Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Torsten Klengel, Ph.D., M.D.


Available: 10/16/20, Expires: 10/15/21

This project is a remote only data analysis project on spatial transcriptomics data of the mammalian brain. RNA sequencing of intact tissue offers an avenue to understand gene expression in situ within the morphological context of the brain. The goal of the project is to further develop analytical tools and to understand gene expression in the mammalian brain. We work primarily in mouse tissue, but this project will offer non-human primate and post-mortem brain tissue analyses as well. www.klengellab.com

The role of the student is to work within a larger team on implementing analytical tools, evaluate their performance and interpret results. Experience using R is required, understanding of other environments is desirable including working on Linux systems. The project can be modified to fit the students’ needs and skills. 

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 1 R21 HD097524-01A1 (Klengel, Torsten) Apr 1, 2019 - Mar 31, 2021
    Effects of Stress and Obesity on Longitudinal Epigenetic Programming
    Role: PI
  2. R21HD097524 (KLENGEL, TORSTEN) Apr 1, 2019 - Mar 31, 2021
    Effects of Stress and Obesity on Longitudinal Epigenetic Programming
    Role: Principal Investigator
  3. R21MH117609 (KLENGEL, TORSTEN) Dec 1, 2018 - Nov 30, 2021
    A role for circular RNAs in schizophrenia
    Role: Principal Investigator
  4. 1R21MH117609-01A1 (Klengel, Torsten) Dec 1, 2018 - Nov 30, 2020
    Role: PI
  5. R01MH117292 (RESSLER, KERRY J.) Jul 25, 2018 - Apr 30, 2023
    Site 3/3, Understanding PTSD through Postmortem Targeted Brain Multiomics
    Role: Co-Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pantazopoulos H, Katsel P, Haroutunian V, Chelini G, Klengel T, Berretta S. Molecular signature of extracellular matrix pathology in schizophrenia. Eur J Neurosci. 2020 Oct 18. PMID: 33070392.
    Citations:    Fields:    
  2. Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH, Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 06 02; 31(9):107716. PMID: 32492425.
    Citations: 3     Fields:    
  3. Sillivan SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA. Correction: MicroRNA regulation of persistent stress-enhanced memory. Mol Psychiatry. 2020 May; 25(5):1154. PMID: 31253953.
    Citations: 2     Fields:    
  4. Bierer LM, Bader HN, Daskalakis NP, Lehrner A, Provençal N, Wiechmann T, Klengel T, Makotkine I, Binder EB, Yehuda R. Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation. Am J Psychiatry. 2020 08 01; 177(8):744-753. PMID: 32312110.
    Citations: 2     Fields:    Translation:HumansCells
  5. McEwen LM, O'Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS. The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23329-23335. PMID: 31611402.
    Citations: 12     Fields:    Translation:HumansCells
  6. Nievergelt CM, Maihofer AX, Klengel T, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Dalvie S, Duncan LE, Gelernter J, Levey DF, Logue MW, Polimanti R, Provost AC, Ratanatharathorn A, Stein MB, Torres K, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Babic D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Børglum AD, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Dale AM, Daly MJ, Daskalakis NP, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Dzubur-Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Geuze E, Gillespie C, Uka AG, Gordon SD, Guffanti G, Hammamieh R, Harnal S, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Junglen AG, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis CE, Linnstaedt SD, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller J, Marmar C, Martin AR, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, McLeay S, Mehta D, Milberg WP, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Neale BM, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Ripke S, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero K, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Wolff JD, Yehuda R, Young RM, Young KA, Zhao H, Zoellner LA, Liberzon I, Ressler KJ, Haas M, Koenen KC. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nat Commun. 2019 10 08; 10(1):4558. PMID: 31594949.
    Citations: 26     Fields:    Translation:Humans
  7. Provençal N, Arloth J, Cattaneo A, Anacker C, Cattane N, Wiechmann T, Röh S, Ködel M, Klengel T, Czamara D, Müller NS, Lahti J, Räikkönen K, Pariante CM, Binder EB. Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23280-23285. PMID: 31399550.
    Citations: 13     Fields:    Translation:HumansCells
  8. Sillivan SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA. MicroRNA regulation of persistent stress-enhanced memory. Mol Psychiatry. 2020 05; 25(5):965-976. PMID: 31142820.
    Citations: 6     Fields:    
  9. Dunn EC, Soare TW, Zhu Y, Simpkin AJ, Suderman MJ, Klengel T, Smith ADAC, Ressler KJ, Relton CL. Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study. Biol Psychiatry. 2019 05 15; 85(10):838-849. PMID: 30905381.
    Citations: 19     Fields:    Translation:HumansCells
  10. Klengel T. A Potential Role for the Noncoding Transcriptome in Psychiatric Disorders. Harv Rev Psychiatry. 2018 Nov/Dec; 26(6):364-373. PMID: 30407235.
    Citations: 1     Fields:    Translation:HumansCells
  11. Guffanti G, Bartlett A, Klengel T, Klengel C, Hunter R, Glinsky G, Macciardi F. Novel Bioinformatics Approach Identifies Transcriptional Profiles of Lineage-Specific Transposable Elements at Distinct Loci in the Human Dorsolateral Prefrontal Cortex. Mol Biol Evol. 2018 10 01; 35(10):2435-2453. PMID: 30053206.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Kennedy EM, Goehring GN, Nichols MH, Robins C, Mehta D, Klengel T, Eskin E, Smith AK, Conneely KN. An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells. BMC Genomics. 2018 Jun 19; 19(1):476. PMID: 29914364.
    Citations: 9     Fields:    Translation:HumansCells
  13. Teicher MH, Ohashi K, Khan A, Hernandez Garcia LC, Klengel T, Anderson CM, Silveri MM. Does sleep disruption mediate the effects of childhood maltreatment on brain structure? Eur J Psychotraumatol. 2017; 8(Suppl 7):1450594. PMID: 29844885.
    Citations: 3     
  14. Jovanovic T, Vance LA, Cross D, Knight AK, Kilaru V, Michopoulos V, Klengel T, Smith AK. Exposure to Violence Accelerates Epigenetic Aging in Children. Sci Rep. 2017 08 21; 7(1):8962. PMID: 28827677.
    Citations: 18     Fields:    Translation:HumansCells
  15. Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016 Oct; 9(5):436-447. PMID: 27651444.
    Citations: 185     Fields:    Translation:HumansCells
  16. Guffanti G, Gaudi S, Klengel T, Fallon JH, Mangalam H, Madduri R, Rodriguez A, DeCrescenzo P, Glovienka E, Sobell J, Klengel C, Pato M, Ressler KJ, Pato C, Macciardi F. LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family. . 2016 06; 171(4):534-45. PMID: 26990047.
    Citations: 8     Translation:HumansCells
  17. Wingo AP, Almli LM, Stevens JS, Klengel T, Uddin M, Li Y, Bustamante AC, Lori A, Koen N, Stein DJ, Smith AK, Aiello AE, Koenen KC, Wildman DE, Galea S, Bradley B, Binder EB, Jin P, Gibson G, Ressler KJ. Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression. Nat Commun. 2016 Mar 03; 7:10958. PMID: 26936533.
    Citations: 1     Fields:    
  18. Wingo AP, Almli LM, Stevens JS, Stevens JJ, Klengel T, Uddin M, Li Y, Bustamante AC, Lori A, Koen N, Stein DJ, Smith AK, Aiello AE, Koenen KC, Wildman DE, Galea S, Bradley B, Binder EB, Jin P, Gibson G, Ressler KJ. DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression. Nat Commun. 2015 Dec 03; 6:10106. PMID: 26632874.
    Citations: 23     Fields:    Translation:HumansCells
  19. Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD. The transcriptional landscape of age in human peripheral blood. Nat Commun. 2015 Oct 22; 6:8570. PMID: 26490707.
    Citations: 148     Fields:    Translation:HumansCells
  20. Kaminsky Z, Wilcox HC, Eaton WW, Van Eck K, Kilaru V, Jovanovic T, Klengel T, Bradley B, Binder EB, Ressler KJ, Smith AK. Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder. Transl Psychiatry. 2015 Aug 25; 5:e627. PMID: 26305478.
    Citations: 33     Fields:    Translation:Humans
  21. Klengel T, Dias BG, Ressler KJ. Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice. Neuropsychopharmacology. 2016 Jan; 41(1):219-31. PMID: 26283147.
    Citations: 22     Fields:    Translation:HumansAnimals
  22. Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biol Psychiatry. 2016 09 01; 80(5):372-80. PMID: 26410355.
    Citations: 109     Fields:    Translation:HumansCells
  23. Sawamura T, Klengel T, Armario A, Jovanovic T, Norrholm SD, Ressler KJ, Andero R. Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala. Neuropsychopharmacology. 2016 Feb; 41(3):832-46. PMID: 26174596.
    Citations: 20     Fields:    Translation:Animals
  24. Klengel T, Binder EB. Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions. Neuron. 2015 Jun 17; 86(6):1343-57. PMID: 26087162.
    Citations: 60     Fields:    Translation:Humans
  25. Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED, Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron. 2015 Jun 03; 86(5):1189-202. PMID: 26050039.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  26. Hennings JM, Uhr M, Klengel T, Weber P, Pütz B, Touma C, Czamara D, Ising M, Holsboer F, Lucae S. RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response. Transl Psychiatry. 2015 Mar 31; 5:e538. PMID: 25826113.
    Citations: 13     Fields:    Translation:HumansAnimals
  27. Klengel T, Binder EB. FKBP5 allele-specific epigenetic modification in gene by environment interaction. Neuropsychopharmacology. 2015 Jan; 40(1):244-6. PMID: 25482174.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  28. Dias BG, Maddox S, Klengel T, Ressler KJ. Epigenetic mechanisms underlying learning and the inheritance of learned behaviors. Trends Neurosci. 2015 Feb; 38(2):96-107. PMID: 25544352.
    Citations: 30     Fields:    Translation:HumansAnimals
  29. Hennings JM, Ising M, Klengel T, Knop M, Rosenhagen MC. Hypothalamic-pituitary-adrenocortical axis activity as a potential predictor for withdrawal symptoms in addiction to flupirtine, a nonopiate analgesic. J Clin Psychopharmacol. 2014 Dec; 34(6):e6-8. PMID: 24633005.
    Citations:    Fields:    Translation:Humans
  30. Smith AK, Kilaru V, Klengel T, Mercer KB, Bradley B, Conneely KN, Ressler KJ, Binder EB. DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain. . 2015 Jan; 168B(1):36-44. PMID: 25355443.
    Citations: 101     Translation:HumansCells
  31. Sabbagh JJ, O'Leary JC, Blair LJ, Klengel T, Nordhues BA, Fontaine SN, Binder EB, Dickey CA. Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. PLoS One. 2014; 9(9):e107241. PMID: 25191701.
    Citations: 18     Fields:    Translation:AnimalsCells
  32. Barfield RT, Almli LM, Kilaru V, Smith AK, Mercer KB, Duncan R, Klengel T, Mehta D, Binder EB, Epstein MP, Ressler KJ, Conneely KN. Accounting for population stratification in DNA methylation studies. Genet Epidemiol. 2014 Apr; 38(3):231-41. PMID: 24478250.
    Citations: 78     Fields:    Translation:HumansCells
  33. Klengel T, Pape J, Binder EB, Mehta D. The role of DNA methylation in stress-related psychiatric disorders. Neuropharmacology. 2014 May; 80:115-32. PMID: 24452011.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  34. Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J Clin Invest. 2013 Oct; 123(10):4158-69. PMID: 23999428.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  35. Hennings JM, Kohli MA, Czamara D, Giese M, Eckert A, Wolf C, Heck A, Domschke K, Arolt V, Baune BT, Horstmann S, Brückl T, Klengel T, Menke A, Müller-Myhsok B, Ising M, Uhr M, Lucae S. Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approach. PLoS One. 2013; 8(6):e64947. PMID: 23750220.
    Citations: 4     Fields:    Translation:Humans
  36. Sun YV, Smith AK, Conneely KN, Chang Q, Li W, Lazarus A, Smith JA, Almli LM, Binder EB, Klengel T, Cross D, Turner ST, Ressler KJ, Kardia SL. Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. Hum Genet. 2013 Sep; 132(9):1027-37. PMID: 23657504.
    Citations: 77     Fields:    Translation:HumansCells
  37. Mehta D, Klengel T, Conneely KN, Smith AK, Altmann A, Pace TW, Rex-Haffner M, Loeschner A, Gonik M, Mercer KB, Bradley B, Müller-Myhsok B, Ressler KJ, Binder EB. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8302-7. PMID: 23630272.
    Citations: 139     Fields:    Translation:HumansCells
  38. Norrholm SD, Jovanovic T, Smith AK, Binder E, Klengel T, Conneely K, Mercer KB, Davis JS, Kerley K, Winkler J, Gillespie CF, Bradley B, Ressler KJ. Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder. Front Behav Neurosci. 2013; 7:30. PMID: 23596403.
    Citations: 42     
  39. Klengel T, Binder EB. Allele-specific epigenetic modification: a molecular mechanism for gene-environment interactions in stress-related psychiatric disorders? Epigenomics. 2013 Apr; 5(2):109-12. PMID: 23566086.
    Citations: 18     Fields:    Translation:HumansCells
  40. Menke A, Klengel T, Rubel J, Brückl T, Pfister H, Lucae S, Uhr M, Holsboer F, Binder EB. Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. Genes Brain Behav. 2013 Apr; 12(3):289-96. PMID: 23406438.
    Citations: 54     Fields:    Translation:HumansCells
  41. Klengel T, Binder EB. Gene-environment interactions in major depressive disorder. Can J Psychiatry. 2013 Feb; 58(2):76-83. PMID: 23442893.
    Citations: 32     Fields:    Translation:HumansPHPublic Health
  42. Klengel T, Binder EB. Gene × environment interactions in the prediction of response to antidepressant treatment. Int J Neuropsychopharmacol. 2013 Apr; 16(3):701-11. PMID: 23237009.
    Citations: 8     Fields:    Translation:HumansAnimals
  43. Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, Binder EB. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci. 2013 Jan; 16(1):33-41. PMID: 23201972.
    Citations: 409     Fields:    Translation:HumansCells
  44. Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, Uhr M, Dose T, Unschuld PG, Zihl J, Binder E, Müller-Myhsok B, Holsboer F, Lucae S. Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels. Eur Neuropsychopharmacol. 2013 Jul; 23(7):653-62. PMID: 23026132.
    Citations: 10     Fields:    Translation:Humans
  45. Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Neuropsychopharmacology. 2012 May; 37(6):1455-64. PMID: 22237309.
    Citations: 58     Fields:    Translation:Humans
  46. Menke A, Rex-Haffner M, Klengel T, Binder EB, Mehta D. Peripheral blood gene expression: it all boils down to the RNA collection tubes. BMC Res Notes. 2012 Jan 04; 5:1. PMID: 22214347.
    Citations: 13     Fields:    
  47. Menke A, Klengel T, Binder EB. Epigenetics, depression and antidepressant treatment. Curr Pharm Des. 2012; 18(36):5879-89. PMID: 22681167.
    Citations: 20     Fields:    Translation:HumansAnimals
  48. Menke A, Domschke K, Czamara D, Klengel T, Hennings J, Lucae S, Baune BT, Arolt V, Müller-Myhsok B, Holsboer F, Binder EB. Genome-wide association study of antidepressant treatment-emergent suicidal ideation. Neuropsychopharmacology. 2012 Feb; 37(3):797-807. PMID: 22030708.
    Citations: 23     Fields:    Translation:Humans
  49. Klengel T, Heck A, Pfister H, Brückl T, Hennings JM, Menke A, Czamara D, Müller-Myhsok B, Ising M. Somatization in major depression--clinical features and genetic associations. Acta Psychiatr Scand. 2011 Oct; 124(4):317-28. PMID: 21838737.
    Citations: 3     Fields:    Translation:Humans
  50. Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB. Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. Arch Gen Psychiatry. 2011 Sep; 68(9):901-10. PMID: 21536970.
    Citations: 74     Fields:    Translation:Humans
  51. Klengel T, Binder EB. Using gene-environment interactions to target personalized treatment in mood disorder. Per Med. 2011 Jan; 8(1):23-34. PMID: 29768787.
    Citations:    Fields:    
  52. Mogensen EG, Janbon G, Chaloupka J, Steegborn C, Fu MS, Moyrand F, Klengel T, Pearson DS, Geeves MA, Buck J, Levin LR, Mühlschlegel FA. Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryot Cell. 2006 Jan; 5(1):103-11. PMID: 16400172.
    Citations: 50     Fields:    Translation:AnimalsCells
  53. Klengel T, Liang WJ, Chaloupka J, Ruoff C, Schröppel K, Naglik JR, Eckert SE, Mogensen EG, Haynes K, Tuite MF, Levin LR, Buck J, Mühlschlegel FA. Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol. 2005 Nov 22; 15(22):2021-6. PMID: 16303561.
    Citations: 138     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.