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PierPaolo Peruzzi, Ph.D., M.D.


Available: 04/05/22, Expires: 06/01/23

My laboratory investigates epigenetic mechanisms enacted by cancer cells to escape immune surveillance, and survive toxicity from therapies. We have established a gene therapy based on artificial microRNAs and non coding RNAs to interfere with this survival response. Studies to support a clinical trial are ongoing.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Raghu ALB, Chen JA, Valdes PA, Essayed W, Claus E, Arnaout O, Smith TR, Chiocca EA, Peruzzi PP, Bernstock JD. Cerebellar High-Grade Glioma: A Translationally Oriented Review of the Literature. Cancers (Basel). 2022 Dec 28; 15(1). PMID: 36612169; PMCID: PMC9818238.
  2. Lim-Fat MJ, Youssef GC, Touat M, Iorgulescu JB, Whorral S, Allen M, Rahman R, Chukwueke U, McFaline-Figueroa JR, Nayak L, Lee EQ, Batchelor TT, Arnaout O, Peruzzi PP, Chiocca EA, Reardon DA, Meredith D, Santagata S, Beroukhim R, Bi WL, Ligon KL, Wen PY. Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149. PMID: 34878541; PMCID: PMC9248387.
    Citations: 4     Fields:    Translation:Humans
  3. Yearley AG, Iorgulescu JB, Chiocca EA, Peruzzi PP, Smith TR, Reardon DA, Mooney MA. The current state of glioma data registries. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac099. PMID: 36196363; PMCID: PMC9521197.
  4. Chiocca EA, Gelb AB, Chen CC, Rao G, Reardon DA, Wen PY, Bi WL, Peruzzi P, Amidei C, Triggs D, Seften L, Park G, Grant J, Truman K, Buck JY, Hadar N, Demars N, Miao J, Estupinan T, Loewy J, Chadha K, Tringali J, Cooper L, Lukas RV. Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial. Neuro Oncol. 2022 06 01; 24(6):951-963. PMID: 34850166; PMCID: PMC9159462.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  5. Blitz SE, Kappel AD, Gessler FA, Klinger NV, Arnaout O, Lu Y, Peruzzi PP, Smith TR, Chiocca EA, Friedman GK, Bernstock JD. Tumor-Associated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A Double-Edged Sword. Int J Mol Sci. 2022 Feb 04; 23(3). PMID: 35163730; PMCID: PMC8836356.
    Citations: 1     Fields:    Translation:HumansCells
  6. Peruzzi P, Valdes PQ, Aghi MK, Berger M, Chiocca EA, Golby AJ. The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors. Hematol Oncol Clin North Am. 2022 02; 36(1):63-75. PMID: 34565649.
    Citations:    Fields:    Translation:Humans
  7. Blitz SE, Bernstock JD, Dmytriw AA, Ditoro DF, Kappel AD, Gormley WB, Peruzzi P. Ruptured Suprasellar Dermoid Cyst Treated With Lumbar Drain to Prevent Postoperative Hydrocephalus: Case Report and Focused Review of Literature. Front Surg. 2021; 8:714771. PMID: 34458316; PMCID: PMC8385128.
  8. Olsen HE, Lynn GM, Valdes PA, Cerecedo Lopez CD, Ishizuka AS, Arnaout O, Bi WL, Peruzzi PP, Chiocca EA, Friedman GK, Bernstock JD. Therapeutic cancer vaccines for pediatric malignancies: advances, challenges, and emerging technologies. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab027. PMID: 33860227; PMCID: PMC8034661.
    Citations: 3     
  9. Bhaskaran V, Yao Y, Bei F, Peruzzi P. Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications. Nat Protoc. 2019 12; 14(12):3538-3553. PMID: 31748752; PMCID: PMC7089775.
    Citations: 4     Fields:    Translation:HumansAnimals
  10. Bhaskaran V, Peruzzi P. Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy. J Vis Exp. 2019 10 04; (152). PMID: 31633695.
    Citations: 1     Fields:    Translation:Humans
  11. Peruzzi P, Bhaskaran V. MicroRNAs in Brain Cancer: Look at the Forest, Not at the Tree. J Exp Neurosci. 2019; 13:1179069519839693. PMID: 30956527; PMCID: PMC6442075.
  12. Bhaskaran V, Nowicki MO, Idriss M, Jimenez MA, Lugli G, Hayes JL, Mahmoud AB, Zane RE, Passaro C, Ligon KL, Haas-Kogan D, Bronisz A, Godlewski J, Lawler SE, Chiocca EA, Peruzzi P. The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma. Nat Commun. 2019 01 25; 10(1):442. PMID: 30683859; PMCID: PMC6347618.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  13. Chiocca EA, Nassiri F, Wang J, Peruzzi P, Zadeh G. Viral and other therapies for recurrent glioblastoma: is a 24-month durable response unusual? Neuro Oncol. 2019 01 01; 21(1):14-25. PMID: 30346600; PMCID: PMC6303472.
    Citations: 30     Fields:    Translation:HumansAnimals
  14. Peruzzi P, Chiocca EA. Viruses in cancer therapy - from benchwarmers to quarterbacks. Nat Rev Clin Oncol. 2018 11; 15(11):657-658. PMID: 30057404; PMCID: PMC6689225.
    Citations: 7     Fields:    Translation:HumansCells
  15. Peruzzi PP, Chiocca EA. Cancer immunotherapy: A vaccine from plant virus proteins. Nat Nanotechnol. 2016 Mar; 11(3):214-5. PMID: 26689377.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Peruzzi PP, Lonser RR. Therapeutic targeting based on gene-expression profiling in vestibular schwannomas. J Neurosurg. 2014 Dec; 121(6):1432-3. PMID: 25245342.
    Citations:    Fields:    Translation:HumansCells
  17. Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014 Aug; 20(8):460-9. PMID: 25027972.
    Citations: 879     Fields:    Translation:HumansAnimals
  18. Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari K, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J. Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res. 2014 Feb 01; 74(3):738-750. PMID: 24310399.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  19. Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski J. MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24. PMID: 23733246; PMCID: PMC3748913.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  20. Peruzzi P, Chiocca EA. Bringing the endovascular neurosurgeon into the neuro-oncology treatment team. World Neurosurg. 2012 Jan; 77(1):59-61. PMID: 22405385.
    Citations: 1     Fields:    Translation:Humans
  21. Peruzzi P, Chiocca EA. Understanding glioma invasion: a necessity for effective therapy. World Neurosurg. 2013 Sep-Oct; 80(3-4):281-3. PMID: 22120237.
    Citations: 1     Fields:    Translation:Humans
  22. Peruzzi P, Chiocca EA. Prognosis and treatment of melanoma metastases to the central nervous system: lots of retrospective data, very few certainties. World Neurosurg. 2011 Jul-Aug; 76(1-2):48-50. PMID: 21839942.
    Citations:    Fields:    Translation:Humans
  23. Peruzzi P, Puente E, Bergese S, Chiocca EA. Intraoperative MRI (ioMRI) in the setting of awake craniotomies for supratentorial glioma resection. Acta Neurochir Suppl. 2011; 109:43-8. PMID: 20960319.
    Citations: 7     Fields:    Translation:Humans
  24. Peruzzi P, Corbitt RJ, Raffel C. Magnetic resonance imaging versus ultrasonography for the in utero evaluation of central nervous system anomalies. J Neurosurg Pediatr. 2010 Oct; 6(4):340-5. PMID: 20887106.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  25. Peruzzi P, Chiocca EA. Treating glioblastoma multiforme with electrical fields. World Neurosurg. 2010 Aug-Sep; 74(2-3):208-11. PMID: 21492532.
    Citations:    Fields:    Translation:Humans
  26. Peruzzi P, Bergese SD, Viloria A, Puente EG, Abdel-Rasoul M, Chiocca EA. A retrospective cohort-matched comparison of conscious sedation versus general anesthesia for supratentorial glioma resection. Clinical article. J Neurosurg. 2011 Mar; 114(3):633-9. PMID: 20560720; PMCID: PMC4256674.
    Citations: 11     Fields:    Translation:Humans
  27. Peruzzi P, Ray-Chaudhuri A, Slone WH, Mekhjian HS, Porcu P, Chiocca E. Reversal of neurological deficit after chemotherapy in BCL-6-positive neurolymphomatosis. Case report. J Neurosurg. 2009 Aug; 111(2):247-51. PMID: 19216652.
    Citations: 3     Fields:    Translation:Humans
  28. Peruzzi PP, Lawler SE, Senior SL, Dmitrieva N, Edser PA, Gianni D, Chiocca EA, Wade-Martins R. Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons. Mol Ther. 2009 Sep; 17(9):1517-26. PMID: 19352323.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  29. Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC. Design and application of oncolytic HSV vectors for glioblastoma therapy. Expert Rev Neurother. 2009 Apr; 9(4):505-17. PMID: 19344302.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.