):1031-1034.
  33. Junfeng Wang, Qin Li, Zemei Ge, Runtao Li. A versatile and convenient route to ketone C-pyranosides and ketone C-furanosides from unprotected sugars. Tetrahedron. 2012; 4(68):1315-1320.
  34. Yi Liu, Junfeng Wang, Qi Sun, Runtao Li. Chiral 1, 2-diaminocyclohexane as organocatalyst for enantioselective aldol reaction. Tetrahedron Letters. 2011; 28(52):3584-3587.
  35. G DAI, W MA, H LIU, H XU, Q YANG, F WANG, L AN, L HAO, J WANG. The in vitro anti-tumor activities of andrographolide derivatives and the structure-activity relationships. Chinese Journal of New Drugs. 2011; 4(20):362-366 .
  36. H Xu, P Jiang, W Li, J Wang, H Liu. Synthesis and Bioactivities of Andrographolide Derivatives: New (-)-Limonidilactone Analogues. Chinese Journal of Chemistry. 2011; 10(29): 2114-2118.
  37. Wang J, Li Q, Qi C, Liu Y, Ge Z, Li R. Primary 1,2-diamine catalysis III: an unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines. Org Biomol Chem. 2010 Oct 07; 8(19):4240-2. PMID: 20694251.
    Citations:    
  38. Lei M, Xia S, Wang J, Ge Z, Cheng T, Li R. An efficient dipeptide-catalyzed direct asymmetric aldol reaction of equimolar reactants in solid media. Chirality. 2010 Jun; 22(6):580-6. PMID: 19899160.
    Citations:    
  39. Wang J, Qi C, Ge Z, Cheng T, Li R. Efficient direct asymmetric vinylogous Michael addition reactions of gamma-butenolides to chalcones catalyzed by vicinal primary-diamine salts. Chem Commun (Camb). 2010 Mar 28; 46(12):2124-6. PMID: 20221513.
    Citations:    
  40. Wang J, Wang X, Ge Z, Cheng T, Li R. Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem Commun (Camb). 2010 Mar 14; 46(10):1751-3. PMID: 20177638.
    Citations:    
  41. Junfeng Wang, Meng Lei, Qin Li, Zemei Ge, Xin Wang, Runtao Li. A novel and efficient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway. Tetrahedron. 2009; 25(65):4826-4833.
  42. Liu HM, Xu HW, Dai GF, Wang JF . Andrographolide C15 substituted series derivates and their preparing method. 2009.
  43. Xu HW, Wang JF, Liu GZ, Hong GF, Liu HM. Facile synthesis of gamma-alkylidenebutenolides. Org Biomol Chem. 2007 Apr 21; 5(8):1247-50. PMID: 17406723.
    Citations:    
  44. HW Xu, GF Dai, GZ Liu, JF Wang, HM Liu. Synthesis of andrographolide derivatives: a new family of a-glucosidase inhibitors. Bioorganic & medicinal chemistry. 2007; 12(15):4247-4255.
  45. Liu, Hongmin; Xu, Haiwei; Wang, Junfeng; Dai, Guifu; Liu, Gaizhi. Method for preparation of Andrographolide C15-?hydroxymethyl derivatives. 2007.
  46. Liu, Hongmin; Xu, Haiwei; Liu, Gaizhi; Dai, Guifu; Wang, Junfeng. Isoandrographolide analogue and its preparation process. 2007.
  47. Liu HM, Yan L, XU HW, Wang JF, Zhao ML. 15-(14-deoxy 11,12 dehydro) andrographolide carbonic side derivate and preparation process thereof. 2007.
  48. Dai GF, Xu HW, Wang JF, Liu FW, Liu HM. Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues. Bioorg Med Chem Lett. 2006 May 15; 16(10):2710-3. PMID: 16504503.
    Citations:    
  49. HW Xu, J Zhang, HM Liu, JF Wang. Synthesis of andrographolide cyclophosphate derivatives and their antitumor activities. Synthetic communications. 2006; 4(36):407-414.
  50. G Dai, J Wang, H Xu. Proliferation inhibition and apoptosis of human esophageal carcinoma Ec9706 cells by andrographolide. CHINESE NEW DRUGS JOURNAL. 2006; 16(15):1363.
  51. H Xu, J Wang, H Liu, J Zhang. Synthesis and crystal structure of dehydroandrographolide dipolycyclophosphate. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY. 2005; 10(24):1198-1202.
  52. Hongmin Liu, Guifu Dai, Hongyu Sun, Junfeng Wang. Progress of Glucosidase inhibitors. Progress in Medicinal Chemistry. 2005.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.