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Jingyi Qian, Ph.D.

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Biography
Fudan University, Shanghai, ChinaB.S.
University of California, Los Angeles, Los Angeles, CA, USAPh.D.

Overview
I have been actively involved in the research of circadian system and physiology since my PhD training at University of California, Los Angeles. My PhD thesis focused on the physiological and molecular mechanisms underlying the association between circadian disruption and poor glycemic control, with particular focus on regulation of pancreatic beta-cell function and survival in rodent model.This line of my research was among the first to identify the potential mechanisms by which environment/behavior-induced circadian disruption-common to modern life-can predispose to islet failure in type 2 diabetes. For my postdoctoral training, I joined the Medical Chronobiology Program at Brigham and Women’s Hospital and Harvard Medical School to continue my interests in circadian rhythm and physiology by transitioning into human studies, which allows me to address research questions that can be directly translated to human health. I led a highly controlled human in-laboratory study to investigate the effects of melatonin on glucose control and cardiovascular function, and their interactions with MTNR1B genotype. I am also interested in the impact of circadian misalignment on glycemic and appetite control, sex differences in energy metabolism under night shift, and the interaction effects of the circadian system and exercise on cardiometabolic health.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. #1-17-PDF-103 (Jingyi Qian) Jan 1, 2017 - Dec 31, 2019
    American Diabetes Association
    Interaction of Melatonin and MTNR1B Genotype on Glucose Control
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Qian J, Scheer FA, Hu K, Shea SA. The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans. Sleep. 2020 Apr 15; 43(4). PMID: 31616941.
    Citations:    
  2. Mason IC, Qian J, Adler GK, Scheer FAJL. Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes. Diabetologia. 2020 03; 63(3):462-472. PMID: 31915891.
    Citations:    
  3. Qian J, Scheer FAJL. Sex-dependent link between circadian misalignment and adiposity. Nat Rev Endocrinol. 2020 01; 16(1):13-15. PMID: 31723227.
    Citations:    
  4. Garaulet M, Qian J, Florez JC, Arendt J, Saxena R, Scheer FAJL. Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. Trends Endocrinol Metab. 2020 Mar; 31(3):192-204. PMID: 31901302.
    Citations:    
  5. Qian J, Morris CJ, Caputo R, Wang W, Garaulet M, Scheer FAJL. Sex differences in the circadian misalignment effects on energy regulation. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23806-23812. PMID: 31685618.
    Citations:    
  6. Qian J, Morris CJ, Caputo R, Garaulet M, Scheer FAJL. Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans. Int J Obes (Lond). 2019 08; 43(8):1644-1649. PMID: 30232416.
    Citations:    Fields:    
  7. Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJL. Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes Obes Metab. 2018 10; 20(10):2481-2485. PMID: 29862620.
    Citations:    Fields:    
  8. Rakshit K, Qian J, Gaonkar KS, Dhawan S, Colwell CS, Matveyenko AV. Postnatal Ontogenesis of the Islet Circadian Clock Plays a Contributory Role in ß-Cell Maturation Process. Diabetes. 2018 05; 67(5):911-922. PMID: 29500314.
    Citations:    Fields:    Translation:AnimalsCells
  9. Qian J, Thomas AP, Schroeder AM, Rakshit K, Colwell CS, Matveyenko AV. Development of diabetes does not alter behavioral and molecular circadian rhythms in a transgenic rat model of type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2017 08 01; 313(2):E213-E221. PMID: 28465284.
    Citations: 2     Fields:    Translation:Animals
  10. Rakshit K, Qian J, Ernst J, Matveyenko AV. Circadian variation of the pancreatic islet transcriptome. Physiol Genomics. 2016 09 01; 48(9):677-87. PMID: 27495157.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Qian J, Scheer FAJL. Circadian System and Glucose Metabolism: Implications for Physiology and Disease. Trends Endocrinol Metab. 2016 05; 27(5):282-293. PMID: 27079518.
    Citations: 25     Fields:    Translation:HumansAnimals
  12. Qian J, Yeh B, Rakshit K, Colwell CS, Matveyenko AV. Circadian Disruption and Diet-Induced Obesity Synergize to Promote Development of ß-Cell Failure and Diabetes in Male Rats. Endocrinology. 2015 Dec; 156(12):4426-36. PMID: 26348474.
    Citations: 11     Fields:    Translation:AnimalsCells
  13. Rakshit K, Qian J, Colwell CS, Matveyenko AV. The islet circadian clock: entrainment mechanisms, function and role in glucose homeostasis. Diabetes Obes Metab. 2015 Sep; 17 Suppl 1:115-22. PMID: 26332976.
    Citations: 7     Fields:    Translation:HumansCells
  14. Qian J, Block GD, Colwell CS, Matveyenko AV. Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes. 2013 Oct; 62(10):3469-78. PMID: 23775768.
    Citations: 33     Fields:    Translation:AnimalsCells
  15. Gale JE, Cox HI, Qian J, Block GD, Colwell CS, Matveyenko AV. Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. J Biol Rhythms. 2011 Oct; 26(5):423-33. PMID: 21921296.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  16. Jin K, Xue C, Wu X, Qian J, Zhu Y, Yang Z, Yonezawa T, Crabbe MJ, Cao Y, Hasegawa M, Zhong Y, Zheng Y. Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals. PLoS One. 2011; 6(7):e22602. PMID: 21818345.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.