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Jonathan B. Cohen, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01GM058448 (MILLER, KEITH W) Dec 1, 1998 - Aug 31, 2019
    NIH/NIGMS
    General Anesthetic Sites on Ligand Gated Ion Channels
    Role: Co-Principal Investigator
  2. T32MH020017 (SEGAL, ROSALIND A.) Sep 30, 1997 - Jun 30, 2023
    NIH/NIMH
    Ph.D. Training in Neuroscience
    Role: Co-Principal Investigator
  3. P01NS029343 (LICHTMAN, JEFF W) Mar 1, 1991 - Feb 29, 1996
    NIH/NINDS
    LONG TERM CHANGES WITH NEUROTRANSMITTER RECEPTORS
    Role: Co-Principal Investigator
  4. R01NS019522 (COHEN, JONATHAN B) Sep 1, 1982 - Nov 30, 2001
    NIH/NINDS
    PERMEABILITY CONTROL OF ACETYLCHOLINE RECEPTOR
    Role: Principal Investigator
  5. R01NS018458 (COHEN, JONATHAN B) Sep 1, 1981 - Apr 30, 2002
    NIH/NINDS
    TROPHIC INTERACTIONS AT NEUROMUSCULAR JUNCTIONS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Inhibitable photolabeling by neurosteroid diazirine analog in the ß3-Subunit of human hetereopentameric type A GABA receptors. Eur J Med Chem. 2019 Jan 15; 162:810-824. PMID: 30544077.
    View in: PubMed
  2. McGrath M, Yu Z, Jayakar SS, Ma C, Tolia M, Zhou X, Miller KW, Cohen JB, Raines DE. Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology. 2018 Nov; 129(5):959-969. PMID: 30052529.
    View in: PubMed
  3. Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE. Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology. 2017 11; 127(5):824-837. PMID: 28857763.
    View in: PubMed
  4. Yu Z, Cohen JB. Enantiomeric barbiturates bind distinct inter- and intrasubunit binding sites in a nicotinic acetylcholine receptor (nAChR). J Biol Chem. 2017 10 20; 292(42):17258-17271. PMID: 28878016.
    View in: PubMed
  5. Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS. Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. Eur J Med Chem. 2017 Aug 18; 136:334-347. PMID: 28505538.
    View in: PubMed
  6. Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. General Anesthetic Binding Sites in Human a4ß3d ?-Aminobutyric Acid Type A Receptors (GABAARs). J Biol Chem. 2016 Dec 16; 291(51):26529-26539. PMID: 27821594.
    View in: PubMed
  7. Hamouda AK, Deba F, Wang ZJ, Cohen JB. Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (a4)3(ß2)2 nAChR-Selective Positive Allosteric Modulator. Mol Pharmacol. 2016 May; 89(5):575-84. PMID: 26976945; PMCID: PMC4851301 [Available on 05/01/17].
  8. Serdiuk A, Khalil F, Cohen JB. Images in Anesthesiology: An Unexpected Embolism during a Craniotomy. Anesthesiology. 2016 Mar; 124(3):721. PMID: 26288269.
    View in: PubMed
  9. Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G. Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol. Curr Neuropharmacol. 2016; 14(7):772-80. PMID: 26830963.
    View in: PubMed
  10. Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Positive and Negative Allosteric Modulation of an a1ß3?2 ?-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the ?+-ß- Interface. J Biol Chem. 2015 Sep 18; 290(38):23432-46. PMID: 26229099; PMCID: PMC4645599.
  11. Hamouda AK, Wang ZJ, Stewart DS, Jain AD, Glennon RA, Cohen JB. Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor. Mol Pharmacol. 2015 Jul; 88(1):1-11. PMID: 25870334; PMCID: PMC4468644.
  12. Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Multiple propofol-binding sites in a ?-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. J Biol Chem. 2014 Oct 03; 289(40):27456-68. PMID: 25086038; PMCID: PMC4183786.
  13. Hamouda AK, Stewart DS, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB. Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate. Mol Pharmacol. 2014 May; 85(5):735-46. PMID: 24563544; PMCID: PMC3990015.
  14. Chiara DC, Gill JF, Chen Q, Tillman T, Dailey WP, Eckenhoff RG, Xu Y, Tang P, Cohen JB. Photoaffinity labeling the propofol binding site in GLIC. Biochemistry. 2014 Jan 14; 53(1):135-42. PMID: 24341978; PMCID: PMC3935609.
  15. Hamouda AK, Jayakar SS, Chiara DC, Cohen JB. Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites! J Mol Neurosci. 2014 Jul; 53(3):480-6. PMID: 24158732.
    View in: PubMed
  16. Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human a1ß3?2 ?-aminobutyric acid type A (GABAA) receptor. J Biol Chem. 2013 Jul 05; 288(27):19343-57. PMID: 23677991; PMCID: PMC3707639.
  17. Hamouda AK, Kimm T, Cohen JB. Physostigmine and galanthamine bind in the presence of agonist at the canonical and noncanonical subunit interfaces of a nicotinic acetylcholine receptor. J Neurosci. 2013 Jan 09; 33(2):485-94. PMID: 23303929; PMCID: PMC3542985.
  18. Jayakar SS, Dailey WP, Eckenhoff RG, Cohen JB. Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog. J Biol Chem. 2013 Mar 01; 288(9):6178-89. PMID: 23300078; PMCID: PMC3585054.
  19. Cohen JB. Bone cement embolism. Anesthesiology. 2012 Aug; 117(2):407. PMID: 22388069.
    View in: PubMed
  20. Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012 Jul 26; 55(14):6554-65. PMID: 22734650; PMCID: PMC3717557.
  21. Pandhare A, Hamouda AK, Staggs B, Aggarwal S, Duddempudi PK, Lever JR, Lapinsky DJ, Jansen M, Cohen JB, Blanton MP. Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72. Biochemistry. 2012 Mar 27; 51(12):2425-35. PMID: 22394379; PMCID: PMC3315157.
  22. Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB. Mapping general anesthetic binding site(s) in human a1ß3 ?-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue. Biochemistry. 2012 Jan 31; 51(4):836-47. PMID: 22243422; PMCID: PMC3274767.
  23. Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW. p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. J Med Chem. 2011 Dec 08; 54(23):8124-35. PMID: 22029276; PMCID: PMC3580944.
  24. Hamouda AK, Stewart DS, Husain SS, Cohen JB. Multiple transmembrane binding sites for p-trifluoromethyldiazirinyl-etomidate, a photoreactive Torpedo nicotinic acetylcholine receptor allosteric inhibitor. J Biol Chem. 2011 Jun 10; 286(23):20466-77. PMID: 21498509; PMCID: PMC3121496.
  25. Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW. p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010 Sep 09; 53(17):6432-44. PMID: 20704351; PMCID: PMC3117435.
  26. Li GD, Chiara DC, Cohen JB, Olsen RW. Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors. J Biol Chem. 2010 Mar 19; 285(12):8615-20. PMID: 20083606; PMCID: PMC2838283.
  27. Yamodo IH, Chiara DC, Cohen JB, Miller KW. Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization. Biochemistry. 2010 Jan 12; 49(1):156-65. PMID: 19961216; PMCID: PMC2818735.
  28. Chiara DC, Hamouda AK, Ziebell MR, Mejia LA, Garcia G, Cohen JB. [(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel. Biochemistry. 2009 Oct 27; 48(42):10066-77. PMID: 19754159; PMCID: PMC2878666.
  29. Sanghvi M, Hamouda AK, Davis MI, Morton RA, Srivastava S, Pandhare A, Duddempudi PK, Machu TK, Lovinger DM, Cohen JB, Blanton MP. Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor. Biochemistry. 2009 Oct 06; 48(39):9278-86. PMID: 19715355; PMCID: PMC2778300.
  30. Srivastava S, Hamouda AK, Pandhare A, Duddempudi PK, Sanghvi M, Cohen JB, Blanton MP. [(3)H]Epibatidine photolabels non-equivalent amino acids in the agonist binding site of Torpedo and alpha4beta2 nicotinic acetylcholine receptors. J Biol Chem. 2009 Sep 11; 284(37):24939-47. PMID: 19620239; PMCID: PMC2757197.
  31. Li GD, Chiara DC, Cohen JB, Olsen RW. Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors. J Biol Chem. 2009 May 01; 284(18):11771-5. PMID: 19282280; PMCID: PMC2673245.
  32. Chiara DC, Hong FH, Arevalo E, Husain SS, Miller KW, Forman SA, Cohen JB. Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor. Mol Pharmacol. 2009 May; 75(5):1084-95. PMID: 19218367; PMCID: PMC2672814.
  33. Hamouda AK, Chiara DC, Blanton MP, Cohen JB. Probing the structure of the affinity-purified and lipid-reconstituted torpedo nicotinic acetylcholine receptor. Biochemistry. 2008 Dec 02; 47(48):12787-94. PMID: 18991407; PMCID: PMC2872774.
  34. Nirthanan S, Garcia G, Chiara DC, Husain SS, Cohen JB. Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector. J Biol Chem. 2008 Aug 08; 283(32):22051-62. PMID: 18524766; PMCID: PMC2494931.
  35. Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, Essock S, Fenton WS, Frese FJ, Gold JM, Goldberg T, Heaton RK, Keefe RS, Kraemer H, Mesholam-Gately R, Seidman LJ, Stover E, Weinberger DR, Young AS, Zalcman S, Marder SR. The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry. 2008 Feb; 165(2):203-13. PMID: 18172019.
    View in: PubMed
  36. Hamouda AK, Sanghvi M, Chiara DC, Cohen JB, Blanton MP. Identifying the lipid-protein interface of the alpha4beta2 neuronal nicotinic acetylcholine receptor: hydrophobic photolabeling studies with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine. Biochemistry. 2007 Dec 04; 46(48):13837-46. PMID: 17994769; PMCID: PMC2597459.
  37. Fales CL, Barch DM, Rundle MM, Mintun MA, Snyder AZ, Cohen JD, Mathews J, Sheline YI. Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression. Biol Psychiatry. 2008 Feb 15; 63(4):377-84. PMID: 17719567; PMCID: PMC2268639.
  38. Garcia G, Chiara DC, Nirthanan S, Hamouda AK, Stewart DS, Cohen JB. [3H]Benzophenone photolabeling identifies state-dependent changes in nicotinic acetylcholine receptor structure. Biochemistry. 2007 Sep 11; 46(36):10296-307. PMID: 17685589.
    View in: PubMed
  39. Li GD, Chiara DC, Sawyer GW, Husain SS, Olsen RW, Cohen JB. Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog. J Neurosci. 2006 Nov 08; 26(45):11599-605. PMID: 17093081.
    View in: PubMed
  40. Stewart DS, Chiara DC, Cohen JB. Mapping the structural requirements for nicotinic acetylcholine receptor activation by using tethered alkyltrimethylammonium agonists and antagonists. Biochemistry. 2006 Sep 05; 45(35):10641-53. PMID: 16939216.
    View in: PubMed
  41. Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW. Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels. J Med Chem. 2006 Aug 10; 49(16):4818-25. PMID: 16884293.
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  42. Kasheverov IE, Chiara DC, Zhmak MN, Maslennikov IV, Pashkov VS, Arseniev AS, Utkin YN, Cohen JB, Tsetlin VI. alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor. FEBS J. 2006 Apr; 273(7):1373-88. PMID: 16689926.
    View in: PubMed
  43. Hamouda AK, Chiara DC, Sauls D, Cohen JB, Blanton MP. Cholesterol interacts with transmembrane alpha-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor: photolabeling studies using [3H]Azicholesterol. Biochemistry. 2006 Jan 24; 45(3):976-86. PMID: 16411773; PMCID: PMC2564873.
  44. Andreeva IE, Nirthanan S, Cohen JB, Pedersen SE. Site specificity of agonist-induced opening and desensitization of the Torpedo californica nicotinic acetylcholine receptor. Biochemistry. 2006 Jan 10; 45(1):195-204. PMID: 16388595.
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  45. Montague PR, King-Casas B, Cohen JD. Imaging valuation models in human choice. Annu Rev Neurosci. 2006; 29:417-48. PMID: 16776592.
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  46. Bianchetta MJ, Betensky RA, Cohen JB. Cell-surface MuSK self-association: a crucial role for the putative signal sequence. Biochemistry. 2005 Dec 13; 44(49):16229-38. PMID: 16331983.
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  47. Nirthanan S, Ziebell MR, Chiara DC, Hong F, Cohen JB. Photolabeling the Torpedo nicotinic acetylcholine receptor with 4-azido-2,3,5,6-tetrafluorobenzoylcholine, a partial agonist. Biochemistry. 2005 Oct 18; 44(41):13447-56. PMID: 16216068.
    View in: PubMed
  48. Arevalo E, Chiara DC, Forman SA, Cohen JB, Miller KW. Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study. J Biol Chem. 2005 Apr 08; 280(14):13631-40. PMID: 15664985.
    View in: PubMed
  49. Montague PR, Hyman SE, Cohen JD. Computational roles for dopamine in behavioural control. Nature. 2004 Oct 14; 431(7010):760-7. PMID: 15483596.
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  50. Trinidad JC, Cohen JB. Neuregulin inhibits acetylcholine receptor aggregation in myotubes. J Biol Chem. 2004 Jul 23; 279(30):31622-8. PMID: 15155732.
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  51. Ziebell MR, Nirthanan S, Husain SS, Miller KW, Cohen JB. Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic. J Biol Chem. 2004 Apr 23; 279(17):17640-9. PMID: 14761946.
    View in: PubMed
  52. Chiara DC, Dangott LJ, Eckenhoff RG, Cohen JB. Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane. Biochemistry. 2003 Nov 25; 42(46):13457-67. PMID: 14621991.
    View in: PubMed
  53. Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA, Olsen RW, Forman SA, Cohen JB, Miller KW. 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem. 2003 Mar 27; 46(7):1257-65. PMID: 12646036.
    View in: PubMed
  54. Chiara DC, Trinidad JC, Wang D, Ziebell MR, Sullivan D, Cohen JB. Identification of amino acids in the nicotinic acetylcholine receptor agonist binding site and ion channel photolabeled by 4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine, a novel photoaffinity antagonist. Biochemistry. 2003 Jan 21; 42(2):271-83. PMID: 12525154.
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  55. Sawyer GW, Chiara DC, Olsen RW, Cohen JB. Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513. J Biol Chem. 2002 Dec 20; 277(51):50036-45. PMID: 12388542.
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  56. Montague PR, Berns GS, Cohen JD, McClure SM, Pagnoni G, Dhamala M, Wiest MC, Karpov I, King RD, Apple N, Fisher RE. Hyperscanning: simultaneous fMRI during linked social interactions. Neuroimage. 2002 Aug; 16(4):1159-64. PMID: 12202103.
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  57. Sullivan D, Chiara DC, Cohen JB. Mapping the agonist binding site of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis: antagonist footprint and secondary structure prediction. Mol Pharmacol. 2002 Feb; 61(2):463-72. PMID: 11809872.
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  58. Blanton MP, Lala AK, Cohen JB. Identification and characterization of membrane-associated polypeptides in Torpedo nicotinic acetylcholine receptor-rich membranes by hydrophobic photolabeling. Biochim Biophys Acta. 2001 Jun 06; 1512(2):215-24. PMID: 11406098.
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  59. Gallagher MJ, Chiara DC, Cohen JB. Interactions between 3-(Trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo series nicotinic acetylcholine receptor ion channel. Mol Pharmacol. 2001 Jun; 59(6):1514-22. PMID: 11353813.
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  60. Bartoli M, Ramarao MK, Cohen JB. Interactions of the rapsyn RING-H2 domain with dystroglycan. J Biol Chem. 2001 Jul 06; 276(27):24911-7. PMID: 11342559.
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  61. Chiara DC, Kloczewiak MA, Addona GH, Yu JA, Cohen JB, Miller KW. Site of resting state inhibition of the nicotinic acetylcholine receptor by a hydrophobic inhibitor. Biochemistry. 2001 Jan 09; 40(1):296-304. PMID: 11141083.
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  62. Trinidad JC, Fischbach GD, Cohen JB. The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction. J Neurosci. 2000 Dec 01; 20(23):8762-70. PMID: 11102484.
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  63. Ramarao MK, Bianchetta MJ, Lanken J, Cohen JB. Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clustering. J Biol Chem. 2001 Mar 09; 276(10):7475-83. PMID: 11087759.
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  64. Xie Y, Cohen JB. Contributions of Torpedo nicotinic acetylcholine receptor gamma Trp-55 and delta Trp-57 to agonist and competitive antagonist function. J Biol Chem. 2001 Jan 26; 276(4):2417-26. PMID: 11056174.
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  65. Pratt MB, Husain SS, Miller KW, Cohen JB. Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic. J Biol Chem. 2000 Sep 22; 275(38):29441-51. PMID: 10859324.
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  66. Pratt MB, Pedersen SE, Cohen JB. Identification of the sites of incorporation of [3H]ethidium diazide within the Torpedo nicotinic acetylcholine receptor ion channel. Biochemistry. 2000 Sep 19; 39(37):11452-62. PMID: 10985791.
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  67. Wang D, Chiara DC, Xie Y, Cohen JB. Probing the structure of the nicotinic acetylcholine receptor with 4-benzoylbenzoylcholine, a novel photoaffinity competitive antagonist. J Biol Chem. 2000 Sep 15; 275(37):28666-74. PMID: 10893246.
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  68. Sullivan DA, Cohen JB. Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonist. J Biol Chem. 2000 Apr 28; 275(17):12651-60. PMID: 10777557.
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  69. Husain SS, Forman SA, Kloczewiak MA, Addona GH, Olsen RW, Pratt MB, Cohen JB, Miller KW. Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. J Med Chem. 1999 Aug 26; 42(17):3300-7. PMID: 10464016.
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  70. Middleton RE, Strnad NP, Cohen JB. Photoaffinity labeling the torpedo nicotinic acetylcholine receptor with [(3)H]tetracaine, a nondesensitizing noncompetitive antagonist. Mol Pharmacol. 1999 Aug; 56(2):290-9. PMID: 10419547.
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  71. Gallagher MJ, Cohen JB. Identification of amino acids of the torpedo nicotinic acetylcholine receptor contributing to the binding site for the noncompetitive antagonist [(3)H]tetracaine. Mol Pharmacol. 1999 Aug; 56(2):300-7. PMID: 10419548.
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  72. Chiara DC, Xie Y, Cohen JB. Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: affinity-labeling and mutational analyses identify gamma Tyr-111/delta Arg-113 as antagonist affinity determinants. Biochemistry. 1999 May 18; 38(20):6689-98. PMID: 10350488.
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  73. Blanton MP, Xie Y, Dangott LJ, Cohen JB. The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface. Mol Pharmacol. 1999 Feb; 55(2):269-78. PMID: 9927618.
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  74. Lugovskoy AA, Maslennikov IV, Utkin YN, Tsetlin VI, Cohen JB, Arseniev AS. Spatial structure of the M3 transmembrane segment of the nicotinic acetylcholine receptor alpha subunit. Eur J Biochem. 1998 Jul 15; 255(2):455-61. PMID: 9716388.
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  75. Blanton MP, Dangott LJ, Raja SK, Lala AK, Cohen JB. Probing the structure of the nicotinic acetylcholine receptor ion channel with the uncharged photoactivable compound -3H-diazofluorene. J Biol Chem. 1998 Apr 10; 273(15):8659-68. PMID: 9535841.
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  76. Ramarao MK, Cohen JB. Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):4007-12. PMID: 9520483; PMCID: PMC19953.
  77. Chiara DC, Middleton RE, Cohen JB. Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the gamma-subunit of the Torpedo nicotinic acetylcholine receptor. FEBS Lett. 1998 Feb 20; 423(2):223-6. PMID: 9512361.
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  78. Chiara DC, Cohen JB. Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor. J Biol Chem. 1997 Dec 26; 272(52):32940-50. PMID: 9407073.
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  79. Sadoulet-Puccio HM, Khurana TS, Cohen JB, Kunkel LM. Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane. Hum Mol Genet. 1996 Apr; 5(4):489-96. PMID: 8845841.
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  80. Blanton MP, Li YM, Stimson ER, Maggio JE, Cohen JB. Agonist-induced photoincorporation of a p-benzoylphenylalanine derivative of substance P into membrane-spanning region 2 of the Torpedo nicotinic acetylcholine receptor delta subunit. Mol Pharmacol. 1994 Dec; 46(6):1048-55. PMID: 7528876.
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  81. Blanton MP, Cohen JB. Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications. Biochemistry. 1994 Mar 15; 33(10):2859-72. PMID: 8130199.
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  82. White BH, Cohen JB. Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist. J Biol Chem. 1992 Aug 05; 267(22):15770-83. PMID: 1639812.
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  83. Pedersen SE, Sharp SD, Liu WS, Cohen JB. Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262. J Biol Chem. 1992 May 25; 267(15):10489-99. PMID: 1587830.
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  84. Blanton MP, Cohen JB. Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor. Biochemistry. 1992 Apr 21; 31(15):3738-50. PMID: 1567828.
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  85. Cohen JB, Sharp SD, Liu WS. Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite. J Biol Chem. 1991 Dec 05; 266(34):23354-64. PMID: 1744130.
    View in: PubMed
  86. White BH, Howard S, Cohen SG, Cohen JB. The hydrophobic photoreagent 3-(trifluoromethyl)-3-m-([125I] iodophenyl) diazirine is a novel noncompetitive antagonist of the nicotinic acetylcholine receptor. J Biol Chem. 1991 Nov 15; 266(32):21595-607. PMID: 1939189.
    View in: PubMed
  87. Middleton RE, Cohen JB. Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label. Biochemistry. 1991 Jul 16; 30(28):6987-97. PMID: 2069955.
    View in: PubMed
  88. Tsui HC, Cohen JB, Fischbach GD. Variation in the ratio of acetylcholine receptors and the Mr 43,000 receptor-associated protein in embryonic chick myotubes and myoblasts. Dev Biol. 1990 Aug; 140(2):437-46. PMID: 2373261.
    View in: PubMed
  89. Pedersen SE, Cohen JB. d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2785-9. PMID: 2320589; PMCID: PMC53775.
  90. Pedersen SE, Bridgman PC, Sharp SD, Cohen JB. Identification of a cytoplasmic region of the Torpedo nicotinic acetylcholine receptor alpha-subunit by epitope mapping. J Biol Chem. 1990 Jan 05; 265(1):569-81. PMID: 1688436.
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  91. Carr C, Fischbach GD, Cohen JB. A novel 87,000-Mr protein associated with acetylcholine receptors in Torpedo electric organ and vertebrate skeletal muscle. J Cell Biol. 1989 Oct; 109(4 Pt 1):1753-64. PMID: 2793938; PMCID: PMC2115790.
  92. Carr C, Tyler AN, Cohen JB. Myristic acid is the NH2-terminal blocking group of the 43-kDa protein of Torpedo nicotinic post-synaptic membranes. FEBS Lett. 1989 Jan 16; 243(1):65-9. PMID: 2920827.
    View in: PubMed
  93. White BH, Cohen JB. Photolabeling of membrane-bound Torpedo nicotinic acetylcholine receptor with the hydrophobic probe 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine. Biochemistry. 1988 Nov 29; 27(24):8741-51. PMID: 3242605.
    View in: PubMed
  94. Musil LS, Carr C, Cohen JB, Merlie JP. Acetylcholine receptor-associated 43K protein contains covalently bound myristate. J Cell Biol. 1988 Sep; 107(3):1113-21. PMID: 3417776; PMCID: PMC2115306.
  95. Carr C, McCourt D, Cohen JB. The 43-kilodalton protein of Torpedo nicotinic postsynaptic membranes: purification and determination of primary structure. Biochemistry. 1987 Nov 03; 26(22):7090-102. PMID: 3427060.
    View in: PubMed
  96. Bridgman PC, Carr C, Pedersen SE, Cohen JB. Visualization of the cytoplasmic surface of Torpedo postsynaptic membranes by freeze-etch and immunoelectron microscopy. J Cell Biol. 1987 Oct; 105(4):1829-46. PMID: 3312239; PMCID: PMC2114641.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.