Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Amit Choudhary, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI154099 (CHOUDHARY, AMIT) Aug 19, 2020 - Jul 31, 2022
    Development of phosphorylation-inducing chimeric small molecules
    Role: Principal Investigator
  2. U01DK123717 (WAGNER, BRIDGET K) Sep 20, 2019 - Jul 31, 2021
    One-compound, one-islet: A high-throughput platform for small-molecule discovery
    Role: Co-Principal Investigator
  3. R01GM132825 (CHOUDHARY, AMIT) Sep 1, 2019 - Jul 31, 2023
    Development of synthetic gene drives using small molecules
    Role: Principal Investigator
  4. UC4DK116255 (CHOUDHARY, AMIT) Sep 20, 2017 - Aug 31, 2020
    Development of small molecule-based methods for targeted cargo delivery to beta cells
    Role: Principal Investigator
  5. R01DK113597 (CHOUDHARY, AMIT) Sep 25, 2016 - May 31, 2021
    Leveraging snakes' extreme physiology to modulate human beta-cell function
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lim D, Sreekanth V, Cox KJ, Law BK, Wagner BK, Karp JM, Choudhary A. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Nat Commun. 2020 08 13; 11(1):4043. PMID: 32792475.
  2. Siriwardena SU, Munkanatta Godage DNP, Shoba VM, Lai S, Shi M, Wu P, Chaudhary SK, Schreiber SL, Choudhary A. Phosphorylation-Inducing Chimeric Small Molecules. J Am Chem Soc. 2020 Aug 19; 142(33):14052-14057. PMID: 32787262.
  3. López Del Amo V, Leger BS, Cox KJ, Gill S, Bishop AL, Scanlon GD, Walker JA, Gantz VM, Choudhary A. Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives. Cell Rep. 2020 Jun 30; 31(13):107841. PMID: 32610142.
  4. Modell AE, Siriwardena SU, Choudhary A. A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems. Biochemistry. 2020 May 26; 59(20):1869-1870. PMID: 32403926.
  5. Lee M, Maji B, Manna D, Kahraman S, Elgamal RM, Small J, Kokkonda P, Vetere A, Goldberg JM, Lippard SJ, Kulkarni RN, Wagner BK, Choudhary A. Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in ß-Cells. J Am Chem Soc. 2020 Apr 08; 142(14):6477-6482. PMID: 32175731.
  6. Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dancík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, Clemons PA, Wagner BK, Choudhary A. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 2019 05 02; 177(4):1067-1079.e19. PMID: 31051099.
  7. Manna D, Maji B, Gangopadhyay SA, Cox KJ, Zhou Q, Law BK, Mazitschek R, Choudhary A. A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR-Cas9. Angew Chem Int Ed Engl. 2019 05 06; 58(19):6285-6289. PMID: 30834641.
  8. Gangopadhyay SA, Cox KJ, Manna D, Lim D, Maji B, Zhou Q, Choudhary A. Precision Control of CRISPR-Cas9 Using Small Molecules and Light. Biochemistry. 2019 01 29; 58(4):234-244. PMID: 30640437.
    Citations:    Fields:    
  9. Cox KJ, Subramanian HKK, Samaniego CC, Franco E, Choudhary A. A universal method for sensitive and cell-free detection of CRISPR-associated nucleases. Chem Sci. 2019 Mar 07; 10(9):2653-2662. PMID: 30996981.
  10. Weidmann AG, Choudhary A. Special Issue on the Chemical Biology of CRISPR. ACS Chem Biol. 2018 Feb 16; 13(2):283-284. PMID: 29448763.
    Citations:    Fields:    Translation:Cells
  11. Vasta JD, Choudhary A, Jensen KH, McGrath NA, Raines RT. Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond. Biochemistry. 2017 Jan 10; 56(1):219-227. PMID: 28001367.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Maji B, Moore CL, Zetsche B, Volz SE, Zhang F, Shoulders MD, Choudhary A. Multidimensional chemical control of CRISPR-Cas9. Nat Chem Biol. 2017 Jan; 13(1):9-11. PMID: 27820801.
    Citations: 13     Fields:    Translation:HumansCells
  13. Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dancík V, Ciarlo C, Paulk J, Dai M, Reddy C, Sun H, Young M, Donato N, Jaffe J, Clemons PA, Palmer M, Carr SA, Schreiber SL, Wagner BK. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. J Am Chem Soc. 2015 Jun 24; 137(24):7929-34. PMID: 26042473.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Choudhary A, Kamer KJ, Shoulders MD, Raines RT. 4-ketoproline: An electrophilic proline analog for bioconjugation. Biopolymers. 2015 Mar; 104(2):110-5. PMID: 25656588.
    Citations: 2     Fields:    Translation:Cells
  15. Choudhary A, Newberry RW, Raines RT. n?p* interactions engender chirality in carbonyl groups. Org Lett. 2014 Jul 03; 16(13):3421-3. PMID: 24926562.
    Citations: 7     Fields:    Translation:Cells
  16. Choudhary A, Hu He K, Mertins P, Udeshi ND, Dancík V, Fomina-Yadlin D, Kubicek S, Clemons PA, Schreiber SL, Carr SA, Wagner BK. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. PLoS One. 2014; 9(4):e95194. PMID: 24759943.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Vetere A, Choudhary A, Burns SM, Wagner BK. Targeting the pancreatic ß-cell to treat diabetes. Nat Rev Drug Discov. 2014 Apr; 13(4):278-89. PMID: 24525781.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  18. Choudhary A, Fry CG, Kamer KJ, Raines RT. An n?p* interaction reduces the electrophilicity of the acceptor carbonyl group. Chem Commun (Camb). 2013 Sep 25; 49(74):8166-8. PMID: 23928794.
    Citations: 5     Fields:    Translation:Cells
  19. Guzei IA, Choudhary A, Raines RT. Pyramidalization of a carbonyl C atom in (2S)-N-(seleno-acet-yl)proline methyl ester. Acta Crystallogr Sect E Struct Rep Online. 2013 May 01; 69(Pt 5):o805-6. PMID: 23723945.
    Citations: 2     
  20. Kamer KJ, Choudhary A, Raines RT. Intimate interactions with carbonyl groups: dipole-dipole or n?p*? J Org Chem. 2013 Mar 01; 78(5):2099-103. PMID: 23163960.
    Citations: 7     Fields:    Translation:Cells
  21. Krow GR, Shoulders MD, Edupuganti R, Gandla D, Yu F, Sonnet PE, Sender M, Choudhary A, DeBrosse C, Ross CW, Carroll P, Raines RT. Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BOC-methanopyrrolidines. Constrained C?-exo and C?-endo Flp and Hyp conformer mimics. J Org Chem. 2012 Jun 15; 77(12):5331-44. PMID: 22607128.
    Citations:    Fields:    Translation:Cells
  22. Choudhary A, Kamer KJ, Raines RT. A conserved interaction with the chromophore of fluorescent proteins. Protein Sci. 2012 Feb; 21(2):171-7. PMID: 22057893.
    Citations: 4     Fields:    Translation:Cells
  23. Choudhary A, Kamer KJ, Raines RT. An n?p* interaction in aspirin: implications for structure and reactivity. J Org Chem. 2011 Oct 07; 76(19):7933-7. PMID: 21842865.
    Citations: 10     Fields:    Translation:Cells
  24. Choudhary A, Raines RT. An evaluation of peptide-bond isosteres. Chembiochem. 2011 Aug 16; 12(12):1801-7. PMID: 21751326.
    Citations: 24     Fields:    Translation:Cells
  25. Choudhary A, Raines RT. Signature of n?p* interactions in a-helices. Protein Sci. 2011 Jun; 20(6):1077-81. PMID: 21442680.
    Citations: 21     Fields:    Translation:Cells
  26. Krow GR, Edupuganti R, Gandla D, Yu F, Sender M, Sonnet PE, Zdilla MJ, DeBrosse C, Cannon KC, Ross CW, Choudhary A, Shoulders MD, Raines RT. Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines. J Org Chem. 2011 May 20; 76(10):3626-34. PMID: 21500838.
    Citations: 1     Fields:    Translation:Cells
  27. Shoulders MD, Kotch FW, Choudhary A, Guzei IA, Raines RT. The aberrance of the 4S diastereomer of 4-hydroxyproline. J Am Chem Soc. 2010 Aug 11; 132(31):10857-65. PMID: 20681719.
    Citations: 9     Fields:    Translation:Cells
  28. Choudhary A, Kamer KJ, Powner MW, Sutherland JD, Raines RT. A stereoelectronic effect in prebiotic nucleotide synthesis. ACS Chem Biol. 2010 Jul 16; 5(7):655-7. PMID: 20499895.
    Citations: 14     Fields:    Translation:Cells
  29. Bartlett GJ, Choudhary A, Raines RT, Woolfson DN. n-->pi* interactions in proteins. Nat Chem Biol. 2010 Aug; 6(8):615-20. PMID: 20622857.
    Citations: 59     Fields:    Translation:Cells
  30. Choudhary A, Fry CG, Raines RT. Modulation of an n?p* interaction with a-fluoro groups. ARKIVOC. 2010 Jul 08; 2010:251-262. PMID: 21643549.
    Citations: 9     
  31. Jakobsche CE, Choudhary A, Miller SJ, Raines RT. n --> pi* Interaction and n)(pi Pauli repulsion are antagonistic for protein stability. J Am Chem Soc. 2010 May 19; 132(19):6651-3. PMID: 20420451.
    Citations: 22     Fields:    Translation:Cells
  32. Choudhary A, Pua KH, Raines RT. Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides. Amino Acids. 2011 Jun; 41(1):181-6. PMID: 20221839.
    Citations: 11     Fields:    Translation:Cells
  33. Krow GR, Edupuganti R, Gandla D, Choudhary A, Lin G, Sonnet PE, DeBrosse C, Ross CW, Cannon KC, Raines RT. 5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: a nucleophilic displacement route. J Org Chem. 2009 Nov 06; 74(21):8232-42. PMID: 19799411.
    Citations:    Fields:    
  34. Choudhary A, Gandla D, Krow GR, Raines RT. Nature of amide carbonyl--carbonyl interactions in proteins. J Am Chem Soc. 2009 Jun 03; 131(21):7244-6. PMID: 19469574.
    Citations: 41     Fields:    Translation:Cells
  35. Prasad KR, Penchalaiah K, Choudhary A, Anbarasan P. Stereoselective synthesis of (-)-microcarpalide. Tetrahedron Letters. 2007; 48(2):309.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.