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Jochen Daniel Muehlschlegel, M.D.

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Biography
2006
Anesthesiology Fellow of the Year
2008 - 2010
Scholar in Translational Anesthesia Research (STAR)
2009
Vivien Thomas Young Investigator Finalist
2010
Valedictorian, Scholars in Clinical Science Program
2013
Elected to Fellow of the American Heart Association
2014
Elected to the Association of University Anesthesiologists (AUA)
2014
Selected as an Oral Board Examiner

Overview
Research goals
My research centers on the impact of genetic variation upon adverse cardiovascular events, and their significance on a functional level. The patients of my clinical practice of cardiac anesthesia are also my research subjects, as they are a group that is profoundly transcriptionally-upregulated, making examination of genetic variation in transcription more readily apparent. I am an investigator in the CABG Genomics study group created by Drs. Body, Shernan, and Collard in 2001 and also the principal investigator of the TRANSCRIBE (transcriptomic analysis of left ventricular gene expression) study, initiated by myself in 2009. Both studies aim to determine the relationship between genetic variation and perioperative myocardial injury in patients undergoing cardiac surgery. In TRANSCRIBE, my goals are to identify differential expression in human left ventricular myocardium upon exposure to ischemia, examine genetic variants that determine expression changes, and characterize these changes among different disease states.

Clinical Contributions:
I am a Cardiac Anesthesiologist in the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital. With extensive subspecialty training in all aspects of cardiac disease and transesophageal echocardiography, I see myself as a perioperative physician guiding the care of very sick patients with cardiovascular disease. While the spectrum of cardiovascular intervention might be shifting from the more invasive operating room to the less invasive catheter-based technologies, as a perioperative cardiovascular physician I see myself involved in all aspects of the care of these dynamic patients for many years to come.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL118266 (MUEHLSCHLEGEL, JOCHEN DANIEL) Aug 1, 2013 - Apr 30, 2018
    NIH/NHLBI
    Genetics of gene expression in human left ventricular myocardium
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Landry E, Muehlschlegel JD. Noteworthy Literature Published in 2018 for Cardiothoracic Anesthesiologists. Semin Cardiothorac Vasc Anesth. 2019 Jun; 23(2):148-155. PMID: 30985243.
    Citations:    
  2. Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Dubé MP, Allayee H, Almgren P, Alver M, Baranova EV, Behlouli H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dufresne L, Eriksson N, Foco L, Gijsberts CM, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kuukasjärvi P, Lee VV, Leiherer A, Lenzini PA, Levin D, Lyytikäinen LP, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, Van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Fitzpatrick N, Gigante B, James S, Lokki ML, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton-Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timmis A, Van de Werf F, Wauters E, Wilde AAM, Ford I, Stott DJ, Algra A, Andreassi MG, Ardissino D, Arsenault BJ, Ballantyne CM, Bergmeijer TO, Bezzina CR, Body SC, Bogaty P, de Borst GJ, Brenner H, Burkhardt R, Carpeggiani C, Condorelli G, Cooper-DeHoff RM, Cresci S, de Faire U, Doughty RN, Drexel H, Engert JC, Fox KAA, Girelli D, Hagström E, Hazen SL, Held C, Hemingway H, Hoefer IE, Hovingh GK, Johnson JA, de Jong PA, Jukema JW, Kaczor MP, Kähönen M, Kettner J, Kiliszek M, Klungel OH, Lagerqvist B, Lambrechts D, Laurikka JO, Lehtimäki T, Lindholm D, Mahmoodi BK, Maitland-van der Zee AH, McPherson R, Melander O, Metspalu A, Pepinski W, Olivieri O, Opolski G, Palmer CN, Pasterkamp G, Pepine CJ, Pereira AC, Pilote L, Quyyumi AA, Richards AM, Sanak M, Scholz M, Siegbahn A, Sinisalo J, Smith JG, Spertus JA, Stewart AFR, Szczeklik W, Szpakowicz A, Ten Berg JM, Thanassoulis G, Thiery J, van der Graaf Y, Visseren FLJ, Waltenberger J, Van der Harst P, Tardif JC, Sattar N, Lang CC, Paré G, Brophy JM, Anderson JL, März W, Wallentin L, Cameron VA, Horne BD, Samani NJ, Hingorani AD, Asselbergs FW. Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data. Circ Genom Precis Med. 2019 Mar 21. PMID: 30897348.
    Citations:    
  3. Patel R, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Allayee H, Almgren P, Alver M, Baranova EV, Behlouli H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dubé MP, Dufresne L, Eriksson N, Foco L, Scholz M, Gijsberts CM, Glinge C, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kotti S, Kuukasjärvi P, Lee VV, Leiherer A, Lenzini PA, Levin D, Lyytikäinen LP, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, Van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Al Ali L, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Engström T, Fitzpatrick N, Fox K, Gigante B, James S, Lokki ML, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton-Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timmis A, Van de Werf F, Wauters E, Wilde AAM, Ford I, Stott DJ, Algra A, Andreassi MG, Ardissino D, Arsenault BJ, Ballantyne CM, Bergmeijer TO, Bezzina CR, Body SC, Boersma EH, Bogaty P, Bots M, Brenner H, Brugts JJ, Burkhardt R, Carpeggiani C, Condorelli G, Cooper-DeHoff RM, Cresci S, Danchin N, de Faire U, Doughty RN, Drexel H, Engert JC, Fox KAA, Girelli D, Grobbee DE, Hagström E, Hazen SL, Held C, Hemingway H, Hoefer IE, Hovingh GK, Jabbari R, Johnson JA, Jukema JW, Kaczor MP, Kähönen M, Kettner J, Kiliszek M, Klungel OH, Lagerqvist B, Lambrechts D, Laurikka JO, Lehtimäki T, Lindholm D, Mahmoodi BK, Maitland-van der Zee AH, McPherson R, Melander O, Metspalu A, Niemcunowicz-Janica A, Olivieri O, Opolski G, Palmer CN, Pasterkamp G, Pepine CJ, Pereira AC, Pilote L, Quyyumi AA, Richards AM, Sanak M, Siegbahn A, Simon T, Sinisalo J, Smith JG, Spertus JA, Stender S, Stewart AFR, Szczeklik W, Szpakowicz A, Tardif JC, Ten Berg JM, Tfelt-Hansen J, Thanassoulis G, Thiery J, Torp-Pedersen C, van der Graaf Y, Visseren FLJ, Waltenberger J, Weeke PE, Van der Harst P, Lang CC, Sattar N, Cameron VA, Anderson JL, Brophy JM, Paré G, Horne BD, März W, Wallentin L, Samani NJ, Hingorani AD, Asselbergs FW. Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium. Circ Genom Precis Med. 2019 Mar 21. PMID: 30896328.
    Citations:    
  4. Stone G, Choi A, Oliva M, Gorham J, Heydarpour M, Seidman CE, Seidman JG, Aranki SF, Body SC, Carey VJ, Raby BA, Stranger BE, Muehlschlegel JD. Sex differences in gene expression in response to ischemia in the human left ventricular myocardium. Hum Mol Genet. 2019 Jan 14. PMID: 30649309.
    Citations:    Fields:    
  5. O'Brien B, Burrage PS, Ngai JY, Prutkin JM, Huang CC, Xu X, Chae SH, Bollen BA, Piccini JP, Schwann NM, Mahajan A, Ruel M, Body SC, Sellke FW, Mathew J, Muehlschlegel JD. Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2019 Jan; 33(1):12-26. PMID: 30591178.
    Citations:    Fields:    
  6. Muehlschlegel JD, Burrage PS, Ngai JY, Prutkin JM, Huang CC, Xu X, Chae SH, Bollen BA, Piccini JP, Schwann NM, Mahajan A, Ruel M, Body SC, Sellke FW, Mathew J, O'Brien B. Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery. Anesth Analg. 2019 Jan; 128(1):33-42. PMID: 30550473.
    Citations:    Fields:    
  7. Ko H, Ejiofor JI, Rydingsward JE, Rawn JD, Muehlschlegel JD, Christopher KB. Decreased preoperative functional status is associated with increased mortality following coronary artery bypass graft surgery. PLoS One. 2018; 13(12):e0207883. PMID: 30543643.
    Citations:    Fields:    
  8. Landry E, Burns S, Pelletier MP, Muehlschlegel JD. A Successful Opioid-Free Anesthetic in a Patient Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2018 Nov 28. PMID: 30611614.
    Citations:    Fields:    
  9. Heydarpour M, Ejiofor J, Gilfeather M, Stone G, Gorham J, Seidman CE, Seidman JG, Yammine M, Body SC, Aranki SF, Muehlschlegel JD. Molecular Genetics of Lidocaine-Containing Cardioplegia in the Human Heart During Cardiac Surgery. Ann Thorac Surg. 2018 Nov; 106(5):1379-1387. PMID: 30028983.
    Citations:    Fields:    
  10. Varelmann DJ, Muehlschlegel JD. Noteworthy Literature published in 2017 for Cardiothoracic Anesthesiologists. Semin Cardiothorac Vasc Anesth. 2018 Mar; 22(1):9-17. PMID: 29400260.
    Citations:    Fields:    Translation:Humans
  11. Kaneko T, Shekar P, Ivkovic V, Longford NT, Huang CC, Sigurdsson MI, Neely RC, Yammine M, Ejiofor JI, Montiero Vieira V, Shahram JT, Habchi KM, Malzberg GW, Martin PS, Bloom J, Isselbacher EM, Muehlschlegel JD, Sundt TM, Body SC. Should the dilated ascending aorta be repaired at the time of bicuspid aortic valve replacement? Eur J Cardiothorac Surg. 2018 03 01; 53(3):560-568. PMID: 29149323.
    Citations:    Fields:    Translation:Humans
  12. Swain JD, Sinnott C, Breakey S, Hasson Charles R, Mody G, Nyirimanzi N, Patton-Bolman C, Come P, Ganza G, Rusingiza E, Ruhamya N, Mucumbitsi J, Borges J, Zammert M, Muehlschlegel JD, Oakes R, Leavitt B, Bolman RM. Ten-year clinical experience of humanitarian cardiothoracic surgery in Rwanda: Building a platform for ultimate sustainability in a resource-limited setting. J Thorac Cardiovasc Surg. 2018 Jun; 155(6):2541-2550. PMID: 29499865.
    Citations:    Fields:    
  13. Stuebe J, Rydingsward J, Lander H, Ng J, Xu X, Kaneko T, Shekar P, Muehlschlegel JD, Body SC. A Pragmatic Preoperative Prediction Score for Nonhome Discharge After Cardiac Operations. Ann Thorac Surg. 2018 05; 105(5):1384-1391. PMID: 29288657.
    Citations:    Fields:    
  14. Kelly BJ, Ho Luxford JM, Butler CG, Huang CC, Wilusz K, Ejiofor JI, Rawn JD, Fox JA, Shernan SK, Muehlschlegel JD. Severity of tricuspid regurgitation is associated with long-term mortality. J Thorac Cardiovasc Surg. 2018 Mar; 155(3):1032-1038.e2. PMID: 29246545.
    Citations: 1     Fields:    
  15. Saddic LA, Nicoloro SM, Gupta OT, Czech MP, Gorham J, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Fitzgibbons TP, Muehlschlegel JD. Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia. Cardiovasc Diabetol. 2017 07 07; 16(1):87. PMID: 28687077.
    Citations: 2     Fields:    Translation:Humans
  16. Butler CG, Ho Luxford JM, Huang CC, Ejiofor JI, Rawn JD, Wilusz K, Fox JA, Shernan SK, Muehlschlegel JD. Aortic Atheroma Increases the Risk of Long-Term Mortality in 20,000 Patients. Ann Thorac Surg. 2017 Oct; 104(4):1325-1331. PMID: 28577841.
    Citations:    Fields:    Translation:Humans
  17. Kiyota Y, Della Corte A, Montiero Vieira V, Habchi K, Huang CC, Della Ratta EE, Sundt TM, Shekar P, Muehlschlegel JD, Body SC. Risk and outcomes of aortic valve endocarditis among patients with bicuspid and tricuspid aortic valves. Open Heart. 2017; 4(1):e000545. PMID: 28674620.
    Citations: 1     
  18. Sigurdsson MI, Saddic L, Heydarpour M, Chang TW, Shekar P, Aranki S, Couper GS, Shernan SK, Muehlschlegel JD, Body SC. Post-operative atrial fibrillation examined using whole-genome RNA sequencing in human left atrial tissue. BMC Med Genomics. 2017 05 02; 10(1):25. PMID: 28464817.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  19. Varelmann DJ, Muehlschlegel JD. Noteworthy Literature Published in 2016 for the Cardiothoracic Anesthesiologist. Semin Cardiothorac Vasc Anesth. 2017 Mar; 21(1):8-16. PMID: 28118792.
    Citations:    Fields:    Translation:Humans
  20. Saddic LA, Sigurdsson MI, Chang TW, Mazaika E, Heydarpour M, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Muehlschlegel JD. The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle. Circ Cardiovasc Genet. 2017 Jan; 10(1). PMID: 28115490.
    Citations: 1     Fields:    Translation:HumansCells
  21. Sigurdsson MI, Saddic L, Heydarpour M, Chang TW, Shekar P, Aranki S, Couper GS, Shernan SK, Seidman JG, Body SC, Muehlschlegel JD. Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia. Genome Med. 2016 12 06; 8(1):127. PMID: 27923400.
    Citations: 1     Fields:    Translation:HumansAnimals
  22. Gago-Díaz M, Brion M, Gallego P, Calvo F, Robledo-Carmona J, Saura D, Sánchez V, Bermejo J, Sevilla T, Newton-Cheh C, Carracedo Á, Muehlschlegel JD, García-Dorado D, Body SC, Evangelista A. The genetic component of bicuspid aortic valve and aortic dilation. An exome-wide association study. J Mol Cell Cardiol. 2017 01; 102:3-9. PMID: 27894865.
    Citations: 1     Fields:    Translation:Humans
  23. Habchi KM, Ashikhmina E, Vieira VM, Shahram JT, Isselbacher EM, Sundt TM, Shekar P, Muehlschlegel JD, Body SC. Association between bicuspid aortic valve morphotype and regional dilatation of the aortic root and trunk. Int J Cardiovasc Imaging. 2017 Mar; 33(3):341-349. PMID: 27838896.
    Citations: 1     Fields:    Translation:Humans
  24. Ejiofor JI, Yammine M, Harloff MT, McGurk S, Muehlschlegel JD, Shekar PS, Cohn LH, Shah P, Kaneko T. Reoperative Surgical Aortic Valve Replacement Versus Transcatheter Valve-in-Valve Replacement for Degenerated Bioprosthetic Aortic Valves. Ann Thorac Surg. 2016 Nov; 102(5):1452-1458. PMID: 27526654.
    Citations: 1     Fields:    Translation:Humans
  25. Sigurdsson MI, Longford NT, Heydarpour M, Saddic L, Chang TW, Fox AA, Collard CD, Aranki S, Shekar P, Shernan SK, Muehlschlegel JD, Body SC. Duration of Postoperative Atrial Fibrillation After Cardiac Surgery Is Associated With Worsened Long-Term Survival. Ann Thorac Surg. 2016 Dec; 102(6):2018-2026. PMID: 27424470.
    Citations: 1     Fields:    Translation:Humans
  26. Leaf DE, Body SC, Muehlschlegel JD, McMahon GM, Lichtner P, Collard CD, Shernan SK, Fox AA, Waikar SS. Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery. J Am Soc Nephrol. 2016 Nov; 27(11):3291-3297. PMID: 27257045.
    Citations: 8     Fields:    Translation:Humans
  27. Saddic LA, Muehlschlegel JD. Sarco"MiR" friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy. Ann Transl Med. 2016 May; 4(10):203. PMID: 27294099.
    Citations: 2     
  28. Varelmann DJ, Muehlschlegel JD. Noteworthy Articles in 2015 for the Cardiothoracic Anesthesiologist. Semin Cardiothorac Vasc Anesth. 2016 Mar; 20(1):7-13. PMID: 26783263.
    Citations:    Fields:    Translation:Humans
  29. Sigurdsson MI, Muehlschlegel JD. Perioperative genomics: coming soon to (operating) theatres near you. Can J Anaesth. 2016 Apr; 63(4):382-5. PMID: 26721649.
    Citations:    Fields:    
  30. Saddic LA, Chang TW, Sigurdsson MI, Heydarpour M, Raby BA, Shernan SK, Aranki SF, Body SC, Muehlschlegel JD. Integrated microRNA and mRNA responses to acute human left ventricular ischemia. Physiol Genomics. 2015 Oct; 47(10):455-62. PMID: 26175501.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  31. Muehlschlegel JD, Christodoulou DC, McKean D, Gorham J, Mazaika E, Heydarpour M, Lee G, DePalma SR, Perry TE, Fox AA, Shernan SK, Seidman CE, Aranki SF, Seidman JG, Body SC. Using next-generation RNA sequencing to examine ischemic changes induced by cold blood cardioplegia on the human left ventricular myocardium transcriptome. Anesthesiology. 2015 Mar; 122(3):537-50. PMID: 25581909.
    Citations: 9     Fields:    Translation:HumansCells
  32. Hilberath JN, Sotillo CL, Muehlschlegel JD. Noteworthy articles in 2014 for cardiothoracic anesthesiologists. Semin Cardiothorac Vasc Anesth. 2015 Mar; 19(1):6-11. PMID: 25608971.
    Citations:    Fields:    Translation:Humans
  33. Ferreira RG, Worthington A, Huang CC, Aranki SF, Muehlschlegel JD. Sex differences in the prevalence of diastolic dysfunction in cardiac surgical patients. J Card Surg. 2015 Mar; 30(3):238-45. PMID: 25571945.
    Citations: 4     Fields:    Translation:Humans
  34. Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D. Genetic and clinical risk prediction model for postoperative atrial fibrillation. Circ Arrhythm Electrophysiol. 2015 Feb; 8(1):25-31. PMID: 25567478.
    Citations: 3     Fields:    Translation:Humans
  35. Barnet CS, Liu X, Body SC, Collard CD, Shernan SK, Muehlschlegel JD, Jarolim P, Fox AA. Plasma corin decreases after coronary artery bypass graft surgery and is associated with postoperative heart failure: a pilot study. J Cardiothorac Vasc Anesth. 2015 Apr; 29(2):374-81. PMID: 25649697.
    Citations: 5     Fields:    Translation:Humans
  36. Sigurdsson MI, Muehlschlegel JD, Fox AA, Heydarpour M, Lichtner P, Meitinger T, Collard CD, Shernan SK, Body SC. Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery. J Cardiothorac Vasc Anesth. 2015; 29(3):605-10. PMID: 26009287.
    Citations: 2     Fields:    Translation:Humans
  37. Hilberath JN, Smith T, Jara C, Thomas M, FitzGerald DJ, Muehlschlegel JD. Blood volumes in cardiac surgery with cardiopulmonary bypass. Perfusion. 2015 Jul; 30(5):395-9. PMID: 25249518.
    Citations:    Fields:    Translation:Humans
  38. Swain JD, Pugliese DN, Mucumbitsi J, Rusingiza EK, Ruhamya N, Kagame A, Ganza G, Come PC, Breakey S, Greenwood B, Muehlschlegel JD, Patton-Bolman C, Binagwaho A, Morton Bolman R. Partnership for sustainability in cardiac surgery to address critical rheumatic heart disease in sub-Saharan Africa: the experience from Rwanda. World J Surg. 2014 Sep; 38(9):2205-11. PMID: 24728579.
    Citations: 1     Fields:    Translation:Humans
  39. Prakash SK, Bossé Y, Muehlschlegel JD, Michelena HI, Limongelli G, Della Corte A, Pluchinotta FR, Russo MG, Evangelista A, Benson DW, Body SC, Milewicz DM. A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium). J Am Coll Cardiol. 2014 Aug 26; 64(8):832-9. PMID: 25145529.
    Citations: 25     Fields:    Translation:HumansAnimals
  40. Hilberath JN, Thomas ME, Smith T, Jara C, Fitzgerald DJ, Wilusz K, Liu X, Muehlschlegel JD. Blood volume measurement by hemodilution: association with valve disease and re-evaluation of the Allen Formula. Perfusion. 2015 May; 30(4):305-11. PMID: 25125291.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  41. Muehlschlegel JD. Closing the pore on reperfusion injury: myocardial protection with cyclosporine. Anesthesiology. 2014 Aug; 121(2):212-3. PMID: 24895914.
    Citations: 1     Fields:    Translation:Humans
  42. Frey UH, Muehlschlegel JD, Ochterbeck C, Fox AA, Shernan SK, Collard CD, Lichtner P, Peters J, Body S. GNAS gene variants affect ß-blocker-related survival after coronary artery bypass grafting. Anesthesiology. 2014 May; 120(5):1109-1117. PMID: 24755784.
    Citations: 2     Fields:    Translation:Humans
  43. Ferreira RG, Nicoara A, Phillips-Bute BG, Daneshmand M, Muehlschlegel JD, Swaminathan M. Diastolic dysfunction in patients undergoing cardiac surgery: the role of gender and age-gender interaction. J Cardiothorac Vasc Anesth. 2014 Jun; 28(3):626-30. PMID: 24675001.
    Citations:    Fields:    Translation:Humans
  44. van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP. A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest. 2014 Apr; 124(4):1844-52. PMID: 24642470.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  45. Christodoulou DC, Wakimoto H, Onoue K, Eminaga S, Gorham JM, DePalma SR, Herman DS, Teekakirikul P, Conner DA, McKean DM, Domenighetti AA, Aboukhalil A, Chang S, Srivastava G, McDonough B, De Jager PL, Chen J, Bulyk ML, Muehlschlegel JD, Seidman CE, Seidman JG. 5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy. J Clin Invest. 2014 Mar; 124(3):1364-70. PMID: 24509080.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  46. Hilberath JN, Muehlschlegel JD. Noteworthy articles in 2013 for cardiothoracic anesthesiologists. Semin Cardiothorac Vasc Anesth. 2014 Mar; 18(1):6-11. PMID: 24345780.
    Citations:    Fields:    Translation:Humans
  47. Qi L, Qi Q, Prudente S, Mendonca C, Andreozzi F, di Pietro N, Sturma M, Novelli V, Mannino GC, Formoso G, Gervino EV, Hauser TH, Muehlschlegel JD, Niewczas MA, Krolewski AS, Biolo G, Pandolfi A, Rimm E, Sesti G, Trischitta V, Hu F, Doria A. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA. 2013 Aug 28; 310(8):821-8. PMID: 23982368.
    Citations: 27     Fields:    Translation:HumansCells
  48. Fox AA, Nascimben L, Body SC, Collard CD, Mitani AA, Liu KY, Muehlschlegel JD, Shernan SK, Marcantonio ER. Increased perioperative b-type natriuretic peptide associates with heart failure hospitalization or heart failure death after coronary artery bypass graft surgery. Anesthesiology. 2013 Aug; 119(2):284-94. PMID: 23695172.
    Citations: 3     Fields:    Translation:Humans
  49. Lampert SM, Michaud GF, Couper GS, Muehlschlegel JD. Epicardial cryoablation resulting in precipitous left ventricular dysfunction. J Thorac Cardiovasc Surg. 2013 Apr; 145(4):e41-e42. PMID: 23374988.
    Citations:    Fields:    Translation:Humans
  50. Urdaneta F, Muehlschlege JD, Chawla LS, Palacios JM, Janelle GM. Roundtable discussion: status asthmaticus in a patient with an anterior mediastinal mass. Semin Cardiothorac Vasc Anesth. 2012 Dec; 16(4):243-9. PMID: 23111155.
    Citations:    Fields:    Translation:Humans
  51. Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Smith SA, Lichtner P, Collard CD, Shernan SK, Hartwig JH, Body SC, Hoffmeister KM. Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury. Am J Hematol. 2012 Feb; 87(2):161-6. PMID: 22228373.
    Citations: 6     Fields:    Translation:HumansCells
  52. Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. PLoS One. 2011; 6(9):e24593. PMID: 21980348.
    Citations: 1     Fields:    Translation:Humans
  53. Fox AA, Marcantonio ER, Collard CD, Thoma M, Perry TE, Shernan SK, Muehlschlegel JD, Body SC. Increased peak postoperative B-type natriuretic peptide predicts decreased longer-term physical function after primary coronary artery bypass graft surgery. Anesthesiology. 2011 Apr; 114(4):807-16. PMID: 21427536.
    Citations: 4     Fields:    Translation:Humans
  54. Muehlschlegel JD. If a troponin falls in a forest but no one measures it, does it really matter? Anesthesiology. 2011 Apr; 114(4):732-3. PMID: 21317631.
    Citations: 1     Fields:    Translation:Humans
  55. Lipman PJ, Liu KY, Muehlschlegel JD, Body S, Lange C. Inferring genetic causal effects on survival data with associated endo-phenotypes. Genet Epidemiol. 2011 Feb; 35(2):119-24. PMID: 21254219.
    Citations: 3     Fields:    Translation:Humans
  56. Muehlschlegel JD, Shernan SK, Body SC. From creatine kinase-MB to troponin: do we really need to differentiate between myocardial injury and infarction? Anesthesiology. 2010 Dec; 113(6):1479-80. PMID: 21102190.
    Citations:    Fields:    Translation:Humans
  57. Muehlschlegel JD, Liu KY, Perry TE, Fox AA, Collard CD, Shernan SK, Body SC. Chromosome 9p21 variant predicts mortality after coronary artery bypass graft surgery. Circulation. 2010 Sep 14; 122(11 Suppl):S60-5. PMID: 20837927.
    Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
  58. Herman SC, Muehlschlegel JD, Couper GS, Kelly E. Colonic perforation from left ventricular assist device: a rare complication. Interact Cardiovasc Thorac Surg. 2010 Sep; 11(3):369-70. PMID: 20566624.
    Citations: 1     Fields:    Translation:Humans
  59. Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Collard CD, Shernan SK, Body SC. Heart-type fatty acid binding protein is an independent predictor of death and ventricular dysfunction after coronary artery bypass graft surgery. Anesth Analg. 2010 Nov; 111(5):1101-9. PMID: 20457766.
    Citations: 7     Fields:    Translation:Humans
  60. Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Shernan SK, Body SC. Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients. Anesth Analg. 2010 Jun 01; 110(6):1541-7. PMID: 20435938.
    Citations: 25     Fields:    Translation:Humans
  61. Fox AA, Muehlschlegel JD, Body SC, Shernan SK, Liu KY, Perry TE, Aranki SF, Cook EF, Marcantonio ER, Collard CD. Comparison of the utility of preoperative versus postoperative B-type natriuretic peptide for predicting hospital length of stay and mortality after primary coronary artery bypass grafting. Anesthesiology. 2010 Apr; 112(4):842-51. PMID: 20216395.
    Citations: 9     Fields:    Translation:Humans
  62. Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Body SC, Shernan SK. Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting. Anesthesiology. 2010 Mar; 112(3):607-13. PMID: 20179497.
    Citations: 5     Fields:    Translation:Humans
  63. Garvin S, Fitzgerald D, Muehlschlegel JD, Perry TE, Fox AA, Shernan SK, Collard CD, Aranki S, Body SC. Heparin dose response is independent of preoperative antithrombin activity in patients undergoing coronary artery bypass graft surgery using low heparin concentrations. Anesth Analg. 2010 Oct; 111(4):856-61. PMID: 20142342.
    Citations: 1     Fields:    Translation:Humans
  64. Liu KY, Muehlschlegel JD, Perry TE, Fox AA, Collard CD, Body SC, Shernan SK. Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg. 2010 Feb; 139(2):483-8, 488.e1-2. PMID: 19819472.
    Citations: 9     Fields:    Translation:HumansCells
  65. Garvin S, Muehlschlegel JD, Perry TE, Chen J, Liu KY, Fox AA, Collard CD, Aranki SF, Shernan SK, Body SC. Postoperative activity, but not preoperative activity, of antithrombin is associated with major adverse cardiac events after coronary artery bypass graft surgery. Anesth Analg. 2010 Oct; 111(4):862-9. PMID: 19820236.
    Citations: 2     Fields:    Translation:HumansAnimalsCTClinical Trials
  66. Litofe T, Muehlschlegel J, Peng Y, Sidi A, Bleiweis MS. The diagnostic process and perioperative and anesthetic management of an undiagnosed congenital cyanotic cardiac defect in an adult for trauma surgery. J Clin Anesth. 2009 Sep; 21(6):454-8. PMID: 19833282.
    Citations:    Fields:    Translation:Humans
  67. Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet. 2009 Oct; 2(5):499-506. PMID: 20031626.
    Citations: 45     Fields:    Translation:HumansCellsCTClinical Trials
  68. Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Body SC, Shernan SK. C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery. BMC Med Genet. 2009 May 08; 10:38. PMID: 19426506.
    Citations: 10     Fields:    Translation:Humans
  69. Muehlschlegel JD, Perry TE, Liu KY, Nascimben L, Fox AA, Collard CD, Avery EG, Aranki SF, D'Ambra MN, Shernan SK, Body SC. Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting. Eur Heart J. 2009 Jul; 30(13):1574-83. PMID: 19406870.
    Citations: 21     Fields:    Translation:Humans
  70. Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology. 2009 Apr; 110(4):738-47. PMID: 19326473.
    Citations: 18     Fields:    Translation:Humans
  71. Perry TE, Muehlschlegel JD, Body SC. Genomics: risk and outcomes in cardiac surgery. Anesthesiol Clin. 2008 Sep; 26(3):399-417. PMID: 18765214.
    Citations: 4     Fields:    Translation:HumansCells
  72. Muehlschlegel JD, Body SC. Impact of genetic variation on perioperative bleeding. Am J Hematol. 2008 Sep; 83(9):732-7. PMID: 18508320.
    Citations: 1     Fields:    Translation:Humans
  73. Sidi A, Naik B, Urdaneta F, Muehlschlegel JD, Kirby DS, Lobato EB. Treatment of ethanol-induced acute pulmonary hypertension and right ventricular dysfunction in pigs, by sildenafil analogue (UK343-664) or nitroglycerin. Ann Card Anaesth. 2008 Jul-Dec; 11(2):97-104. PMID: 18603749.
    Citations: 2     Fields:    Translation:Animals
  74. Muehlschlegel JD, Peng YG, Lobato EB, Hess PJ, Martin TD, Klodell CT. Temporary biventricular pacing postcardiopulmonary bypass in patients with reduced ejection fraction. J Card Surg. 2008 Jul-Aug; 23(4):324-30. PMID: 18598321.
    Citations: 10     Fields:    Translation:Humans
  75. Sidi A, Naik B, Muehlschlegel JD, Kirby DS, Lobato EB. Ethanol-induced acute pulmonary hypertension and right ventricular dysfunction in pigs. Br J Anaesth. 2008 Apr; 100(4):568-9. PMID: 18344581.
    Citations: 1     Fields:    Translation:Animals
  76. Robinson AR, Robinson MS, Martin TD, Muehlschlegel JD, Peng YG. Intraoperative transesophageal echocardiography alters the surgical course for patients undergoing ascending aortic aneurysm repair. J Cardiothorac Vasc Anesth. 2009 Feb; 23(1):71-4. PMID: 18834772.
    Citations:    Fields:    Translation:Humans
  77. Urdaneta F, Lobato EB, Beaver T, Muehlschlegel JD, Kirby DS, Klodell C, Sidi A. Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog. Perfusion. 2008 Mar; 23(2):117-25. PMID: 18840581.
    Citations:    Fields:    Translation:Animals
  78. Sidi A, Muehlschlegel JD, Kirby DS, Lobato EB. Administration of milrinone before ischemia, in the presence of beta-blockade, to treat metabolic impairment and myocardial stunning in pigs. Acta Anaesthesiol Scand. 2008 Mar; 52(3):397-405. PMID: 18269389.
    Citations: 1     Fields:    Translation:Animals
  79. Collard CD, Muehlschlegel JD. Literature Review. J Cardiothorac Vasc Anesth. 2008; 22(1):162-64.
  80. Neuman MD, Fox JA, Muehlschlegel JD. Incidental discovery of a large patent ductus arteriosus in an adult during aortic reconstruction: echocardiographic findings and diagnostic dilemmas. Anesth Analg. 2007 Nov; 105(5):1227-8. PMID: 17959946.
    Citations:    Fields:    Translation:Humans
  81. Lobato EB, Muehlschlegel JD. Echocardiography in the ICU. A Practical Approach to Transesophageal Echocardiography, Albert C Perrino Jr., MD Scott T Reeves MD, MBA, FACC. 2007.
  82. Muehlschlegel JD, Dobija N, Lobato EB. Acute Pulmonary Hypertension and Right Ventricular Failure. Complications in Anesthesiology. 2007.
  83. Muehlschlegel JD, Lobato EB, Kirby DS, Arnaoutakis G, Sidi A. Inhaled amyl nitrite effectively reverses acute catastrophic thromboxane-mediated pulmonary hypertension in pigs. Ann Card Anaesth. 2007 Jul; 10(2):113-20. PMID: 17644883.
    Citations: 1     Fields:    Translation:Animals
  84. Sidi A, Muehlschlegel JD, Kirby DS, Kirby RR, Lobato EB. Treating ischemic left ventricular dysfunction with hypertonic saline administered after coronary occlusion in pigs. J Cardiothorac Vasc Anesth. 2007 Jun; 21(3):400-5. PMID: 17544894.
    Citations:    Fields:    Translation:Animals
  85. Sidi A, Muehlschlegel JD, Muehschlegel JD, Kirby DS, Lobato EB. Treating metabolic impairment and myocardial stunning with phosphodiesterase inhibitor type III, milrinone, administered prior to coronary artery occlusion in the presence of calcium channel blockade in pigs. Ann Card Anaesth. 2007 Jan; 10(1):34-41. PMID: 17455406.
    Citations:    Fields:    Translation:Animals
  86. Muehlschlegel JD, Alomar-Melero E, Staples ED, Janelle GM. Acute high-output failure from an aortoventricular fistula due to a ruptured sinus of Valsalva aneurysm after blunt chest trauma. Anesth Analg. 2006 Dec; 103(6):1408-9. PMID: 17122212.
    Citations: 1     Fields:    Translation:Humans
  87. Sidi A, Muehlschlegel JD, Kirby DS, Lobato EB. Treatment of ischaemic left ventricular dysfunction with milrinone or dobutamine administered during coronary artery stenosis in the presence of beta blockade in pigs. Br J Anaesth. 2006 Dec; 97(6):799-807. PMID: 17035336.
    Citations:    Fields:    Translation:Animals
  88. Lobato EB, Beaver T, Muehlschlegel J, Kirby DS, Klodell C, Sidi A. Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension. Br J Anaesth. 2006 Mar; 96(3):317-22. PMID: 16443640.
    Citations: 7     Fields:    Translation:Animals
  89. Kirchner EA, Mols G, Hermle G, Muehlschlegel JD, Geiger KK, Guttmann J, Pahl HL. Reduced activation of immunomodulatory transcription factors during positive end-expiratory pressure adjustment based on volume-dependent compliance in isolated perfused rabbit lungs. Br J Anaesth. 2005 Apr; 94(4):530-5. PMID: 15665073.
    Citations: 3     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.