Harvard Catalyst Profiles

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Jennifer Sung Whangbo, M.D., Ph.D.

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  1. K08HL094460 (WHANGBO, JENNIFER SUNG) Jan 16, 2009 - Sep 30, 2014
    NIH
    Regulation of Systemic RNA Interference in the Nematode C. elegans
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Whangbo JS, Nikiforow S, Kim HT, Wahl J, Reynolds CG, Rai SC, Kim S, Burden A, Alho AC, Lacerda JF, Alyea EP, Cutler CS, Ho VT, Antin JH, Soiffer RJ, Ritz J, Koreth J. A phase 1 study of donor regulatory T-cell infusion plus low-dose interleukin-2 for steroid-refractory chronic graft-vs-host disease. Blood Adv. 2022 11 08; 6(21):5786-5796. PMID: 35475885; PMCID: PMC9647832.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  2. Donato V, Kim HT, Stowe P, Reynolds CG, Ritz J, Koreth J, Whangbo JS. Durability of clinical and immunologic responses to extended low-dose interleukin-2 therapy in patients with refractory chronic graft-versus-host disease. Front Immunol. 2022; 13:954966. PMID: 36189229; PMCID: PMC9515381.
    Citations:    Fields:    Translation:Humans
  3. Silbert S, Cole K, Bedoya SZ, Freeman AF, Whangbo JS, Avila DN, Su HC, Yates B, Epstein M, Wendler DS, Pai SY, Hickstein DD, Wiener L, Shah NN. Tandem hematopoietic stem cell transplant considerations in families with multiple siblings affected by DOCK8 deficiency. Bone Marrow Transplant. 2022 11; 57(11):1721-1723. PMID: 35999252.
    Citations:    Fields:    Translation:Humans
  4. Kim HT, Koreth J, Whangbo J, Nikiforow S, Reynolds CG, Stowe P, Ho VT, Cutler C, Antin JH, Soiffer RJ, Ritz J. Organ-specific response after low-dose interleukin-2 therapy for steroid-refractory chronic graft-versus-host disease. Blood Adv. 2022 08 09; 6(15):4392-4402. PMID: 35617682; PMCID: PMC9636330.
    Citations: 2     Fields:    Translation:HumansCells
  5. Ji L, Whangbo J, Levine JE, Alonzo TA. Inefficiency of two-stage designs in phase II oncology clinical trials with high proportion of inevaluable patients. Contemp Clin Trials. 2022 09; 120:106849. PMID: 35868503; PMCID: PMC9489679.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  6. Liu KX, Poux N, Shin KY, Moore N, Chen YH, Margossian S, Whangbo JS, Duncan CN, Lehmann LE, Marcus KJ. Comparison of Pulmonary Toxicity after Total Body Irradiation- and Busulfan-Based Myeloablative Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients. Transplant Cell Ther. 2022 08; 28(8):502.e1-502.e12. PMID: 35623615.
    Citations:    Fields:    Translation:Humans
  7. Wobma H, Perkins R, Bartnikas L, Dedeoglu F, Chou J, Vleugels RA, Lo MS, Janssen E, Henderson LA, Whangbo J, Vargas SO, Fishman M, Krone KA, Casey A. Genetic diagnosis of immune dysregulation can lead to targeted therapy for interstitial lung disease: A case series and single center approach. Pediatr Pulmonol. 2022 07; 57(7):1577-1587. PMID: 35426264; PMCID: PMC9627679.
    Citations: 1     Fields:    Translation:Humans
  8. Habiballah SB, Whangbo JS, Cardona ID, Platt CD. Spontaneous resolution of severe idiopathic T cell lymphopenia. Clin Immunol. 2022 05; 238:109014. PMID: 35447312.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  9. Severyn CJ, Siranosian BA, Kong ST, Moreno A, Li MM, Chen N, Duncan CN, Margossian SP, Lehmann LE, Sun S, Andermann TM, Birbrayer O, Silverstein S, Reynolds CG, Kim S, Banaei N, Ritz J, Fodor AA, London WB, Bhatt AS, Whangbo JS. Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation. JCI Insight. 2022 04 08; 7(7). PMID: 35239511; PMCID: PMC9057614.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  10. Whangbo JS, Chou J, Al-Dhekri H, Harris M, Geha RS, Pai SY, Al-Herz W. Hematopoietic Stem Cell Transplantation Is a Curative Therapy for Transferrin Receptor 1 (TFRC) Deficiency. J Allergy Clin Immunol Pract. 2021 02; 9(2):753-759.e2. PMID: 33096268.
    Citations:    Fields:    Translation:Humans
  11. Whangbo JS, Antin JH, Koreth J. The role of regulatory T cells in graft-versus-host disease management. Expert Rev Hematol. 2020 02; 13(2):141-154. PMID: 31874061.
    Citations: 20     Fields:    Translation:HumansCells
  12. Whangbo JS, Kim HT, Mirkovic N, Leonard L, Poryanda S, Silverstein S, Kim S, Reynolds CG, Rai SC, Verrill K, Lee MA, Margossian S, Duncan C, Lehmann L, Huang J, Nikiforow S, Alyea EP, Armand P, Cutler CS, Ho VT, Blazar BR, Antin JH, Soiffer RJ, Ritz J, Koreth J. Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children. Blood Adv. 2019 09 10; 3(17):2550-2561. PMID: 31471324.
    Citations: 19     Fields:    Translation:HumansCellsCTClinical Trials
  13. Joyce CE, Saadatpour A, Ruiz-Gutierrez M, Bolukbasi OV, Jiang L, Thomas DD, Young S, Hofmann I, Sieff CA, Myers KC, Whangbo J, Libermann TA, Nusbaum C, Yuan GC, Shimamura A, Novina CD. TGFß signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome. J Clin Invest. 2019 06 18; 129(9):3821-3826. PMID: 31211692; PMCID: PMC6715362.
    Citations: 16     Fields:    Translation:HumansCells
  14. Whangbo JS, Kim HT, Nikiforow S, Koreth J, Alho AC, Falahee B, Kim S, Dusenbury K, Fields MJ, Reynolds CG, Alyea EP, Armand P, Cutler CS, Ho VT, Antin JH, Soiffer RJ, Ritz J. Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease. Blood Adv. 2019 04 09; 3(7):984-994. PMID: 30936059.
    Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
  15. Belizaire R, Kim HT, Poryanda SJ, Mirkovic NV, Hipolito E, Savage WJ, Reynolds CG, Fields MJ, Whangbo J, Kubo T, Nikiforow S, Alyea EP, Armand P, Cutler CS, Ho VT, Blazar BR, Antin JH, Ritz J, Soiffer RJ, Koreth J. Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease. Blood Adv. 2019 04 09; 3(7):969-979. PMID: 30936057.
    Citations: 17     Fields:    Translation:HumansCellsCTClinical Trials
  16. Alborghetti MR, Correa MEP, Whangbo J, Shi X, Aricetti JA, da Silva AA, Miranda ECM, Sforca ML, Caldana C, Gerszten RE, Ritz J, Zeri ACM. Clinical Metabolomics Identifies Blood Serum Branched Chain Amino Acids as Potential Predictive Biomarkers for Chronic Graft vs. Host Disease. Front Oncol. 2019; 9:141. PMID: 30949447; PMCID: PMC6436081.
    Citations: 8     
  17. Ben Farhat K, Alosaimi MF, Shendi H, Al-Hammadi S, Jones J, Schwarz K, Schulz A, Alawdah LS, Burchett S, Albuhairi S, Whangbo J, Kwatra N, Shamseldin HE, Alkuraya FS, Chou J, Geha RS. Immunologic reconstitution following hematopoietic stem cell transplantation despite lymph node paucity in NF-?B-inducing kinase deficiency. J Allergy Clin Immunol. 2019 03; 143(3):1240-1243.e4. PMID: 30445060; PMCID: PMC6408971.
    Citations:    Fields:    Translation:HumansCells
  18. Miggelbrink AM, Logan BR, Buckley RH, Parrott RE, Dvorak CC, Kapoor N, Abdel-Azim H, Prockop SE, Shyr D, Decaluwe H, Hanson IC, Gillio A, Dávila Saldaña BJ, Eibel H, Hopkins G, Walter JE, Whangbo JS, Kohn DB, Puck JM, Cowan MJ, Griffith LM, Haddad E, O'Reilly RJ, Notarangelo LD, Pai SY. B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation. Blood. 2018 06 28; 131(26):2967-2977. PMID: 29728406; PMCID: PMC6024640.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  19. Andermann TM, Peled JU, Ho C, Reddy P, Riches M, Storb R, Teshima T, van den Brink MRM, Alousi A, Balderman S, Chiusolo P, Clark WB, Holler E, Howard A, Kean LS, Koh AY, McCarthy PL, McCarty JM, Mohty M, Nakamura R, Rezvani K, Segal BH, Shaw BE, Shpall EJ, Sung AD, Weber D, Whangbo J, Wingard JR, Wood WA, Perales MA, Jenq RR, Bhatt AS. The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future. Biol Blood Marrow Transplant. 2018 07; 24(7):1322-1340. PMID: 29471034.
    Citations: 38     Fields:    Translation:Humans
  20. Whangbo JS, Weisman AS, Chae J, Hunter CP. SID-1 Domains Important for dsRNA Import in Caenorhabditis elegans. G3 (Bethesda). 2017 12 04; 7(12):3887-3899. PMID: 29025917; PMCID: PMC5714486.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Platt CD, Fried AJ, Hoyos-Bachiloglu R, Usmani GN, Schmidt B, Whangbo J, Chiarle R, Chou J, Geha RS. Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. Clin Immunol. 2017 10; 183:142-144. PMID: 28822832; PMCID: PMC5673555.
    Citations: 18     Fields:    Translation:HumansCells
  22. Hirakawa M, Matos TR, Liu H, Koreth J, Kim HT, Paul NE, Murase K, Whangbo J, Alho AC, Nikiforow S, Cutler C, Ho VT, Armand P, Alyea EP, Antin JH, Blazar BR, Lacerda JF, Soiffer RJ, Ritz J. Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells. JCI Insight. 2016 11 03; 1(18):e89278. PMID: 27812545.
    Citations: 71     Fields:    Translation:HumansCells
  23. Whangbo J, Ritz J, Bhatt A. Antibiotic-mediated modification of the intestinal microbiome in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2017 Feb; 52(2):183-190. PMID: 27526283; PMCID: PMC5288295.
    Citations: 24     Fields:    Translation:Humans
  24. Koreth J, Kim HT, Jones KT, Lange PB, Reynolds CG, Chammas MJ, Dusenbury K, Whangbo J, Nikiforow S, Alyea EP, Armand P, Cutler CS, Ho VT, Chen YB, Avigan D, Blazar BR, Antin JH, Ritz J, Soiffer RJ. Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease. Blood. 2016 07 07; 128(1):130-7. PMID: 27073224; PMCID: PMC4937358.
    Citations: 98     Fields:    Translation:HumansCellsCTClinical Trials
  25. Alho AC, Kim HT, Chammas MJ, Reynolds CG, Matos TR, Forcade E, Whangbo J, Nikiforow S, Cutler CS, Koreth J, Ho VT, Armand P, Antin JH, Alyea EP, Lacerda JF, Soiffer RJ, Ritz J. Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD. Blood. 2016 Feb 04; 127(5):646-57. PMID: 26670634; PMCID: PMC4742552.
    Citations: 90     Fields:    Translation:HumansCells
  26. Thomas MP, Liu X, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J. Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep. 2015 May 19; 11(7):1079-89. PMID: 25959823.
    Citations: 62     Fields:    Translation:HumansCells
  27. Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J. Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins. J Immunol. 2014 Jun 01; 192(11):5390-7. PMID: 24771851; PMCID: PMC4041364.
    Citations: 22     Fields:    Translation:HumansCellsCTClinical Trials
  28. Whangbo JS, Hunter CP. Environmental RNA interference. Trends Genet. 2008 Jun; 24(6):297-305. PMID: 18450316.
    Citations: 87     Fields:    Translation:Animals
  29. Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL. Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell. 2006 May; 9(5):405-16. PMID: 16697960.
    Citations: 172     Fields:    Translation:HumansAnimalsCells
  30. Ch'ng Q, Williams L, Lie YS, Sym M, Whangbo J, Kenyon C. Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. Genetics. 2003 Aug; 164(4):1355-67. PMID: 12930745.
    Citations: 36     Fields:    Translation:AnimalsCells
  31. Whangbo J, Harris J, Kenyon C. Multiple levels of regulation specify the polarity of an asymmetric cell division in C. elegans. Development. 2000 Nov; 127(21):4587-98. PMID: 11023862.
    Citations: 23     Fields:    Translation:AnimalsCells
  32. Whangbo J, Kenyon C. A Wnt signaling system that specifies two patterns of cell migration in C. elegans. Mol Cell. 1999 Nov; 4(5):851-8. PMID: 10619031.
    Citations: 80     Fields:    Translation:AnimalsCells
  33. Maloof JN, Whangbo J, Harris JM, Jongeward GD, Kenyon C. A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. Development. 1999 Jan; 126(1):37-49. PMID: 9834184.
    Citations: 91     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.