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Jingyi Qian, Ph.D.

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Biography
Fudan University, Shanghai, ChinaB.S.
University of California, Los Angeles, Los Angeles, CA, USAPh.D.
2016
Finalist for the Outstanding Trainee Manuscript Award, Endocrin Society
2017
1st place of Club Hypnos Cup data blitz competition, Sleep Research Society
2017 - 2018
SRS Trainee Merit Based Award, Sleep Reseach Society
2018
CVDM Obesity Incubator Poster Award, Brigham Research Institute
2017 - 2019
Postdoctoral Fellowship, American Diabetes Association
2020
Outstanding Manuscript Award, Nutrition Obesity Research Center at Harvard
2022
Research Excellence Award

Overview
Dr. Qian is an Instructor of Medicine at Harvard Medical School, an Associate Physiologist at Brigham and Women’s Hospital (BWH), and the Associate Director of the Medical Chronobiology Program at BWH. She has been actively involved in the research of the circadian system and physiology for over 10 years. Dr.Qian joined the Medical Chronobiology Program at Brigham and Women’s Hospital and Harvard Medical School in 2015. Since then, she led a highly controlled human in-laboratory study to investigate the effects of melatonin on glucose control and cardiovascular function, and their interactions with MTNR1B genotype. Her research is primarily focused on the physiological mechanisms by which timing of behavior, such as food intake and physical activity, can interact with the circadian system, and synergistically affect cardiometabolic outcomes. She is also interested in understanding the interindividual differences based on sex and genetics in these interactions. For example, She has demonstrated the impacts of circadian misalignment on glycemic and appetite control, sex differences in energy metabolism under night shift, and the interaction effects of the circadian system and physical activity on cardiometabolic health. At every stage of her training she has been awarded fellowships or training grants that recognize academic excellence, research ability, and leadership, including a postdoctoral fellowship from American Diabetes Association, a pilot and feasibility grant from Nutrition Obesity Research Center at Harvard, and a prestigious K99 Award from NIH.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99HL148500 (Jingyi, Qian) Sep 1, 2020 - Aug 31, 2022
    NIH/NHLBI
    Timing of Physical Activity on Cardiometabolic Health Outcomes
    Role: Principle Investigator
  2. Pilot & Feasibility Award (Jingyi, Qian) Aug 1, 2020 - Jul 31, 2021
    Nutrition Obesity Research Center at Harvard
    Effects of Circadian Misalignment and Meal Timing on Metabolomic Profiling
    Role: Principal Investigator
  3. 1-17-PDF-103 (Jingyi Qian) Jan 1, 2017 - Dec 31, 2019
    American Diabetes Association
    Interaction of melatonin and MTNR1B genotype on glucose control
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vujovic N, Piron MJ, Qian J, Chellappa SL, Nedeltcheva A, Barr D, Heng SW, Kerlin K, Srivastav S, Wang W, Shoji B, Garaulet M, Brady MJ, Scheer FAJL. Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity. Cell Metab. 2022 10 04; 34(10):1486-1498.e7. PMID: 36198293.
    Citations: 1     Fields:    Translation:Humans
  2. Qian J, Vujovic N, Nguyen H, Rahman N, Heng SW, Amira S, Scheer FAJL, Chellappa SL. Daytime eating prevents mood vulnerability in night work. Proc Natl Acad Sci U S A. 2022 09 20; 119(38):e2206348119. PMID: 36095195; PMCID: PMC9499546.
    Citations:    Fields:    Translation:Humans
  3. Lane JM, Qian J, Mignot E, Redline S, Scheer FAJL, Saxena R. Genetics of circadian rhythms and sleep in human health and disease. Nat Rev Genet. 2023 Jan; 24(1):4-20. PMID: 36028773.
    Citations: 1     Fields:    Translation:Humans
  4. Qian J, Morris CJ, Phillips AJK, Li P, Rahman SA, Wang W, Hu K, Arendt J, Czeisler CA, Scheer FAJL. Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24-h melatonin rhythm with antiphasic daytime and nighttime peaks. J Pineal Res. 2022 Apr; 72(3):e12791. PMID: 35133678; PMCID: PMC8930611.
    Citations:    Fields:    Translation:Humans
  5. Xiao Q, Qian J, Evans DS, Redline S, Lane NE, Ancoli-Israel S, Scheer FAJL, Stone K. Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men. J Gerontol A Biol Sci Med Sci. 2022 01 07; 77(1):55-65. PMID: 33822930; PMCID: PMC8751803.
    Citations: 2     Fields:    Translation:Humans
  6. Knaier R, Qian J, Roth R, Infanger D, Notter T, Wang W, Cajochen C, Scheer FAJL. Diurnal Variation in Maximum Endurance and Maximum Strength Performance: A Systematic Review and Meta-analysis. Med Sci Sports Exerc. 2022 01 01; 54(1):169-180. PMID: 34431827.
    Citations:    Fields:    Translation:Humans
  7. Chellappa SL, Engen PA, Naqib A, Qian J, Vujovic N, Rahman N, Green SJ, Garaulet M, Keshavarzian A, Scheer FAJL. Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota. FASEB J. 2022 01; 36(1):e22043. PMID: 34861073; PMCID: PMC8938955.
    Citations: 1     Fields:    Translation:Humans
  8. Chellappa SL, Qian J, Vujovic N, Morris CJ, Nedeltcheva A, Nguyen H, Rahman N, Heng SW, Kelly L, Kerlin-Monteiro K, Srivastav S, Wang W, Aeschbach D, Czeisler CA, Shea SA, Adler GK, Garaulet M, Scheer FAJL. Daytime eating prevents internal circadian misalignment and glucose intolerance in night work. Sci Adv. 2021 Dec 03; 7(49):eabg9910. PMID: 34860550; PMCID: PMC8641939.
    Citations: 9     Fields:    
  9. Qian J, Martinez-Lozano N, Tvarijonaviciute A, Rios R, Scheer FAJL, Garaulet M. Blunted rest-activity rhythms link to higher body mass index and inflammatory markers in children. Sleep. 2021 05 14; 44(5). PMID: 33249510; PMCID: PMC8120335.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  10. Qian J, Walkup MP, Chen SH, Brubaker PH, Bond DS, Richey PA, Jakicic JM, Hu K, Scheer FAJL, Middelbeek RJW. Association of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes. Diabetes Care. 2021 04; 44(4):1046-1054. PMID: 33597215; PMCID: PMC7985432.
    Citations: 2     Fields:    Translation:Humans
  11. Dashti HS, Gómez-Abellán P, Qian J, Esteban A, Morales E, Scheer FAJL, Garaulet M. Late eating is associated with cardiometabolic risk traits, obesogenic behaviors, and impaired weight loss. Am J Clin Nutr. 2021 Jan 04; 113(1):154-161. PMID: 33022698; PMCID: PMC7779221.
    Citations: 23     Fields:    
  12. Xiao Q, Qian J, Evans DS, Redline S, Lane NE, Ancoli-Israel S, Scheer FAJL, Stone K. Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men. Diabetes Care. 2020 11; 43(11):2702-2712. PMID: 32887712.
    Citations: 7     Fields:    Translation:Humans
  13. Qian J, Scheer FA, Hu K, Shea SA. The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans. Sleep. 2020 04 15; 43(4). PMID: 31616941.
    Citations: 6     Fields:    Translation:Humans
  14. Mason IC, Qian J, Adler GK, Scheer FAJL. Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes. Diabetologia. 2020 03; 63(3):462-472. PMID: 31915891.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  15. Qian J, Scheer FAJL. Sex-dependent link between circadian misalignment and adiposity. Nat Rev Endocrinol. 2020 01; 16(1):13-15. PMID: 31723227.
    Citations: 2     Fields:    Translation:Humans
  16. Garaulet M, Qian J, Florez JC, Arendt J, Saxena R, Scheer FAJL. Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. Trends Endocrinol Metab. 2020 03; 31(3):192-204. PMID: 31901302.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  17. Qian J, Morris CJ, Caputo R, Wang W, Garaulet M, Scheer FAJL. Sex differences in the circadian misalignment effects on energy regulation. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23806-23812. PMID: 31685618.
    Citations: 32     Fields:    Translation:HumansCells
  18. Qian J, Morris CJ, Caputo R, Garaulet M, Scheer FAJL. Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans. Int J Obes (Lond). 2019 08; 43(8):1644-1649. PMID: 30232416; PMCID: PMC6424662.
    Citations: 23     Fields:    Translation:Humans
  19. Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJL. Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes Obes Metab. 2018 10; 20(10):2481-2485. PMID: 29862620.
    Citations: 34     Fields:    Translation:HumansCells
  20. Rakshit K, Qian J, Gaonkar KS, Dhawan S, Colwell CS, Matveyenko AV. Postnatal Ontogenesis of the Islet Circadian Clock Plays a Contributory Role in ß-Cell Maturation Process. Diabetes. 2018 05; 67(5):911-922. PMID: 29500314; PMCID: PMC5910002.
    Citations: 10     Fields:    Translation:AnimalsCells
  21. Qian J, Thomas AP, Schroeder AM, Rakshit K, Colwell CS, Matveyenko AV. Development of diabetes does not alter behavioral and molecular circadian rhythms in a transgenic rat model of type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2017 08 01; 313(2):E213-E221. PMID: 28465284; PMCID: PMC5582890.
    Citations: 2     Fields:    Translation:Animals
  22. Rakshit K, Qian J, Ernst J, Matveyenko AV. Circadian variation of the pancreatic islet transcriptome. Physiol Genomics. 2016 09 01; 48(9):677-87. PMID: 27495157; PMCID: PMC5111880.
    Citations: 20     Fields:    Translation:AnimalsCells
  23. Qian J, Scheer FAJL. Circadian System and Glucose Metabolism: Implications for Physiology and Disease. Trends Endocrinol Metab. 2016 05; 27(5):282-293. PMID: 27079518; PMCID: PMC4842150.
    Citations: 107     Fields:    Translation:HumansAnimals
  24. Qian J, Yeh B, Rakshit K, Colwell CS, Matveyenko AV. Circadian Disruption and Diet-Induced Obesity Synergize to Promote Development of ß-Cell Failure and Diabetes in Male Rats. Endocrinology. 2015 Dec; 156(12):4426-36. PMID: 26348474; PMCID: PMC4655211.
    Citations: 33     Fields:    Translation:AnimalsCells
  25. Rakshit K, Qian J, Colwell CS, Matveyenko AV. The islet circadian clock: entrainment mechanisms, function and role in glucose homeostasis. Diabetes Obes Metab. 2015 Sep; 17 Suppl 1:115-22. PMID: 26332976.
    Citations: 17     Fields:    Translation:HumansCells
  26. Qian J, Block GD, Colwell CS, Matveyenko AV. Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes. 2013 Oct; 62(10):3469-78. PMID: 23775768; PMCID: PMC3781472.
    Citations: 61     Fields:    Translation:AnimalsCells
  27. Gale JE, Cox HI, Qian J, Block GD, Colwell CS, Matveyenko AV. Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. J Biol Rhythms. 2011 Oct; 26(5):423-33. PMID: 21921296.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  28. Jin K, Xue C, Wu X, Qian J, Zhu Y, Yang Z, Yonezawa T, Crabbe MJ, Cao Y, Hasegawa M, Zhong Y, Zheng Y. Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals. PLoS One. 2011; 6(7):e22602. PMID: 21818345.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.