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Junfeng Wang, Ph.D.

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Peking University, BeijingPhD07/2009Chemical Biology
Zhengzhou University, ZhengzhouMS07/2006Medicinal Chemistry

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Thrall Innovation Grant (Junfeng Wang) Feb 1, 2022 - Jan 31, 2023
    Development of a 12/15-LOX selective positron emission tomography (PET) imaging ligand for Stoke
    Role: Principal Investigator
  2. K25AG061282 (WANG, JUNFENG) Apr 1, 2019 - Mar 31, 2024
    Development of PET imaging probes for metabolic glutamate receptor 3 (mGLuR3)
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang J, Takahashi K, Shoup TM, Gong L, Li Y, El Fakhri G, Zhang Z, Brownell AL. Organomediated cleavage of benzoyl group enables an efficient synthesis of 1-(6-nitropyridin-2-yl)thiourea and its application for developing 18F-labeled PET tracers. Bioorg Chem. 2022 07; 124:105804. PMID: 35468416; PMCID: PMC9189786.
    Citations:    Fields:    Translation:Animals
  2. Shuai Wang, Lichong Gong, Georges El Fakhri and Junfeng Wang. Efficient synthesis of 6,6'-diamido-2,2'-dipicolylamine ligands for potential phosphate anion sensing. New Journal of Chemistry. 2021. View Publication.
  3. Zhou K, Yang F, Li Y, Chen Y, Zhang X, Zhang J, Wang J, Dai J, Cai L, Cui M. Synthesis and Evaluation of Fluorine-18 Labeled 2-Phenylquinoxaline Derivatives as Potential Tau Imaging Agents. Mol Pharm. 2021 03 01; 18(3):1176-1195. PMID: 33475377.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Yuan G, Qu X, Zheng B, Neelamegam R, Afshar S, Iyengar S, Pan C, Wang J, Kang HJ, Ondrechen MJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2. J Med Chem. 2020 10 22; 63(20):12060-12072. PMID: 32981322.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Wang J, Qu X, Shoup TM, Yuan G, Afshar S, Pan C, Zhu A, Choi JK, Kang HJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain. J Med Chem. 2020 03 26; 63(6):3381-3389. PMID: 32081008.
    Citations:    Fields:    Translation:AnimalsCells
  6. Yang J, Yang J, Wang H, Wang J, Xiong J, Qiao C, Ran C. An atom-economical design of PET tracer for imaging avß3 integrin via utilizing the three-in-one function of 64Copper. Chem Commun (Camb). 2020 Feb 11; 56(12):1788-1791. PMID: 31960841.
    Citations:    Fields:    Translation:HumansCells
  7. Wang J, Baumann H, Bi X, Shriver LP, Zhang Z, Pang Y. Efficient synthesis of NIR emitting bis[2-(2'-hydroxylphenyl)benzoxazole] derivative and its potential for imaging applications. Bioorg Chem. 2020 03; 96:103585. PMID: 31981912.
    Citations: 1     Fields:    Translation:HumansCells
  8. Gao H, Feng H, Bai Y, Li Z, Chen L, Jin L, Wang J, Georges EF, Liu G, Li J, Wang M. Multifunctional Polymeric Carrier for Co-Delivery of MRI Contrast Agents and siRNA to Tumors. J Biomed Nanotechnol. 2019 Aug 01; 15(8):1764-1770. PMID: 31219016.
    Citations: 2     Fields:    Translation:Humans
  9. JunfengWang, Timothy M.Shoup, Anna-LiisaBrownell, ZhaodaZhang. Improved synthesis of the thiophenol precursor N-(4-chloro-3-mercaptophenyl)picolinamide for making the mGluR4 PET ligands. Tetrahedron. 2019; 75(29):3917-3922. View Publication.
  10. Junfeng Wang, Xiying Qu, Timothy Shoup, Gengyang Yuan, Pan Chuzhi, Aijun Zhu, Ji-Kyung Choi, Hye Jin Kang, Pekka Poutiainen, Georges El Fakhri, Zhaoda Zhang and Anna-Liisa Brownell. J Nucl Med. Synthesis and characterization of [18F]mG4P027 as a PET imaging ligand for mGluR4. 2019; 60(1):479. View Publication.
  11. Wahsner J, Désogère P, Abston E, Graham-O'Regan KA, Wang J, Rotile NJ, Schirmer MD, Santos Ferreira DD, Sui J, Fuchs BC, Lanuti M, Caravan P. 68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis. J Am Chem Soc. 2019 04 10; 141(14):5593-5596. PMID: 30908032; PMCID: PMC6494104.
    Citations: 6     Fields:    Translation:Animals
  12. Wei Q, Wang J, Akam EA, Yin D, Ge Z, Cheng T, Wang X, Brownell AL, Li R. Transition Metal-Free Intermolecular C(sp2)-H Direct Amination of Furanones via a Redox Pathway. J Org Chem. 2019 02 01; 84(3):1310-1319. PMID: 30607949.
    Citations:    Fields:    Translation:Cells
  13. Ruonan Wang, Jingcai Wang, Qingxuan Tang, Xin Zhao, Junfeng Wang, Yuting Leng, Yangjie Wu, Junbiao Chang, Yusheng Wu, Zhaoda Zhang, Shiwei Wang. Copper(I)-Catalyzed Direct C-H Trifluoromethylation of Imidazoheterocycles with Togni’s Reagent. Tetrahedron Letters. 2019; 60(8):586-590.
  14. Wang J, Wang H, Ramsay IA, Erstad DJ, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation. J Med Chem. 2018 10 11; 61(19):8811-8824. PMID: 30204438; PMCID: PMC6442678.
    Citations: 12     Fields:    Translation:HumansAnimals
  15. Wang P, Goodwill PW, Pandit P, Gaudet J, Ross A, Wang J, Yu E, Hensley DW, Doyle TC, Contag CH, Conolly S, Moore A. Magnetic particle imaging of islet transplantation in the liver and under the kidney capsule in mouse models. Quant Imaging Med Surg. 2018 Mar; 8(2):114-122. PMID: 29675353; PMCID: PMC5891680.
    Citations: 22     
  16. J Wahsner, P Desogere, J Wang, N Rotile, D Erstad, B Fuchs, M Lanuti, Peter Caravan. Journal of Nuclear Medicine. 68Ga-NODAGA-indole, an allysine-reactive PET probe for molecular imaging of actively progressive pulmonary fibrogenesis. 2018; 1(59):260-260.
  17. Yi Pang, Junfeng Wang. Fluorescent sensor for metal cation detection based on 2-(2?-hydroxyphenyl)benzazole containing a Schiff base moiety. 2018.
  18. Li B, Zhao W, Zhang X, Wang J, Luo X, Baker SD, Jordan CT, Dong Y. Design, synthesis and evaluation of anti-CD123 antibody drug conjugates. Bioorg Med Chem. 2016 11 15; 24(22):5855-5860. PMID: 27687970; PMCID: PMC5318162.
    Citations: 5     Fields:    Translation:HumansCells
  19. McDonald L, Wang J, Alexander N, Li H, Liu T, Pang Y. Origin of Water-Induced Fluorescence Turn-On from a Schiff Base Compound: AIE or H-Bonding Promoted ESIPT? J Phys Chem B. 2016 Feb 04; 120(4):766-72. PMID: 26761400.
    Citations: 3     Fields:    Translation:Cells
  20. Junfeng Wang†, Bin Li†, Weiyu Zhao†, Xinfu Zhang†, Xiao Luo†, Mark E. Corkins‡, Sara L. Cole§, Chao Wang?, Yi Xiao?, Xiaoman Bi?, Yi Pang?, Craig A. McElroy†, Amanda J. Bird‡, and Yizhou Dong*†. Two-Photon Near Infrared Fluorescent Turn-On Probe Toward Cysteine and Its Imaging Applications. ACS Sensors. 2016; 7(1):882-887.
  21. Kanokthorn Boonkitpatarakul†‡, Junfeng Wang†, Nakorn Niamnont?, Bin Liu†, Lucas Mcdonald†, Yi Pang*†, and Mongkol Sukwattanasinitt*§. Novel Turn-On Fluorescent Sensors with Mega Stokes Shifts for Dual Detection of Al3+ and Zn2+. ACS Sensors. 2016; 2(1):144-150.
  22. Yizhoug Dong, Junfeng Wang. Anti-CD123 Antibody Drug Conjugates and Uses Thereof. 2016.
  23. Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler KM, Tan X, Dunn AL, Kerlin BA, Dong Y. An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo. Nano Lett. 2015 Dec 09; 15(12):8099-107. PMID: 26529392; PMCID: PMC4869688.
    Citations: 69     Fields:    Translation:Humans
  24. Wang J, Lu Z, Wang J, Cui M, Yeung BZ, Cole DJ, Wientjes MG, Au JL. Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors. J Control Release. 2015 Oct 28; 216:103-10. PMID: 26272765.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  27. Yi Pang, Junfeng Wang. Hydroxyphenylbenzazole compounds that are useful for the selective detection of zinc, aluminum, chromium, and iron cations in vitro and in vivo. 2015.
  28. Wang J, Li Y, Patel NG, Zhang G, Zhou D, Pang Y. A single molecular probe for multi-analyte (Cr³?, Al³? and Fe³?) detection in aqueous medium and its biological application. Chem Commun (Camb). 2014 Oct 21; 50(82):12258-61. PMID: 25178169.
    Citations: 4     Fields:    Translation:HumansCells
  29. Wang J, Liu X, Pang Y. A Benzothiazole-Based Sensor for Pyrophosphate (PPi) and ATP: Mechanistic Insight for Anion-Induced ESIPT Turn-On. J Mater Chem B. 2014 Oct 14; 2(38):6634-6638. PMID: 25530852.
    Citations: 3     Fields:    
  30. Wang J, Liu B, Liu X, Panzner MJ, Wesdemiotis C, Pang Y. A binuclear Zn(II)-Zn(II) complex from a 2-hydroxybenzohydrazide-derived Schiff base for selective detection of pyrophosphate. Dalton Trans. 2014 Oct 07; 43(37):14142-6. PMID: 25135613.
    Citations: 1     Fields:    Translation:Cells
  31. Wang J, Chen W, Liu X, Wesdemiotis C, Pang Y. A Mononuclear Zinc Complex for Selective Detection of Diphosphate via Fluorescence ESIPT Turn-On. J Mater Chem B. 2014 Jun 07; 2(21):3349-3354. PMID: 24999430.
    Citations: 4     Fields:    
  32. Yi Pang, Junfeng Wang. Class of near infrared molecular probes for biological applications. 2014.
  33. Liu B, Wang J, Zhang G, Bai R, Pang Y. Flavone-based ESIPT ratiometric chemodosimeter for detection of cysteine in living cells. ACS Appl Mater Interfaces. 2014 Mar 26; 6(6):4402-7. PMID: 24571859.
    Citations: 18     Fields:    Translation:HumansCells
  34. Guangzhuo Rong, Yusheng Chen, Lei Wang, Joanne Li, Junfeng Wang, Matthew J. Panzer, Yi Pang. A benzoxazole sulfenamide accelerator: Synthesis, structure, property, and implication in rubber vulcanization mechanism. Journal of Applied Polymer Science . 2014; 6(131):39699.
  35. Bin Liu, Qin Liu, Mickey Shah, Junfeng Wang, Ge Zhang, Yi Pang. Fluorescence monitor of hydrazine in vivo by selective deprotection of flavonoid. Sensors and Actuators B: Chemical. 2014; 31(202):194-200.
  36. Bin Liu, Junfeng Wang, Yi Pang, Zemei Ge, Runtao Li. Unexpected synthesis of 1,3,5-triarly-1,5-diketones from aryl ketones via di-enamine mechanism. Tetrahedron. 2014; 48(70):9240-9244.
  37. Wang J, Li Y, Duah E, Paruchuri S, Zhou D, Pang Y. A selective NIR-emitting zinc sensor by using Schiff base binding to turn-on excited-state intramolecular proton transfer. J Mater Chem B. 2014; 2(14):2008-2012. PMID: 25411638.
    Citations: 2     Fields:    
  38. Wang J, Pang Y. A Simple Sensitive ESIPT On-Off Fluorescent Sensor for Selective Detection of Al3+ in Water. RSC Adv. 2013 Dec 18; 4(12):5845-5848. PMID: 24839545.
    Citations: 2     
  39. Wang J, Chu Q, Liu X, Wesdemiotis C, Pang Y. Large fluorescence response by alcohol from a bis(benzoxazole)-zinc(II) complex: the role of excited state intramolecular proton transfer. J Phys Chem B. 2013 Apr 18; 117(15):4127-33. PMID: 23514312.
    Citations: 3     Fields:    Translation:Cells
  40. Wang W, Wang J, Zhou S, Sun Q, Ge Z, Wang X, Li R. An efficient organocatalytic enantioselective Michael addition of aryl methyl ketones with 2-furanones: highly functionalized chiral 3,4-substituted lactones. Chem Commun (Camb). 2013 Feb 14; 49(13):1333-5. PMID: 23304701.
    Citations: 2     Fields:    Translation:Cells
  41. Junfeng Wang, Yi Pang. A versatile synthesis of bis [2-(2'-hydroxylphenyl) benzoxazole] derivatives as zinc sensors. RSC Advances. 2013; 26(3):10208-10212 .
  42. Junfeng Wang, Qin Li, Zemei Ge, Runtao Li. A versatile and convenient route to ketone C-pyranosides and ketone C-furanosides from unprotected sugars. Tetrahedron. 2012; 4(68):1315-1320.
  43. Yi Liu, Pengchao Gao, Junfeng Wang, Qi Sun*, Zemei Ge, Runtao Li. Primary 1, 2-diamine catalysis (v): Efficient asymmetric aldol reactions of isatins with cyclohexanone. Synlett. 2012; 7(23):1031-1034.
  44. Yi Liu, Junfeng Wang, Qi Sun, Runtao Li. Chiral 1, 2-diaminocyclohexane as organocatalyst for enantioselective aldol reaction. Tetrahedron Letters. 2011; 28(52):3584-3587.
  45. G DAI, W MA, H LIU, H XU, Q YANG, F WANG, L AN, L HAO, J WANG. The in vitro anti-tumor activities of andrographolide derivatives and the structure-activity relationships. Chinese Journal of New Drugs. 2011; 4(20):362-366 .
  46. H Xu, P Jiang, W Li, J Wang, H Liu. Synthesis and Bioactivities of Andrographolide Derivatives: New (-)-Limonidilactone Analogues. Chinese Journal of Chemistry. 2011; 10(29): 2114-2118.
  47. Wang J, Li Q, Qi C, Liu Y, Ge Z, Li R. Primary 1,2-diamine catalysis III: an unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines. Org Biomol Chem. 2010 Oct 07; 8(19):4240-2. PMID: 20694251.
    Citations: 1     Fields:    Translation:Cells
  48. Lei M, Xia S, Wang J, Ge Z, Cheng T, Li R. An efficient dipeptide-catalyzed direct asymmetric aldol reaction of equimolar reactants in solid media. Chirality. 2010 Jun; 22(6):580-6. PMID: 19899160.
    Citations:    Fields:    Translation:Cells
  49. Wang J, Qi C, Ge Z, Cheng T, Li R. Efficient direct asymmetric vinylogous Michael addition reactions of gamma-butenolides to chalcones catalyzed by vicinal primary-diamine salts. Chem Commun (Camb). 2010 Mar 28; 46(12):2124-6. PMID: 20221513.
    Citations: 8     Fields:    Translation:Cells
  50. Wang J, Wang X, Ge Z, Cheng T, Li R. Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem Commun (Camb). 2010 Mar 14; 46(10):1751-3. PMID: 20177638.
    Citations: 4     Fields:    Translation:Cells
  51. Junfeng Wang, Meng Lei, Qin Li, Zemei Ge, Xin Wang, Runtao Li. A novel and efficient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway. Tetrahedron. 2009; 25(65):4826-4833.
  52. Liu HM, Xu HW, Dai GF, Wang JF . Andrographolide C15 substituted series derivates and their preparing method. 2009.
  53. Xu HW, Wang JF, Liu GZ, Hong GF, Liu HM. Facile synthesis of gamma-alkylidenebutenolides. Org Biomol Chem. 2007 Apr 21; 5(8):1247-50. PMID: 17406723.
    Citations: 2     Fields:    Translation:Cells
  54. HW Xu, GF Dai, GZ Liu, JF Wang, HM Liu. Synthesis of andrographolide derivatives: a new family of a-glucosidase inhibitors. Bioorganic & medicinal chemistry. 2007; 12(15):4247-4255.
  55. Liu, Hongmin; Xu, Haiwei; Wang, Junfeng; Dai, Guifu; Liu, Gaizhi. Method for preparation of Andrographolide C15-?hydroxymethyl derivatives. 2007.
  56. Liu, Hongmin; Xu, Haiwei; Liu, Gaizhi; Dai, Guifu; Wang, Junfeng. Isoandrographolide analogue and its preparation process. 2007.
  57. Liu HM, Yan L, XU HW, Wang JF, Zhao ML. 15-(14-deoxy 11,12 dehydro) andrographolide carbonic side derivate and preparation process thereof. 2007.
  58. Dai GF, Xu HW, Wang JF, Liu FW, Liu HM. Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues. Bioorg Med Chem Lett. 2006 May 15; 16(10):2710-3. PMID: 16504503.
    Citations: 5     Fields:    Translation:Animals
  59. HW Xu, J Zhang, HM Liu, JF Wang. Synthesis of andrographolide cyclophosphate derivatives and their antitumor activities. Synthetic communications. 2006; 4(36):407-414.
  60. G Dai, J Wang, H Xu. Proliferation inhibition and apoptosis of human esophageal carcinoma Ec9706 cells by andrographolide. CHINESE NEW DRUGS JOURNAL. 2006; 16(15):1363.
  61. H Xu, J Wang, H Liu, J Zhang. Synthesis and crystal structure of dehydroandrographolide dipolycyclophosphate. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY. 2005; 10(24):1198-1202.
  62. Hongmin Liu, Guifu Dai, Hongyu Sun, Junfeng Wang. Progress of Glucosidase inhibitors. Progress in Medicinal Chemistry. 2005.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.