Harvard Catalyst Profiles

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Philip Arthur Cole, M.D.,Ph.D.

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Other Positions
Title
Institution
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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK118266 (ZHAO, YINGMING) Jul 1, 2018 - Jun 30, 2022
    NIH/NIDDK
    Biochemistry of the lysine beta-hydroxybutyrylation pathway
    Role: Co-Principal Investigator
  2. R01GM099092 (LEAHY, DANIEL J) Mar 1, 2012 - Jan 31, 2016
    NIH/NIGMS
    Mechanistic Studies of EGFR/ErbB Receptor Tyrosine Kinases
    Role: Co-Principal Investigator
  3. R24DK093434 (COLE, PHILIP A) Sep 15, 2011 - Aug 31, 2013
    NIH/NIDDK
    Development and Application of Ghrelin O-acyltransferase Inhibitors
    Role: Principal Investigator
  4. R01AG019186 (COLE, PHILIP A) Apr 1, 2001 - Mar 31, 2010
    NIH/NIA
    Serotonin N-acethyltransferase Regulation &Inhibition
    Role: Principal Investigator
  5. R37GM062437 (COLE, PHILIP A) Feb 1, 2001 - Feb 28, 2023
    NIH/NIGMS
    Protein Acylation and Methylation Mechanisms
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW. Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells. Cancers (Basel). 2019 Apr 18; 11(4). PMID: 31003455.
    Citations:    
  2. Zucconi BE, Makofske JL, Meyers DJ, Hwang Y, Wu M, Kuroda MI, Cole PA. Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP. Biochemistry. 2019 Apr 23; 58(16):2133-2143. PMID: 30924641.
    Citations:    
  3. Kim E, Zucconi BE, Wu M, Nocco SE, Meyers DJ, McGee JS, Venkatesh S, Cohen DL, Gonzalez EC, Ryu B, Cole PA, Alani RM. MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma. Cancer Res. 2019 May 15; 79(10):2649-2661. PMID: 30910803.
    Citations:    
  4. Cole PA, Chu N, Salguero AL, Bae H. AKTivation mechanisms. Curr Opin Struct Biol. 2019 Mar 19; 59:47-53. PMID: 30901610.
    Citations:    
  5. Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA, Dinkova-Kostova AT. Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. PLoS One. 2019; 14(3):e0213095. PMID: 30865688.
    Citations:    
  6. Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB. Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II. Molecules. 2019 Jan 30; 24(3). PMID: 30704096.
    Citations:    Fields:    
  7. Weiser BP, Rodriguez G, Cole PA, Stivers JT. N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions. Nucleic Acids Res. 2018 Aug 21; 46(14):7169-7178. PMID: 29917162.
    Citations:    Fields:    
  8. Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018 08 09; 174(4):897-907.e14. PMID: 30078705.
    Citations:    Fields:    
  9. Bhat S, Hwang Y, Gibson MD, Morgan MT, Taverna SD, Zhao Y, Wolberger C, Poirier MG, Cole PA. Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action. J Am Chem Soc. 2018 Aug 01; 140(30):9478-9485. PMID: 29991262.
    Citations:    Fields:    
  10. Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA. Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms. J Am Chem Soc. 2018 Aug 01; 140(30):9374-9378. PMID: 30016585.
    Citations:    Fields:    
  11. Dempsey DR, Cole PA. Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation. Methods Enzymol. 2018; 607:405-422. PMID: 30149868.
    Citations:    Fields:    
  12. Tipton P, Su T, Hannink M. Assembly of PGAM5 into Multimeric Complexes Provides a Mechanism for Allosteric Regulation of Phosphatase Activity. Methods Enzymol. 2018; 607:353-372. PMID: 30149865.
    Citations:    Fields:    
  13. Wu M, Hayward D, Kalin JH, Song Y, Schwabe JW, Cole PA. Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex. Elife. 2018 06 05; 7. PMID: 29869982.
    Citations:    Fields:    
  14. Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Kluge AF, Patane MA, Van Drie JH, Wang C, McElligott D, Kesicki EA, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD. Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2018 06; 558(7710):E1. PMID: 29769713.
    Citations:    Fields:    
  15. Weinert BT, Narita T, Satpathy S, Srinivasan B, Hansen BK, Schölz C, Hamilton WB, Zucconi BE, Wang WW, Liu WR, Brickman JM, Kesicki EA, Lai A, Bromberg KD, Cole PA, Choudhary C. Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome. Cell. 2018 06 28; 174(1):231-244.e12. PMID: 29804834.
    Citations:    Fields:    
  16. Wang Z, Kim MS, Martinez-Ferrando I, Koleske AJ, Pandey A, Cole PA. Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry. 2018 02 27; 57(8):1390-1398. PMID: 29341593.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 01 04; 9(1):53. PMID: 29302039.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Michaelides MR, Kluge A, Patane M, Van Drie JH, Wang C, Hansen TM, Risi RM, Mantei R, Hertel C, Karukurichi K, Nesterov A, McElligott D, de Vries P, Langston JW, Cole PA, Marmorstein R, Liu H, Lasko L, Bromberg KD, Lai A, Kesicki EA. Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases. ACS Med Chem Lett. 2018 Jan 11; 9(1):28-33. PMID: 29348807.
    Citations: 1     
  19. Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT. Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells. Nucleic Acids Res. 2017 Dec 01; 45(21):12413-12424. PMID: 29036472.
    Citations: 2     Fields:    Translation:HumansCells
  20. Boija A, Mahat DB, Zare A, Holmqvist PH, Philip P, Meyers DJ, Cole PA, Lis JT, Stenberg P, Mannervik M. CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell. 2017 Nov 02; 68(3):491-503.e5. PMID: 29056321.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Van Drie JH, McElligott D, Kesicki E, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2017 10 05; 550(7674):128-132. PMID: 28953875.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  22. Rodriguez G, Esadze A, Weiser BP, Schonhoft JD, Cole PA, Stivers JT. Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation. ACS Chem Biol. 2017 09 15; 12(9):2260-2263. PMID: 28787572.
    Citations: 2     Fields:    Translation:HumansCells
  23. Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nat Commun. 2017 07 25; 8(1):131. PMID: 28743992.
    Citations: 5     Fields:    Translation:AnimalsCells
  24. Weiser BP, Stivers JT, Cole PA. Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis. Biophys J. 2017 Jul 25; 113(2):393-401. PMID: 28746850.
    Citations: 5     Fields:    Translation:HumansCells
  25. Zucconi BE, Cole PA. Allosteric regulation of epigenetic modifying enzymes. Curr Opin Chem Biol. 2017 Aug; 39:109-115. PMID: 28689145.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  26. Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Mol Cell. 2017 May 04; 66(3):345-357.e6. PMID: 28475870.
    Citations: 6     Fields:    Translation:HumansCells
  27. Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, Jimenez R, Xiao J, Dedecker P, Zhang J. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nat Methods. 2017 Apr; 14(4):427-434. PMID: 28288122.
    Citations: 7     Fields:    Translation:HumansCells
  28. Henry RA, Mancuso P, Kuo YM, Tricarico R, Tini M, Cole PA, Bellacosa A, Andrews AJ. Interaction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300. Biochemistry. 2016 Dec 13; 55(49):6766-6775. PMID: 27951654.
    Citations: 1     Fields:    Translation:AnimalsCells
  29. Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. Enzyme-catalyzed expressed protein ligation. Nat Methods. 2016 Nov; 13(11):925-927. PMID: 27669326.
    Citations: 3     Fields:    Translation:AnimalsCells
  30. Philip P, Boija A, Vaid R, Churcher AM, Meyers DJ, Cole PA, Mannervik M, Stenberg P. Erratum to: CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics Chromatin. 2016; 9(1):38. PMID: 27625704.
    Citations:    Fields:    
  31. Hsiao PY, Kalin JH, Sun IH, Amin MN, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell JD, Cole PA. An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor. Chembiochem. 2016 10 17; 17(20):1951-1960. PMID: 27432157.
    Citations:    Fields:    Translation:HumansAnimalsCells
  32. Zucconi BE, Luef B, Xu W, Henry RA, Nodelman IM, Bowman GD, Andrews AJ, Cole PA. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112. Biochemistry. 2016 07 12; 55(27):3727-34. PMID: 27332697.
    Citations: 9     Fields:    Translation:HumansCells
  33. Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA. Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases. Biochemistry. 2016 07 05; 55(26):3658-66. PMID: 27295432.
    Citations: 7     Fields:    Translation:HumansCells
  34. Dancy BM, Cole PA. Correction to Protein Lysine Acetylation by p300/CBP. Chem Rev. 2016 07 27; 116(14):8314. PMID: 27304234.
    Citations:    Fields:    
  35. Chen Z, Dempsey DR, Thomas SN, Hayward D, Bolduc DM, Cole PA. Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation. J Biol Chem. 2016 Jul 01; 291(27):14160-9. PMID: 27226612.
    Citations: 4     Fields:    Translation:HumansCells
  36. Robert C, Nagaria PK, Pawar N, Adewuyi A, Gojo I, Meyers DJ, Cole PA, Rassool FV. Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. Leuk Res. 2016 06; 45:14-23. PMID: 27064363.
    Citations: 6     Fields:    Translation:HumansCells
  37. Hayward D, Cole PA. LSD1 Histone Demethylase Assays and Inhibition. Methods Enzymol. 2016; 573:261-78. PMID: 27372757.
    Citations: 5     Fields:    Translation:HumansAnimals
  38. Tu S, Guo SJ, Chen CS, Liu CX, Jiang HW, Ge F, Deng JY, Zhou YM, Czajkowsky DM, Li Y, Qi BR, Ahn YH, Cole PA, Zhu H, Tao SC. YcgC represents a new protein deacetylase family in prokaryotes. Elife. 2015 Dec 30; 4. PMID: 26716769.
    Citations: 12     Fields:    Translation:Cells
  39. Philip P, Boija A, Vaid R, Churcher AM, Meyers DJ, Cole PA, Mannervik M, Stenberg P. CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics Chromatin. 2015; 8:48. PMID: 26604986.
    Citations: 6     Fields:    
  40. Chen Z, Cole PA. Synthetic approaches to protein phosphorylation. Curr Opin Chem Biol. 2015 Oct; 28:115-22. PMID: 26196731.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  41. Taylor MS, Dempsey DR, Hwang Y, Chen Z, Chu N, Boeke JD, Cole PA. Mechanistic analysis of ghrelin-O-acyltransferase using substrate analogs. Bioorg Chem. 2015 Oct; 62:64-73. PMID: 26246082.
    Citations: 2     Fields:    Translation:AnimalsCells
  42. Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Göttgens B, Van Deursen JM, Cole PA, Huntly BJ. The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia. Oncogene. 2016 Jan 21; 35(3):279-89. PMID: 25893291.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  43. Chu N, Cole PA. Switching immune signals on and off. Elife. 2015 Apr 02; 4. PMID: 25838130.
    Citations: 1     Fields:    Translation:Animals
  44. He C, Cole P. Introduction: epigenetics. Chem Rev. 2015 Mar 25; 115(6):2223-4. PMID: 25804907.
    Citations:    Fields:    Translation:HumansAnimals
  45. Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015 Jun; 4(6):437-60. PMID: 26042199.
    Citations: 97     Fields:    
  46. Dancy BM, Cole PA. Protein lysine acetylation by p300/CBP. Chem Rev. 2015 Mar 25; 115(6):2419-52. PMID: 25594381.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  47. Leurs U, Lohse B, Ming S, Cole PA, Clausen RP, Kristensen JL, Rand KD. Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry. Anal Chem. 2014 Dec 02; 86(23):11734-41. PMID: 25325890.
    Citations: 3     Fields:    Translation:HumansCells
  48. Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ. How IGF-1 activates its receptor. Elife. 2014 Sep 25; 3. PMID: 25255214.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  49. Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA. Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. J Biol Chem. 2014 Nov 07; 289(45):31361-72. PMID: 25248746.
    Citations: 8     Fields:    Translation:HumansCells
  50. Brown LJ, Baranowski M, Wang Y, Schrey AK, Lenz T, Taverna SD, Cole PA, Sefkow M. Using S-adenosyl-L-homocysteine capture compounds to characterize S-adenosyl-L-methionine and S-adenosyl-L-homocysteine binding proteins. Anal Biochem. 2014 Dec 15; 467:14-21. PMID: 25172130.
    Citations: 3     Fields:    Translation:Humans
  51. Liu Y, Wang L, Han R, Beier UH, Akimova T, Bhatti T, Xiao H, Cole PA, Brindle PK, Hancock WW. Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Mol Cell Biol. 2014 Nov; 34(21):3993-4007. PMID: 25154413.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  52. Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3Ka. Oncotarget. 2014 Jul 30; 5(14):5198-208. PMID: 25105564.
    Citations: 6     Fields:    Translation:AnimalsCells
  53. Leurs U, Lohse B, Rand KD, Ming S, Riise ES, Cole PA, Kristensen JL, Clausen RP. Substrate- and cofactor-independent inhibition of histone demethylase KDM4C. ACS Chem Biol. 2014 Sep 19; 9(9):2131-8. PMID: 25014588.
    Citations: 6     Fields:    Translation:HumansCells
  54. Maksimoska J, Segura-Peña D, Cole PA, Marmorstein R. Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues. Biochemistry. 2014 Jun 03; 53(21):3415-22. PMID: 24819397.
    Citations: 7     Fields:    Translation:HumansCells
  55. Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 2014 Jun 20; 9(6):1284-93. PMID: 24707965.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  56. Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, Powell JD, Cole PA. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. J Am Chem Soc. 2014 Mar 05; 136(9):3370-3. PMID: 24533830.
    Citations: 4     Fields:    Translation:AnimalsCells
  57. Wang Z, Cole PA. Catalytic mechanisms and regulation of protein kinases. Methods Enzymol. 2014; 548:1-21. PMID: 25399640.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  58. Wondisford AR, Xiong L, Chang E, Meng S, Meyers DJ, Li M, Cole PA, He L. Control of Foxo1 gene expression by co-activator P300. J Biol Chem. 2014 Feb 14; 289(7):4326-33. PMID: 24379407.
    Citations: 14     Fields:    Translation:AnimalsCells
  59. Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH, Dinkova-Kostova AT. Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. Br J Cancer. 2014 Jan 07; 110(1):71-82. PMID: 24322890.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  60. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24. PMID: 24207025.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  61. Taylor MS, Ruch TR, Hsiao PY, Hwang Y, Zhang P, Dai L, Huang CR, Berndsen CE, Kim MS, Pandey A, Wolberger C, Marmorstein R, Machamer C, Boeke JD, Cole PA. Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. J Biol Chem. 2013 Nov 08; 288(45):32211-28. PMID: 24045953.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  62. Wang Z, Raines LL, Hooy RM, Roberson H, Leahy DJ, Cole PA. Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor. ACS Chem Biol. 2013 Nov 15; 8(11):2372-6. PMID: 24004111.
    Citations: 8     Fields:    Translation:HumansCells
  63. Liu Y, Wang L, Predina J, Han R, Beier UH, Wang LC, Kapoor V, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. Inhibition of p300 impairs Foxp3? T regulatory cell function and promotes antitumor immunity. Nat Med. 2013 Sep; 19(9):1173-7. PMID: 23955711.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  64. Cole PA. Open questions: two challenges in chemical biology--chemical engineering and the science of diet. BMC Biol. 2013 Jul 30; 11:87. PMID: 23899134.
    Citations:    Fields:    Translation:HumansAnimalsCells
  65. Sugar JG, Chu QD, Cole PA, Li BD, Kim RH. Effect of January vacations and prior night call status on resident ABSITE performance. J Surg Educ. 2013 Nov-Dec; 70(6):720-4. PMID: 24209647.
    Citations: 1     Fields:    Translation:Humans
  66. Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife. 2013 Jul 09; 2:e00691. PMID: 23853711.
    Citations: 24     Fields:    Translation:Cells
  67. Yan G, Eller MS, Elm C, Larocca CA, Ryu B, Panova IP, Dancy BM, Bowers EM, Meyers D, Lareau L, Cole PA, Taverna SD, Alani RM. Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells. J Invest Dermatol. 2013 Oct; 133(10):2444-2452. PMID: 23698071.
    Citations: 26     Fields:    Translation:HumansCells
  68. Teubner BJ, Garretson JT, Hwang Y, Cole PA, Bartness TJ. Inhibition of ghrelin O-acyltransferase attenuates food deprivation-induced increases in ingestive behavior. Horm Behav. 2013 Apr; 63(4):667-73. PMID: 23399323.
    Citations: 9     Fields:    Translation:Animals
  69. Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. Construction of human activity-based phosphorylation networks. Mol Syst Biol. 2013; 9:655. PMID: 23549483.
    Citations: 55     Fields:    Translation:HumansCells
  70. Dancy BM, Crump NT, Peterson DJ, Mukherjee C, Bowers EM, Ahn YH, Yoshida M, Zhang J, Mahadevan LC, Meyers DJ, Boeke JD, Cole PA. Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Chembiochem. 2012 Sep 24; 13(14):2113-21. PMID: 22961914.
    Citations: 13     Fields:    Translation:AnimalsCells
  71. Wei W, Coelho CM, Li X, Marek R, Yan S, Anderson S, Meyers D, Mukherjee C, Sbardella G, Castellano S, Milite C, Rotili D, Mai A, Cole PA, Sah P, Kobor MS, Bredy TW. p300/CBP-associated factor selectively regulates the extinction of conditioned fear. J Neurosci. 2012 Aug 29; 32(35):11930-41. PMID: 22933779.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  72. Ferrando IM, Chaerkady R, Zhong J, Molina H, Jacob HK, Herbst-Robinson K, Dancy BM, Katju V, Bose R, Zhang J, Pandey A, Cole PA. Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics. Mol Cell Proteomics. 2012 Aug; 11(8):355-69. PMID: 22499769.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  73. Wang Y, Toh HC, Chow P, Chung AY, Meyers DJ, Cole PA, Ooi LL, Lee CG. MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms. FASEB J. 2012 Jul; 26(7):3032-41. PMID: 22459148.
    Citations: 45     Fields:    Translation:HumansCells
  74. Francetic T, Le May M, Hamed M, Mach H, Meyers D, Cole PA, Chen J, Li Q. Regulation of Myf5 Early Enhancer by Histone Acetyltransferase p300 during Stem Cell Differentiation. Mol Biol. 2012 Mar 17; 1. PMID: 25382872.
    Citations: 9     Fields:    
  75. Dancy BC, Ming SA, Papazyan R, Jelinek CA, Majumdar A, Sun Y, Dancy BM, Drury WJ, Cotter RJ, Taverna SD, Cole PA. Azalysine analogues as probes for protein lysine deacetylation and demethylation. J Am Chem Soc. 2012 Mar 21; 134(11):5138-48. PMID: 22352831.
    Citations: 11     Fields:    Translation:Cells
  76. Tarrant MK, Rho HS, Xie Z, Jiang YL, Gross C, Culhane JC, Yan G, Qian J, Ichikawa Y, Matsuoka T, Zachara N, Etzkorn FA, Hart GW, Jeong JS, Blackshaw S, Zhu H, Cole PA. Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol. 2012 Jan 22; 8(3):262-9. PMID: 22267120.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  77. Taylor MS, Hwang Y, Hsiao PY, Boeke JD, Cole PA. Ghrelin O-acyltransferase assays and inhibition. Methods Enzymol. 2012; 514:205-28. PMID: 22975055.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  78. Zhang Y, Ahn YH, Benjamin IJ, Honda T, Hicks RJ, Calabrese V, Cole PA, Dinkova-Kostova AT. HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Chem Biol. 2011 Nov 23; 18(11):1355-61. PMID: 22118669.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  79. Wang Z, Longo PA, Tarrant MK, Kim K, Head S, Leahy DJ, Cole PA. Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1388-93. PMID: 22101934.
    Citations: 27     Fields:    Translation:HumansCells
  80. Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science. 2011 Aug 05; 333(6043):765-9. PMID: 21764752.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  81. Santer FR, Höschele PP, Oh SJ, Erb HH, Bouchal J, Cavarretta IT, Parson W, Meyers DJ, Cole PA, Culig Z. Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines. Mol Cancer Ther. 2011 Sep; 10(9):1644-55. PMID: 21709130.
    Citations: 59     Fields:    Translation:HumansCells
  82. Smirnova NA, Haskew-Layton RE, Basso M, Hushpulian DM, Payappilly JB, Speer RE, Ahn YH, Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG. Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Chem Biol. 2011 Jun 24; 18(6):752-65. PMID: 21700211.
    Citations: 26     Fields:    Translation:HumansCells
  83. Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J. Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur J Epidemiol. 2011 Jun; 26 Suppl 1:S1-58. PMID: 21626386.
    Citations: 218     Fields:    Translation:HumansPHPublic Health
  84. Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KS. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science. 2011 May 20; 332(6032):963-6. PMID: 21596989.
    Citations: 72     Fields:    Translation:AnimalsCells
  85. Marek R, Coelho CM, Sullivan RK, Baker-Andresen D, Li X, Ratnu V, Dudley KJ, Meyers D, Mukherjee C, Cole PA, Sah P, Bredy TW. Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. J Neurosci. 2011 May 18; 31(20):7486-91. PMID: 21593332.
    Citations: 33     Fields:    Translation:AnimalsCells
  86. Crump NT, Hazzalin CA, Bowers EM, Alani RM, Cole PA, Mahadevan LC. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7814-9. PMID: 21518915.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  87. Collins SL, Black KE, Chan-Li Y, Ahn YH, Cole PA, Powell JD, Horton MR. Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor. Am J Respir Cell Mol Biol. 2011 Oct; 45(4):675-83. PMID: 21257926.
    Citations: 13     Fields:    Translation:AnimalsCells
  88. Tang Y, Holbert MA, Delgoshaie N, Wurtele H, Guillemette B, Meeth K, Yuan H, Drogaris P, Lee EH, Durette C, Thibault P, Verreault A, Cole PA, Marmorstein R. Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation. Structure. 2011 Feb 09; 19(2):221-31. PMID: 21256037.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  89. Taverna SD, Cole PA. Drug discovery: Reader's block. Nature. 2010 Dec 23; 468(7327):1050-1. PMID: 21179160.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  90. Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, Cole PA. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science. 2010 Dec 17; 330(6011):1689-92. PMID: 21097901.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  91. Bellows ML, Taylor MS, Cole PA, Shen L, Siliciano RF, Fung HK, Floudas CA. Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework. Biophys J. 2010 Nov 17; 99(10):3445-53. PMID: 21081094.
    Citations: 20     Fields:    Translation:HumansCells
  92. Cerchietti LC, Hatzi K, Caldas-Lopes E, Yang SN, Figueroa ME, Morin RD, Hirst M, Mendez L, Shaknovich R, Cole PA, Bhalla K, Gascoyne RD, Marra M, Chiosis G, Melnick A. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. J Clin Invest. 2010 Dec 01; 120(12):4569-82. PMID: 21041953.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  93. Karukurichi KR, Cole PA. Probing the reaction coordinate of the p300/CBP histone acetyltransferase with bisubstrate analogs. Bioorg Chem. 2011 Feb; 39(1):42-7. PMID: 21111442.
    Citations: 4     Fields:    Translation:HumansCells
  94. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23; 67(6):953-66. PMID: 20869593.
    Citations: 208     Fields:    Translation:HumansAnimalsCells
  95. Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, Mukherjee C, Caron C, Kimura H, Rousseaux S, Cole PA, Panne D, French CA, Khochbin S. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 2010 Sep 01; 29(17):2943-52. PMID: 20676058.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  96. Huang R, Holbert MA, Tarrant MK, Curtet S, Colquhoun DR, Dancy BM, Dancy BC, Hwang Y, Tang Y, Meeth K, Marmorstein R, Cole RN, Khochbin S, Cole PA. Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. J Am Chem Soc. 2010 Jul 28; 132(29):9986-7. PMID: 20608637.
    Citations: 25     Fields:    Translation:AnimalsCells
  97. Huang R, Martinez-Ferrando I, Cole PA. Enhanced interrogation: emerging strategies for cell signaling inhibition. Nat Struct Mol Biol. 2010 Jun; 17(6):646-9. PMID: 20520657.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  98. Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H, Larocca C, Saldanha SA, Abagyan R, Sun Y, Meyers DJ, Marmorstein R, Mahadevan LC, Alani RM, Cole PA. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28; 17(5):471-82. PMID: 20534345.
    Citations: 157     Fields:    Translation:AnimalsCells
  99. Ahn YH, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-Kostova AT, Talalay P, Cole PA. Electrophilic tuning of the chemoprotective natural product sulforaphane. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9590-5. PMID: 20439747.
    Citations: 44     Fields:    Translation:AnimalsCells
  100. Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr; 28(4):713-20. PMID: 20201064.
    Citations: 159     Fields:    Translation:HumansCells
  101. Culhane JC, Wang D, Yen PM, Cole PA. Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc. 2010 Mar 10; 132(9):3164-76. PMID: 20148560.
    Citations: 49     Fields:    Translation:AnimalsCells
  102. Karukurichi KR, Wang L, Uzasci L, Manlandro CM, Wang Q, Cole PA. Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis. J Am Chem Soc. 2010 Feb 03; 132(4):1222-3. PMID: 20063892.
    Citations: 7     Fields:    Translation:Cells
  103. Qiu C, Tarrant MK, Boronina T, Longo PA, Kavran JM, Cole RN, Cole PA, Leahy DJ. In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry. 2009 Jul 21; 48(28):6624-32. PMID: 19518076.
    Citations: 19     Fields:    Translation:HumansCells
  104. Oussaief L, Hippocrate A, Ramirez V, Rampanou A, Zhang W, Meyers D, Cole P, Khelifa R, Joab I. Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation. J Biol Chem. 2009 Sep 04; 284(36):23912-24. PMID: 19589780.
    Citations: 10     Fields:    Translation:HumansCells
  105. Muratore KE, Seeliger MA, Wang Z, Fomina D, Neiswinger J, Havranek JJ, Baker D, Kuriyan J, Cole PA. Comparative analysis of mutant tyrosine kinase chemical rescue. Biochemistry. 2009 Apr 21; 48(15):3378-86. PMID: 19260709.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  106. Hansson ML, Popko-Scibor AE, Saint Just Ribeiro M, Dancy BM, Lindberg MJ, Cole PA, Wallberg AE. The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. Nucleic Acids Res. 2009 May; 37(9):2996-3006. PMID: 19304754.
    Citations: 19     Fields:    Translation:Cells
  107. Wang D, Xia X, Liu Y, Oetting A, Walker RL, Zhu Y, Meltzer P, Cole PA, Shi YB, Yen PM. Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation. Mol Endocrinol. 2009 May; 23(5):600-9. PMID: 19196836.
    Citations: 12     Fields:    Translation:AnimalsCells
  108. Szewczuk LM, Tarrant MK, Cole PA. Protein phosphorylation by semisynthesis: from paper to practice. Methods Enzymol. 2009; 462:1-24. PMID: 19632467.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  109. Tarrant MK, Cole PA. The chemical biology of protein phosphorylation. Annu Rev Biochem. 2009; 78:797-825. PMID: 19489734.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  110. Wang L, Tang Y, Cole PA, Marmorstein R. Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr Opin Struct Biol. 2008 Dec; 18(6):741-7. PMID: 18845255.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  111. Cole PA. Chemical probes for histone-modifying enzymes. Nat Chem Biol. 2008 Oct; 4(10):590-7. PMID: 18800048.
    Citations: 94     Fields:    Translation:Cells
  112. Szewczuk LM, Tarrant MK, Sample V, Drury WJ, Zhang J, Cole PA. Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry. 2008 Sep 30; 47(39):10407-19. PMID: 18771288.
    Citations: 7     Fields:    Translation:HumansCells
  113. Levinson NM, Seeliger MA, Cole PA, Kuriyan J. Structural basis for the recognition of c-Src by its inactivator Csk. Cell. 2008 Jul 11; 134(1):124-34. PMID: 18614016.
    Citations: 46     Fields:    Translation:AnimalsCells
  114. Tang Y, Holbert MA, Wurtele H, Meeth K, Rocha W, Gharib M, Jiang E, Thibault P, Verreault A, Verrault A, Cole PA, Marmorstein R. Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat Struct Mol Biol. 2008 Jul; 15(7):738-45. PMID: 18568037.
    Citations: 56     Fields:    Translation:AnimalsCells
  115. Pickin KA, Chaudhury S, Dancy BC, Gray JJ, Cole PA. Analysis of protein kinase autophosphorylation using expressed protein ligation and computational modeling. J Am Chem Soc. 2008 Apr 30; 130(17):5667-9. PMID: 18396877.
    Citations: 9     Fields:    Translation:Cells
  116. Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure. 2008 Mar; 16(3):460-7. PMID: 18334220.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  117. MacMahon B, Cole P. Is the incidence of breast cancer declining? Epidemiology. 2008 Mar; 19(2):268-9. PMID: 18277162.
    Citations: 2     Fields:    Translation:Humans
  118. Liu X, Wang L, Zhao K, Thompson PR, Hwang Y, Marmorstein R, Cole PA. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 2008 Feb 14; 451(7180):846-50. PMID: 18273021.
    Citations: 113     Fields:    Translation:Cells
  119. Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008 Feb; 26(2):164-7. PMID: 18259167.
    Citations: 68     Fields:    
  120. Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature. 2007 Nov 29; 450(7170):741-4. PMID: 18046415.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  121. Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. De novo discovery of serotonin N-acetyltransferase inhibitors. J Med Chem. 2007 Nov 01; 50(22):5330-8. PMID: 17924613.
    Citations: 5     Fields:    Translation:AnimalsCells
  122. Culhane JC, Cole PA. LSD1 and the chemistry of histone demethylation. Curr Opin Chem Biol. 2007 Oct; 11(5):561-8. PMID: 17851108.
    Citations: 45     Fields:    Translation:HumansCells
  123. Kenneth NS, Ramsbottom BA, Gomez-Roman N, Marshall L, Cole PA, White RJ. TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):14917-22. PMID: 17848523.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  124. Muratore KE, Cole PA. A lock on phosphotyrosine signaling. ACS Chem Biol. 2007 Jul 20; 2(7):454-6. PMID: 17649969.
    Citations: 4     Fields:    Translation:HumansCells
  125. Hu X, Dang Y, Tenney K, Crews P, Tsai CW, Sixt KM, Cole PA, Liu JO. Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol. 2007 Jul; 14(7):764-74. PMID: 17656313.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  126. Karanam B, Wang L, Wang D, Liu X, Marmorstein R, Cotter R, Cole PA. Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry. 2007 Jul 17; 46(28):8207-16. PMID: 17590016.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  127. Yang M, Culhane JC, Szewczuk LM, Jalili P, Ball HL, Machius M, Cole PA, Yu H. Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry. 2007 Jul 10; 46(27):8058-65. PMID: 17569509.
    Citations: 57     Fields:    
  128. Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol. 2007 Jun; 14(6):535-9. PMID: 17529991.
    Citations: 57     Fields:    Translation:HumansCells
  129. Szewczuk LM, Culhane JC, Yang M, Majumdar A, Yu H, Cole PA. Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry. 2007 Jun 12; 46(23):6892-902. PMID: 17511474.
    Citations: 30     Fields:    Translation:HumansCells
  130. Hwang Y, Thompson PR, Wang L, Jiang L, Kelleher NL, Cole PA. A selective chemical probe for coenzyme A-requiring enzymes. Angew Chem Int Ed Engl. 2007; 46(40):7621-4. PMID: 17768748.
    Citations: 14     Fields:    Translation:Cells
  131. Hwang Y, Ganguly S, Ho AK, Klein DC, Cole PA. Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug. Bioorg Med Chem. 2007 Mar 01; 15(5):2147-55. PMID: 17258461.
    Citations: 3     Fields:    Translation:AnimalsCells
  132. Bose R, Holbert MA, Pickin KA, Cole PA. Protein tyrosine kinase-substrate interactions. Curr Opin Struct Biol. 2006 Dec; 16(6):668-75. PMID: 17085043.
    Citations: 23     Fields:    Translation:HumansCells
  133. Karanam B, Jiang L, Wang L, Kelleher NL, Cole PA. Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J Biol Chem. 2006 Dec 29; 281(52):40292-301. PMID: 17065153.
    Citations: 32     Fields:    Translation:Cells
  134. Bose R, Molina H, Patterson AS, Bitok JK, Periaswamy B, Bader JS, Pandey A, Cole PA. Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):9773-8. PMID: 16785428.
    Citations: 90     Fields:    Translation:AnimalsCells
  135. Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell. 2006 Jun 16; 125(6):1137-49. PMID: 16777603.
    Citations: 443     Fields:    Translation:HumansAnimalsCells
  136. Cheng KY, Noble ME, Skamnaki V, Brown NR, Lowe ED, Kontogiannis L, Shen K, Cole PA, Siligardi G, Johnson LN. The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J Biol Chem. 2006 Aug 11; 281(32):23167-79. PMID: 16707497.
    Citations: 26     Fields:    Translation:HumansCells
  137. Levinson NM, Kuchment O, Shen K, Young MA, Koldobskiy M, Karplus M, Cole PA, Kuriyan J. A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol. 2006 May; 4(5):e144. PMID: 16640460.
    Citations: 95     Fields:    Translation:HumansCells
  138. Culhane JC, Szewczuk LM, Liu X, Da G, Marmorstein R, Cole PA. A mechanism-based inactivator for histone demethylase LSD1. J Am Chem Soc. 2006 Apr 12; 128(14):4536-7. PMID: 16594666.
    Citations: 48     Fields:    Translation:Cells
  139. Schwarzer D, Zhang Z, Zheng W, Cole PA. Negative regulation of a protein tyrosine phosphatase by tyrosine phosphorylation. J Am Chem Soc. 2006 Apr 05; 128(13):4192-3. PMID: 16568970.
    Citations: 9     Fields:    Translation:AnimalsCells
  140. Qiao Y, Molina H, Pandey A, Zhang J, Cole PA. Chemical rescue of a mutant enzyme in living cells. Science. 2006 Mar 03; 311(5765):1293-7. PMID: 16513984.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  141. Zheng Y, Balasubramanyam K, Cebrat M, Buck D, Guidez F, Zelent A, Alani RM, Cole PA. Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor. J Am Chem Soc. 2005 Dec 14; 127(49):17182-3. PMID: 16332055.
    Citations: 22     Fields:    
  142. Schwarzer D, Cole PA. Protein semisynthesis and expressed protein ligation: chasing a protein's tail. Curr Opin Chem Biol. 2005 Dec; 9(6):561-9. PMID: 16226484.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  143. Lewczuk B, Zheng W, Prusik M, Cole PA, Przybylska-Gornowicz B. N-bromoacetyltryptamine strongly and reversibly inhibits in vitro melatonin secretion from mammalian pinealocytes. Neuro Endocrinol Lett. 2005 Oct; 26(5):581-92. PMID: 16264397.
    Citations: 4     Fields:    Translation:Animals
  144. Shen K, Hines AC, Schwarzer D, Pickin KA, Cole PA. Protein kinase structure and function analysis with chemical tools. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):65-78. PMID: 16213197.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  145. Zheng Y, Mamdani F, Toptygin D, Brand L, Stivers JT, Cole PA. Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase. Biochemistry. 2005 Aug 09; 44(31):10501-9. PMID: 16060659.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  146. Guidez F, Howell L, Isalan M, Cebrat M, Alani RM, Ivins S, Hormaeche I, McConnell MJ, Pierce S, Cole PA, Licht J, Zelent A. Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol. 2005 Jul; 25(13):5552-66. PMID: 15964811.
    Citations: 40     Fields:    Translation:HumansCells
  147. Cleary J, Sitwala KV, Khodadoust MS, Kwok RP, Mor-Vaknin N, Cebrat M, Cole PA, Markovitz DM. p300/CBP-associated factor drives DEK into interchromatin granule clusters. J Biol Chem. 2005 Sep 09; 280(36):31760-7. PMID: 15987677.
    Citations: 29     Fields:    Translation:HumansCells
  148. Wang D, Thompson P, Cole PA, Cotter RJ. Structural analysis of a highly acetylated protein using a curved-field reflectron mass spectrometer. Proteomics. 2005 Jun; 5(9):2288-96. PMID: 15887180.
    Citations: 3     Fields:    Translation:Cells
  149. Hines AC, Parang K, Kohanski RA, Hubbard SR, Cole PA. Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design. Bioorg Chem. 2005 Aug; 33(4):285-97. PMID: 16023488.
    Citations: 5     Fields:    Translation:Cells
  150. Cheung E, Acevedo ML, Cole PA, Kraus WL. Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):559-64. PMID: 15642950.
    Citations: 18     Fields:    Translation:HumansCells
  151. Zheng W, Schwarzer D, Lebeau A, Weller JL, Klein DC, Cole PA. Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205. J Biol Chem. 2005 Mar 18; 280(11):10462-7. PMID: 15632116.
    Citations: 16     Fields:    Translation:AnimalsCells
  152. Yoon HG, Choi Y, Cole PA, Wong J. Reading and function of a histone code involved in targeting corepressor complexes for repression. Mol Cell Biol. 2005 Jan; 25(1):324-35. PMID: 15601853.
    Citations: 42     Fields:    Translation:HumansCells
  153. Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004 Dec 29; 119(7):941-53. PMID: 15620353.
    Citations: 1055     Fields:    Translation:HumansCells
  154. Casanova M, Cole P, Collins JJ, Conolly R, Delzell E, Heck Hd Hd, Leonard R, Lewis R, Marsh GM, Ott MG, Sorahan T, Axten CW. Re: Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries. J Natl Cancer Inst. 2004 Jun 16; 96(12):966-7; author reply 967-8. PMID: 15199116.
    Citations:    Fields:    Translation:HumansPHPublic Health
  155. Sagar V, Zheng W, Thompson PR, Cole PA. Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors. Bioorg Med Chem. 2004 Jun 15; 12(12):3383-90. PMID: 15158807.
    Citations: 7     Fields:    Translation:Cells
  156. Hines AC, Cole PA. Design, synthesis, and characterization of an ATP-peptide conjugate inhibitor of protein kinase A. Bioorg Med Chem Lett. 2004 Jun 07; 14(11):2951-4. PMID: 15125966.
    Citations: 8     Fields:    Translation:Cells
  157. Hwang Y, Cole PA. Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride. Org Lett. 2004 May 13; 6(10):1555-6. PMID: 15128234.
    Citations: 4     Fields:    Translation:Cells
  158. Farrell CJ, Lee JM, Shin EC, Cebrat M, Cole PA, Hayward SD. Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4625-30. PMID: 15070768.
    Citations: 12     Fields:    Translation:HumansCells
  159. Thompson PR, Wang D, Wang L, Fulco M, Pediconi N, Zhang D, An W, Ge Q, Roeder RG, Wong J, Levrero M, Sartorelli V, Cotter RJ, Cole PA. Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol. 2004 Apr; 11(4):308-15. PMID: 15004546.
    Citations: 122     Fields:    Translation:AnimalsCells
  160. Zheng Y, Thompson PR, Cebrat M, Wang L, Devlin MK, Alani RM, Cole PA. Selective HAT inhibitors as mechanistic tools for protein acetylation. Methods Enzymol. 2004; 376:188-99. PMID: 14975306.
    Citations: 12     Fields:    Translation:Cells
  161. Shen K, Cole PA. Conversion of a tyrosine kinase protein substrate to a high affinity ligand by ATP linkage. J Am Chem Soc. 2003 Dec 31; 125(52):16172-3. PMID: 14692742.
    Citations: 7     Fields:    Translation:AnimalsCells
  162. Zheng W, Zhang Z, Ganguly S, Weller JL, Klein DC, Cole PA. Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nat Struct Biol. 2003 Dec; 10(12):1054-7. PMID: 14578935.