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Shuanhu Zhou, PH.D.

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Biography
Sichuan University, Chengdu, ChinaBSChemistry
Hebrew University of Jerusalem, Jerusalem, IsraelPhDMolecular and Cellular Biology
1994 - 1995
Lady David scholarship
2001
Rector Award for Excellent Ph.D. student
2006
John Haddad Young Investigator Award
2007
Musculoskeletal Translational Research Award
2010
Junior Investigator Laboratory Support Award
2012
Musculoskeletal Best Paper Award

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Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Luo C, Yang Q, Liu Y, Zhou S, Jiang J, Reiter RJ, Bhattacharya P, Cui Y, Yang H, Ma H, Yao J, Lawler SE, Zhang X, Fu J, Rozental R, Aly H, Johnson MD, Chiocca EA, Wang X. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2018 Oct 11; 130:215-233. PMID: 30315933.
    View in: PubMed
  2. Zhou S, Glowacki J. Dehydroepiandrosterone and Bone. Vitam Horm. 2018; 108:251-271. PMID: 30029729.
    View in: PubMed
  3. Sinha B, Wu Q, Li W, Tu Y, Sirianni AC, Chen Y, Jiang J, Zhang X, Chen W, Zhou S, Reiter RJ, Manning SM, Patel NJ, Aziz-Sultan AM, Inder TE, Friedlander RM, Fu J, Wang X. Protection of melatonin in experimental models of newborn hypoxic-ischemic brain injury through MT1 receptor. J Pineal Res. 2018 Jan; 64(1). PMID: 28796402.
    View in: PubMed
  4. Zhou S, Glowacki J. Chronic kidney disease and vitamin D metabolism in human bone marrow-derived MSCs. Ann N Y Acad Sci. 2017 08; 1402(1):43-55. PMID: 28926112.
    View in: PubMed
  5. Li J, Padwa BL, Zhou S, Mullokandova J, LeBoff MS, Glowacki J. Synergistic effect of 1a,25-dihydroxyvitamin D3 and 17ß-estradiol on osteoblast differentiation of pediatric MSCs. J Steroid Biochem Mol Biol. 2018 Mar; 177:103-108. PMID: 28765038.
    View in: PubMed
  6. Liang X, Glowacki J, Hahne J, Xie L, LeBoff MS, Zhou S. Dehydroepiandrosterone Stimulation of Osteoblastogenesis in Human MSCs Requires IGF-I Signaling. J Cell Biochem. 2016 08; 117(8):1769-74. PMID: 26682953.
    View in: PubMed
  7. Zhou S, Thornhill TS, Meng F, Xie L, Wright J, Glowacki J. Influence of osteoarthritis grade on molecular signature of human cartilage. J Orthop Res. 2016 Mar; 34(3):454-62. PMID: 26336057.
    View in: PubMed
  8. Wu Q, Chen W, Sinha B, Tu Y, Manning S, Thomas N, Zhou S, Jiang H, Ma H, Kroessler DA, Yao J, Li Z, Inder TE, Wang X. Neuroprotective agents for neonatal hypoxic-ischemic brain injury. Drug Discov Today. 2015 Nov; 20(11):1372-81. PMID: 26360053.
    View in: PubMed
  9. Fu W, Zhuang W, Zhou S, Wang X. Plant-derived neuroprotective agents in Parkinson's disease. Am J Transl Res. 2015; 7(7):1189-202. PMID: 26328004; PMCID: PMC4548312.
  10. Sirianni AC, Jiang J, Zeng J, Mao LL, Zhou S, Sugarbaker P, Zhang X, Li W, Friedlander RM, Wang X. N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis. J Neurochem. 2015 Sep; 134(5):956-68. PMID: 26031348.
    View in: PubMed
  11. Zhou S. Paracrine effects of haematopoietic cells on human mesenchymal stem cells. Sci Rep. 2015 Jun 01; 5:10573. PMID: 26030407; PMCID: PMC4450757.
  12. Li Xie, Xin Wang, Shuanhu Zhou. Mesenchymal Stem Cells and Cartilage Regeneration in Traumatic and Osteoarthritic Cartilage Defects. Enliven: Journal of Stem Cell Research & Regenerative Medicine. 2014; 1(1):1-4.
  13. Hu H, Zhao B, Zhou S, Shen L. Wnt signal transduction pathways and the differentiation of mesenchymal stem cells. Int. J. Orthop. 2014; 35(5):325-328.
  14. Chung PL, Zhou S, Eslami B, Shen L, LeBoff MS, Glowacki J. Effect of age on regulation of human osteoclast differentiation. J Cell Biochem. 2014 Aug; 115(8):1412-9. PMID: 24700654; PMCID: PMC4096781.
  15. Liu H, Chen Y, Zhou F, Jie L, Pu L, Ju J, Li F, Dai Z, Wang X, Zhou S. Sox9 regulates hyperexpression of Wnt1 and Fzd1 in human osteosarcoma tissues and cells. Int J Clin Exp Pathol. 2014; 7(8):4795-805. PMID: 25197350; PMCID: PMC4152040.
  16. Zhou H, Wang J, Jiang J, Stavrovskaya IG, Li M, Li W, Wu Q, Zhang X, Luo C, Zhou S, Sirianni AC, Sarkar S, Kristal BS, Friedlander RM, Wang X. N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury. J Neurosci. 2014 Feb 19; 34(8):2967-78. PMID: 24553937; PMCID: PMC3929763.
  17. Xin Wang, Yingjun Guan, Wenyu Fu, Shuanhu Zhou, Zheng-Hong Qin. "Melatonin's Antiapoptotic Activity in Neurodegenerative Diseases" in Melatonin :Therapeutic value and Neuroprotection (Editors: V Srinivasan, Gabriella Gobbi, Samuel D Shillcutt, Sibel Suzen), Taylor & Francis , CRC Press. 2014; 111-132.
  18. Geng S, Zhou S, Bi Z, Glowacki J. Vitamin D metabolism in human bone marrow stromal (mesenchymal stem) cells. Metabolism. 2013 Jun; 62(6):768-77. PMID: 23375059; PMCID: PMC3644521.
  19. Zhou S, Mizuno S, Glowacki J. Wnt pathway regulation by demineralized bone is approximated by both BMP-2 and TGF-ß1 signaling. J Orthop Res. 2013 Apr; 31(4):554-60. PMID: 23239467.
    View in: PubMed
  20. Zhou S, Leboff MS, Waikar SS, Glowacki J. Vitamin D metabolism and action in human marrow stromal cells: effects of chronic kidney disease. J Steroid Biochem Mol Biol. 2013 Jul; 136:342-4. PMID: 22989482; PMCID: PMC3535685.
  21. Zhou S, Geng S, Glowacki J. Histone deacetylation mediates the rejuvenation of osteoblastogenesis by the combination of 25(OH)D3 and parathyroid hormone in MSCs from elders. J Steroid Biochem Mol Biol. 2013 Jul; 136:156-9. PMID: 22982627; PMCID: PMC3548026.
  22. Zhou S, Glowacki J, Kim SW, Hahne J, Geng S, Mueller SM, Shen L, Bleiberg I, LeBoff MS. Clinical characteristics influence in vitro action of 1,25-dihydroxyvitamin D(3) in human marrow stromal cells. J Bone Miner Res. 2012 Sep; 27(9):1992-2000. PMID: 22576852; PMCID: PMC3423497.
  23. Gao H, Wu X, Sun Y, Zhou S, Silberstein LE, Zhu Z. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012 Aug 24; 287(35):29979-87. PMID: 22791709; PMCID: PMC3436167.
  24. O'Sullivan RP, Greenberger JS, Goff J, Cao S, Kingston KA, Zhou S, Dixon T, Houghton FD, Epperly MW, Wang H, Glowacki J. Dysregulated in vitro hematopoiesis, radiosensitivity, proliferation, and osteoblastogenesis with marrow from SAMP6 mice. Exp Hematol. 2012 Jun; 40(6):499-509. PMID: 22326715; PMCID: PMC3353019.
  25. Glowacki J, Geng S, Zhou S. Vitamin D Metabolism in Osteoblast Progenitor Cells in Human Marrow. Orthop J Harvard Medical School. 2012; (13).
  26. Wang X, Sirianni A, Pei Z, Cormier K, Smith K, Jiang J, Zhou S, Wang H, Zhao R, Yano H, Kim JE, Li W, Kristal BS, Ferrante RJ, Friedlander RM. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity. J Neurosci. 2011 Oct 12; 31(41):14496-507. PMID: 21994366; PMCID: PMC3213696.
  27. Geng S, Zhou S, Glowacki J. Age-related decline in osteoblastogenesis and 1a-hydroxylase/CYP27B1 in human mesenchymal stem cells: stimulation by parathyroid hormone. Aging Cell. 2011 Dec; 10(6):962-71. PMID: 21824271; PMCID: PMC3215854.
  28. Zhou S. From bone to brain: human skeletal stem cell therapy for stroke. Cent Nerv Syst Agents Med Chem. 2011 Jun 01; 11(2):157-63. PMID: 21521166.
    View in: PubMed
  29. Zhou S. TGF-ß regulates ß-catenin signaling and osteoblast differentiation in human mesenchymal stem cells. J Cell Biochem. 2011 Jun; 112(6):1651-60. PMID: 21344492; PMCID: PMC3079785.
  30. Pandya RS, Mao L, Zhou H, Zhou S, Zeng J, Popp AJ, Wang X. Central nervous system agents for ischemic stroke: neuroprotection mechanisms. Cent Nerv Syst Agents Med Chem. 2011 Jun 01; 11(2):81-97. PMID: 21521165.
    View in: PubMed
  31. Shen L, Glowacki J, Zhou S. Inhibition of adipocytogenesis by canonical WNT signaling in human mesenchymal stem cells. Exp Cell Res. 2011 Aug 01; 317(13):1796-803. PMID: 21640723; PMCID: PMC3131145.
  32. Zhou S, Bueno EM, Kim SW, Amato I, Shen L, Hahne J, Bleiberg I, Morley P, Glowacki J. Effects of age on parathyroid hormone signaling in human marrow stromal cells. Aging Cell. 2011 Oct; 10(5):780-8. PMID: 21518242; PMCID: PMC3158270.
  33. Geng S, Zhou S, Glowacki J. Effects of 25-hydroxyvitamin D(3) on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1a-hydroxylase. J Bone Miner Res. 2011 May; 26(5):1145-53. PMID: 21542014.
    View in: PubMed
  34. Eslami B, Zhou S, Van Eekeren I, LeBoff MS, Glowacki J. Reduced osteoclastogenesis and RANKL expression in marrow from women taking alendronate. Calcif Tissue Int. 2011 Apr; 88(4):272-80. PMID: 21327765; PMCID: PMC3060993.
  35. Shen L, Zhou S, Glowacki J. Chinese Journal of Experimental Surgery. The effects of WNT activator SB-216763 on chondrocytogenesis of human bone marrow stromal cells. 2010; 27(1):116-119.
  36. Zhou S, LeBoff MS, Glowacki J. Vitamin D metabolism and action in human bone marrow stromal cells. Endocrinology. 2010 Jan; 151(1):14-22. PMID: 19966181; PMCID: PMC2803155.
  37. Shen L, Lin H, Zhou S, Chen Z. Chinese Journal of Experimental Surgery. The effects of WNT activator SB-216763 on chondrocytes. 2009; 26(12):29-31.
  38. Glowacki J, Zhou S, Mizuno S. Mechanisms of osteoinduction/chondroinduction by demineralized bone. J Craniofac Surg. 2009 Mar; 20 Suppl 1:634-8. PMID: 19169155.
    View in: PubMed
  39. Shen L, Zhou S, Glowacki J. Effects of age and gender on WNT gene expression in human bone marrow stromal cells. J Cell Biochem. 2009 Feb 01; 106(2):337-43. PMID: 19115259; PMCID: PMC4452949.
  40. Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, Leboff MS, Glowacki J. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell. 2008 Jun; 7(3):335-43. PMID: 18248663; PMCID: PMC2398731.
  41. Glowacki J, Zhou S, LeBoff MS, Thornhill TS . Human skeletal biology: Insights from surgical biospecimens. Orthop J Harvard Medical School. 10:69-72. 2008.
  42. Zhang XW, Li RG, Wang X, Zhou SH. Effects of copper-phenanthroline on pentachlorophenol-induced adaptation and cell death of Escherichia coli. Biomed Environ Sci. 2007 Apr; 20(2):106-12. PMID: 17624183.
    View in: PubMed
  43. Glowacki J, Zhou S. . Extrinsic and Intrinsic Mechanisms of Human Skeletal Aging. Orthop J Harvard Medical School. 9:80-82. 2007.
  44. Lechpammer S, Epperly MW, Zhou S, Nie S, Glowacki J, Greenberger JS. Adipocyte differentiation in Sod2(-/-) and Sod2(+/+) murine bone marrow stromal cells is associated with low antioxidant pools. Exp Hematol. 2005 Oct; 33(10):1201-8. PMID: 16219542.
    View in: PubMed
  45. Zhou S, Lechpammer S, Greenberger JS, Glowacki J. Hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires transforming growth factor-beta/Smad3 signaling. J Biol Chem. 2005 Jun 17; 280(24):22688-96. PMID: 15845540; PMCID: PMC1242109.
  46. Epperly MW, Cao S, Goff J, Shields D, Zhou S, Glowacki J, Greenberger JS. Increased longevity of hematopoiesis in continuous bone marrow cultures and adipocytogenesis in marrow stromal cells derived from Smad3(-/-) mice. Exp Hematol. 2005 Mar; 33(3):353-62. PMID: 15730859.
    View in: PubMed
  47. Zhou S, Yates KE, Eid K, Glowacki J. Demineralized bone promotes chondrocyte or osteoblast differentiation of human marrow stromal cells cultured in collagen sponges. Cell Tissue Bank. 2005; 6(1):33-44. PMID: 15735899; PMCID: PMC1282516.
  48. Zhou S, Glowacki J, Yates KE. Comparison of TGF-beta/BMP pathways signaled by demineralized bone powder and BMP-2 in human dermal fibroblasts. J Bone Miner Res. 2004 Oct; 19(10):1732-41. PMID: 15355569.
    View in: PubMed
  49. Zhou S, Eid K, Glowacki J. Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J Bone Miner Res. 2004 Mar; 19(3):463-70. PMID: 15040835.
    View in: PubMed
  50. Aslan H, Zhou S, Pelled G, Turgeman G, Mclarney S, Komm B, Bodine P, Gazit D. Transcriptional profiling of estrogen-induced osteogenic differentiation of murine adult mesenchymal stem cells (AMSCs) in vitro. In: Mesenchymal Stem cells: Biology and Potential Clinical Uses Grisolía, S.; Minyana, D. & Bendala-Tufanisco, E., eds. Ministerio de Sanidad y Consumo, Madrid, Spain. 2003.
  51. Zhou S, Turgeman G, Harris SE, Leitman DC, Komm BS, Bodine PV, Gazit D. Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells. Mol Endocrinol. 2003 Jan; 17(1):56-66. PMID: 12511606.
    View in: PubMed
  52. Turgeman G, Zilberman Y, Zhou S, Kelly P, Moutsatsos IK, Kharode YP, Borella LE, Bex FJ, Komm BS, Bodine PV, Gazit D. Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice. J Cell Biochem. 2002; 86(3):461-74. PMID: 12210753.
    View in: PubMed
  53. Turgeman G, Pittman DD, Müller R, Kurkalli BG, Zhou S, Pelled G, Peyser A, Zilberman Y, Moutsatsos IK, Gazit D. Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med. 2001 May-Jun; 3(3):240-51. PMID: 11437329.
    View in: PubMed
  54. Moutsatsos IK, Turgeman G, Zhou S, Kurkalli BG, Pelled G, Tzur L, Kelley P, Stumm N, Mi S, Müller R, Zilberman Y, Gazit D. Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol Ther. 2001 Apr; 3(4):449-61. PMID: 11319905.
    View in: PubMed
  55. Zhou S, Zilberman Y, Wassermann K, Bain SD, Sadovsky Y, Gazit D. Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice. J Cell Biochem Suppl. 2001; Suppl 36:144-55. PMID: 11455579.
    View in: PubMed
  56. Gazit D, Zilberman Y, Turgeman G, Zhou S, Kahn A. Recombinant TGF-beta1 stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice. J Cell Biochem. 1999 Jun 01; 73(3):379-89. PMID: 10321837.
    View in: PubMed
  57. Zhou S and Wang X. . The correlation of bond-parameter and topological index of lattice enthalpy. Chemical Research and Application. 1992; 48(4):48-52.
  58. Wulin Ying, Shuanhu Zhou . The effect of solvent on Fe(III) coloring glass by hot spraying glass. China Glass. 1992; (6):1-3.
  59. Xin Wang, Shuanhu Zhou, Yitai Qian, Zhuyao Chen . The research of phase and conductivity of Ba-La-Cu-O, Ba2xSrxLaCu3O7-d, Ba2La1xCexCu3O7-delta systems. Bulletin of the Chinese Ceramic Society. 1991; (10):12-17.
  60. Shuanhu Zhou et al. All Subjects Dictionary, Xioushong Li Ed., Anhui People Publishing House, Hefei. 1990.
  61. Shuanhu Zhou, Xin Wang, Shengzhe Nie . The electrode potentials and atomic sotentiols scale of the hardness- softness of acids and bases. Chemical Research and Application. 1990; (2):88-93.
  62. Nie S, Zhou S, Pan Z . The New Subjects Of Modern Chemistry, Univ. of Sci.& Tech. of China Press, Hefei, China. 1990.
  63. Zhou S et. al . The Chinese Encyclopedia Dictionary, Guangyuan Yu, Ed. Huaxia Publishing House, Beijing. 1990.
  64. Yuankai Wen, Shuanhu Zhou, Shenzhe Nie . Bond-parameter analysis of superconducting oxide compounds. Bulletin of Chinese Science. 1989; 18(34):1545-1547.
  65. Wen Y, Liu H, Li P, Nie S, Zhou S . The study of pattern recognition of high critical temperature oxide superconductors. Journal of Chinese Silicate Society. 1989; 1(17):13-17.
  66. Gu Junji, Shengzhe Nie, Shuanhu Zhou . The application of HSAB theory in materials science I: The study of superconductivity of ß-W structure binary compounds. Acta Chimica Sinica. 1989; 9(47):932-934.
  67. Xu Z, Yong X, Song S, Zhou S, Nie S . Superconductivity at 91.5 K in single phase YBa2Cu3O7-y compound system. Journal of Anhui University (Sci. ed.). 1988; (1):86-88.
  68. Gu G, Zhou S, Nie S . Quantitative structure-property correlation and prediction of superconductivity VIII. Journal of Anhui University (Sci. ed.). 1988; (3):68-70.
  69. Wen Y, Zhou S, Nie S . Bond-parameter analysis of superconducting oxide compounds. Kexue Tongbao (Bulletin of Science). 1988; (10):751-753.
  70. Shuanhu Zhou, Shengzhe Nie, Zheng Xu, Hongbo Liu and Yuankai Wen. The effect of iron impurity on the superconductivity and preparation of the Ba-Y-Cu-O system. Journal of Low Temperature Physics. 1988; 1-2(73):97-100.
  71. Wen Y, Zhou S, Nie S . Structure-property of superconductive oxide compounds. Journal of Inorganic Materials. 1987; 3(2):280-284.
  72. Wen Y, Nie S, Zhou S. . Bond-parameter criteria in the formation of glass of oxides. Journal of the Chinese Silicate Society. 1987; 6(15):560-562.
  73. Nie S, Zhou S, Chen J, Dai W, Zhang W. Determination of stability constants of binary acids using PH potential titration method I: Spline interpolation-calculation method and Rossotti graphical method. Fenxi Huaxie (Anal. Chem.). 1987; 5(15):458-460.
  74. Zhou S, Nie S, Dai W. Application of computer to infrared spectrophotometry of organic compounds. Journal of Anhui University (Science Edition). 1987; (3):54-56.
  75. Zhou S, Nie S, Wen Y . Stability of binary metallic glasses. Journal of Young Chemists. 1986; 1(1):15-17.
  76. Zhou S, Xiao S, Li Z, Yan G . The calculation of electron structure of W(CO)5CS and Cr(CO)5CS with SCM-DV-Xa method. Journal of Young Chemists. 1986; 1(1):22-23.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.