Harvard Catalyst Profiles

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Philip Arthur Cole, M.D.,Ph.D.

Concepts

This page shows the publications Philip Cole has written about p300-CBP Transcription Factors.
Connection Strength

6.196
  1. Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP. Biochemistry. 2019 04 23; 58(16):2133-2143.
    View in: PubMed
    Score: 0.746
  2. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112. Biochemistry. 2016 07 12; 55(27):3727-34.
    View in: PubMed
    Score: 0.615
  3. Protein lysine acetylation by p300/CBP. Chem Rev. 2015 Mar 25; 115(6):2419-52.
    View in: PubMed
    Score: 0.556
  4. Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Chembiochem. 2012 Sep 24; 13(14):2113-21.
    View in: PubMed
    Score: 0.472
  5. Probing the reaction coordinate of the p300/CBP histone acetyltransferase with bisubstrate analogs. Bioorg Chem. 2011 Feb; 39(1):42-7.
    View in: PubMed
    Score: 0.415
  6. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28; 17(5):471-82.
    View in: PubMed
    Score: 0.403
  7. Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis. J Am Chem Soc. 2010 Feb 03; 132(4):1222-3.
    View in: PubMed
    Score: 0.395
  8. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 2008 Feb 14; 451(7180):846-50.
    View in: PubMed
    Score: 0.344
  9. Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome. Cell. 2018 06 28; 174(1):231-244.e12.
    View in: PubMed
    Score: 0.175
  10. CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell. 2017 Nov 02; 68(3):491-503.e5.
    View in: PubMed
    Score: 0.168
  11. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2017 10 05; 550(7674):128-132.
    View in: PubMed
    Score: 0.168
  12. Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues. Biochemistry. 2014 Jun 03; 53(21):3415-22.
    View in: PubMed
    Score: 0.133
  13. Inhibition of p300 impairs Foxp3? T regulatory cell function and promotes antitumor immunity. Nat Med. 2013 Sep; 19(9):1173-7.
    View in: PubMed
    Score: 0.126
  14. Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells. J Invest Dermatol. 2013 Oct; 133(10):2444-2452.
    View in: PubMed
    Score: 0.123
  15. p300/CBP-associated factor selectively regulates the extinction of conditioned fear. J Neurosci. 2012 Aug 29; 32(35):11930-41.
    View in: PubMed
    Score: 0.118
  16. Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines. . 2011 Sep; 10(9):1644-55.
    View in: PubMed
    Score: 0.109
  17. Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. J Neurosci. 2011 May 18; 31(20):7486-91.
    View in: PubMed
    Score: 0.108
  18. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7814-9.
    View in: PubMed
    Score: 0.107
  19. The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. Nucleic Acids Res. 2009 May; 37(9):2996-3006.
    View in: PubMed
    Score: 0.093
  20. Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr Opin Struct Biol. 2008 Dec; 18(6):741-7.
    View in: PubMed
    Score: 0.090
  21. Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat Struct Mol Biol. 2008 Jul; 15(7):738-45.
    View in: PubMed
    Score: 0.088
  22. TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):14917-22.
    View in: PubMed
    Score: 0.084
  23. Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry. 2007 Jul 17; 46(28):8207-16.
    View in: PubMed
    Score: 0.082
  24. A selective chemical probe for coenzyme A-requiring enzymes. Angew Chem Int Ed Engl. 2007; 46(40):7621-4.
    View in: PubMed
    Score: 0.080
  25. Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J Biol Chem. 2006 Dec 29; 281(52):40292-301.
    View in: PubMed
    Score: 0.079
  26. Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase. Biochemistry. 2005 Aug 09; 44(31):10501-9.
    View in: PubMed
    Score: 0.072
  27. Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors. Bioorg Med Chem. 2004 Jun 15; 12(12):3383-90.
    View in: PubMed
    Score: 0.067
  28. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24.
    View in: PubMed
    Score: 0.032
  29. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science. 2011 May 20; 332(6032):963-6.
    View in: PubMed
    Score: 0.027
  30. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23; 67(6):953-66.
    View in: PubMed
    Score: 0.026
  31. p300/CBP-associated factor drives DEK into interchromatin granule clusters. J Biol Chem. 2005 Sep 09; 280(36):31760-7.
    View in: PubMed
    Score: 0.018
  32. Structural analysis of a highly acetylated protein using a curved-field reflectron mass spectrometer. Proteomics. 2005 Jun; 5(9):2288-96.
    View in: PubMed
    Score: 0.018
  33. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell. 2003 Jul; 12(1):167-76.
    View in: PubMed
    Score: 0.016
  34. Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes. Cancer Res. 2002 Nov 01; 62(21):6231-9.
    View in: PubMed
    Score: 0.015
  35. Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14065-70.
    View in: PubMed
    Score: 0.015
  36. Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms. Cancer Res. 2002 May 01; 62(9):2522-30.
    View in: PubMed
    Score: 0.014
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.