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Heidi Irma Louisa Jacobs, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurol. 2019 Feb 04. PMID: 30715078.
    Citations:    
  2. Freeze WM, Bacskai BJ, Frosch MP, Jacobs HIL, Backes WH, Greenberg SM, van Veluw SJ. Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy. Stroke. 2019 Feb; 50(2):328-335. PMID: 30661497.
    Citations:    Fields:    
  3. Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol. 2019 Feb; 85(2):181-193. PMID: 30549303.
    Citations:    Fields:    
  4. Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT. Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred. J Prev Alzheimers Dis. 2019; 6(2):112-120. PMID: 30756118.
    Citations:    
  5. d'Oleire Uquillas F, Jacobs HIL, Biddle KD, Properzi M, Hanseeuw B, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Regional tau pathology and loneliness in cognitively normal older adults. Transl Psychiatry. 2018 Dec 18; 8(1):282. PMID: 30563962.
    Citations:    Fields:    
  6. Wolters AF, van de Weijer SCF, Leentjens AFG, Duits AA, Jacobs HIL, Kuijf ML. Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis. Parkinsonism Relat Disord. 2018 Dec 17. PMID: 30580907.
    Citations:    Fields:    
  7. Freeze WM, Jacobs HIL, Schreuder FHBM, van Oostenbrugge RJ, Backes WH, Verhey FR, Klijn CJM. Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage. Front Neurol. 2018; 9:926. PMID: 30483207.
    Citations:    
  8. Sepulcre J, Grothe MJ, d'Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat Med. 2018 Dec; 24(12):1910-1918. PMID: 30374196.
    Citations:    Fields:    
  9. Jacobs HIL, Buckley RF. Where do white matter alterations dovetail with the cascade model of Alzheimer's disease? Brain. 2018 Oct 01; 141(10):2830-2833. PMID: 30535117.
    Citations:    Fields:    
  10. Bachmann C, Jacobs HIL, Porta Mana P, Dillen K, Richter N, von Reutern B, Dronse J, Onur OA, Langen KJ, Fink GR, Kukolja J, Morrison A. On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease. Front Neurosci. 2018; 12:528. PMID: 30323734.
    Citations:    
  11. Mayrhofer HC, Duecker F, van de Ven V, Jacobs HIL, Sack AT. Hemifield-specific Correlations between Cue-related Blood Oxygen Level Dependent Activity in Bilateral Nodes of the Dorsal Attention Network and Attentional Benefits in a Spatial Orienting Paradigm. J Cogn Neurosci. 2018 Sep 21; 1-14. PMID: 30240311.
    Citations:    Fields:    
  12. Rienäcker F, Jacobs HIL, Van Heugten CM, Van Gerven PWM. Practice makes perfect: High performance gains in older adults engaged in selective attention within and across sensory modalities. Acta Psychol (Amst). 2018 Nov; 191:101-111. PMID: 30240890.
    Citations:    Fields:    Translation:Humans
  13. Van Hooren RWE, Riphagen JM, Jacobs HIL. Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer's disease: a longitudinal cohort study. Alzheimers Res Ther. 2018 Aug 28; 10(1):88. PMID: 30153858.
    Citations:    Fields:    
  14. Rosenberg J, Jacobs HIL, Maximov II, Reske M, Shah NJ. Chronotype differences in cortical thickness: grey matter reflects when you go to bed. Brain Struct Funct. 2018 Sep; 223(7):3411-3421. PMID: 29948193.
    Citations:    Fields:    Translation:Humans
  15. Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA. Sex, amyloid, and APOE e4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimers Dement. 2018 Sep; 14(9):1193-1203. PMID: 29803541.
    Citations:    Fields:    
  16. Jacobs HIL, Müller-Ehrenberg L, Priovoulos N, Roebroeck A. Curvilinear locus coeruleus functional connectivity trajectories over the adult lifespan: a 7T MRI study. Neurobiol Aging. 2018 Sep; 69:167-176. PMID: 29908415.
    Citations:    Fields:    
  17. Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 Oct; 14(10):1281-1292. PMID: 29792874.
    Citations: 2     Fields:    
  18. Riphagen JM, Gronenschild EHBM, Salat DH, Freeze WM, Ivanov D, Clerx L, Verhey FRJ, Aalten P, Jacobs HIL. Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia. Neurobiol Aging. 2018 08; 68:48-58. PMID: 29704648.
    Citations:    Fields:    Translation:Humans
  19. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 Mar; 21(3):424-431. PMID: 29403032.
    Citations: 3     Fields:    
  20. Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS, Schultz AP, Frosch MP, Gómez-Isla T, Sperling RA, Johnson KA. 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. J Alzheimers Dis. 2018; 62(4):1691-1702. PMID: 29614677.
    Citations:    Fields:    
  21. Jacobs HIL, Hopkins DA, Mayrhofer HC, Bruner E, van Leeuwen FW, Raaijmakers W, Schmahmann JD. The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline. Brain. 2018 01 01; 141(1):37-47. PMID: 29053771.
    Citations:    Fields:    
  22. Müller-Ehrenberg L, Riphagen JM, Verhey FRJ, Sack AT, Jacobs HIL. Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. J Alzheimers Dis. 2018; 66(2):811-823. PMID: 30320590.
    Citations:    Fields:    
  23. Bos I, Verhey FR, Ramakers IHGB, Jacobs HIL, Soininen H, Freund-Levi Y, Hampel H, Tsolaki M, Wallin ÅK, van Buchem MA, Oleksik A, Verbeek MM, Olde Rikkert M, van der Flier WM, Scheltens P, Aalten P, Visser PJ, Vos SJB. Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimers Res Ther. 2017 Dec 29; 9(1):101. PMID: 29284531.
    Citations: 3     Fields:    
  24. d'Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin. 2018; 17:388-396. PMID: 29159051.
    Citations:    Fields:    Translation:Humans
  25. Priovoulos N, Jacobs HIL, Ivanov D, Uludag K, Verhey FRJ, Poser BA. High-resolution in vivo imaging of human locus coeruleus by magnetization transfer MRI at 3T and 7T. Neuroimage. 2018 03; 168:427-436. PMID: 28743460.
    Citations: 2     Fields:    Translation:Humans
  26. Freeze WM, Schnerr RS, Palm WM, Jansen JF, Jacobs HI, Hoff EI, Verhey FR, Backes WH. Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease. AJNR Am J Neuroradiol. 2017 Sep; 38(9):1742-1747. PMID: 28684457.
    Citations: 1     Fields:    Translation:Humans
  27. Dekhtyar M, Papp KV, Buckley R, Jacobs HIL, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia. 2017 06; 100:164-170. PMID: 28472627.
    Citations: 3     Fields:    Translation:Humans
  28. Cleutjens FAHM, Ponds RWHM, Spruit MA, Burgmans S, Jacobs HIL, Gronenschild EHBM, Staals J, Franssen FME, Dijkstra JB, Vanfleteren LEGW, Hofman PA, Wouters EFM, Janssen DJA. The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study. Front Aging Neurosci. 2017; 9:88. PMID: 28424613.
    Citations: 1     
  29. Dillen KNH, Jacobs HIL, Kukolja J, Richter N, von Reutern B, Onur ÖA, Langen KJ, Fink GR. Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease. J Alzheimers Dis. 2017; 59(1):169-187. PMID: 28598839.
    Citations: 4     Fields:    Translation:Humans
  30. Freeze WM, Jacobs HI, Gronenschild EH, Jansen JF, Burgmans S, Aalten P, Clerx L, Vos SJ, van Buchem MA, Barkhof F, van der Flier WM, Verbeek MM, Rikkert MO, Backes WH, Verhey FR. White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-ß. J Alzheimers Dis. 2017; 55(1):333-342. PMID: 27662299.
    Citations: 4     Fields:    Translation:Humans
  31. Dillen KNH, Jacobs HIL, Kukolja J, von Reutern B, Richter N, Onur ÖA, Dronse J, Langen KJ, Fink GR. Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease. Neurobiol Aging. 2016 08; 44:114-126. PMID: 27318139.
    Citations: 5     Fields:    Translation:Humans
  32. Jacobs HI, Riphagen JM, Razat CM, Wiese S, Sack AT. Transcutaneous vagus nerve stimulation boosts associative memory in older individuals. Neurobiol Aging. 2015 May; 36(5):1860-7. PMID: 25805212.
    Citations: 9     Fields:    Translation:Humans
  33. Jacobs HI, Dillen KN, Risius O, Göreci Y, Onur OA, Fink GR, Kukolja J. Consolidation in older adults depends upon competition between resting-state networks. Front Aging Neurosci. 2014; 6:344. PMID: 25620930; PMCID: PMC4288239.
    Citations: 1     
  34. Clerx L, Gronenschild EH, Echavarri C, Verhey F, Aalten P, Jacobs HI. Can FreeSurfer Compete with Manual Volumetric Measurements in Alzheimer's Disease? Curr Alzheimer Res. 2015; 12(4):358-67. PMID: 25817249.
    Citations: 4     Fields:    Translation:Humans
  35. Jacobs HI, Wiese S, van de Ven V, Gronenschild EH, Verhey FR, Matthews PM. Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia. Neurobiol Aging. 2015 Feb; 36(2):618-26. PMID: 25433457.
    Citations: 9     Fields:    Translation:Humans
  36. Lückmann HC, Jacobs HI, Sack AT. The cross-functional role of frontoparietal regions in cognition: internal attention as the overarching mechanism. Prog Neurobiol. 2014 May; 116:66-86. PMID: 24530293.
    Citations: 13     Fields:    Translation:HumansAnimals
  37. Bruner E, Rangel de Lázaro G, de la Cuétara JM, Martín-Loeches M, Colom R, Jacobs HI. Midsagittal brain variation and MRI shape analysis of the precuneus in adult individuals. J Anat. 2014 Apr; 224(4):367-76. PMID: 24397462.
    Citations: 3     Fields:    Translation:Humans
  38. Jacobs HI, Clerx L, Gronenschild EH, Aalten P, Verhey FR. White matter hyperintensities are positively associated with cortical thickness in Alzheimer's disease. J Alzheimers Dis. 2014; 39(2):409-22. PMID: 24169238.
    Citations: 4     Fields:    Translation:HumansCells
  39. Clerx L, Jacobs HI, Burgmans S, Gronenschild EH, Uylings HB, Echávarri C, Visser PJ, Verhey FR, Aalten P. Sensitivity of different MRI-techniques to assess gray matter atrophy patterns in Alzheimer's disease is region-specific. Curr Alzheimer Res. 2013 Nov; 10(9):940-51. PMID: 23947582.
    Citations: 6     Fields:    Translation:HumansCells
  40. Jacobs HI, Radua J, Lückmann HC, Sack AT. Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker. Neurosci Biobehav Rev. 2013 Jun; 37(5):753-65. PMID: 23523750.
    Citations: 26     Fields:    Translation:Humans
  41. Mills JD, Nalpathamkalam T, Jacobs HI, Janitz C, Merico D, Hu P, Janitz M. RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism. Neurosci Lett. 2013 Mar 01; 536:90-5. PMID: 23305720.
    Citations: 17     Fields:    Translation:HumansCells
  42. Bruner E, Jacobs HI. Alzheimer's disease: the downside of a highly evolved parietal lobe? J Alzheimers Dis. 2013; 35(2):227-40. PMID: 23435412.
    Citations: 13     Fields:    Translation:Humans
  43. Jacobs HI, van Boxtel MP, Gronenschild EH, Williams VJ, Burgmans S, Uylings HB, Jolles J, Verhey FR. Patterns of gray and white matter changes in individuals at risk for Alzheimer's disease. Curr Alzheimer Res. 2012 Nov; 9(9):1097-105. PMID: 22920268.
    Citations: 1     Fields:    Translation:Humans
  44. Gronenschild EH, Habets P, Jacobs HI, Mengelers R, Rozendaal N, van Os J, Marcelis M. The effects of FreeSurfer version, workstation type, and Macintosh operating system version on anatomical volume and cortical thickness measurements. PLoS One. 2012; 7(6):e38234. PMID: 22675527; PMCID: PMC3365894.
    Citations: 75     Fields:    Translation:Humans
  45. Jacobs HI, van Boxtel MP, Gronenschild EH, Uylings HB, Jolles J, Verhey FR. Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker? Alzheimers Dement. 2013 Jan; 9(1):93-7. PMID: 22651939.
    Citations: 7     Fields:    Translation:Humans
  46. Jacobs HI, Gronenschild EH, Evers EA, Ramakers IH, Hofman PA, Backes WH, Jolles J, Verhey FR, Van Boxtel MP. Visuospatial processing in early Alzheimer's disease: a multimodal neuroimaging study. Cortex. 2015 Mar; 64:394-406. PMID: 22342463.
    Citations: 6     Fields:    Translation:Humans
  47. Jacobs HI, Van Boxtel MP, Heinecke A, Gronenschild EH, Backes WH, Ramakers IH, Jolles J, Verhey FR. Functional integration of parietal lobe activity in early Alzheimer disease. Neurology. 2012 Jan 31; 78(5):352-60. PMID: 22262753.
    Citations: 12     Fields:    Translation:Humans
  48. Jacobs HI, Leritz EC, Williams VJ, Van Boxtel MP, van der Elst W, Jolles J, Verhey FR, McGlinchey RE, Milberg WP, Salat DH. Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health. Hum Brain Mapp. 2013 Jan; 34(1):77-95. PMID: 21954054; PMCID: PMC3830829.
    Citations: 38     Fields:    Translation:HumansCells
  49. Jacobs HI, Van Boxtel MP, Jolles J, Verhey FR, Uylings HB. Parietal cortex matters in Alzheimer's disease: an overview of structural, functional and metabolic findings. Neurosci Biobehav Rev. 2012 Jan; 36(1):297-309. PMID: 21741401.
    Citations: 36     Fields:    Translation:Humans
  50. Jacobs HI, Van Boxtel MP, van der Elst W, Burgmans S, Smeets F, Gronenschild EH, Verhey FR, Uylings HB, Jolles J. Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease. J Alzheimers Dis. 2011; 25(3):477-90. PMID: 21471642.
    Citations: 2     Fields:    Translation:Humans
  51. Jacobs HI, Van Boxtel MP, Uylings HB, Gronenschild EH, Verhey FR, Jolles J. Atrophy of the parietal lobe in preclinical dementia. Brain Cogn. 2011 Mar; 75(2):154-63. PMID: 21130554.
    Citations: 6     Fields:    Translation:Humans
  52. Echávarri C, Aalten P, Uylings HB, Jacobs HI, Visser PJ, Gronenschild EH, Verhey FR, Burgmans S. Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer's disease. Brain Struct Funct. 2011 Jan; 215(3-4):265-71. PMID: 20957494; PMCID: PMC3041901.
    Citations: 22     Fields:    Translation:Humans
  53. Jacobs HI, Visser PJ, Van Boxtel MP, Frisoni GB, Tsolaki M, Papapostolou P, Nobili F, Wahlund LO, Minthon L, Frölich L, Hampel H, Soininen H, van de Pol L, Scheltens P, Tan FE, Jolles J, Verhey FR. Association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent. Neurobiol Aging. 2012 Jan; 33(1):201.e1-8. PMID: 20739101.
    Citations: 10     Fields:    Translation:Humans
  54. Burgmans S, van Boxtel MP, van den Berg KE, Gronenschild EH, Jacobs HI, Jolles J, Uylings HB. The posterior parahippocampal gyrus is preferentially affected in age-related memory decline. Neurobiol Aging. 2011 Sep; 32(9):1572-8. PMID: 19879667.
    Citations: 10     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.