Harvard Catalyst Profiles

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Philip Arthur Cole, M.D.,Ph.D.

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Title
Institution
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R13CA239234 (COLE, PHILIP A) Jul 1, 2019 - Jun 30, 2020
    NIH
    FASEB SRC on Reversible Acetylation in Health and Disease
    Role: Principal Investigator
  2. R01DK118266 (ZHAO, YINGMING) Jul 1, 2018 - Jun 30, 2022
    NIH
    Biochemistry of the lysine beta-hydroxybutyrylation pathway
    Role: Co-Principal Investigator
  3. R01GM099092 (LEAHY, DANIEL J) Mar 1, 2012 - Jan 31, 2017
    NIH
    Mechanistic Studies of EGFR/ErbB Receptor Tyrosine Kinases
    Role: Co-Principal Investigator
  4. R24DK093434 (COLE, PHILIP A) Sep 15, 2011 - Aug 31, 2013
    NIH
    Development and Application of Ghrelin O-acyltransferase Inhibitors
    Role: Principal Investigator
  5. R01AG019186 (COLE, PHILIP A) Apr 1, 2001 - Mar 31, 2010
    NIH
    Serotonin N-acethyltransferase Regulation &Inhibition
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, Cole PA, Elledge SJ. A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. Mol Cell. 2023 01 05; 83(1):57-73.e9. PMID: 36608670; PMCID: PMC9908011.
    Citations:    Fields:    Translation:AnimalsCells
  2. Whedon SD, Cole PA. KATs off: Biomedical insights from lysine acetyltransferase inhibitors. Curr Opin Chem Biol. 2023 Feb; 72:102255. PMID: 36584580; PMCID: PMC9870960.
    Citations:    Fields:    Translation:HumansCells
  3. Bae H, Viennet T, Park E, Chu N, Salguero A, Eck MJ, Arthanari H, Cole PA. PH domain-mediated autoinhibition and oncogenic activation of Akt. Elife. 2022 08 15; 11. PMID: 35968932; PMCID: PMC9417420.
    Citations:    Fields:    Translation:Cells
  4. Lee K, Whedon SD, Wang ZA, Cole PA. Distinct biochemical properties of the class I histone deacetylase complexes. Curr Opin Chem Biol. 2022 10; 70:102179. PMID: 35803024.
    Citations:    Fields:    
  5. Jiang H, Chiang CY, Chen Z, Nathan S, D'Agostino G, Paulo JA, Song G, Zhu H, Gabelli SB, Cole PA. Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates. J Biol Chem. 2022 05; 298(5):101854. PMID: 35331737; PMCID: PMC9034101.
    Citations:    Fields:    Translation:HumansCells
  6. Wang ZA, Whedon SD, Wu M, Wang S, Brown EA, Anmangandla A, Regan L, Lee K, Du J, Hong JY, Fairall L, Kay T, Lin H, Zhao Y, Schwabe JWR, Cole PA. Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase. J Am Chem Soc. 2022 03 02; 144(8):3360-3364. PMID: 35175758; PMCID: PMC8895396.
    Citations: 1     Fields:    Translation:Cells
  7. Salguero AL, Chen M, Balana AT, Chu N, Jiang H, Palanski BA, Bae H, Wright KM, Nathan S, Zhu H, Gabelli SB, Pratt MR, Cole PA. Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications. ACS Chem Biol. 2022 01 21; 17(1):68-76. PMID: 34941261; PMCID: PMC8864695.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Pujari SS, Wu M, Thomforde J, Wang ZA, Chao C, Olson NM, Erber L, Pomerantz WCK, Cole P, Tretyakova NY. Site-Specific 5-Formyl Cytosine Mediated DNA-Histone Cross-Links: Synthesis and Polymerase Bypass by Human DNA Polymerase ?. Angew Chem Int Ed Engl. 2021 12 13; 60(51):26489-26494. PMID: 34634172; PMCID: PMC8775767.
    Citations: 2     Fields:    Translation:HumansCells
  9. Dempsey DR, Viennet T, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA. The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 2021 10; 28(10):858-868. PMID: 34625746; PMCID: PMC8549118.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Man N, Mas G, Karl DL, Sun J, Liu F, Yang Q, Torres-Martin M, Itonaga H, Martinez C, Chen S, Xu Y, Duffort S, Hamard PJ, Chen C, Zucconi BE, Cimmino L, Yang FC, Xu M, Cole PA, Figueroa ME, Nimer SD. p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia. JCI Insight. 2021 10 08; 6(19). PMID: 34622806; PMCID: PMC8525640.
    Citations:    Fields:    Translation:AnimalsCells
  11. Min D, Byun J, Lee EJ, Khan AA, Liu C, Loudig O, Hu W, Zhao Y, Herlyn M, Tycko B, Cole PA, Ryu B. Epigenetic Silencing of BMP6 by the SIN3A-HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1. Mol Cancer Res. 2022 02; 20(2):217-230. PMID: 34610961; PMCID: PMC9744461.
    Citations:    Fields:    Translation:HumansAnimals
  12. Shiota H, Alekseyenko AA, Wang ZA, Filic I, Knox TM, Luong NM, Huang Y, Scott DA, Jones KL, Gokhale PC, Lemieux ME, Cole PA, Kuroda MI, French CA. Chemical Screen Identifies Diverse and Novel Histone Deacetylase Inhibitors as Repressors of NUT Function: Implications for NUT Carcinoma Pathogenesis and Treatment. Mol Cancer Res. 2021 11; 19(11):1818-1830. PMID: 34285087; PMCID: PMC8568634.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Aufhauser DD, Hernandez P, Concors SJ, O'Brien C, Wang Z, Murken DR, Samanta A, Beier UH, Krumeich L, Bhatti TR, Wang Y, Ge G, Wang L, Cheraghlou S, Wagner FF, Holson EB, Kalin JH, Cole PA, Hancock WW, Levine MH. HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury. Sci Rep. 2021 04 27; 11(1):9018. PMID: 33907245; PMCID: PMC8079686.
    Citations: 4     Fields:    Translation:Animals
  14. Huang H, Zhang D, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y. The regulatory enzymes and protein substrates for the lysine ß-hydroxybutyrylation pathway. Sci Adv. 2021 02; 7(9). PMID: 33627428; PMCID: PMC7904266.
    Citations: 18     Fields:    Translation:AnimalsCells
  15. Ji Z, Clark RF, Bhat V, Matthew Hansen T, Lasko LM, Bromberg KD, Manaves V, Algire M, Martin R, Qiu W, Torrent M, Jakob CG, Liu H, Cole PA, Marmorstein R, Kesicki EA, Lai A, Michaelides MR. Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases. Bioorg Med Chem Lett. 2021 05 01; 39:127854. PMID: 33631370.
    Citations: 4     Fields:    Translation:HumansCells
  16. Jiang H, Dempsey DR, Cole PA. Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S. Biochemistry. 2021 02 09; 60(5):357-364. PMID: 33470109; PMCID: PMC8262107.
    Citations: 4     Fields:    Translation:HumansCells
  17. Jiang H, Cole PA. N-Terminal Protein Labeling with N-Hydroxysuccinimide Esters and Microscale Thermophoresis Measurements of Protein-Protein Interactions Using Labeled Protein. Curr Protoc. 2021 Jan; 1(1):e14. PMID: 33484499; PMCID: PMC7839251.
    Citations: 4     Fields:    Translation:Cells
  18. Akinci E, Cha M, Lin L, Yeo G, Hamilton MC, Donahue CJ, Bermudez-Cabrera HC, Zanetti LC, Chen M, Barkal SA, Khowpinitchai B, Chu N, Velimirovic M, Jodhani R, Fife JD, Sovrovic M, Cole PA, Davey RA, Cassa CA, Sherwood RI. Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics. bioRxiv. 2020 Aug 28. PMID: 32869031; PMCID: PMC7457617.
    Citations:    
  19. Chu N, Viennet T, Bae H, Salguero A, Boeszoermenyi A, Arthanari H, Cole PA. The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling. Elife. 2020 08 03; 9. PMID: 32744507.
    Citations: 13     Fields:    Translation:HumansCells
  20. Wang ZA, Cole PA. The Chemical Biology of Reversible Lysine Post-translational Modifications. Cell Chem Biol. 2020 08 20; 27(8):953-969. PMID: 32698016.
    Citations: 12     Fields:    Translation:Cells
  21. Hsu JW, Bai M, Li K, Yang JS, Chu N, Cole PA, Eck MJ, Li J, Hsu VW. The protein kinase Akt acts as a coat adaptor in endocytic recycling. Nat Cell Biol. 2020 08; 22(8):927-933. PMID: 32541877.
    Citations: 4     Fields:    Translation:HumansCells
  22. Wang ZA, Millard CJ, Lin CL, Gurnett JE, Wu M, Lee K, Fairall L, Schwabe JW, Cole PA. Diverse nucleosome Site-Selectivity among histone deacetylase complexes. Elife. 2020 06 05; 9. PMID: 32501215.
    Citations: 11     Fields:    Translation:HumansCells
  23. Morrison-Smith CD, Knox TM, Filic I, Soroko KM, Eschle BK, Wilkens MK, Gokhale PC, Giles F, Griffin A, Brown B, Shapiro GI, Zucconi BE, Cole PA, Lemieux ME, French CA. Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734. Mol Cancer Ther. 2020 07; 19(7):1406-1414. PMID: 32371576.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  24. Jiang H, D'Agostino GD, Cole PA, Dempsey DR. Selective protein N-terminal labeling with N-hydroxysuccinimide esters. Methods Enzymol. 2020; 639:333-353. PMID: 32475408.
    Citations: 1     Fields:    
  25. Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW. Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity. J Clin Invest. 2020 04 01; 130(4):1830-1842. PMID: 31917688; PMCID: PMC7108912.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  26. Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR. Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex. Cell Rep. 2020 02 25; 30(8):2699-2711.e8. PMID: 32101746; PMCID: PMC7043024.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  27. Wang ZA, Cole PA. Methods and Applications of Expressed Protein Ligation. Methods Mol Biol. 2020; 2133:1-13. PMID: 32144660.
    Citations: 2     Fields:    Translation:Cells
  28. Miller SA, Policastro RA, Savant SS, Sriramkumar S, Ding N, Lu X, Mohammad HP, Cao S, Kalin JH, Cole PA, Zentner GE, O'Hagan HM. Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer. Mol Cancer Res. 2020 02; 18(2):264-277. PMID: 31704733; PMCID: PMC7002231.
    Citations: 8     Fields:    Translation:HumansCells
  29. Cole PA, Mattevi A. Editorial overview: Biological catalysis at the cross-roads of signaling and metabolism. Curr Opin Struct Biol. 2019 12; 59:iii-v. PMID: 31653360.
    Citations:    Fields:    Translation:Cells
  30. Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y. Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10. PMID: 31631026.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  31. Jiang H, Thomas SN, Chen Z, Chiang CY, Cole PA. Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases. J Biol Chem. 2019 11 15; 294(46):17421-17436. PMID: 31578285.
    Citations: 11     Fields:    Translation:HumansCells
  32. Henager SH, Henriquez S, Dempsey DR, Cole PA. Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation. Chembiochem. 2020 01 15; 21(1-2):64-68. PMID: 31206229.
    Citations: 6     Fields:    Translation:HumansCells
  33. Van de Velde S, Wiater E, Tran M, Hwang Y, Cole PA, Montminy M. CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers. Mol Cell Biol. 2019 09 01; 39(17). PMID: 31182641; PMCID: PMC6692124.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Grimes AD, Cole PA, Grimes WR. Evaluation of a High-risk Patient Reminder System for Colonoscopy Surveillance. Am J Health Behav. 2019 07 01; 43(4):671-679. PMID: 31239011.
    Citations: 1     Fields:    Translation:Humans
  35. Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW. Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells. Cancers (Basel). 2019 Apr 18; 11(4). PMID: 31003455; PMCID: PMC6520961.
    Citations: 6     
  36. Zucconi BE, Makofske JL, Meyers DJ, Hwang Y, Wu M, Kuroda MI, Cole PA. Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP. Biochemistry. 2019 04 23; 58(16):2133-2143. PMID: 30924641; PMCID: PMC6948846.
    Citations: 11     Fields:    Translation:HumansCells
  37. Kim E, Zucconi BE, Wu M, Nocco SE, Meyers DJ, McGee JS, Venkatesh S, Cohen DL, Gonzalez EC, Ryu B, Cole PA, Alani RM. MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma. Cancer Res. 2019 05 15; 79(10):2649-2661. PMID: 30910803; PMCID: PMC6522293.
    Citations: 14     Fields:    Translation:HumansCells
  38. Cole PA, Chu N, Salguero AL, Bae H. AKTivation mechanisms. Curr Opin Struct Biol. 2019 12; 59:47-53. PMID: 30901610.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  39. Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA, Dinkova-Kostova AT. Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. PLoS One. 2019; 14(3):e0213095. PMID: 30865688.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  40. Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB. Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II. Molecules. 2019 Jan 30; 24(3). PMID: 30704096.
    Citations: 7     Fields:    Translation:Cells
  41. Weiser BP, Rodriguez G, Cole PA, Stivers JT. N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions. Nucleic Acids Res. 2018 08 21; 46(14):7169-7178. PMID: 29917162; PMCID: PMC6101581.
    Citations: 10     Fields:    Translation:HumansCells
  42. Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018 08 09; 174(4):897-907.e14. PMID: 30078705.
    Citations: 46     Fields:    Translation:HumansCells
  43. Bhat S, Hwang Y, Gibson MD, Morgan MT, Taverna SD, Zhao Y, Wolberger C, Poirier MG, Cole PA. Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action. J Am Chem Soc. 2018 08 01; 140(30):9478-9485. PMID: 29991262; PMCID: PMC6070418.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  44. Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA. Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms. J Am Chem Soc. 2018 08 01; 140(30):9374-9378. PMID: 30016585; PMCID: PMC6093203.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  45. Dempsey DR, Cole PA. Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation. Methods Enzymol. 2018; 607:405-422. PMID: 30149868; PMCID: PMC6231048.
    Citations: 3     Fields:    Translation:AnimalsCells
  46. Tipton P, Su T, Hannink M. Assembly of PGAM5 into Multimeric Complexes Provides a Mechanism for Allosteric Regulation of Phosphatase Activity. Methods Enzymol. 2018; 607:353-372. PMID: 30149865.
    Citations: 1     Fields:    Translation:Cells
  47. Wu M, Hayward D, Kalin JH, Song Y, Schwabe JW, Cole PA. Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex. Elife. 2018 06 05; 7. PMID: 29869982.
    Citations: 22     Fields:    Translation:HumansCells
  48. Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Kluge AF, Patane MA, Van Drie JH, Wang C, McElligott D, Kesicki EA, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD. Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2018 06; 558(7710):E1. PMID: 29769713.
    Citations: 1     Fields:    
  49. Weinert BT, Narita T, Satpathy S, Srinivasan B, Hansen BK, Schölz C, Hamilton WB, Zucconi BE, Wang WW, Liu WR, Brickman JM, Kesicki EA, Lai A, Bromberg KD, Cole PA, Choudhary C. Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome. Cell. 2018 06 28; 174(1):231-244.e12. PMID: 29804834.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  50. Wang Z, Kim MS, Martinez-Ferrando I, Koleske AJ, Pandey A, Cole PA. Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry. 2018 02 27; 57(8):1390-1398. PMID: 29341593.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  51. Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 01 04; 9(1):53. PMID: 29302039; PMCID: PMC5754352.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  52. Michaelides MR, Kluge A, Patane M, Van Drie JH, Wang C, Hansen TM, Risi RM, Mantei R, Hertel C, Karukurichi K, Nesterov A, McElligott D, de Vries P, Langston JW, Cole PA, Marmorstein R, Liu H, Lasko L, Bromberg KD, Lai A, Kesicki EA. Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases. ACS Med Chem Lett. 2018 Jan 11; 9(1):28-33. PMID: 29348807.
    Citations: 17     
  53. Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT. Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells. Nucleic Acids Res. 2017 Dec 01; 45(21):12413-12424. PMID: 29036472; PMCID: PMC5716149.
    Citations: 13     Fields:    Translation:HumansCells
  54. Boija A, Mahat DB, Zare A, Holmqvist PH, Philip P, Meyers DJ, Cole PA, Lis JT, Stenberg P, Mannervik M. CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell. 2017 Nov 02; 68(3):491-503.e5. PMID: 29056321; PMCID: PMC5826544.
    Citations: 27     Fields:    Translation:AnimalsCells
  55. Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Van Drie JH, McElligott D, Kesicki E, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2017 10 05; 550(7674):128-132. PMID: 28953875.
    Citations: 208     Fields:    Translation:HumansAnimalsCells
  56. Rodriguez G, Esadze A, Weiser BP, Schonhoft JD, Cole PA, Stivers JT. Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation. ACS Chem Biol. 2017 09 15; 12(9):2260-2263. PMID: 28787572; PMCID: PMC5600714.
    Citations: 9     Fields:    Translation:HumansCells
  57. Weiser BP, Stivers JT, Cole PA. Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis. Biophys J. 2017 Jul 25; 113(2):393-401. PMID: 28746850; PMCID: PMC5529330.
    Citations: 16     Fields:    Translation:HumansCells
  58. Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nat Commun. 2017 07 25; 8(1):131. PMID: 28743992; PMCID: PMC5526866.
    Citations: 27     Fields:    Translation:AnimalsCells
  59. Zucconi BE, Cole PA. Allosteric regulation of epigenetic modifying enzymes. Curr Opin Chem Biol. 2017 Aug; 39:109-115. PMID: 28689145; PMCID: PMC5675028.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  60. Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Mol Cell. 2017 May 04; 66(3):345-357.e6. PMID: 28475870; PMCID: PMC5489419.
    Citations: 47     Fields:    Translation:HumansCells
  61. Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, Jimenez R, Xiao J, Dedecker P, Zhang J. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nat Methods. 2017 Apr; 14(4):427-434. PMID: 28288122; PMCID: PMC5388356.
    Citations: 47     Fields:    Translation:HumansCells
  62. Henry RA, Mancuso P, Kuo YM, Tricarico R, Tini M, Cole PA, Bellacosa A, Andrews AJ. Interaction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300. Biochemistry. 2016 Dec 13; 55(49):6766-6775. PMID: 27951654.
    Citations: 9     Fields:    Translation:AnimalsCells
  63. Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. Enzyme-catalyzed expressed protein ligation. Nat Methods. 2016 Nov; 13(11):925-927. PMID: 27669326; PMCID: PMC5088058.
    Citations: 20     Fields:    Translation:AnimalsCells
  64. Philip P, Boija A, Vaid R, Churcher AM, Meyers DJ, Cole PA, Mannervik M, Stenberg P. Erratum to: CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics Chromatin. 2016; 9(1):38. PMID: 27625704.
    Citations:    Fields:    
  65. Hsiao PY, Kalin JH, Sun IH, Amin MN, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell JD, Cole PA. An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor. Chembiochem. 2016 10 17; 17(20):1951-1960. PMID: 27432157.
    Citations:    Fields:    Translation:HumansAnimalsCells
  66. Zucconi BE, Luef B, Xu W, Henry RA, Nodelman IM, Bowman GD, Andrews AJ, Cole PA. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112. Biochemistry. 2016 07 12; 55(27):3727-34. PMID: 27332697.
    Citations: 25     Fields:    Translation:HumansCells
  67. Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA. Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases. Biochemistry. 2016 07 05; 55(26):3658-66. PMID: 27295432.
    Citations: 18     Fields:    Translation:HumansCells
  68. Dancy BM, Cole PA. Correction to Protein Lysine Acetylation by p300/CBP. Chem Rev. 2016 07 27; 116(14):8314. PMID: 27304234.
    Citations: 1     Fields:    
  69. Chen Z, Dempsey DR, Thomas SN, Hayward D, Bolduc DM, Cole PA. Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation. J Biol Chem. 2016 Jul 01; 291(27):14160-14169. PMID: 27226612.
    Citations: 18     Fields:    Translation:HumansCells
  70. Robert C, Nagaria PK, Pawar N, Adewuyi A, Gojo I, Meyers DJ, Cole PA, Rassool FV. Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. Leuk Res. 2016 06; 45:14-23. PMID: 27064363; PMCID: PMC5007632.
    Citations: 31     Fields:    Translation:HumansCells
  71. Hayward D, Cole PA. LSD1 Histone Demethylase Assays and Inhibition. Methods Enzymol. 2016; 573:261-78. PMID: 27372757; PMCID: PMC5178825.
    Citations: 14     Fields:    Translation:HumansAnimals
  72. Tu S, Guo SJ, Chen CS, Liu CX, Jiang HW, Ge F, Deng JY, Zhou YM, Czajkowsky DM, Li Y, Qi BR, Ahn YH, Cole PA, Zhu H, Tao SC. YcgC represents a new protein deacetylase family in prokaryotes. Elife. 2015 Dec 30; 4. PMID: 26716769.
    Citations: 23     Fields:    Translation:Cells
  73. Philip P, Boija A, Vaid R, Churcher AM, Meyers DJ, Cole PA, Mannervik M, Stenberg P. CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics Chromatin. 2015; 8:48. PMID: 26604986.
    Citations: 11     Fields:    
  74. Chen Z, Cole PA. Synthetic approaches to protein phosphorylation. Curr Opin Chem Biol. 2015 Oct; 28:115-22. PMID: 26196731.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  75. Taylor MS, Dempsey DR, Hwang Y, Chen Z, Chu N, Boeke JD, Cole PA. Mechanistic analysis of ghrelin-O-acyltransferase using substrate analogs. Bioorg Chem. 2015 Oct; 62:64-73. PMID: 26246082; PMCID: PMC4567917.
    Citations: 5     Fields:    Translation:AnimalsCells
  76. Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Göttgens B, Van Deursen JM, Cole PA, Huntly BJ. The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia. Oncogene. 2016 Jan 21; 35(3):279-89. PMID: 25893291; PMCID: PMC4729186.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  77. Chu N, Cole PA. Switching immune signals on and off. Elife. 2015 Apr 02; 4. PMID: 25838130.
    Citations: 1     Fields:    Translation:Animals
  78. He C, Cole P. Introduction: epigenetics. Chem Rev. 2015 Mar 25; 115(6):2223-4. PMID: 25804907; PMCID: PMC4729185.
    Citations: 2     Fields:    Translation:HumansAnimals
  79. Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015 Jun; 4(6):437-60. PMID: 26042199.
    Citations: 319     Fields:    
  80. Dancy BM, Cole PA. Protein lysine acetylation by p300/CBP. Chem Rev. 2015 Mar 25; 115(6):2419-52. PMID: 25594381; PMCID: PMC4378506.
    Citations: 170     Fields:    Translation:HumansAnimalsCells
  81. Leurs U, Lohse B, Ming S, Cole PA, Clausen RP, Kristensen JL, Rand KD. Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry. Anal Chem. 2014 Dec 02; 86(23):11734-41. PMID: 25325890.
    Citations: 6     Fields:    Translation:HumansCells
  82. Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ. How IGF-1 activates its receptor. Elife. 2014 Sep 25; 3. PMID: 25255214.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  83. Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA. Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. J Biol Chem. 2014 Nov 07; 289(45):31361-72. PMID: 25248746.
    Citations: 16     Fields:    Translation:HumansCells
  84. Brown LJ, Baranowski M, Wang Y, Schrey AK, Lenz T, Taverna SD, Cole PA, Sefkow M. Using S-adenosyl-L-homocysteine capture compounds to characterize S-adenosyl-L-methionine and S-adenosyl-L-homocysteine binding proteins. Anal Biochem. 2014 Dec 15; 467:14-21. PMID: 25172130.
    Citations: 7     Fields:    Translation:Humans
  85. Liu Y, Wang L, Han R, Beier UH, Akimova T, Bhatti T, Xiao H, Cole PA, Brindle PK, Hancock WW. Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Mol Cell Biol. 2014 Nov; 34(21):3993-4007. PMID: 25154413.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  86. Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3Ka. Oncotarget. 2014 Jul 30; 5(14):5198-208. PMID: 25105564.
    Citations: 24     Fields:    Translation:AnimalsCells
  87. Leurs U, Lohse B, Rand KD, Ming S, Riise ES, Cole PA, Kristensen JL, Clausen RP. Substrate- and cofactor-independent inhibition of histone demethylase KDM4C. ACS Chem Biol. 2014 Sep 19; 9(9):2131-8. PMID: 25014588.
    Citations: 9     Fields:    Translation:HumansCells
  88. Maksimoska J, Segura-Peña D, Cole PA, Marmorstein R. Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues. Biochemistry. 2014 Jun 03; 53(21):3415-22. PMID: 24819397.
    Citations: 20     Fields:    Translation:HumansCells
  89. Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 2014 Jun 20; 9(6):1284-93. PMID: 24707965.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  90. Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, Powell JD, Cole PA. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. J Am Chem Soc. 2014 Mar 05; 136(9):3370-3. PMID: 24533830.
    Citations: 7     Fields:    Translation:AnimalsCells
  91. Wang Z, Cole PA. Catalytic mechanisms and regulation of protein kinases. Methods Enzymol. 2014; 548:1-21. PMID: 25399640; PMCID: PMC4373616.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  92. Wondisford AR, Xiong L, Chang E, Meng S, Meyers DJ, Li M, Cole PA, He L. Control of Foxo1 gene expression by co-activator P300. J Biol Chem. 2014 Feb 14; 289(7):4326-33. PMID: 24379407.
    Citations: 27     Fields:    Translation:AnimalsCells
  93. Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH, Dinkova-Kostova AT. Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. Br J Cancer. 2014 Jan 07; 110(1):71-82. PMID: 24322890; PMCID: PMC3887302.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  94. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24. PMID: 24207025.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  95. Taylor MS, Ruch TR, Hsiao PY, Hwang Y, Zhang P, Dai L, Huang CRL, Berndsen CE, Kim MS, Pandey A, Wolberger C, Marmorstein R, Mach