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Kerry J Ressler, M.D.,Ph.D.


Available: 10/01/17, Expires: 09/30/20

This project would have an HMS student join our clinical research team across a variety of specific research studies related to the study of Posttraumatic Stress Disorder following trauma exposure.

Using a variety of quantitative neurophysiology (EEG, EMG, startle, and galvanic skin response), neuroimaging (structural and functional MRI), genomic (genetic and epigenetic analyses from blood/saliva), and clinical research (clinician administered, behavioral and self-report data), we are collecting deep-phenotyping measures for understanding the nature of PTSD in civilian populations.

The student will have the opportunity to become skilled in clinical research at McLean Hospital related to Neuropsychiatric clinical research, specifically related to PTSD, Depression, and Anxiety, and to gain a working knowledge of a variety of neurophysiological approaches.

The student would be part of a research team, but would take the lead on specific neurophysiological analyses and manuscript writing and data presentation at various local and national venues. A few recent relevant manuscripts from this group include:
Duncan LE, et al., 2017, Molecular Psychiatry. 2017 10.1038/mp.2017.77. Ross DA, et al., 2017, JAMA Psychiatry. 74(4):407-415.
Stevens JS, et al., 2017, Biological Psychiatry. 81(12):1023-1029. Maddox SA, et al., 2017, Molecular Psychiatry. 10.1038/mp.2016.250.
Wingo AP, et al., 2015,Nature Communications. 6:10106.
Michopoulos V, 2015, Am J Psychiatry. 172(4):353-62.
Ressler KJ, et al (2011) Nature, 470: 492-497.

Available: 10/01/17, Expires: 09/30/20

The amygdala can be considered a ‘hub’ of emotional learning and memory. Furthermore, the neural plasticity that underlies associative learning, classical or Pavlovian conditioning, is relatively well understood, and the neural circuitry supporting threat or fear processing is among the most well-worked out circuits in behavioral neuroscience. In translation, fear-related disorders such as post-traumatic stress disorder, panic disorder and phobia manifest in ways that are consistent with an uncontrollable state of fear. Their development involves heredity, previous sensitizing experiences, association of aversive events with previous neutral stimuli, and inability to inhibit or extinguish fear, leading to a chronic and disabling state following from the initial learned fear event. In many ways, the ‘over-learning of threats’ or ‘impaired extinction learning’ related to fear processing can be considered central to these debilitating disorders.

Work in our lab uses mouse models to study the neurobiology of fear learning and memory, differential genetic susceptibility to disorders of fear, and how these findings are being applied to the understanding, treatment and possible prevention of fear-related disorders, such as PTSD. Cutting edge approaches are being used to understand the genetic and epigenetic regulation at a cell-type specific level within amygdala, medial prefrontal, and hippocampal circuitry as it relates to fear extinction and neurobiologically-driven approaches to disorders of fear regulation. For the scholarly project, the student would be paired with a postdoctoral fellow and work under my supervision, focusing on a cell-type specific basis underlying fear and its inhibition. The project is likely to involve molecular biology, optogenetics, DREADD virus approaches following on some of our recently publications below:

Banerjee SB, et al (2017) Neuron, 95(1):169-179.e3.
McCullough KM, et al (2016) Nature Communications, Oct 21;7:13149.
Dias BG, et al (2014) Neuron, 83(4):906-18.
Andero R, et al (2014) Neuron, 83(2):444-54.
Ressler KJ, et al (2011) Nature, 470: 492-497.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01MH115484 (STEIN, DAN JOSEPH) Sep 15, 2017 - Jun 30, 2022
    Transgenerational Effects of Maternal Stressors: Investigating the Role of Infant Gene Expression
    Role: Co-Principal Investigator
  2. R01MH111671 (MOREY, RAJENDRA A.) Sep 6, 2017 - Jul 31, 2021
    Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
    Role: Co-Principal Investigator
  3. R13DA043296 (RESSLER, KERRY J.) Jul 1, 2017 - Jun 30, 2018
    2017 Amygdala Function in Emotion, Cognition and Disease Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator
  4. R21MH112956 (RESSLER, KERRY J.) Apr 1, 2017 - Jan 31, 2019
    Neurobiology of Traumatic Dissociation in a Transdiagnostic Study of Women with Childhood Maltreatment
    Role: Principal Investigator
  5. R21HD088931 (RESSLER, KERRY J.) Jan 1, 2017 - Dec 31, 2018
    Longitudinal DNA methylation in a non-human primate model of early-life stress
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact
McLean Hospital Animal Care Facility - Core services (3) and Instruments (8)

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Ressler KJ. Molecular Signatures of Stress and Posttraumatic Stress Disorder: An Overview. Biol Psychiatry. 2018 May 15; 83(10):792-794. PMID: 29685184.
    View in: PubMed
  2. Booker JA, Graci ME, Hudak LA, Jovanovic T, Rothbaum BO, Ressler KJ, Fivush R, Stevens J. Narratives in the Immediate Aftermath of Traumatic Injury: Markers of Ongoing Depressive and Posttraumatic Stress Disorder Symptoms. J Trauma Stress. 2018 Apr; 31(2):273-285. PMID: 29624725.
    View in: PubMed
  3. Daskalakis NP, Rijal CM, King C, Huckins LM, Ressler KJ. Recent Genetics and Epigenetics Approaches to PTSD. Curr Psychiatry Rep. 2018 Apr 05; 20(5):30. PMID: 29623448.
    View in: PubMed
  4. Ressler KJ. Alpha-Adrenergic Receptors in PTSD - Failure or Time for Precision Medicine? N Engl J Med. 2018 02 08; 378(6):575-576. PMID: 29414268.
    View in: PubMed
  5. McCullough KM, Morrison FG, Hartmann J, Carlezon WA, Ressler KJ. Quantified Coexpression Analysis of Central Amygdala Subpopulations. eNeuro. 2018 Jan-Feb; 5(1). PMID: 29445764.
    View in: PubMed
  6. Zimmermann KS, Li CC, Rainnie DG, Ressler KJ, Gourley SL. Memory Retention Involves the Ventrolateral Orbitofrontal Cortex: Comparison with the Basolateral Amygdala. Neuropsychopharmacology. 2018 Feb; 43(3):674. PMID: 29326434.
    View in: PubMed
  7. Wolf EJ, Maniates H, Nugent N, Maihofer AX, Armstrong D, Ratanatharathorn A, Ashley-Koch AE, Garrett M, Kimbrel NA, Lori A, Aiello AE, Baker DG, Beckham JC, Boks MP, Galea S, Geuze E, Hauser MA, Kessler RC, Koenen KC, Miller MW, Ressler KJ, Risbrough V, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Uddin M, Smith AK, Nievergelt CM, Logue MW. Traumatic stress and accelerated DNA methylation age: A meta-analysis. Psychoneuroendocrinology. 2018 Jun; 92:123-134. PMID: 29452766.
    View in: PubMed
  8. Rahman AF, Manatunga A, Guo Y, Peng L, Warnock M, Ressler KJ, Jovanovic T. A latent class analysis of PTSD symptoms among inner city primary care patients. J Psychiatr Res. 2018 Mar; 98:1-8. PMID: 29241028.
    View in: PubMed
  9. Barfield ET, Gerber KJ, Zimmermann KS, Ressler KJ, Parsons RG, Gourley SL. Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure. PLoS Biol. 2017 Nov; 15(11):e2003000. PMID: 29186135.
    View in: PubMed
  10. Polimanti R, Amstadter AB, Stein MB, Almli LM, Baker DG, Bierut LJ, Bradley B, Farrer LA, Johnson EO, King A, Kranzler HR, Maihofer AX, Rice JP, Roberts AL, Saccone NL, Zhao H, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC, Gelernter J. A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder. Genome Med. 2017 Nov 27; 9(1):99. PMID: 29178946.
    View in: PubMed
  11. Stevens JS, Reddy R, Kim YJ, van Rooij SJH, Ely TD, Hamann S, Ressler KJ, Jovanovic T. Episodic memory after trauma exposure: Medial temporal lobe function is positively related to re-experiencing and inversely related to negative affect symptoms. Neuroimage Clin. 2018; 17:650-658. PMID: 29204343.
    View in: PubMed
  12. Ramikie TS, Ressler KJ. Mechanisms of Sex Differences in Fear and Posttraumatic Stress Disorder. Biol Psychiatry. 2018 May 15; 83(10):876-885. PMID: 29331353.
    View in: PubMed
  13. Almli LM, Lori A, Meyers JL, Shin J, Fani N, Maihofer AX, Nievergelt CM, Smith AK, Mercer KB, Kerley K, Leveille JM, Feng H, Abu-Amara D, Flory JD, Yehuda R, Marmar CR, Baker DG, Bradley B, Koenen KC, Conneely KN, Ressler KJ. Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations. Addict Biol. 2017 Oct 30. PMID: 29082582.
    View in: PubMed
  14. van Rooij SJH, Stevens JS, Ely TD, Hinrichs R, Michopoulos V, Winters SJ, Ogbonmwan YE, Shin J, Nugent NR, Hudak LA, Rothbaum BO, Ressler KJ, Jovanovic T. The Role of the Hippocampus in Predicting Future Posttraumatic Stress Disorder Symptoms in Recently Traumatized Civilians. Biol Psychiatry. 2017 Sep 20. PMID: 29110899.
    View in: PubMed
  15. Logue MW, van Rooij SJH, Dennis EL, Davis SL, Hayes JP, Stevens JS, Densmore M, Haswell CC, Ipser J, Koch SBJ, Korgaonkar M, Lebois LAM, Peverill M, Baker JT, Boedhoe PSW, Frijling JL, Gruber SA, Harpaz-Rotem I, Jahanshad N, Koopowitz S, Levy I, Nawijn L, O'Connor L, Olff M, Salat DH, Sheridan MA, Spielberg JM, van Zuiden M, Winternitz SR, Wolff JD, Wolf EJ, Wang X, Wrocklage K, Abdallah CG, Bryant RA, Geuze E, Jovanovic T, Kaufman ML, King AP, Krystal JH, Lagopoulos J, Bennett M, Lanius R, Liberzon I, McGlinchey RE, McLaughlin KA, Milberg WP, Miller MW, Ressler KJ, Veltman DJ, Stein DJ, Thomaes K, Thompson PM, Morey RA. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biol Psychiatry. 2018 Feb 01; 83(3):244-253. PMID: 29217296.
    View in: PubMed
  16. Wingo AP, Velasco ER, Florido A, Lori A, Choi DC, Jovanovic T, Ressler KJ, Andero R. Expression of the PPM1F Gene Is Regulated by Stress and Associated With Anxiety and Depression. Biol Psychiatry. 2018 Feb 01; 83(3):284-295. PMID: 29054677.
    View in: PubMed
  17. Balu DT, Presti KT, Huang CCY, Muszynski K, Radzishevsky I, Wolosker H, Guffanti G, Ressler KJ, Coyle JT. Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning. Biol Psychiatry. 2018 Feb 01; 83(3):273-283. PMID: 29025687.
    View in: PubMed
  18. Berg CJ, Haardörfer R, McBride CM, Kilaru V, Ressler KJ, Wingo AP, Saba NF, Payne JB, Smith A. Resilience and biomarkers of health risk in Black smokers and nonsmokers. Health Psychol. 2017 11; 36(11):1047-1058. PMID: 28825494.
    View in: PubMed
  19. Thompson NJ, Fiorillo D, Rothbaum BO, Ressler KJ, Michopoulos V. Coping strategies as mediators in relation to resilience and posttraumatic stress disorder. J Affect Disord. 2018 01 01; 225:153-159. PMID: 28837948.
    View in: PubMed
  20. Maheu ME, Ressler KJ. Developmental pathway genes and neural plasticity underlying emotional learning and stress-related disorders. Learn Mem. 2017 Sep; 24(9):492-501. PMID: 28814475.
    View in: PubMed
  21. Barrett CE, Hennessey TM, Gordon KM, Ryan SJ, McNair ML, Ressler KJ, Rainnie DG. Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally. Mol Autism. 2017; 8:42. PMID: 28775827.
    View in: PubMed
  22. Dedic N, Pöhlmann ML, Richter JS, Mehta D, Czamara D, Metzger MW, Dine J, Bedenk BT, Hartmann J, Wagner KV, Jurik A, Almli LM, Lori A, Moosmang S, Hofmann F, Wotjak CT, Rammes G, Eder M, Chen A, Ressler KJ, Wurst W, Schmidt MV, Binder EB, Deussing JM. Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood. Mol Psychiatry. 2018 Mar; 23(3):533-543. PMID: 28696432.
    View in: PubMed
  23. Ratanatharathorn A, Boks MP, Maihofer AX, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bromet E, Dennis M, Garrett ME, Geuze E, Guffanti G, Hauser MA, Kilaru V, Kimbrel NA, Koenen KC, Kuan PF, Logue MW, Luft BJ, Miller MW, Mitchell C, Nugent NR, Ressler KJ, Rutten BPF, Stein MB, Vermetten E, Vinkers CH, Youssef NA, Uddin M, Nievergelt CM, Smith AK. Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. Am J Med Genet B Neuropsychiatr Genet. 2017 Sep; 174(6):619-630. PMID: 28691784.
    View in: PubMed
  24. Smith AK, Jovanovic T, Kilaru V, Lori A, Gensler L, Lee SS, Norrholm SD, Massa N, Cuthbert B, Bradley B, Ressler KJ, Duncan E. A Gene-Based Analysis of Acoustic Startle Latency. Front Psychiatry. 2017; 8:117. PMID: 28729842.
    View in: PubMed
  25. Zimmermann KS, Li CC, Rainnie DG, Ressler KJ, Gourley SL. Memory Retention Involves the Ventrolateral Orbitofrontal Cortex: Comparison with the Basolateral Amygdala. Neuropsychopharmacology. 2018 Jan; 43(2):373-383. PMID: 28664926.
    View in: PubMed
  26. Vahia IV, Ressler KJ. Beyond the Buzz: The Maturing of Technology Use in Geriatric Psychiatry. Am J Geriatr Psychiatry. 2017 Aug; 25(8):815-818. PMID: 28687153.
    View in: PubMed
  27. Banerjee SB, Gutzeit VA, Baman J, Aoued HS, Doshi NK, Liu RC, Ressler KJ. Perineuronal Nets in the Adult Sensory Cortex Are Necessary for Fear Learning. Neuron. 2017 Jul 05; 95(1):169-179.e3. PMID: 28648500.
    View in: PubMed
  28. Michopoulos V, Norrholm SD, Stevens JS, Glover EM, Rothbaum BO, Gillespie CF, Schwartz AC, Ressler KJ, Jovanovic T. Dexamethasone facilitates fear extinction and safety discrimination in PTSD: A placebo-controlled, double-blind study. Psychoneuroendocrinology. 2017 Sep; 83:65-71. PMID: 28595089.
    View in: PubMed
  29. Mataix-Cols D, Fernández de la Cruz L, Monzani B, Rosenfield D, Andersson E, Pérez-Vigil A, Frumento P, de Kleine RA, Difede J, Dunlop BW, Farrell LJ, Geller D, Gerardi M, Guastella AJ, Hofmann SG, Hendriks GJ, Kushner MG, Lee FS, Lenze EJ, Levinson CA, McConnell H, Otto MW, Plag J, Pollack MH, Ressler KJ, Rodebaugh TL, Rothbaum BO, Scheeringa MS, Siewert-Siegmund A, Smits JAJ, Storch EA, Ströhle A, Tart CD, Tolin DF, van Minnen A, Waters AM, Weems CF, Wilhelm S, Wyka K, Davis M, Rück C, Altemus M, Anderson P, Cukor J, Finck C, Geffken GR, Golfels F, Goodman WK, Gutner C, Heyman I, Jovanovic T, Lewin AB, McNamara JP, Murphy TK, Norrholm S, Thuras P. D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders: A Systematic Review and Meta-analysis of Individual Participant Data. JAMA Psychiatry. 2017 May 01; 74(5):501-510. PMID: 28122091.
    View in: PubMed
  30. Powers A, Stevens JS, van Rooij SJH, Ely TD, Fani N, Jovanovic T, Ressler KJ, Bradley B. Neural correlates and structural markers of emotion dysregulation in traumatized civilians. Soc Cogn Affect Neurosci. 2017 05 01; 12(5):823-831. PMID: 28158800.
    View in: PubMed
  31. Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. Largest GWAS of PTSD (N=20?070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol Psychiatry. 2018 Mar; 23(3):666-673. PMID: 28439101.
    View in: PubMed
  32. Post LM, Michopoulos V, Stevens JS, Reddy R, Maples JL, Morgan JR, Rothbaum AO, Jovanovic T, Ressler KJ, Rothbaum BO. Psychological and psychobiological responses to immediate early intervention in the emergency department: Case report of one-session exposure therapy for the prevention of PTSD. Pract Innov (Wash D C). 2017; 2(2):55-65. PMID: 28993816.
    View in: PubMed
  33. Ross DA, Arbuckle MR, Travis MJ, Dwyer JB, van Schalkwyk GI, Ressler KJ. An Integrated Neuroscience Perspective on Formulation and Treatment Planning for Posttraumatic Stress Disorder: An Educational Review. JAMA Psychiatry. 2017 Apr 01; 74(4):407-415. PMID: 28273291.
    View in: PubMed
  34. Ressler KJ. Neurocircuits to Behavior: The New Revolution. Harv Rev Psychiatry. 2017 Mar/Apr; 25(2):47-49. PMID: 28272129.
    View in: PubMed
  35. Banerjee SB, Morrison FG, Ressler KJ. Genetic approaches for the study of PTSD: Advances and challenges. Neurosci Lett. 2017 May 10; 649:139-146. PMID: 28242325.
    View in: PubMed
  36. Hinrichs R, Michopoulos V, Winters S, Rothbaum AO, Rothbaum BO, Ressler KJ, Jovanovic T. Mobile assessment of heightened skin conductance in posttraumatic stress disorder. Depress Anxiety. 2017 06; 34(6):502-507. PMID: 28221710.
    View in: PubMed
  37. Maddox SA, Kilaru V, Shin J, Jovanovic T, Almli LM, Dias BG, Norrholm SD, Fani N, Michopoulos V, Ding Z, Conneely KN, Binder EB, Ressler KJ, Smith AK. Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD. Mol Psychiatry. 2018 Mar; 23(3):658-665. PMID: 28093566.
    View in: PubMed
  38. Orcutt HK, Hannan SM, Seligowski AV, Jovanovic T, Norrholm SD, Ressler KJ, McCanne T. Fear-Potentiated Startle and Fear Extinction in a Sample of Undergraduate Women Exposed to a Campus Mass Shooting. Front Psychol. 2016; 7:2031. PMID: 28111559.
    View in: PubMed
  39. Stevens JS, Kim YJ, Galatzer-Levy IR, Reddy R, Ely TD, Nemeroff CB, Hudak LA, Jovanovic T, Rothbaum BO, Ressler KJ. Amygdala Reactivity and Anterior Cingulate Habituation Predict Posttraumatic Stress Disorder Symptom Maintenance After Acute Civilian Trauma. Biol Psychiatry. 2017 06 15; 81(12):1023-1029. PMID: 28117048.
    View in: PubMed
  40. Galatzer-Levy IR, Andero R, Sawamura T, Jovanovic T, Papini S, Ressler KJ, Norrholm SD. A cross species study of heterogeneity in fear extinction learning in relation to FKBP5 variation and expression: Implications for the acute treatment of posttraumatic stress disorder. Neuropharmacology. 2017 Apr; 116:188-195. PMID: 28025095.
    View in: PubMed
  41. Mercer KB, Dias B, Shafer D, Maddox SA, Mulle JG, Hu P, Walton J, Ressler KJ. Functional evaluation of a PTSD-associated genetic variant: estradiol regulation and ADCYAP1R1. Transl Psychiatry. 2016 12 13; 6(12):e978. PMID: 27959335.
    View in: PubMed
  42. Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, Bressler J, Ward-Caviness CK, Chen BH, Huan T, Bakulski K, Salfati EL, Fiorito G, Wahl S, Schramm K, Sha J, Hernandez DG, Just AC, Smith JA, Sotoodehnia N, Pilling LC, Pankow JS, Tsao PS, Liu C, Zhao W, Guarrera S, Michopoulos VJ, Smith AK, Peters MJ, Melzer D, Vokonas P, Fornage M, Prokisch H, Bis JC, Chu AY, Herder C, Grallert H, Yao C, Shah S, McRae AF, Lin H, Horvath S, Fallin D, Hofman A, Wareham NJ, Wiggins KL, Feinberg AP, Starr JM, Visscher PM, Murabito JM, Kardia SL, Absher DM, Binder EB, Singleton AB, Bandinelli S, Peters A, Waldenberger M, Matullo G, Schwartz JD, Demerath EW, Uitterlinden AG, van Meurs JB, Franco OH, Chen YI, Levy D, Turner ST, Deary IJ, Ressler KJ, Dupuis J, Ferrucci L, Ong KK, Assimes TL, Boerwinkle E, Koenig W, Arnett DK, Baccarelli AA, Benjamin EJ, Dehghan A. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 12 12; 17(1):255. PMID: 27955697.
    View in: PubMed
  43. Ramikie TS, Ressler KJ. Stress-related disorders, pituitary adenylate cyclase-activating peptide (PACAP)ergic system, and sex differences. Dialogues Clin Neurosci. 2016 12; 18(4):403-413. PMID: 28179812.
    View in: PubMed
  44. Massa NM, Duncan E, Jovanovic T, Kerley K, Weng L, Gensler L, Lee SS, Norrholm S, Powers A, Almli LM, Gillespie CF, Ressler K, Pearce BD. Relationship between Toxoplasma gondii seropositivity and acoustic startle response in an inner-city population. Brain Behav Immun. 2017 Mar; 61:176-183. PMID: 27884623.
    View in: PubMed
  45. Liu C, Marioni RE, Hedman ÅK, Pfeiffer L, Tsai PC, Reynolds LM, Just AC, Duan Q, Boer CG, Tanaka T, Elks CE, Aslibekyan S, Brody JA, Kühnel B, Herder C, Almli LM, Zhi D, Wang Y, Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love SA, Guan W, Shah S, McRae AF, Kretschmer A, Prokisch H, Strauch K, Peters A, Visscher PM, Wray NR, Guo X, Wiggins KL, Smith AK, Binder EB, Ressler KJ, Irvin MR, Absher DM, Hernandez D, Ferrucci L, Bandinelli S, Lohman K, Ding J, Trevisi L, Gustafsson S, Sandling JH, Stolk L, Uitterlinden AG, Yet I, Castillo-Fernandez JE, Spector TD, Schwartz JD, Vokonas P, Lind L, Li Y, Fornage M, Arnett DK, Wareham NJ, Sotoodehnia N, Ong KK, van Meurs JBJ, Conneely KN, Baccarelli AA, Deary IJ, Bell JT, North KE, Liu Y, Waldenberger M, London SJ, Ingelsson E, Levy D. A DNA methylation biomarker of alcohol consumption. Mol Psychiatry. 2018 Feb; 23(2):422-433. PMID: 27843151.
    View in: PubMed
  46. Clive ML, Boks MP, Vinkers CH, Osborne LM, Payne JL, Ressler KJ, Smith AK, Wilcox HC, Kaminsky Z. Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model. Clin Epigenetics. 2016; 8:113. PMID: 27822318.
    View in: PubMed
  47. McCullough KM, Choi D, Guo J, Zimmerman K, Walton J, Rainnie DG, Ressler KJ. Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala. Nat Commun. 2016 Oct 21; 7:13149. PMID: 27767183.
    View in: PubMed
  48. Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016 Oct; 9(5):436-447. PMID: 27651444.
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  49. van Rooij SJ, Stevens JS, Ely TD, Fani N, Smith AK, Kerley KA, Lori A, Ressler KJ, Jovanovic T. Childhood Trauma and COMT Genotype Interact to Increase Hippocampal Activation in Resilient Individuals. Front Psychiatry. 2016; 7:156. PMID: 27683563.
    View in: PubMed
  50. Mandavia A, Robinson GG, Bradley B, Ressler KJ, Powers A. Exposure to Childhood Abuse and Later Substance Use: Indirect Effects of Emotion Dysregulation and Exposure to Trauma. J Trauma Stress. 2016 10; 29(5):422-429. PMID: 27622844.
    View in: PubMed
  51. Powers A, Almli L, Smith A, Lori A, Leveille J, Ressler KJ, Jovanovic T, Bradley B. A genome-wide association study of emotion dysregulation: Evidence for interleukin 2 receptor alpha. J Psychiatr Res. 2016 12; 83:195-202. PMID: 27643478.
    View in: PubMed
  52. Wingo AP, Almli LM, Stevens JS, Jovanovic T, Wingo TS, Tharp G, Li Y, Lori A, Briscione M, Jin P, Binder EB, Bradley B, Gibson G, Ressler KJ. Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs. Mol Psychiatry. 2017 05; 22(5):774-783. PMID: 27595594.
    View in: PubMed
  53. Missig G, Mei L, Vizzard MA, Braas KM, Waschek JA, Ressler KJ, Hammack SE, May V. Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain. Biol Psychiatry. 2017 04 15; 81(8):671-682. PMID: 28057459.
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  54. Michopoulos V, Powers A, Gillespie CF, Ressler KJ, Jovanovic T. Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond. Neuropsychopharmacology. 2017 01; 42(1):254-270. PMID: 27510423.
    View in: PubMed
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  84. Chen Y, Molet J, Gunn BG, Ressler K, Baram TZ. Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons. Endocrinology. 2015 Dec; 156(12):4769-80. PMID: 26402844; PMCID: PMC4655217 [Available on 12/01/16].
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  90. Klengel T, Dias BG, Ressler KJ. Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice. Neuropsychopharmacology. 2016 Jan; 41(1):219-31. PMID: 26283147; PMCID: PMC4677139 [Available on 01/01/17].
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  130. Barfield RT, Almli LM, Kilaru V, Smith AK, Mercer KB, Duncan R, Klengel T, Mehta D, Binder EB, Epstein MP, Ressler KJ, Conneely KN. Accounting for population stratification in DNA methylation studies. Genet Epidemiol. 2014 Apr; 38(3):231-41. PMID: 24478250; PMCID: PMC4090102.
  131. Almli LM, Srivastava A, Fani N, Kerley K, Mercer KB, Feng H, Bradley B, Ressler KJ. Follow-up and extension of a prior genome-wide association study of posttraumatic stress disorder: gene × environment associations and structural magnetic resonance imaging in a highly traumatized African-American civilian population. Biol Psychiatry. 2014 Aug 15; 76(4):e3-4. PMID: 24576688; PMCID: PMC4285665.
  132. Wingo AP, Ressler KJ, Bradley B. Resilience characteristics mitigate tendency for harmful alcohol and illicit drug use in adults with a history of childhood abuse: a cross-sectional study of 2024 inner-city men and women. J Psychiatr Res. 2014 Apr; 51:93-9. PMID: 24485848; PMCID: PMC4605671.
  133. Ressler KJ, Schoomaker EB. Commentary on "The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)": Army STARRS: a Framingham-like study of psychological health risk factors in soldiers. Psychiatry. 2014; 77(2):120-9. PMID: 24865196.
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  134. Andero R, Choi DC, Ressler KJ. BDNF-TrkB receptor regulation of distributed adult neural plasticity, memory formation, and psychiatric disorders. Prog Mol Biol Transl Sci. 2014; 122:169-92. PMID: 24484701.
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  135. Dias BG, Ressler KJ. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat Neurosci. 2014 Jan; 17(1):89-96. PMID: 24292232; PMCID: PMC3923835.
  136. Morrison FG, Ressler KJ. From the neurobiology of extinction to improved clinical treatments. Depress Anxiety. 2014 Apr; 31(4):279-90. PMID: 24254958; PMCID: PMC4293038.
  137. Fani N, King TZ, Reiser E, Binder EB, Jovanovic T, Bradley B, Ressler KJ. FKBP5 genotype and structural integrity of the posterior cingulum. Neuropsychopharmacology. 2014 Apr; 39(5):1206-13. PMID: 24253961; PMCID: PMC3957115.
  138. Ressler KJ, Rothbaum BO. Augmenting obsessive-compulsive disorder treatment: from brain to mind. JAMA Psychiatry. 2013 Nov; 70(11):1129-31. PMID: 24026506.
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  139. Koenen KC, Duncan LE, Liberzon I, Ressler KJ. From candidate genes to genome-wide association: the challenges and promise of posttraumatic stress disorder genetic studies. Biol Psychiatry. 2013 Nov 01; 74(9):634-6. PMID: 24120289; PMCID: PMC4617623.
  140. Casey BJ, Craddock N, Cuthbert BN, Hyman SE, Lee FS, Ressler KJ. DSM-5 and RDoC: progress in psychiatry research? Nat Rev Neurosci. 2013 Nov; 14(11):810-4. PMID: 24135697; PMCID: PMC4372467.
  141. Powers A, Fani N, Pallos A, Stevens J, Ressler KJ, Bradley B. Childhood abuse and the experience of pain in adulthood: the mediating effects of PTSD and emotion dysregulation on pain levels and pain-related functional impairment. Psychosomatics. 2014 Sep-Oct; 55(5):491-9. PMID: 24360527; PMCID: PMC3997632.
  142. Spann SJ, Gillespie CF, Davis JS, Brown A, Schwartz A, Wingo A, Habib L, Ressler KJ. The association between childhood trauma and lipid levels in an adult low-income, minority population. Gen Hosp Psychiatry. 2014 Mar-Apr; 36(2):150-5. PMID: 24315076; PMCID: PMC3951665.
  143. Almli LM, Fani N, Smith AK, Ressler KJ. Genetic approaches to understanding post-traumatic stress disorder. Int J Neuropsychopharmacol. 2014 Feb; 17(2):355-70. PMID: 24103155; PMCID: PMC4293029.
  144. Marvar PJ, Goodman J, Fuchs S, Choi DC, Banerjee S, Ressler KJ. Angiotensin type 1 receptor inhibition enhances the extinction of fear memory. Biol Psychiatry. 2014 Jun 01; 75(11):864-72. PMID: 24094510; PMCID: PMC3975818.
  145. Mou L, Dias BG, Gosnell H, Ressler KJ. Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAARs. Neuroscience. 2013; 255:33-44. PMID: 24096136; PMCID: PMC3910431.
  146. Bradley B, Davis TA, Wingo AP, Mercer KB, Ressler KJ. Family environment and adult resilience: contributions of positive parenting and the oxytocin receptor gene. Eur J Psychotraumatol. 2013; 4. PMID: 24058725; PMCID: PMC3778209.
  147. Glover EM, Mercer KB, Norrholm SD, Davis M, Duncan E, Bradley B, Ressler KJ, Jovanovic T. Inhibition of fear is differentially associated with cycling estrogen levels in women. J Psychiatry Neurosci. 2013 Sep; 38(5):341-8. PMID: 23611176; PMCID: PMC3756118.
  148. Maddox SA, Schafe GE, Ressler KJ. Exploring epigenetic regulation of fear memory and biomarkers associated with post-traumatic stress disorder. Front Psychiatry. 2013; 4:62. PMID: 23847551; PMCID: PMC3697031.
  149. Stevens JS, Jovanovic T, Fani N, Ely TD, Glover EM, Bradley B, Ressler KJ. Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder. J Psychiatr Res. 2013 Oct; 47(10):1469-78. PMID: 23827769; PMCID: PMC3743923.
  150. Huang X, Hartley AV, Yin Y, Herskowitz JH, Lah JJ, Ressler KJ. AAV2 production with optimized N/P ratio and PEI-mediated transfection results in low toxicity and high titer for in vitro and in vivo applications. J Virol Methods. 2013 Nov; 193(2):270-7. PMID: 23791963; PMCID: PMC3775943.
  151. Jasnow AM, Ehrlich DE, Choi DC, Dabrowska J, Bowers ME, McCullough KM, Rainnie DG, Ressler KJ. Thy1-expressing neurons in the basolateral amygdala may mediate fear inhibition. J Neurosci. 2013 Jun 19; 33(25):10396-404. PMID: 23785152; PMCID: PMC3685835.
  152. Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD. Sci Transl Med. 2013 Jun 05; 5(188):188ra73. PMID: 23740899; PMCID: PMC3732318.
  153. Sun YV, Smith AK, Conneely KN, Chang Q, Li W, Lazarus A, Smith JA, Almli LM, Binder EB, Klengel T, Cross D, Turner ST, Ressler KJ, Kardia SL. Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. Hum Genet. 2013 Sep; 132(9):1027-37. PMID: 23657504; PMCID: PMC3744600.
  154. Gourley SL, Olevska A, Zimmermann KS, Ressler KJ, Dileone RJ, Taylor JR. The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum. Eur J Neurosci. 2013 Aug; 38(3):2382-8. PMID: 23651226; PMCID: PMC3864662.
  155. Mehta D, Klengel T, Conneely KN, Smith AK, Altmann A, Pace TW, Rex-Haffner M, Loeschner A, Gonik M, Mercer KB, Bradley B, Müller-Myhsok B, Ressler KJ, Binder EB. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8302-7. PMID: 23630272; PMCID: PMC3657772.
  156. Norrholm SD, Jovanovic T, Smith AK, Binder E, Klengel T, Conneely K, Mercer KB, Davis JS, Kerley K, Winkler J, Gillespie CF, Bradley B, Ressler KJ. Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder. Front Behav Neurosci. 2013; 7:30. PMID: 23596403; PMCID: PMC3622057.
  157. Fani N, Gutman D, Tone EB, Almli L, Mercer KB, Davis J, Glover E, Jovanovic T, Bradley B, Dinov ID, Zamanyan A, Toga AW, Binder EB, Ressler KJ. FKBP5 and attention bias for threat: associations with hippocampal function and shape. JAMA Psychiatry. 2013 Apr; 70(4):392-400. PMID: 23407841; PMCID: PMC3732315.
  158. Gillespie CF, Almli LM, Smith AK, Bradley B, Kerley K, Crain DF, Mercer KB, Weiss T, Phifer J, Tang Y, Cubells JF, Binder EB, Conneely KN, Ressler KJ. Sex dependent influence of a functional polymorphism in steroid 5-a-reductase type 2 (SRD5A2) on post-traumatic stress symptoms. Am J Med Genet B Neuropsychiatr Genet. 2013 Apr; 162B(3):283-292. PMID: 23505265; PMCID: PMC3770127.
  159. Almli LM, Mercer KB, Kerley K, Feng H, Bradley B, Conneely KN, Ressler KJ. ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females. Am J Med Genet B Neuropsychiatr Genet. 2013 Apr; 162B(3):262-72. PMID: 23505260; PMCID: PMC3738001.
  160. Dias BG, Banerjee SB, Goodman JV, Ressler KJ. Towards new approaches to disorders of fear and anxiety. Curr Opin Neurobiol. 2013 Jun; 23(3):346-52. PMID: 23402950; PMCID: PMC3672317.
  161. DeFife JA, Peart J, Bradley B, Ressler K, Drill R, Westen D. Validity of prototype diagnosis for mood and anxiety disorders. JAMA Psychiatry. 2013 Feb; 70(2):140-8. PMID: 23403467.
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  162. Sink KS, Chung A, Ressler KJ, Davis M, Walker DL. Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors. Behav Brain Res. 2013 Apr 15; 243:286-93. PMID: 23376701; PMCID: PMC3593796.
  163. Parsons RG, Ressler KJ. Implications of memory modulation for post-traumatic stress and fear disorders. Nat Neurosci. 2013 Feb; 16(2):146-53. PMID: 23354388; PMCID: PMC3752300.
  164. Dias BG, Ressler KJ. PACAP and the PAC1 receptor in post-traumatic stress disorder. Neuropsychopharmacology. 2013 Jan; 38(1):245-6. PMID: 23147486; PMCID: PMC3521970.
  165. Uddin M, Chang SC, Zhang C, Ressler K, Mercer KB, Galea S, Keyes KM, McLaughlin KA, Wildman DE, Aiello AE, Koenen KC. Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment. Depress Anxiety. 2013 Mar; 30(3):251-8. PMID: 23280952; PMCID: PMC4081452.
  166. Flandreau EI, Bourke CH, Ressler KJ, Vale WW, Nemeroff CB, Owens MJ. Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala. Psychoneuroendocrinology. 2013 Aug; 38(8):1349-61. PMID: 23267723; PMCID: PMC3749072.
  167. Choi DC, Gourley SL, Ressler KJ. Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning. Transl Psychiatry. 2012 Dec 18; 2:e205. PMID: 23250006; PMCID: PMC3565191.
  168. Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, Binder EB. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci. 2013 Jan; 16(1):33-41. PMID: 23201972; PMCID: PMC4136922.
  169. Heldt SA, Mou L, Ressler KJ. In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice. Transl Psychiatry. 2012 Nov 13; 2:e181. PMID: 23149445; PMCID: PMC3565763.
  170. Gafford GM, Guo JD, Flandreau EI, Hazra R, Rainnie DG, Ressler KJ. Cell-type specific deletion of GABA(A)a1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16330-5. PMID: 22992651; PMCID: PMC3479581.
  171. Jovanovic T, Ely T, Fani N, Glover EM, Gutman D, Tone EB, Norrholm SD, Bradley B, Ressler KJ. Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample. Cortex. 2013 Jul-Aug; 49(7):1884-91. PMID: 23020899; PMCID: PMC3540153.
  172. Kearns MC, Ressler KJ, Zatzick D, Rothbaum BO. Early interventions for PTSD: a review. Depress Anxiety. 2012 Oct; 29(10):833-42. PMID: 22941845; PMCID: PMC3665083.
  173. Fani N, King TZ, Jovanovic T, Glover EM, Bradley B, Choi K, Ely T, Gutman DA, Ressler KJ. White matter integrity in highly traumatized adults with and without post-traumatic stress disorder. Neuropsychopharmacology. 2012 Nov; 37(12):2740-6. PMID: 22871912; PMCID: PMC3473340.
  174. Gutman DA, Keifer OP, Magnuson ME, Choi DC, Majeed W, Keilholz S, Ressler KJ. A DTI tractography analysis of infralimbic and prelimbic connectivity in the mouse using high-throughput MRI. Neuroimage. 2012 Nov 01; 63(2):800-11. PMID: 22796992; PMCID: PMC3488432.
  175. Jovanovic T, Norrholm SD, Davis J, Mercer KB, Almli L, Nelson A, Cross D, Smith A, Ressler KJ, Bradley B. PAC1 receptor (ADCYAP1R1) genotype is associated with dark-enhanced startle in children. Mol Psychiatry. 2013 Jul; 18(7):742-3. PMID: 22776899; PMCID: PMC3750970.
  176. Rothbaum BO, Kearns MC, Price M, Malcoun E, Davis M, Ressler KJ, Lang D, Houry D. Early intervention may prevent the development of posttraumatic stress disorder: a randomized pilot civilian study with modified prolonged exposure. Biol Psychiatry. 2012 Dec 01; 72(11):957-63. PMID: 22766415; PMCID: PMC3467345.
  177. Andero R, Ressler KJ. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes Brain Behav. 2012 Jul; 11(5):503-12. PMID: 22530815; PMCID: PMC3389160.
  178. Khoury NM, Marvar PJ, Gillespie CF, Wingo A, Schwartz A, Bradley B, Kramer M, Ressler KJ. The renin-angiotensin pathway in posttraumatic stress disorder: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are associated with fewer traumatic stress symptoms. J Clin Psychiatry. 2012 Jun; 73(6):849-55. PMID: 22687631; PMCID: PMC4087173.
  179. Gutman DA, Magnuson M, Majeed W, Keifer OP, Davis M, Ressler KJ, Keilholz S. Mapping of the mouse olfactory system with manganese-enhanced magnetic resonance imaging and diffusion tensor imaging. Brain Struct Funct. 2013 Mar; 218(2):527-37. PMID: 22527121; PMCID: PMC3425724.
  180. Glover EM, Jovanovic T, Mercer KB, Kerley K, Bradley B, Ressler KJ, Norrholm SD. Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder. Biol Psychiatry. 2012 Jul 01; 72(1):19-24. PMID: 22502987; PMCID: PMC3675159.
  181. Mahan AL, Mou L, Shah N, Hu JH, Worley PF, Ressler KJ. Epigenetic modulation of Homer1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning. J Neurosci. 2012 Mar 28; 32(13):4651-9. PMID: 22457511; PMCID: PMC3329762.
  182. Maguschak KA, Ressler KJ. A role for WNT/ß-catenin signaling in the neural mechanisms of behavior. J Neuroimmune Pharmacol. 2012 Dec; 7(4):763-73. PMID: 22415718; PMCID: PMC3749067.
  183. Fani N, Jovanovic T, Ely TD, Bradley B, Gutman D, Tone EB, Ressler KJ. Neural correlates of attention bias to threat in post-traumatic stress disorder. Biol Psychol. 2012 May; 90(2):134-42. PMID: 22414937; PMCID: PMC3340884.
  184. Bowers ME, Choi DC, Ressler KJ. Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y. Physiol Behav. 2012 Dec 05; 107(5):699-710. PMID: 22429904; PMCID: PMC3532931.
  185. Marvar PJ, Vinh A, Thabet S, Lob HE, Geem D, Ressler KJ, Harrison DG. T lymphocytes and vascular inflammation contribute to stress-dependent hypertension. Biol Psychiatry. 2012 May 01; 71(9):774-82. PMID: 22361077; PMCID: PMC3354001.
  186. Sink KS, Walker DL, Freeman SM, Flandreau EI, Ressler KJ, Davis M. Effects of continuously enhanced corticotropin releasing factor expression within the bed nucleus of the stria terminalis on conditioned and unconditioned anxiety. Mol Psychiatry. 2013 Mar; 18(3):308-19. PMID: 22290119; PMCID: PMC3578178.
  187. Kamkwalala A, Norrholm SD, Poole JM, Brown A, Donley S, Duncan E, Bradley B, Ressler KJ, Jovanovic T. Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorder. Psychosom Med. 2012 Feb-Mar; 74(2):153-9. PMID: 22286850; PMCID: PMC3674026.
  188. Binder EB, Ressler KJ. Emerging methods in the molecular biology of neuropsychiatric disorders. Handb Clin Neurol. 2012; 106:191-209. PMID: 22608622.
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  189. Donley S, Habib L, Jovanovic T, Kamkwalala A, Evces M, Egan G, Bradley B, Ressler KJ. Civilian PTSD symptoms and risk for involvement in the criminal justice system. J Am Acad Psychiatry Law. 2012; 40(4):522-9. PMID: 23233474; PMCID: PMC3752299.
  190. Taylor SL, Stanek LM, Ressler KJ, Huhman KL. Differential brain-derived neurotrophic factor expression in limbic brain regions following social defeat or territorial aggression. Behav Neurosci. 2011 Dec; 125(6):911-20. PMID: 22122152; PMCID: PMC3232038.
  191. Rakofsky JJ, Ressler KJ, Dunlop BW. BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity. Mol Psychiatry. 2012 Jan; 17(1):22-35. PMID: 21931317; PMCID: PMC3690922.
  192. Maguschak KA, Ressler KJ. Wnt signaling in amygdala-dependent learning and memory. J Neurosci. 2011 Sep 14; 31(37):13057-67. PMID: 21917789.
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  193. Mercer KB, Orcutt HK, Quinn JF, Fitzgerald CA, Conneely KN, Barfield RT, Gillespie CF, Ressler KJ. Acute and posttraumatic stress symptoms in a prospective gene x environment study of a university campus shooting. Arch Gen Psychiatry. 2012 Jan; 69(1):89-97. PMID: 21893641; PMCID: PMC3738299.
  194. Glover EM, Phifer JE, Crain DF, Norrholm SD, Davis M, Bradley B, Ressler KJ, Jovanovic T. Tools for translational neuroscience: PTSD is associated with heightened fear responses using acoustic startle but not skin conductance measures. Depress Anxiety. 2011 Dec 21; 28(12):1058-66. PMID: 21898707; PMCID: PMC3229665.
  195. Maguschak KA, Ressler KJ. The dynamic role of beta-catenin in synaptic plasticity. Neuropharmacology. 2012 Jan; 62(1):78-88. PMID: 21903109; PMCID: PMC3196058.
  196. Fani N, Tone EB, Phifer J, Norrholm SD, Bradley B, Ressler KJ, Kamkwalala A, Jovanovic T. Attention bias toward threat is associated with exaggerated fear expression and impaired extinction in PTSD. Psychol Med. 2012 Mar; 42(3):533-43. PMID: 21854700; PMCID: PMC3690118.
  197. Mahan AL, Ressler KJ. Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci. 2012 Jan; 35(1):24-35. PMID: 21798604.
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  198. Campeau S, Liberzon I, Morilak D, Ressler K. Stress modulation of cognitive and affective processes. Stress. 2011 Sep; 14(5):503-19. PMID: 21790481; PMCID: PMC3313908.
  199. Wrenn GL, Wingo AP, Moore R, Pelletier T, Gutman AR, Bradley B, Ressler KJ. The effect of resilience on posttraumatic stress disorder in trauma-exposed inner-city primary care patients. J Natl Med Assoc. 2011 Jul; 103(7):560-6. PMID: 21999030; PMCID: PMC3691279.
  200. Smith AK, Conneely KN, Kilaru V, Mercer KB, Weiss TE, Bradley B, Tang Y, Gillespie CF, Cubells JF, Ressler KJ. Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Sep; 156B(6):700-8. PMID: 21714072; PMCID: PMC3292872.
  201. Phifer J, Skelton K, Weiss T, Schwartz AC, Wingo A, Gillespie CF, Sands LA, Sayyar S, Bradley B, Jovanovic T, Ressler KJ. Pain symptomatology and pain medication use in civilian PTSD. Pain. 2011 Oct; 152(10):2233-40. PMID: 21665366; PMCID: PMC3201986.
  202. Flandreau EI, Ressler KJ, Owens MJ, Nemeroff CB. Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus. Psychoneuroendocrinology. 2012 Jan; 37(1):27-38. PMID: 21616602; PMCID: PMC3164918.
  203. Jovanovic T, Phifer JE, Sicking K, Weiss T, Norrholm SD, Bradley B, Ressler KJ. Cortisol suppression by dexamethasone reduces exaggerated fear responses in posttraumatic stress disorder. Psychoneuroendocrinology. 2011 Nov; 36(10):1540-52. PMID: 21601366; PMCID: PMC3686475.
  204. Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB. Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. Arch Gen Psychiatry. 2011 Sep; 68(9):901-10. PMID: 21536970; PMCID: PMC3686481.
  205. Bradley B, DeFife JA, Guarnaccia C, Phifer J, Fani N, Ressler KJ, Westen D. Emotion dysregulation and negative affect: association with psychiatric symptoms. J Clin Psychiatry. 2011 May; 72(5):685-91. PMID: 21658350; PMCID: PMC4605672.
  206. Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB. The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron. 2011 Apr 28; 70(2):252-65. PMID: 21521612; PMCID: PMC3112053.
  207. Jovanovic T, Smith A, Kamkwalala A, Poole J, Samples T, Norrholm SD, Ressler KJ, Bradley B. Physiological markers of anxiety are increased in children of abused mothers. J Child Psychol Psychiatry. 2011 Aug; 52(8):844-52. PMID: 21501167; PMCID: PMC3134615.
  208. Tang YL, Khoury L, Bradley B, Gillespie CF, Ressler KJ, Cubells JF. Substance use disorders assessed using the Kreek-McHugh-Schluger-Kellogg (KMSK) scale in an urban low-income and predominantly African American sample of primary care patients. Am J Addict. 2011 May-Jun; 20(3):292-9. PMID: 21477058; PMCID: PMC3076102.
  209. Weiss T, Skelton K, Phifer J, Jovanovic T, Gillespie CF, Smith A, Umpierrez G, Bradley B, Ressler KJ. Posttraumatic stress disorder is a risk factor for metabolic syndrome in an impoverished urban population. Gen Hosp Psychiatry. 2011 Mar-Apr; 33(2):135-42. PMID: 21596206; PMCID: PMC3099039.
  210. Skelton K, Ressler KJ, Norrholm SD, Jovanovic T, Bradley-Davino B. PTSD and gene variants: new pathways and new thinking. Neuropharmacology. 2012 Feb; 62(2):628-37. PMID: 21356219; PMCID: PMC3136568.
  211. Ressler KJ, Mercer KB, Bradley B, Jovanovic T, Mahan A, Kerley K, Norrholm SD, Kilaru V, Smith AK, Myers AJ, Ramirez M, Engel A, Hammack SE, Toufexis D, Braas KM, Binder EB, May V. Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature. 2011 Feb 24; 470(7335):492-7. PMID: 21350482; PMCID: PMC3046811.
  212. Gapen M, Cross D, Ortigo K, Graham A, Johnson E, Evces M, Ressler KJ, Bradley B. Perceived neighborhood disorder, community cohesion, and PTSD symptoms among low-income African Americans in an urban health setting. Am J Orthopsychiatry. 2011 Jan; 81(1):31-37. PMID: 21219273.
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  213. Mou L, Heldt SA, Ressler KJ. Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways. Neuroscience. 2011 Mar 10; 176:72-85. PMID: 21195749; PMCID: PMC3077298.
  214. Khoury L, Tang YL, Bradley B, Cubells JF, Ressler KJ. Substance use, childhood traumatic experience, and Posttraumatic Stress Disorder in an urban civilian population. Depress Anxiety. 2010 Dec; 27(12):1077-86. PMID: 21049532; PMCID: PMC3051362.
  215. Andero R, Heldt SA, Ye K, Liu X, Armario A, Ressler KJ. Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am J Psychiatry. 2011 Feb; 168(2):163-72. PMID: 21123312; PMCID: PMC3770732.
  216. Martin EI, Ressler KJ, Binder E, Nemeroff CB. The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology. Clin Lab Med. 2010 Dec; 30(4):865-91. PMID: 20832657.
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  217. Glover EM, Ressler KJ, Davis M. Differing effects of systemically administered rapamycin on consolidation and reconsolidation of context vs. cued fear memories. Learn Mem. 2010 Nov; 17(11):577-81. PMID: 21036892; PMCID: PMC3256567.
  218. Norrholm SD, Jovanovic T, Olin IW, Sands LA, Karapanou I, Bradley B, Ressler KJ. Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity. Biol Psychiatry. 2011 Mar 15; 69(6):556-63. PMID: 21035787; PMCID: PMC3052965.
  219. Xu X, Yang H, Lin YF, Li X, Cape A, Ressler KJ, Li S, Li XJ. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):19126-31. PMID: 20956301; PMCID: PMC2973903.
  220. Powers AD, Thomas KM, Ressler KJ, Bradley B. The differential effects of child abuse and posttraumatic stress disorder on schizotypal personality disorder. Compr Psychiatry. 2011 Jul-Aug; 52(4):438-45. PMID: 21683181; PMCID: PMC3122145.
  221. Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):16994-8. PMID: 20837545.
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  222. Tang YL, Li W, Mercer K, Bradley B, Gillespie CF, Bonsall R, Ressler KJ, Cubells JF. Genotype-controlled analysis of serum dopamine ß-hydroxylase activity in civilian post-traumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 01; 34(8):1396-401. PMID: 20621148; PMCID: PMC2974949.
  223. Wingo AP, Fani N, Bradley B, Ressler KJ. Psychological resilience and neurocognitive performance in a traumatized community sample. Depress Anxiety. 2010 Aug; 27(8):768-74. PMID: 20186970; PMCID: PMC2918658.
  224. Jang SW, Liu X, Chan CB, France SA, Sayeed I, Tang W, Lin X, Xiao G, Andero R, Chang Q, Ressler KJ, Ye K. Deoxygedunin, a natural product with potent neurotrophic activity in mice. PLoS One. 2010 Jul 13; 5(7):e11528. PMID: 20644624; PMCID: PMC2903477.
  225. Ressler KJ. Amygdala activity, fear, and anxiety: modulation by stress. Biol Psychiatry. 2010 Jun 15; 67(12):1117-9. PMID: 20525501.
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  226. Heldt SA, Ressler KJ. Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice. J Neurosci. 2010 May 26; 30(21):7139-51. PMID: 20505082.
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  227. Wingo AP, Wrenn G, Pelletier T, Gutman AR, Bradley B, Ressler KJ. Moderating effects of resilience on depression in individuals with a history of childhood abuse or trauma exposure. J Affect Disord. 2010 Nov; 126(3):411-4. PMID: 20488545; PMCID: PMC3606050.
  228. Ressler KJ, Bradley B, Mercer KB, Deveau TC, Smith AK, Gillespie CF, Nemeroff CB, Cubells JF, Binder EB. Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 05; 153B(3):812-24. PMID: 20029939; PMCID: PMC2924813.
  229. Binder EB, Owens MJ, Liu W, Deveau TC, Rush AJ, Trivedi MH, Fava M, Bradley B, Ressler KJ, Nemeroff CB. Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response. Arch Gen Psychiatry. 2010 Apr; 67(4):369-79. PMID: 20368512.
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  230. Martin EI, Ressler KJ, Jasnow AM, Dabrowska J, Hazra R, Rainnie DG, Nemeroff CB, Owens MJ. A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor. Biol Psychiatry. 2010 Jun 15; 67(12):1212-6. PMID: 20303068; PMCID: PMC3039842.
  231. Jovanovic T, Ressler KJ. How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD. Am J Psychiatry. 2010 Jun; 167(6):648-62. PMID: 20231322; PMCID: PMC3603297.
  232. Jovanovic T, Norrholm SD, Blanding NQ, Davis M, Duncan E, Bradley B, Ressler KJ. Impaired fear inhibition is a biomarker of PTSD but not depression. Depress Anxiety. 2010 Mar; 27(3):244-51. PMID: 20143428; PMCID: PMC2841213.
  233. Kohli MA, Salyakina D, Pfennig A, Lucae S, Horstmann S, Menke A, Kloiber S, Hennings J, Bradley BB, Ressler KJ, Uhr M, Müller-Myhsok B, Holsboer F, Binder EB. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Arch Gen Psychiatry. 2010 Apr; 67(4):348-59. PMID: 20124106; PMCID: PMC3696349.
  234. Choi DC, Maguschak KA, Ye K, Jang SW, Myers KM, Ressler KJ. Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2675-80. PMID: 20133801; PMCID: PMC2823921.
  235. Choi DC, Rothbaum BO, Gerardi M, Ressler KJ. Pharmacological enhancement of behavioral therapy: focus on posttraumatic stress disorder. Curr Top Behav Neurosci. 2010; 2:279-99. PMID: 21309114.
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  236. Jovanovic T, Norrholm SD, Blanding NQ, Phifer JE, Weiss T, Davis M, Duncan E, Bradley B, Ressler K. Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD. Psychoneuroendocrinology. 2010 Jul; 35(6):846-57. PMID: 20036466; PMCID: PMC2875386.
  237. Heldt SA, Ressler KJ. The Use of Lentiviral Vectors and Cre/loxP to Investigate the Function of Genes in Complex Behaviors. Front Mol Neurosci. 2009; 2:22. PMID: 20011219; PMCID: PMC2790954.
  238. Heim C, Bradley B, Mletzko TC, Deveau TC, Musselman DL, Nemeroff CB, Ressler KJ, Binder EB. Effect of Childhood Trauma on Adult Depression and Neuroendocrine Function: Sex-Specific Moderation by CRH Receptor 1 Gene. Front Behav Neurosci. 2009; 3:41. PMID: 20161813; PMCID: PMC2821197.
  239. Heldt SA, Davis M, Ratti E, Corsi M, Trist D, Ressler KJ. Anxiolytic-like effects of the neurokinin 1 receptor antagonist GR-205171 in the elevated plus maze and contextual fear-potentiated startle model of anxiety in gerbils. Behav Pharmacol. 2009 Oct; 20(7):584-95. PMID: 19675456; PMCID: PMC2946835.
  240. Martin EI, Ressler KJ, Binder E, Nemeroff CB. The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology. Psychiatr Clin North Am. 2009 Sep; 32(3):549-75. PMID: 19716990; PMCID: PMC3684250.
  241. Norrholm SD, Ressler KJ. Genetics of anxiety and trauma-related disorders. Neuroscience. 2009 Nov 24; 164(1):272-87. PMID: 19540311; PMCID: PMC2760665.
  242. Gillespie CF, Bradley B, Mercer K, Smith AK, Conneely K, Gapen M, Weiss T, Schwartz AC, Cubells JF, Ressler KJ. Trauma exposure and stress-related disorders in inner city primary care patients. Gen Hosp Psychiatry. 2009 Nov-Dec; 31(6):505-14. PMID: 19892208; PMCID: PMC2785858.
  243. Jasnow AM, Ressler KJ, Hammack SE, Chhatwal JP, Rainnie DG. Distinct subtypes of cholecystokinin (CCK)-containing interneurons of the basolateral amygdala identified using a CCK promoter-specific lentivirus. J Neurophysiol. 2009 Mar; 101(3):1494-506. PMID: 19164102; PMCID: PMC2666417.
  244. Jasnow AM, Rainnie DG, Maguschak KA, Chhatwal JP, Ressler KJ. Construction of cell-type specific promoter lentiviruses for optically guiding electrophysiological recordings and for targeted gene delivery. Methods Mol Biol. 2009; 515:199-213. PMID: 19378132.
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  245. Gillespie CF, Phifer J, Bradley B, Ressler KJ. Risk and resilience: genetic and environmental influences on development of the stress response. Depress Anxiety. 2009; 26(11):984-92. PMID: 19750552; PMCID: PMC2852579.
  246. Jovanovic T, Blanding NQ, Norrholm SD, Duncan E, Bradley B, Ressler KJ. Childhood abuse is associated with increased startle reactivity in adulthood. Depress Anxiety. 2009; 26(11):1018-26. PMID: 19691032; PMCID: PMC2852033.
  247. Powers A, Ressler KJ, Bradley RG. The protective role of friendship on the effects of childhood abuse and depression. Depress Anxiety. 2009; 26(1):46-53. PMID: 18972449; PMCID: PMC2629811.
  248. Jones SV, Choi DC, Davis M, Ressler KJ. Learning-dependent structural plasticity in the adult olfactory pathway. J Neurosci. 2008 Dec 03; 28(49):13106-11. PMID: 19052201; PMCID: PMC2613972.
  249. Gutman AR, Yang Y, Ressler KJ, Davis M. The role of neuropeptide Y in the expression and extinction of fear-potentiated startle. J Neurosci. 2008 Nov 26; 28(48):12682-90. PMID: 19036961; PMCID: PMC2621075.
  250. Maguschak KA, Ressler KJ. Beta-catenin is required for memory consolidation. Nat Neurosci. 2008 Nov; 11(11):1319-26. PMID: 18820693; PMCID: PMC2597638.
  251. Keen-Rhinehart E, Michopoulos V, Toufexis DJ, Martin EI, Nair H, Ressler KJ, Davis M, Owens MJ, Nemeroff CB, Wilson ME. Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. Mol Psychiatry. 2009 Jan; 14(1):37-50. PMID: 18698320; PMCID: PMC2652696.
  252. Chhatwal JP, Gutman AR, Maguschak KA, Bowser ME, Yang Y, Davis M, Ressler KJ. Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning. Neuropsychopharmacology. 2009 Jan; 34(2):509-21. PMID: 18580872.
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  253. Gerardi M, Rothbaum BO, Ressler K, Heekin M, Rizzo A. Virtual reality exposure therapy using a virtual Iraq: case report. J Trauma Stress. 2008 Apr; 21(2):209-13. PMID: 18404648; PMCID: PMC3734540.
  254. Davis RG, Ressler KJ, Schwartz AC, Stephens KJ, Bradley RG. Treatment barriers for low-income, urban African Americans with undiagnosed posttraumatic stress disorder. J Trauma Stress. 2008 Apr; 21(2):218-22. PMID: 18404649; PMCID: PMC2444044.
  255. Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, Tang Y, Gillespie CF, Heim CM, Nemeroff CB, Schwartz AC, Cubells JF, Ressler KJ. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA. 2008 Mar 19; 299(11):1291-305. PMID: 18349090; PMCID: PMC2441757.
  256. Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, Gillespie CF, Berg T, Evces M, Newport DJ, Stowe ZN, Heim CM, Nemeroff CB, Schwartz A, Cubells JF, Ressler KJ. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry. 2008 Feb; 65(2):190-200. PMID: 18250257; PMCID: PMC2443704.
  257. Jones SV, Stanek-Rattiner L, Davis M, Ressler KJ. Differential regional expression of brain-derived neurotrophic factor following olfactory fear learning. Learn Mem. 2007 Dec; 14(12):816-20. PMID: 18086824; PMCID: PMC2444033.
  258. Heldt SA, Ressler KJ. Training-induced changes in the expression of GABAA-associated genes in the amygdala after the acquisition and extinction of Pavlovian fear. Eur J Neurosci. 2007 Dec; 26(12):3631-44. PMID: 18088283; PMCID: PMC2443698.
  259. Heldt SA, Ressler KJ. Forebrain and midbrain distribution of major benzodiazepine-sensitive GABAA receptor subunits in the adult C57 mouse as assessed with in situ hybridization. Neuroscience. 2007 Dec 05; 150(2):370-85. PMID: 17950542; PMCID: PMC2292345.
  260. Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci. 2007 Sep; 10(9):1116-24. PMID: 17726478; PMCID: PMC2444035.
  261. Almonte AG, Hamill CE, Chhatwal JP, Wingo TS, Barber JA, Lyuboslavsky PN, David Sweatt J, Ressler KJ, White DA, Traynelis SF. Learning and memory deficits in mice lacking protease activated receptor-1. Neurobiol Learn Mem. 2007 Oct; 88(3):295-304. PMID: 17544303; PMCID: PMC2040495.
  262. Bush CF, Jones SV, Lyle AN, Minneman KP, Ressler KJ, Hall RA. Specificity of olfactory receptor interactions with other G protein-coupled receptors. J Biol Chem. 2007 Jun 29; 282(26):19042-51. PMID: 17472961.
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  263. Chhatwal JP, Ressler KJ. Modulation of fear and anxiety by the endogenous cannabinoid system. CNS Spectr. 2007 Mar; 12(3):211-20. PMID: 17329982; PMCID: PMC2789283.
  264. Heldt SA, Stanek L, Chhatwal JP, Ressler KJ. Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry. 2007 Jul; 12(7):656-70. PMID: 17264839; PMCID: PMC2442923.
  265. Chhatwal JP, Hammack SE, Jasnow AM, Rainnie DG, Ressler KJ. Identification of cell-type-specific promoters within the brain using lentiviral vectors. Gene Ther. 2007 Apr; 14(7):575-83. PMID: 17235291; PMCID: PMC2442925.
  266. Davis M, Ressler K, Rothbaum BO, Richardson R. Effects of D-cycloserine on extinction: translation from preclinical to clinical work. Biol Psychiatry. 2006 Aug 15; 60(4):369-75. PMID: 16919524.
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  267. Chhatwal JP, Stanek-Rattiner L, Davis M, Ressler KJ. Amygdala BDNF signaling is required for consolidation but not encoding of extinction. Nat Neurosci. 2006 Jul; 9(7):870-2. PMID: 16783370; PMCID: PMC2562628.
  268. Heldt SA, Ressler KJ. Localized injections of midazolam into the amygdala and hippocampus induce differential changes in anxiolytic-like motor activity in mice. Behav Pharmacol. 2006 Jun; 17(4):349-56. PMID: 16914953; PMCID: PMC2525667.
  269. Myers KM, Ressler KJ, Davis M. Different mechanisms of fear extinction dependent on length of time since fear acquisition. Learn Mem. 2006 Mar-Apr; 13(2):216-23. PMID: 16585797; PMCID: PMC1409828.
  270. Schwartz AC, Bradley R, Penza KM, Sexton M, Jay D, Haggard PJ, Garlow SJ, Ressler KJ. Pain medication use among patients with posttraumatic stress disorder. Psychosomatics. 2006 Mar-Apr; 47(2):136-42. PMID: 16508025; PMCID: PMC2764737.
  271. Heldt SA, Ressler KJ. Lesions of the habenula produce stress- and dopamine-dependent alterations in prepulse inhibition and locomotion. Brain Res. 2006 Feb 16; 1073-1074:229-39. PMID: 16442084; PMCID: PMC2561201.
  272. Davis M, Myers KM, Chhatwal J, Ressler KJ. Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy. NeuroRx. 2006 Jan; 3(1):82-96. PMID: 16490415; PMCID: PMC2919202.
  273. Gillespie CF, Ressler KJ. Emotional learning and glutamate: translational perspectives. CNS Spectr. 2005 Oct; 10(10):831-9. PMID: 16400246; PMCID: PMC2764739.
  274. Rattiner LM, Davis M, Ressler KJ. Brain-derived neurotrophic factor in amygdala-dependent learning. Neuroscientist. 2005 Aug; 11(4):323-33. PMID: 16061519.
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  275. Chhatwal JP, Davis M, Maguschak KA, Ressler KJ. Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear. Neuropsychopharmacology. 2005 Mar; 30(3):516-24. PMID: 15637635.
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  276. Schwartz AC, Bradley RL, Sexton M, Sherry A, Ressler KJ. Posttraumatic stress disorder among African Americans in an inner city mental health clinic. Psychiatr Serv. 2005 Feb; 56(2):212-5. PMID: 15703352.
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  277. Jones SV, Heldt SA, Davis M, Ressler KJ. Olfactory-mediated fear conditioning in mice: simultaneous measurements of fear-potentiated startle and freezing. Behav Neurosci. 2005 Feb; 119(1):329-35. PMID: 15727538; PMCID: PMC2881597.
  278. Chhatwal JP, Myers KM, Ressler KJ, Davis M. Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction. J Neurosci. 2005 Jan 12; 25(2):502-6. PMID: 15647495.
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  279. Rattiner LM, Davis M, Ressler KJ. Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning. Learn Mem. 2004 Nov-Dec; 11(6):727-31. PMID: 15537738.
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  280. Ressler KJ, Rothbaum BO, Tannenbaum L, Anderson P, Graap K, Zimand E, Hodges L, Davis M. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 2004 Nov; 61(11):1136-44. PMID: 15520361.
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  281. Hague C, Uberti MA, Chen Z, Bush CF, Jones SV, Ressler KJ, Hall RA, Minneman KP. Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13672-6. PMID: 15347813; PMCID: PMC518811.
  282. Heldt SA, Green A, Ressler KJ. Prepulse inhibition deficits in GAD65 knockout mice and the effect of antipsychotic treatment. Neuropsychopharmacology. 2004 Sep; 29(9):1610-9. PMID: 15114343.
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  283. Rattiner LM, Davis M, French CT, Ressler KJ. Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning. J Neurosci. 2004 May 19; 24(20):4796-806. PMID: 15152040.
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  284. Schwartz A, Bradley R, Ressler K, Sexton M, Sherry A. Treating posttraumatic stress disorder in urban African American mental health patients. J Am Psychoanal Assoc. 2004; 52(2):464-5. PMID: 15222443.
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  285. Ressler K, Davis M. Genetics of childhood disorders: L. Learning and memory, part 3: fear conditioning. J Am Acad Child Adolesc Psychiatry. 2003 May; 42(5):612-5. PMID: 12707566.
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  286. Ressler KJ, Paschall G, Zhou XL, Davis M. Regulation of synaptic plasticity genes during consolidation of fear conditioning. J Neurosci. 2002 Sep 15; 22(18):7892-902. PMID: 12223542.
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  287. Walker DL, Ressler KJ, Lu KT, Davis M. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci. 2002 Mar 15; 22(6):2343-51. PMID: 11896173.
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  288. Ressler KJ, Nemeroff CB. Role of norepinephrine in the pathophysiology of neuropsychiatric disorders. CNS Spectr. 2001 Aug; 6(8):663-6, 670. PMID: 15520614.
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  289. Ressler KJ, Nemeroff CB. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety. 2000; 12 Suppl 1:2-19. PMID: 11098410.
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  290. Ressler KJ, Nemeroff CB. Role of norepinephrine in the pathophysiology and treatment of mood disorders. Biol Psychiatry. 1999 Nov 01; 46(9):1219-33. PMID: 10560027.
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  291. Sullivan SL, Adamson MC, Ressler KJ, Kozak CA, Buck LB. The chromosomal distribution of mouse odorant receptor genes. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):884-8. PMID: 8570653; PMCID: PMC40152.
  292. Sullivan SL, Bohm S, Ressler KJ, Horowitz LF, Buck LB. Target-independent pattern specification in the olfactory epithelium. Neuron. 1995 Oct; 15(4):779-89. PMID: 7576628.
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  293. Sullivan SL, Ressler KJ, Buck LB. Spatial patterning and information coding in the olfactory system. Curr Opin Genet Dev. 1995 Aug; 5(4):516-23. PMID: 7580145.
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  294. Ressler KJ, Sullivan SL, Buck LB. Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell. 1994 Dec 30; 79(7):1245-55. PMID: 7528109.
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  295. Ressler KJ, Sullivan SL, Buck LB. A molecular dissection of spatial patterning in the olfactory system. Curr Opin Neurobiol. 1994 Aug; 4(4):588-96. PMID: 7812149.
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  296. Sullivan SL, Ressler KJ, Buck LB. Odorant receptor diversity and patterned gene expression in the mammalian olfactory epithelium. Prog Clin Biol Res. 1994; 390:75-84. PMID: 7724652.
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  297. Ressler KJ, Sullivan SL, Buck LB. A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell. 1993 May 07; 73(3):597-609. PMID: 7683976.
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  298. Acworth IN, Ressler K, Wurtman RJ. Feeding-associated alterations in striatal neurotransmitter release. Ann N Y Acad Sci. 1989 Dec 18; 575:596-8. PMID: 11538862.
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