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Sylvain D. Lehoux, Ph.D.

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Biography
Emory University, Atlanta, GAPost-doctoral training2015Glycobiology
Universite des Sciences et Technologies de Lille, Lille - FrancePhD2009Glycobiology

Overview

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Huang L, Bockorny B, Paul I, Akshinthala D, Frappart PO, Gandarilla O, Bose A, Sanchez-Gonzalez V, Rouse E, Lehoux S, Pandell N, Lim C, Clohessy JG, Grossman JE, Gonzalez RS, Perea S, Daaboul G, Sawhney M, Freedman SD, Kleger A, Cummings RD, Emili A, Muthuswamy L, Hidalgo M, Muthuswamy S. PDX-derived organoids model in vivo drug response and secrete biomarkers. JCI Insight. 2020 Sep 29. PMID: 32990680.
    Citations:    
  2. Zeng J, Eljalby M, Aryal RP, Lehoux S, Stavenhagen K, Kudelka MR, Wang Y, Wang J, Ju T, von Andrian UH, Cummings RD. Cosmc controls B cell homing. Nat Commun. 2020 08 10; 11(1):3990. PMID: 32778659.
    Citations:    
  3. Mealer RG, Jenkins BG, Chen CY, Daly MJ, Ge T, Lehoux S, Marquardt T, Palmer CD, Park JH, Parsons PJ, Sackstein R, Williams SE, Cummings RD, Scolnick EM, Smoller JW. The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation. Sci Rep. 2020 Aug 04; 10(1):13162. PMID: 32753748.
    Citations:    
  4. Matsumoto Y, Kudelka MR, Hanes MS, Lehoux S, Dutta S, Jones MB, Stackhouse KA, Cervoni GE, Heimburg-Molinaro J, Smith DF, Ju T, Chaikof EL, Cummings RD. Erratum to: Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies. Glycobiology. 2020 May 16. PMID: 32415964.
    Citations:    
  5. Matsumoto Y, Kudelka MR, Hanes MS, Lehoux S, Dutta S, Jones MB, Stackhouse KA, Cervoni GE, Heimburg-Molinaro J, Smith DF, Ju T, Chaikof EL, Cummings RD. Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies. Glycobiology. 2020 04 20; 30(5):282-300. PMID: 31742337.
    Citations:    
  6. Kelm M, Lehoux S, Azcutia V, Cummings RD, Nusrat A, Parkos CA, Brazil JC. Regulation of neutrophil function by selective targeting of glycan epitopes expressed on the integrin CD11b/CD18. FASEB J. 2020 02; 34(2):2326-2343. PMID: 31907993.
    Citations:    
  7. Routhu NK, Lehoux SD, Rouse EA, Bidokhti MRM, Giron LB, Anzurez A, Reid SP, Abdel-Mohsen M, Cummings RD, Byrareddy SN. Glycosylation of Zika Virus is Important in Host-Virus Interaction and Pathogenic Potential. Int J Mol Sci. 2019 Oct 21; 20(20). PMID: 31640124.
    Citations:    
  8. Wheeler KM, Cárcamo-Oyarce G, Turner BS, Dellos-Nolan S, Co JY, Lehoux S, Cummings RD, Wozniak DJ, Ribbeck K. Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection. Nat Microbiol. 2019 12; 4(12):2146-2154. PMID: 31611643.
    Citations:    
  9. Tuccinardi D, Farr OM, Upadhyay J, Oussaada SM, Klapa MI, Candela M, Rampelli S, Lehoux S, Lázaro I, Sala-Vila A, Brigidi P, Cummings RD, Mantzoros CS. Mechanisms underlying the cardiometabolic protective effect of walnut consumption in obese people: A cross-over, randomized, double-blind, controlled inpatient physiology study. Diabetes Obes Metab. 2019 09; 21(9):2086-2095. PMID: 31087608.
    Citations:    
  10. Pettinato G, Lehoux S, Ramanathan R, Salem MM, He LX, Muse O, Flaumenhaft R, Thompson MT, Rouse EA, Cummings RD, Wen X, Fisher RA. Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells. Sci Rep. 2019 06 20; 9(1):8920. PMID: 31222080.
    Citations:    
  11. Woodward AM, Lehoux S, Mantelli F, Di Zazzo A, Brockhausen I, Bonini S, Argüeso P. Inflammatory Stress Causes N-Glycan Processing Deficiency in Ocular Autoimmune Disease. Am J Pathol. 2019 02; 189(2):283-294. PMID: 30448401.
    Citations:    Fields:    
  12. Behrens AJ, Duke RM, Petralia LMC, Lehoux S, Carlow CKS, Taron CH, Foster JM. Changes in canine serum N-glycosylation as a result of infection with the heartworm parasite Dirofilaria immitis. Sci Rep. 2018 11 09; 8(1):16625. PMID: 30413744.
    Citations:    Fields:    
  13. Behrens AJ, Duke RM, Petralia LM, Harvey DJ, Lehoux S, Magnelli PE, Taron CH, Foster JM. Glycosylation profiling of dog serum reveals differences compared to human serum. Glycobiology. 2018 11 01; 28(11):825-831. PMID: 30137320.
    Citations: 1     Fields:    
  14. Koelsch KA, Cavett J, Smith K, Moore JS, Lehoux SD, Jia N, Mather T, Quadri SMS, Rasmussen A, Kaufman CE, Lewis DM, Radfar L, Scordino TA, Lessard CJ, Kurien BT, Cummings RD, James JA, Sivils KL, Farris AD, Scofield RH. Evidence of Alternative Modes of B Cell Activation Involving Acquired Fab Regions of N-Glycosylation in Antibody-Secreting Cells Infiltrating the Labial Salivary Glands of Patients With Sjögren's Syndrome. Arthritis Rheumatol. 2018 07; 70(7):1102-1113. PMID: 29457375.
    Citations: 1     Fields:    
  15. Taniguchi T, Woodward AM, Magnelli P, McColgan NM, Lehoux S, Jacobo SMP, Mauris J, Argüeso P. N-Glycosylation affects the stability and barrier function of the MUC16 mucin. J Biol Chem. 2017 06 30; 292(26):11079-11090. PMID: 28487369.
    Citations: 2     Fields:    Translation:HumansCells
  16. Lehoux S, Ju T. Separation of Two Distinct O-Glycoforms of Human IgA1 by Serial Lectin Chromatography Followed by Mass Spectrometry O-Glycan Analysis. Methods Enzymol. 2017; 585:61-75. PMID: 28109443.
    Citations:    Fields:    Translation:Humans
  17. Lehoux S, Mi R, Aryal RP, Wang Y, Schjoldager KT, Clausen H, van Die I, Han Y, Chapman AB, Cummings RD, Ju T. Identification of distinct glycoforms of IgA1 in plasma from patients with immunoglobulin A (IgA) nephropathy and healthy individuals. Mol Cell Proteomics. 2014 Nov; 13(11):3097-113. PMID: 25071157.
    Citations: 5     Fields:    Translation:HumansCells
  18. Ju T, Wang Y, Aryal RP, Lehoux SD, Ding X, Kudelka MR, Cutler C, Zeng J, Wang J, Sun X, Heimburg-Molinaro J, Smith DF, Cummings RD. Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers. Proteomics Clin Appl. 2013 Oct; 7(9-10):618-31. PMID: 23857728.
    Citations: 27     Fields:    Translation:HumansAnimals
  19. Mi R, Song L, Wang Y, Ding X, Zeng J, Lehoux S, Aryal RP, Wang J, Crew VK, van Die I, Chapman AB, Cummings RD, Ju T. Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen. J Biol Chem. 2012 Nov 30; 287(49):41523-33. PMID: 23035125.
    Citations: 24     Fields:    Translation:HumansCells
  20. Lehoux S, Groux-Degroote S, Cazet A, Dhaenens CM, Maurage CA, Caillet-Boudin ML, Delannoy P, Krzewinski-Recchi MA. Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells. Glycoconj J. 2010 Jan; 27(1):99-114. PMID: 19768537.
    Citations: 9     Fields:    Translation:HumansCells
  21. Cazet A, Groux-Degroote S, Teylaert B, Kwon KM, Lehoux S, Slomianny C, Kim CH, Le Bourhis X, Delannoy P. GD3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells. Biol Chem. 2009 Jul; 390(7):601-9. PMID: 19335207.
    Citations: 19     Fields:    Translation:HumansCells
  22. Groux-Degroote S, Krzewinski-Recchi MA, Cazet A, Vincent A, Lehoux S, Lafitte JJ, Van Seuningen I, Delannoy P. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa. Biochem J. 2008 Feb 15; 410(1):213-23. PMID: 17944600.
    Citations: 21     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.