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profileYu Heng Lau, Ph.D.

TitleResearch Fellow in Systems Biology (EXT)
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology WAB 536
200 Longwood Ave
Boston MA 02115
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lau YH, Stirling F, Kuo J, Karrenbelt MAP, Chan YA, Riesselman A, Horton CA, Schäfer E, Lips D, Weinstock MT, Gibson DG, Way JC, Silver PA. Large-scale recoding of a bacterial genome by iterative recombineering of synthetic DNA. Nucleic Acids Res. 2017 Jun 20; 45(11):6971-6980. PMID: 28499033.
    View in: PubMed
  2. Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS. Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase. J Am Chem Soc. 2017 Feb 15; 139(6):2245-2256. PMID: 28084734.
    View in: PubMed
  3. Wu Y, Olsen LB, Lau YH, Jensen CH, Rossmann M, Baker YR, Sore HF, Collins S, Spring DR. Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling. Chembiochem. 2016 Apr 15; 17(8):689-92. PMID: 26919579; PMCID: PMC4862033.
  4. Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR. Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. Angew Chem Int Ed Engl. 2015 Dec 14; 54(51):15410-3. PMID: 26768531.
    View in: PubMed
  5. Lau YH, Wu Y, de Andrade P, Galloway WR, Spring DR. A two-component 'double-click' approach to peptide stapling. Nat Protoc. 2015 Apr; 10(4):585-94. PMID: 25763835.
    View in: PubMed
  6. Lau YH, de Andrade P, McKenzie GJ, Venkitaraman AR, Spring DR. Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides. Chembiochem. 2014 Dec 15; 15(18):2680-3. PMID: 25354189.
    View in: PubMed
  7. Lau YH, de Andrade P, Wu Y, Spring DR. Peptide stapling techniques based on different macrocyclisation chemistries. Chem Soc Rev. 2015 Jan 07; 44(1):91-102. PMID: 25199043.
    View in: PubMed
  8. Lau YH, de Andrade P, Sköld N, McKenzie GJ, Venkitaraman AR, Verma C, Lane DP, Spring DR. Investigating peptide sequence variations for 'double-click' stapled p53 peptides. Org Biomol Chem. 2014 Jun 28; 12(24):4074-7. PMID: 24817343.
    View in: PubMed
  9. Lau YH, de Andrade P, Quah S-T, Rossmann M, Laraia L, Sköld N, Sum TJ, Rowling PJE, Joseph TL, Verma C, Hyvönen M, Itzhaki LS, Venkitaraman AR, Brown CJ, Lane DP, Spring DR. Functionalised staple linkages for modulating the cellular activity of stapled peptides. Chemical Science. 2014; 5:1804-1809.
  10. Lau YH, Spring DR. Efficient synthesis of Fmoc-protected azido amino acids. Synlett. 2011; 2011(13):1917-1919.
  11. Lau YH, Rutledge PJ, Watkinson M, Todd MH. Chemical sensors that incorporate click-derived triazoles. Chem Soc Rev. 2011 May; 40(5):2848-66. PMID: 21380414.
    View in: PubMed
  12. Lau YH, Price JR, Todd MH, Rutledge PJ. A click fluorophore sensor that can distinguish Cu(II) and Hg(II) via selective anion-induced demetallation. Chemistry. 2011 Mar 01; 17(10):2850-8. PMID: 21305620.
    View in: PubMed
  13. Scully CCG, Lau YH, Jensen P, Rutledge PJ. Synthesis, electrochemistry and metal binding properties of monosubstituted ferrocenoyl peptides with thioether-containing sidechains. Journal of Organometallic Chemistry. 2011; 696(3):715-721.
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