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Heidi Irma Louisa Jacobs, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG062559 (JACOBS, HEIDI IRMA) Apr 15, 2019 - Feb 29, 2024
    NIH
    Tracking the origin of tau pathology
    Role: Principal Investigator
  2. IF-GF-706714 (JACOBS, HEIDI IRMA) Jan 1, 2018 - Jan 1, 2020
    Marie Curie Sklodowska H2020 (Europe)
    Connecting neuronal network activity with regional specificity for Alzheimer pathology
    Role: Principal Investigator
  3. 451-14-035 (JACOBS, HEIDI IRMA) Jan 1, 2015 - Jan 1, 2018
    NWO VENI (Netherlands)
    Focus on the locus network with 7Tesla MRI: from normal to impaired memory
    Role: Principal Investigator
  4. JA2336/1-1 (JACOBS, HEIDI IRMA) Apr 1, 2013 - Nov 1, 2017
    DFG (Deutsche Forschungsgemeinschaft - Germany)
    Exciting networks: multi-modal mapping and modulating network breakdown in early Alzheimer’s disease
    Role: Principle Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jacobs HI, Priovoulos N, Poser BA, Pagen LH, Ivanov D, Verhey FR, Uludag K. Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm. Elife. 2020 Jun 24; 9. PMID: 32579109.
    Citations:    
  2. Scott MR, Hampton OL, Buckley RF, Chhatwal JP, Hanseeuw BJ, Jacobs HIL, Properzi MJ, Sanchez JS, Johnson KA, Sperling RA, Schultz AP. Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults. Neuroimage. 2020 Jun 05; 116991. PMID: 32512123.
    Citations:    
  3. Riphagen JM, Schmiedek L, Gronenschild EHBM, Yassa MA, Priovoulos N, Sack AT, Verhey FRJ, Jacobs HIL. Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7?T imaging study. Sci Rep. 2020 May 05; 10(1):7572. PMID: 32371923.
    Citations:    
  4. Jacobs HIL, Augustinack JC, Schultz AP, Hanseeuw BJ, Locascio J, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. 2020 May 05; 94(18):e1916-e1928. PMID: 32273431.
    Citations:    
  5. d'Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cereb Cortex. 2020 Mar 14; 30(3):1974-1983. PMID: 31696223.
    Citations:    
  6. Biddle KD, Jacobs HIL, d'Oleire Uquillas F, Zide BS, Kirn DR, Properzi MR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Associations of Widowhood and ß-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults. JAMA Netw Open. 2020 Feb 05; 3(2):e200121. PMID: 32101313.
    Citations:    
  7. Pagen LHG, van de Ven VG, Gronenschild EHBM, Priovoulos N, Verhey FRJ, Jacobs HIL. Contributions of Cerebro-Cerebellar Default Mode Connectivity Patterns to Memory Performance in Mild Cognitive Impairment. J Alzheimers Dis. 2020; 75(2):633-647. PMID: 32310164.
    Citations:    
  8. Vannini P, d'Oleire Uquillas F, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019; 24:102097. PMID: 31795044.
    Citations:    
  9. Jacobs HIL. Focus on the blue locus for learning. Nat Hum Behav. 2019 11; 3(11):1143-1144. PMID: 31501541.
    Citations:    
  10. Duecker F, Mayrhofer HC, Jacobs HIL, Sack AT. No effect of cold pressor test-induced arousal on attentional benefits and costs in an endogenous spatial orienting paradigm. Neuropsychologia. 2019 12; 135:107250. PMID: 31682926.
    Citations:    
  11. Riphagen JM, Ramakers IHGM, Freeze WM, Pagen LHG, Hanseeuw BJ, Verbeek MM, Verhey FRJ, Jacobs HIL. Linking APOE-e4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology. Neurobiol Aging. 2020 01; 85:96-103. PMID: 31733942.
    Citations:    
  12. Freeze WM, Jacobs HIL, de Jong JJ, Verheggen ICM, Gronenschild EHBM, Palm WM, Hoff EI, Wardlaw JM, Jansen JFA, Verhey FR, Backes WH. White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed. Neurobiol Aging. 2020 01; 85:113-122. PMID: 31718926.
    Citations:    
  13. Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain. 2019 09 01; 142(9):2558-2571. PMID: 31327002.
    Citations:    
  14. Richter N, Nellessen N, Dronse J, Dillen K, Jacobs HIL, Langen KJ, Dietlein M, Kracht L, Neumaier B, Fink GR, Kukolja J, Onur OA. Spatial distributions of cholinergic impairment and neuronal hypometabolism differ in MCI due to AD. Neuroimage Clin. 2019; 24:101978. PMID: 31422337.
    Citations:    
  15. Freeze WM, Ter Weele DN, Palm WM, van Hooren RW, Hoff EI, Jansen JFA, Jacobs HIL, Verhey FR, Backes WH. Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging. AJNR Am J Neuroradiol. 2019 09; 40(9):1481-1483. PMID: 31395665.
    Citations:    
  16. Priovoulos N, Poser BA, Ivanov D, Verhey FRJ, Jacobs HIL. In vivo imaging of the nucleus of the solitary tract with Magnetization Transfer at 7 Tesla. Neuroimage. 2019 11 01; 201:116071. PMID: 31398435.
    Citations:    
  17. Wolters AF, van de Weijer SCF, Leentjens AFG, Duits AA, Jacobs HIL, Kuijf ML. "Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis": Answer to Wang and colleagues. Parkinsonism Relat Disord. 2019 09; 66:253-254. PMID: 31431324.
    Citations:    
  18. Song TA, Roy Chowdhury S, Yang F, Jacobs H, El Fakhri G, Li Q, Johnson K, Dutta J. GRAPH CONVOLUTIONAL NEURAL NETWORKS FOR ALZHEIMER'S DISEASE CLASSIFICATION. Proc IEEE Int Symp Biomed Imaging. 2019 Apr; 2019:414-417. PMID: 31327984.
    Citations:    
  19. Bischof GN, Jacobs HIL. Subthreshold amyloid and its biological and clinical meaning: Long way ahead. Neurology. 2019 07 09; 93(2):72-79. PMID: 31167933.
    Citations:    
  20. Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019 Jun 03. PMID: 31157827.
    Citations:    
  21. Jacobs HIL, Riphagen JM, Ramakers IHGB, Verhey FRJ. Alzheimer's disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms. Mol Psychiatry. 2019 May 28. PMID: 31138892.
    Citations:    
  22. Yang F, Roy Chowdhury S, Jacobs HIL, Johnson KA, Dutta J. A longitudinal model for tau aggregation in Alzheimer's disease based on structural connectivity. Inf Process Med Imaging. 2019; 11492:384-393. PMID: 31156312.
    Citations:    
  23. Biddle KD, d'Oleire Uquillas F, Jacobs HIL, Zide B, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Social Engagement and Amyloid-ß-Related Cognitive Decline in Cognitively Normal Older Adults. Am J Geriatr Psychiatry. 2019 11; 27(11):1247-1256. PMID: 31248770.
    Citations:    
  24. Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurol. 2019 05 01; 76(5):542-551. PMID: 30715078.
    Citations:    
  25. Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiol Aging. 2019 06; 78:178-185. PMID: 30947113.
    Citations:    
  26. Freeze WM, Bacskai BJ, Frosch MP, Jacobs HIL, Backes WH, Greenberg SM, van Veluw SJ. Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy. Stroke. 2019 02; 50(2):328-335. PMID: 30661497.
    Citations:    Fields:    
  27. Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol. 2019 02; 85(2):181-193. PMID: 30549303.
    Citations:    Fields:    
  28. Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT. Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred. J Prev Alzheimers Dis. 2019; 6(2):112-120. PMID: 30756118.
    Citations:    
  29. d'Oleire Uquillas F, Jacobs HIL, Biddle KD, Properzi M, Hanseeuw B, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Regional tau pathology and loneliness in cognitively normal older adults. Transl Psychiatry. 2018 12 18; 8(1):282. PMID: 30563962.
    Citations:    Fields:    
  30. Wolters AF, van de Weijer SCF, Leentjens AFG, Duits AA, Jacobs HIL, Kuijf ML. Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis. Parkinsonism Relat Disord. 2019 05; 62:16-27. PMID: 30580907.
    Citations:    Fields:    
  31. Freeze WM, Jacobs HIL, Schreuder FHBM, van Oostenbrugge RJ, Backes WH, Verhey FR, Klijn CJM. Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage. Front Neurol. 2018; 9:926. PMID: 30483207.
    Citations:    
  32. Sepulcre J, Grothe MJ, d'Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat Med. 2018 12; 24(12):1910-1918. PMID: 30374196.
    Citations:    Fields:    
  33. Jacobs HIL, Buckley RF. Where do white matter alterations dovetail with the cascade model of Alzheimer's disease? Brain. 2018 10 01; 141(10):2830-2833. PMID: 30535117.
    Citations:    Fields:    
  34. Bachmann C, Jacobs HIL, Porta Mana P, Dillen K, Richter N, von Reutern B, Dronse J, Onur OA, Langen KJ, Fink GR, Kukolja J, Morrison A. On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease. Front Neurosci. 2018; 12:528. PMID: 30323734.
    Citations:    
  35. Mayrhofer HC, Duecker F, van de Ven V, Jacobs HIL, Sack AT. Hemifield-specific Correlations between Cue-related Blood Oxygen Level Dependent Activity in Bilateral Nodes of the Dorsal Attention Network and Attentional Benefits in a Spatial Orienting Paradigm. J Cogn Neurosci. 2019 05; 31(5):625-638. PMID: 30240311.
    Citations:    Fields:    
  36. Rienäcker F, Jacobs HIL, Van Heugten CM, Van Gerven PWM. Practice makes perfect: High performance gains in older adults engaged in selective attention within and across sensory modalities. Acta Psychol (Amst). 2018 Nov; 191:101-111. PMID: 30240890.
    Citations:    Fields:    Translation:Humans
  37. Van Hooren RWE, Riphagen JM, Jacobs HIL. Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer's disease: a longitudinal cohort study. Alzheimers Res Ther. 2018 08 28; 10(1):88. PMID: 30153858.
    Citations:    Fields:    
  38. Rosenberg J, Jacobs HIL, Maximov II, Reske M, Shah NJ. Chronotype differences in cortical thickness: grey matter reflects when you go to bed. Brain Struct Funct. 2018 Sep; 223(7):3411-3421. PMID: 29948193.
    Citations:    Fields:    Translation:Humans
  39. Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA. Sex, amyloid, and APOE e4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimers Dement. 2018 09; 14(9):1193-1203. PMID: 29803541.
    Citations:    Fields:    
  40. Jacobs HIL, Müller-Ehrenberg L, Priovoulos N, Roebroeck A. Curvilinear locus coeruleus functional connectivity trajectories over the adult lifespan: a 7T MRI study. Neurobiol Aging. 2018 09; 69:167-176. PMID: 29908415.
    Citations:    Fields:    
  41. Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 10; 14(10):1281-1292. PMID: 29792874.
    Citations: 2     Fields:    
  42. Riphagen JM, Gronenschild EHBM, Salat DH, Freeze WM, Ivanov D, Clerx L, Verhey FRJ, Aalten P, Jacobs HIL. Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia. Neurobiol Aging. 2018 08; 68:48-58. PMID: 29704648.
    Citations:    Fields:    Translation:Humans
  43. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 03; 21(3):424-431. PMID: 29403032.
    Citations: 3     Fields:    
  44. Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS, Schultz AP, Frosch MP, Gómez-Isla T, Sperling RA, Johnson KA. 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. J Alzheimers Dis. 2018; 62(4):1691-1702. PMID: 29614677.
    Citations:    Fields:    
  45. Jacobs HIL, Hopkins DA, Mayrhofer HC, Bruner E, van Leeuwen FW, Raaijmakers W, Schmahmann JD. The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline. Brain. 2018 01 01; 141(1):37-47. PMID: 29053771.
    Citations:    Fields:    
  46. Müller-Ehrenberg L, Riphagen JM, Verhey FRJ, Sack AT, Jacobs HIL. Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. J Alzheimers Dis. 2018; 66(2):811-823. PMID: 30320590.
    Citations:    Fields:    
  47. Bos I, Verhey FR, Ramakers IHGB, Jacobs HIL, Soininen H, Freund-Levi Y, Hampel H, Tsolaki M, Wallin ÅK, van Buchem MA, Oleksik A, Verbeek MM, Olde Rikkert M, van der Flier WM, Scheltens P, Aalten P, Visser PJ, Vos SJB. Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimers Res Ther. 2017 12 29; 9(1):101. PMID: 29284531.
    Citations: 3     Fields:    
  48. d'Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin. 2018; 17:388-396. PMID: 29159051.
    Citations:    Fields:    Translation:Humans
  49. Priovoulos N, Jacobs HIL, Ivanov D, Uludag K, Verhey FRJ, Poser BA. High-resolution in vivo imaging of human locus coeruleus by magnetization transfer MRI at 3T and 7T. Neuroimage. 2018 03; 168:427-436. PMID: 28743460.
    Citations: 2     Fields:    Translation:Humans
  50. Freeze WM, Schnerr RS, Palm WM, Jansen JF, Jacobs HI, Hoff EI, Verhey FR, Backes WH. Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease. AJNR Am J Neuroradiol. 2017 Sep; 38(9):1742-1747. PMID: 28684457.
    Citations: 1     Fields:    Translation:Humans
  51. Dekhtyar M, Papp KV, Buckley R, Jacobs HIL, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia. 2017 06; 100:164-170. PMID: 28472627.
    Citations: 3     Fields:    Translation:Humans
  52. Cleutjens FAHM, Ponds RWHM, Spruit MA, Burgmans S, Jacobs HIL, Gronenschild EHBM, Staals J, Franssen FME, Dijkstra JB, Vanfleteren LEGW, Hofman PA, Wouters EFM, Janssen DJA. The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study. Front Aging Neurosci. 2017; 9:88. PMID: 28424613.
    Citations: 1     
  53. Dillen KNH, Jacobs HIL, Kukolja J, Richter N, von Reutern B, Onur ÖA, Langen KJ, Fink GR. Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease. J Alzheimers Dis. 2017; 59(1):169-187. PMID: 28598839.
    Citations: 4     Fields:    Translation:Humans
  54. Freeze WM, Jacobs HI, Gronenschild EH, Jansen JF, Burgmans S, Aalten P, Clerx L, Vos SJ, van Buchem MA, Barkhof F, van der Flier WM, Verbeek MM, Rikkert MO, Backes WH, Verhey FR. White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-ß. J Alzheimers Dis. 2017; 55(1):333-342. PMID: 27662299.
    Citations: 4     Fields:    Translation:Humans
  55. Dillen KNH, Jacobs HIL, Kukolja J, von Reutern B, Richter N, Onur ÖA, Dronse J, Langen KJ, Fink GR. Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease. Neurobiol Aging. 2016 08; 44:114-126. PMID: 27318139.
    Citations: 5     Fields:    Translation:Humans
  56. Jacobs HI, Riphagen JM, Razat CM, Wiese S, Sack AT. Transcutaneous vagus nerve stimulation boosts associative memory in older individuals. Neurobiol Aging. 2015 May; 36(5):1860-7. PMID: 25805212.
    Citations: 9     Fields:    Translation:Humans
  57. Jacobs HI, Dillen KN, Risius O, Göreci Y, Onur OA, Fink GR, Kukolja J. Consolidation in older adults depends upon competition between resting-state networks. Front Aging Neurosci. 2014; 6:344. PMID: 25620930.
    Citations: 1     
  58. Clerx L, Gronenschild EH, Echavarri C, Verhey F, Aalten P, Jacobs HI. Can FreeSurfer Compete with Manual Volumetric Measurements in Alzheimer's Disease? Curr Alzheimer Res. 2015; 12(4):358-67. PMID: 25817249.
    Citations: 4     Fields:    Translation:Humans
  59. Jacobs HI, Wiese S, van de Ven V, Gronenschild EH, Verhey FR, Matthews PM. Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia. Neurobiol Aging. 2015 Feb; 36(2):618-26. PMID: 25433457.
    Citations: 9     Fields:    Translation:Humans
  60. Lückmann HC, Jacobs HI, Sack AT. The cross-functional role of frontoparietal regions in cognition: internal attention as the overarching mechanism. Prog Neurobiol. 2014 May; 116:66-86. PMID: 24530293.
    Citations: 13     Fields:    Translation:HumansAnimals
  61. Bruner E, Rangel de Lázaro G, de la Cuétara JM, Martín-Loeches M, Colom R, Jacobs HI. Midsagittal brain variation and MRI shape analysis of the precuneus in adult individuals. J Anat. 2014 Apr; 224(4):367-76. PMID: 24397462.
    Citations: 3     Fields:    Translation:Humans
  62. Jacobs HI, Clerx L, Gronenschild EH, Aalten P, Verhey FR. White matter hyperintensities are positively associated with cortical thickness in Alzheimer's disease. J Alzheimers Dis. 2014; 39(2):409-22. PMID: 24169238.
    Citations: 4     Fields:    Translation:HumansCells
  63. Clerx L, Jacobs HI, Burgmans S, Gronenschild EH, Uylings HB, Echávarri C, Visser PJ, Verhey FR, Aalten P. Sensitivity of different MRI-techniques to assess gray matter atrophy patterns in Alzheimer's disease is region-specific. Curr Alzheimer Res. 2013 Nov; 10(9):940-51. PMID: 23947582.
    Citations: 6     Fields:    Translation:HumansCells
  64. Jacobs HI, Radua J, Lückmann HC, Sack AT. Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker. Neurosci Biobehav Rev. 2013 Jun; 37(5):753-65. PMID: 23523750.
    Citations: 26     Fields:    Translation:Humans
  65. Mills JD, Nalpathamkalam T, Jacobs HI, Janitz C, Merico D, Hu P, Janitz M. RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism. Neurosci Lett. 2013 Mar 01; 536:90-5. PMID: 23305720.
    Citations: 17     Fields:    Translation:HumansCells
  66. Bruner E, Jacobs HI. Alzheimer's disease: the downside of a highly evolved parietal lobe? J Alzheimers Dis. 2013; 35(2):227-40. PMID: 23435412.
    Citations: 13     Fields:    Translation:Humans
  67. Jacobs HI, van Boxtel MP, Gronenschild EH, Williams VJ, Burgmans S, Uylings HB, Jolles J, Verhey FR. Patterns of gray and white matter changes in individuals at risk for Alzheimer's disease. Curr Alzheimer Res. 2012 Nov; 9(9):1097-105. PMID: 22920268.
    Citations: 1     Fields:    Translation:Humans
  68. Gronenschild EH, Habets P, Jacobs HI, Mengelers R, Rozendaal N, van Os J, Marcelis M. The effects of FreeSurfer version, workstation type, and Macintosh operating system version on anatomical volume and cortical thickness measurements. PLoS One. 2012; 7(6):e38234. PMID: 22675527.
    Citations: 75     Fields:    Translation:Humans
  69. Jacobs HI, van Boxtel MP, Gronenschild EH, Uylings HB, Jolles J, Verhey FR. Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker? Alzheimers Dement. 2013 Jan; 9(1):93-7. PMID: 22651939.
    Citations: 7     Fields:    Translation:Humans
  70. Jacobs HI, Gronenschild EH, Evers EA, Ramakers IH, Hofman PA, Backes WH, Jolles J, Verhey FR, Van Boxtel MP. Visuospatial processing in early Alzheimer's disease: a multimodal neuroimaging study. Cortex. 2015 Mar; 64:394-406. PMID: 22342463.
    Citations: 6     Fields:    Translation:Humans
  71. Jacobs HI, Van Boxtel MP, Heinecke A, Gronenschild EH, Backes WH, Ramakers IH, Jolles J, Verhey FR. Functional integration of parietal lobe activity in early Alzheimer disease. Neurology. 2012 Jan 31; 78(5):352-60. PMID: 22262753.
    Citations: 12     Fields:    Translation:Humans
  72. Jacobs HI, Leritz EC, Williams VJ, Van Boxtel MP, van der Elst W, Jolles J, Verhey FR, McGlinchey RE, Milberg WP, Salat DH. Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health. Hum Brain Mapp. 2013 Jan; 34(1):77-95. PMID: 21954054.
    Citations: 38     Fields:    Translation:HumansCells
  73. Jacobs HI, Van Boxtel MP, Jolles J, Verhey FR, Uylings HB. Parietal cortex matters in Alzheimer's disease: an overview of structural, functional and metabolic findings. Neurosci Biobehav Rev. 2012 Jan; 36(1):297-309. PMID: 21741401.
    Citations: 36     Fields:    Translation:Humans
  74. Jacobs HI, Van Boxtel MP, van der Elst W, Burgmans S, Smeets F, Gronenschild EH, Verhey FR, Uylings HB, Jolles J. Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease. J Alzheimers Dis. 2011; 25(3):477-90. PMID: 21471642.
    Citations: 2     Fields:    Translation:Humans
  75. Jacobs HI, Van Boxtel MP, Uylings HB, Gronenschild EH, Verhey FR, Jolles J. Atrophy of the parietal lobe in preclinical dementia. Brain Cogn. 2011 Mar; 75(2):154-63. PMID: 21130554.
    Citations: 6     Fields:    Translation:Humans
  76. Echávarri C, Aalten P, Uylings HB, Jacobs HI, Visser PJ, Gronenschild EH, Verhey FR, Burgmans S. Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer's disease. Brain Struct Funct. 2011 Jan; 215(3-4):265-71. PMID: 20957494.
    Citations: 22     Fields:    Translation:Humans
  77. Jacobs HI, Visser PJ, Van Boxtel MP, Frisoni GB, Tsolaki M, Papapostolou P, Nobili F, Wahlund LO, Minthon L, Frölich L, Hampel H, Soininen H, van de Pol L, Scheltens P, Tan FE, Jolles J, Verhey FR. Association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent. Neurobiol Aging. 2012 Jan; 33(1):201.e1-8. PMID: 20739101.
    Citations: 10     Fields:    Translation:Humans
  78. Burgmans S, van Boxtel MP, van den Berg KE, Gronenschild EH, Jacobs HI, Jolles J, Uylings HB. The posterior parahippocampal gyrus is preferentially affected in age-related memory decline. Neurobiol Aging. 2011 Sep; 32(9):1572-8. PMID: 19879667.
    Citations: 10     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.