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Cameron Stuart McAlpine, Ph.D.

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McMaster University, CanadaPhD2015Medical Science - Vascular Biology
Acadia University, CanadaBSc2009Biology
2015 - 2018
Postdoctoral Fellowship
2018 - 2020
Banting Fellowship

My research explores neuro-immune networks in inflammatory disease. I investigate how sleep influences hematopoiesis, the immune system, and cardiovascular disease. I am particularly interested in how sleep related neuropeptides produced in the brain shape inflammatory responses and immune function. Additionally, my work explores the immune system and astrocyte-microglia cross talk in Alzheimer's disease.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99HL151750 (MCALPINE, CAMERON STUART) May 1, 2020 - Apr 30, 2022
    Influence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular disease
    Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK. Liver X receptors are required for thymic resilience and T cell output. J Exp Med. 2020 Oct 05; 217(10). PMID: 32716519.
  2. Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M. Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus. Circulation. 2020 Jul 21; 142(3):244-258. PMID: 32316750.
  3. Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M. Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nat Med. 2019 11; 25(11):1761-1771. PMID: 31700184.
  4. McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019 02; 566(7744):383-387. PMID: 30760925.
  5. He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK. Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease. Nature. 2019 02; 566(7742):115-119. PMID: 30700910.
    Citations:    Fields:    
  6. Anzai A, Mindur JE, Halle L, Sano S, Choi JL, He S, McAlpine CS, Chan CT, Kahles F, Valet C, Fenn AM, Nairz M, Rattik S, Iwamoto Y, Fairweather D, Walsh K, Libby P, Nahrendorf M, Swirski FK. Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis. J Exp Med. 2019 02 04; 216(2):369-383. PMID: 30670465.
    Citations:    Fields:    
  7. Huang A, Patel S, McAlpine CS, Werstuck GH. The Role of Endoplasmic Reticulum Stress-Glycogen Synthase Kinase-3 Signaling in Atherogenesis. Int J Mol Sci. 2018 May 30; 19(6). PMID: 29848965.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK. The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. J Exp Med. 2017 Nov 06; 214(11):3293-3310. PMID: 28978634.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Huang A, Young TL, Dang VT, Shi Y, McAlpine CS, Werstuck GH. 4-phenylbutyrate and valproate treatment attenuates the progression of atherosclerosis and stabilizes existing plaques. Atherosclerosis. 2017 Nov; 266:103-112. PMID: 29024862.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Beriault DR, Dang VT, Zhong LH, Petlura CI, McAlpine CS, Shi Y, Werstuck GH. Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis and N-linked protein glycosylation. Am J Physiol Endocrinol Metab. 2017 01 01; 312(1):E48-E57. PMID: 27879249.
    Citations:    Fields:    Translation:AnimalsCells
  11. Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med. 2016 08; 22(8):945-51. PMID: 27428900.
    Citations: 35     Fields:    Translation:AnimalsCells
  12. McAlpine CS, Swirski FK. Circadian Influence on Metabolism and Inflammation in Atherosclerosis. Circ Res. 2016 06 24; 119(1):131-41. PMID: 27340272.
    Citations: 7     Fields:    Translation:HumansAnimals
  13. McAlpine CS, Huang A, Emdin A, Banko NS, Beriault DR, Shi Y, Werstuck GH. Deletion of Myeloid GSK3a Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1113-22. PMID: 25767272.
    Citations: 6     Fields:    Translation:AnimalsCells
  14. Banko NS, McAlpine CS, Venegas-Pino DE, Raja P, Shi Y, Khan MI, Werstuck GH. Glycogen synthase kinase 3a deficiency attenuates atherosclerosis and hepatic steatosis in high fat diet-fed low density lipoprotein receptor-deficient mice. Am J Pathol. 2014 Dec; 184(12):3394-404. PMID: 25451156.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. McAlpine CS, Werstuck GH. Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3a/ß regulate foam cell formation. J Lipid Res. 2014 Nov; 55(11):2320-33. PMID: 25183803.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  16. McAlpine CS, Beriault DR, Behdinan T, Shi Y, Werstuck GH. Oral glucosamine sulfate supplementation does not induce endoplasmic reticulum stress or activate the unfolded protein response in circulating leukocytes of human subjects. Can J Physiol Pharmacol. 2014 Apr; 92(4):285-91. PMID: 24708210.
    Citations:    Fields:    Translation:HumansCells
  17. McAlpine CS, Werstuck GH. The development and progression of atherosclerosis: evidence supporting a role for endoplasmic reticulum (ER) stress signaling. Cardiovasc Hematol Disord Drug Targets. 2013 Aug; 13(2):158-64. PMID: 23988003.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  18. McAlpine CS, Bowes AJ, Khan MI, Shi Y, Werstuck GH. Endoplasmic reticulum stress and glycogen synthase kinase-3ß activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):82-91. PMID: 21998135.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  19. McAlpine CS, Bowes AJ, Werstuck GH. Diabetes, hyperglycemia and accelerated atherosclerosis: evidence supporting a role for endoplasmic reticulum (ER) stress signaling. Cardiovasc Hematol Disord Drug Targets. 2010 Jun; 10(2):151-7. PMID: 20350283.
    Citations: 20     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.