Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileRichard D. Cummings, Ph.D.

TitleProfessor of Surgery
InstitutionBeth Israel Deaconess Medical Center
DepartmentSurgery
AddressBeth Israel Deaconess Medical Center
Cls 11087
330 Brookline Ave
Boston MA 02215
vCardDownload vCard (login for email)
Profile Picture

Collapse Overview 
Collapse overview
Dr. Cummings' laboratory is interested in the fundamental biological processes regulating cell adhesion and signaling with particular emphasis on the functions of glycans in glycoproteins and other glycoconjugates. Cell adhesion/signaling is essential for animal cell development, differentiation, tumor metastasis, inflammation and microbial pathogenesis and is mediated by glycoconjugates and glycan-binding proteins (GBPs) and antibodies that recognize these glycans. Cummings' laboratory has projects in multiple areas including cancer biology and the roles of glycoconjugates in cancer initiation and metastasis, developmental biology, parasitology, e.g. schistosomiasis and helminth infections, microbial and viral pathogenesis, as well as the general development of glycomics and techniques in the glycoscience area. The laboratory studies a wide variety of GBPs, such as C-type lectins and galectins, which are expressed by all cells and their roles in specific cellular functions. The laboratory utilizes mouse and human genetics and a host of biochemical strategies to define molecular pathways of developmental and disease importance in which specific glycan expression is implicated. Dr. Cummings is the Director of the National Center for Functional Glycomics (NCFG) and Chair of the Consortium for Functional Glycomics, both supported by the NIH/NIGMS. Cummings is also the Director of the newly designated Harvard Medical School Center for Glycoscience (along with Co-Director Dr. Robert Sackstein). The Center makes available a variety of resources and services to investigators for use in performing experiments that contribute to our understanding the roles of carbohydrate-protein interactions at the cell surfaces in cell-cell adhesion and cellular signaling. Some key techniques in the Center are sequence analysis of glycans in glycoproteins, serum or plasma, and cells, the development of shotgun glycomics to sequence the glycans in the human glycome, and the screening of GBPs and antibodies on glycan microarrays of defined glycans, glycopeptides, and glycopeptides, as well as on microarrays of natural glycans derived from human, animal, and microbial sources.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U01GM116196     (CHAIKOF, ELLIOT)Sep 1, 2015 - May 31, 2019
NIH/NIGMS
Facile Synthesis of Glycosulfopeptides and Related Bioconjugates
Role: Co-Principal Investigator

U01CA199882     (CUMMINGS, RICHARD D)Sep 1, 2015 - Jun 30, 2018
NIH/NCI
Smart Anti-Glycan Reagents to Generate the Human Glycome Atlas
Role: Principal Investigator

R01AI101982     (CUMMINGS, RICHARD D)Sep 20, 2013 - Aug 31, 2018
NIH/NIAID
Modulation of Inflammatory Responses by Helminth Glycans
Role: Principal Investigator

P41GM103694     (CUMMINGS, RICHARD D)Aug 1, 2013 - Jun 30, 2018
NIH/NIGMS
National Center for Functional Glycomics
Role: Principal Investigator

U01CA168930     (CUMMINGS, RICHARD D)Aug 23, 2012 - Jun 30, 2017
NIH/NCI
The Tumor Antigens Tn and SialylTn in Human Colorectal Carcinoma
Role: Principal Investigator
Collapse research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Glycomics Core (BIDMC) - Core services (3) and Instruments (7)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Hanes MS, Moremen KW, Cummings RD. Biochemical characterization of functional domains of the chaperone Cosmc. PLoS One. 2017; 12(6):e0180242. PMID: 28665962.
    View in: PubMed
  2. Brazil JC, Sumagin R, Stowell SR, Lee G, Louis NA, Cummings RD, Parkos CA. Expression of Lewis-a glycans on polymorphonuclear leukocytes augments function by increasing transmigration. J Leukoc Biol. 2017 Jun 09. PMID: 28600306.
    View in: PubMed
  3. Kudelka MR, Hinrichs BH, Darby T, Moreno CS, Nishio H, Cutler CE, Wang J, Wu H, Zeng J, Wang Y, Ju T, Stowell SR, Nusrat A, Jones RM, Neish AS, Cummings RD. Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk. Proc Natl Acad Sci U S A. 2016 Dec 20; 113(51):14787-14792. PMID: 27930307.
    View in: PubMed
  4. Laan LC, Williams AR, Stavenhagen K, Giera M, Kooij G, Vlasakov I, Kalay H, Kringel H, Nejsum P, Thamsborg SM, Wuhrer M, Dijkstra CD, Cummings RD, van Die I. The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells. FASEB J. 2017 Feb; 31(2):719-731. PMID: 27806992.
    View in: PubMed
  5. Crawford TD, Romero FA, Lai KW, Tsui V, Taylor AM, de Leon Boenig G, Noland CL, Murray J, Ly J, Choo EF, Hunsaker TL, Chan EW, Merchant M, Kharbanda S, Gascoigne KE, Kaufman S, Beresini MH, Liao J, Liu W, Chen KX, Chen Z, Conery AR, Côté A, Jayaram H, Jiang Y, Kiefer JR, Kleinheinz T, Li Y, Maher J, Pardo E, Poy F, Spillane KL, Wang F, Wang J, Wei X, Xu Z, Xu Z, Yen I, Zawadzke L, Zhu X, Bellon S, Cummings R, Cochran AG, Albrecht BK, Magnuson S. Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. J Med Chem. 2016 Dec 08; 59(23):10549-10563. PMID: 27682507.
    View in: PubMed
  6. Rodrigues LC, Secatto A, Sorgi CA, Dejani NN, Medeiros AI, Prado MK, Ramos SG, Cummings RD, Stowell SR, Faccioli LH, Dias-Baruffi M. Protective Effect of Galectin-1 during Histoplasma capsulatum Infection Is Associated with Prostaglandin E2 and Nitric Oxide Modulation. Mediators Inflamm. 2016; 2016:5813794. PMID: 27698545.
    View in: PubMed
  7. Crawford TD, Tsui V, Flynn EM, Wang S, Taylor AM, Côté A, Audia JE, Beresini MH, Burdick DJ, Cummings R, Dakin LA, Duplessis M, Good AC, Hewitt MC, Huang HR, Jayaram H, Kiefer JR, Jiang Y, Murray J, Nasveschuk CG, Pardo E, Poy F, Romero FA, Tang Y, Wang J, Xu Z, Zawadzke LE, Zhu X, Albrecht BK, Magnuson SR, Bellon S, Cochran AG. Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. J Med Chem. 2016 Jun 09; 59(11):5391-402. PMID: 27219867.
    View in: PubMed
  8. Song X, Ju H, Lasanajak Y, Kudelka MR, Smith DF, Cummings RD. Oxidative release of natural glycans for functional glycomics. Nat Methods. 2016 Jun; 13(6):528-34. PMID: 27135973; PMCID: PMC4887297 [Available on 11/02/16].
  9. Mickum ML, Prasanphanich NS, Song X, Dorabawila N, Mandalasi M, Lasanajak Y, Luyai A, Secor WE, Wilkins PP, Van Die I, Smith DF, Nyame AK, Cummings RD, Rivera-Marrero CA. Identification of Antigenic Glycans from Schistosoma mansoni by Using a Shotgun Egg Glycan Microarray. Infect Immun. 2016 May; 84(5):1371-86. PMID: 26883596; PMCID: PMC4862720 [Available on 10/22/16].
  10. Hoeksema MA, Laan LC, Postma JJ, Cummings RD, de Winther MP, Dijkstra CD, van Die I, Kooij G. Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling. FASEB J. 2016 Aug; 30(8):2826-36. PMID: 27095802.
    View in: PubMed
  11. Noll AJ, Yu Y, Lasanajak Y, Duska-McEwen G, Buck RH, Smith DF, Cummings RD. Human DC-SIGN binds specific human milk glycans. Biochem J. 2016 May 15; 473(10):1343-53. PMID: 26976925; PMCID: PMC4875834.
  12. Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. PMID: 26829621; PMCID: PMC4731185 [Available on 02/01/17].
  13. Ghasemi F, Hosseini ES, Song X, Gottfried DS, Chamanzar M, Raeiszadeh M, Cummings RD, Eftekhar AA, Adibi A. Multiplexed detection of lectins using integrated glycan-coated microring resonators. Biosens Bioelectron. 2016 Jun 15; 80:682-90. PMID: 26826877.
    View in: PubMed
  14. Agravat SB, Song X, Rojsajjakul T, Cummings RD, Smith DF. Computational approaches to define a human milk metaglycome. Bioinformatics. 2016 May 15; 32(10):1471-8. PMID: 26803164; PMCID: PMC4907376 [Available on 05/15/17].
  15. Noll AJ, Gourdine JP, Yu Y, Lasanajak Y, Smith DF, Cummings RD. Galectins are human milk glycan receptors. Glycobiology. 2016 Jun; 26(6):655-69. PMID: 26747425; PMCID: PMC4847615 [Available on 06/01/17].
  16. Brazil JC, Sumagin R, Cummings RD, Louis NA, Parkos CA. Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation. Am J Pathol. 2016 Feb; 186(2):297-311. PMID: 26687991; PMCID: PMC4729268 [Available on 02/01/17].
  17. Varki A, Cummings RD, Aebi M, Packer NH, Seeberger PH, Esko JD, Stanley P, Hart G, Darvill A, Kinoshita T, Prestegard JJ, Schnaar RL, Freeze HH, Marth JD, Bertozzi CR, Etzler ME, Frank M, Vliegenthart JF, Lütteke T, Perez S, Bolton E, Rudd P, Paulson J, Kanehisa M, Toukach P, Aoki-Kinoshita KF, Dell A, Narimatsu H, York W, Taniguchi N, Kornfeld S. Symbol Nomenclature for Graphical Representations of Glycans. Glycobiology. 2015 Dec; 25(12):1323-4. PMID: 26543186; PMCID: PMC4643639 [Available on 12/01/16].
  18. Kudelka MR, Antonopoulos A, Wang Y, Duong DM, Song X, Seyfried NT, Dell A, Haslam SM, Cummings RD, Ju T. Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells. Nat Methods. 2016 Jan; 13(1):81-6. PMID: 26619014; PMCID: PMC4697867.
  19. Mickum ML, Rojsajjakul T, Yu Y, Cummings RD. Schistosoma mansoni a1,3-fucosyltransferase-F generates the Lewis X antigen. Glycobiology. 2016 Mar; 26(3):270-85. PMID: 26582608; PMCID: PMC5007581 [Available on 03/01/17].
  20. Blackler RJ, Evans DW, Smith DF, Cummings RD, Brooks CL, Braulke T, Liu X, Evans SV, Müller-Loennies S. Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†. Glycobiology. 2016 Feb; 26(2):181-92. PMID: 26503547; PMCID: PMC4691289 [Available on 02/01/17].
  21. Aoki-Kinoshita K, Agravat S, Aoki NP, Arpinar S, Cummings RD, Fujita A, Fujita N, Hart GM, Haslam SM, Kawasaki T, Matsubara M, Moreman KW, Okuda S, Pierce M, Ranzinger R, Shikanai T, Shinmachi D, Solovieva E, Suzuki Y, Tsuchiya S, Yamada I, York WS, Zaia J, Narimatsu H. GlyTouCan 1.0--The international glycan structure repository. Nucleic Acids Res. 2016 Jan 04; 44(D1):D1237-42. PMID: 26476458; PMCID: PMC4702779.
  22. Zhang W, James PM, Ng BG, Li X, Xia B, Rong J, Asif G, Raymond K, Jones MA, Hegde M, Ju T, Cummings RD, Clarkson K, Wood T, Boerkoel CF, Freeze HH, He M. A Novel N-Tetrasaccharide in Patients with Congenital Disorders of Glycosylation, Including Asparagine-Linked Glycosylation Protein 1, Phosphomannomutase 2, and Mannose Phosphate Isomerase Deficiencies. Clin Chem. 2016 Jan; 62(1):208-17. PMID: 26430078; PMCID: PMC4819965.
  23. Hu L, Ramani S, Czako R, Sankaran B, Yu Y, Smith DF, Cummings RD, Estes MK, Venkataram Prasad BV. Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus. Nat Commun. 2015 Sep 30; 6:8346. PMID: 26420502; PMCID: PMC4589887.
  24. Kooij G, Braster R, Koning JJ, Laan LC, van Vliet SJ, Los T, Eveleens AM, van der Pol SM, Förster-Waldl E, Boztug K, Belot A, Szilagyi K, van den Berg TK, van Buul JD, van Egmond M, de Vries HE, Cummings RD, Dijkstra CD, van Die I. Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis. Acta Neuropathol Commun. 2015 Jul 25; 3:45. PMID: 26205402; PMCID: PMC4513676.
  25. Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL. Recognition of microbial glycans by human intelectin-1. Nat Struct Mol Biol. 2015 Aug; 22(8):603-10. PMID: 26148048; PMCID: PMC4526365 [Available on 02/01/16].
  26. Zeng J, Mi R, Wang Y, Li Y, Lin L, Yao B, Song L, van Die I, Chapman AB, Cummings RD, Jin P, Ju T. Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation. J Biol Chem. 2015 Jul 31; 290(31):19018-33. PMID: 26063800; PMCID: PMC4521027 [Available on 07/31/16].
  27. Klaver EJ, van der Pouw Kraan TC, Laan LC, Kringel H, Cummings RD, Bouma G, Kraal G, van Die I. Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells. Genes Immun. 2015 Sep; 16(6):378-87. PMID: 25996526.
    View in: PubMed
  28. Marchiori MF, Souto DE, Bortot LO, Pereira JF, Kubota LT, Cummings RD, Dias-Baruffi M, Carvalho I, Campo VL. Synthetic 1,2,3-triazole-linked glycoconjugates bind with high affinity to human galectin-3. Bioorg Med Chem. 2015 Jul 01; 23(13):3414-25. PMID: 25975642.
    View in: PubMed
  29. Klaver EJ, Kuijk LM, Lindhorst TK, Cummings RD, van Die I. Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor. PLoS One. 2015; 10(4):e0124089. PMID: 25897665; PMCID: PMC4405200.
  30. Song X, Heimburg-Molinaro J, Smith DF, Cummings RD. Glycan microarrays of fluorescently-tagged natural glycans. Glycoconj J. 2015 Oct; 32(7):465-73. PMID: 25877830; PMCID: PMC4607549 [Available on 10/01/16].
  31. Krishnamurthy VR, Sardar MY, Ying Y, Song X, Haller C, Dai E, Wang X, Hanjaya-Putra D, Sun L, Morikis V, Simon SI, Woods RJ, Cummings RD, Chaikof EL. Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo. Nat Commun. 2015 Mar 31; 6:6387. PMID: 25824568; PMCID: PMC4423566.
  32. Prasanphanich NS, Song X, Heimburg-Molinaro J, Luyai AE, Lasanajak Y, Cutler CE, Smith DF, Cummings RD. Intact reducing glycan promotes the specific immune response to lacto-N-neotetraose-BSA neoglycoconjugates. Bioconjug Chem. 2015 Mar 18; 26(3):559-71. PMID: 25671348; PMCID: PMC4517824.
  33. Kudelka MR, Ju T, Heimburg-Molinaro J, Cummings RD. Simple sugars to complex disease--mucin-type O-glycans in cancer. Adv Cancer Res. 2015; 126:53-135. PMID: 25727146.
    View in: PubMed
  34. Olson LJ, Castonguay AC, Lasanajak Y, Peterson FC, Cummings RD, Smith DF, Dahms NM. Identification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor. Glycobiology. 2015 Jun; 25(6):591-606. PMID: 25573276; PMCID: PMC4410830.
  35. Schneider C, Smith DF, Cummings RD, Boligan KF, Hamilton RG, Bochner BS, Miescher S, Simon HU, Pashov A, Vassilev T, von Gunten S. The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites. Sci Transl Med. 2015 Jan 07; 7(269):269ra1. PMID: 25568069; PMCID: PMC4864610.
  36. Arthur CM, Cummings RD, Stowell SR. Evaluation of the bactericidal activity of galectins. Methods Mol Biol. 2015; 1207:421-30. PMID: 25253156.
    View in: PubMed
  37. Leppänen A, Arthur CM, Stowell SR, Cummings RD. Examination of whole cell galectin binding by solid phase and flow cytometric analysis. Methods Mol Biol. 2015; 1207:91-104. PMID: 25253135.
    View in: PubMed
  38. Stowell SR, Ju T, Cummings RD. Protein glycosylation in cancer. Annu Rev Pathol. 2015; 10:473-510. PMID: 25621663; PMCID: PMC4396820.
  39. Arthur CM, Rodrigues LC, Baruffi MD, Sullivan HC, Cummings RD, Stowell SR. Detection of phosphatidylserine exposure on leukocytes following treatment with human galectins. Methods Mol Biol. 2015; 1207:185-200. PMID: 25253141.
    View in: PubMed
  40. Arthur CM, Baruffi MD, Cummings RD, Stowell SR. Evolving mechanistic insights into galectin functions. Methods Mol Biol. 2015; 1207:1-35. PMID: 25253130.
    View in: PubMed
  41. Arthur CM, Rodrigues LC, Baruffi MD, Sullivan HC, Heimburg-Molinaro J, Smith DF, Cummings RD, Stowell SR. Examining galectin binding specificity using glycan microarrays. Methods Mol Biol. 2015; 1207:115-31. PMID: 25253137.
    View in: PubMed
  42. Stowell SR, Arthur CM, Cummings RD, Feasley CL. Alkylation of galectin-1 with iodoacetamide and mass spectrometric mapping of the sites of incorporation. Methods Mol Biol. 2015; 1207:51-62. PMID: 25253132.
    View in: PubMed
  43. Javed MA, van Alphen LB, Sacher J, Ding W, Kelly J, Nargang C, Smith DF, Cummings RD, Szymanski CM. A receptor-binding protein of Campylobacter jejuni bacteriophage NCTC 12673 recognizes flagellin glycosylated with acetamidino-modified pseudaminic acid. Mol Microbiol. 2015 Jan; 95(1):101-15. PMID: 25354466.
    View in: PubMed
  44. Toledo KA, Fermino ML, Andrade Cdel C, Riul TB, Alves RT, Muller VD, Russo RR, Stowell SR, Cummings RD, Aquino VH, Dias-Baruffi M. Galectin-1 exerts inhibitory effects during DENV-1 infection. PLoS One. 2014; 9(11):e112474. PMID: 25392933; PMCID: PMC4231055.
  45. Hotaling NA, Ratner DM, Cummings RD, Babensee JE. Presentation Modality of Glycoconjugates Modulates Dendritic Cell Phenotype. Biomater Sci. 2014 Oct 01; 2(10):1426-1439. PMID: 26146546.
    View in: PubMed
  46. Cummings RD. T cells are Smad'ly in love with galectin-9. Immunity. 2014 Aug 21; 41(2):171-3. PMID: 25148018.
    View in: PubMed
  47. Agravat SB, Saltz JH, Cummings RD, Smith DF. GlycoPattern: a web platform for glycan array mining. Bioinformatics. 2014 Dec 01; 30(23):3417-8. PMID: 25143288; PMCID: PMC4296152.
  48. Mickum ML, Prasanphanich NS, Heimburg-Molinaro J, Leon KE, Cummings RD. Deciphering the glycogenome of schistosomes. Front Genet. 2014; 5:262. PMID: 25147556; PMCID: PMC4122909.
  49. Lehoux S, Mi R, Aryal RP, Wang Y, Schjoldager KT, Clausen H, van Die I, Han Y, Chapman AB, Cummings RD, Ju T. Identification of distinct glycoforms of IgA1 in plasma from patients with immunoglobulin A (IgA) nephropathy and healthy individuals. Mol Cell Proteomics. 2014 Nov; 13(11):3097-113. PMID: 25071157; PMCID: PMC4223494.
  50. Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Mickum ML, Ashline DJ, Prasad BV, Estes MK, Reinhold VN, Cummings RD, Smith DF. Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses. Mol Cell Proteomics. 2014 Nov; 13(11):2944-60. PMID: 25048705; PMCID: PMC4223483.
  51. Ashline DJ, Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Prasad V, Estes MK, Cummings RD, Smith DF, Reinhold VN. Structural characterization by multistage mass spectrometry (MSn) of human milk glycans recognized by human rotaviruses. Mol Cell Proteomics. 2014 Nov; 13(11):2961-74. PMID: 25048706; PMCID: PMC4223484.
  52. Smith DF, Cummings RD. Investigating virus-glycan interactions using glycan microarrays. Curr Opin Virol. 2014 Aug; 7:79-87. PMID: 24995558; PMCID: PMC4149940.
  53. Sartim MA, Riul TB, Del Cistia-Andrade C, Stowell SR, Arthur CM, Sorgi CA, Faccioli LH, Cummings RD, Dias-Baruffi M, Sampaio SV. Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation. Glycobiology. 2014 Nov; 24(11):1010-21. PMID: 24973254; PMCID: PMC4181450.
  54. Cummings RD. If it is methylated it must be Tectonic. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9669-70. PMID: 24961371; PMCID: PMC4103357.
  55. Sun X, Fu X, Li J, Xing C, Frierson HF, Wu H, Ding X, Ju T, Cummings RD, Dong JT. Deletion of atbf1/zfhx3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways. Neoplasia. 2014 May; 16(5):377-89. PMID: 24934715; PMCID: PMC4198693.
  56. Byrd-Leotis L, Liu R, Bradley KC, Lasanajak Y, Cummings SF, Song X, Heimburg-Molinaro J, Galloway SE, Culhane MR, Smith DF, Steinhauer DA, Cummings RD. Shotgun glycomics of pig lung identifies natural endogenous receptors for influenza viruses. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2241-50. PMID: 24843157; PMCID: PMC4050609.
  57. Stowell SR, Arthur CM, McBride R, Berger O, Razi N, Heimburg-Molinaro J, Rodrigues LC, Gourdine JP, Noll AJ, von Gunten S, Smith DF, Knirel YA, Paulson JC, Cummings RD. Microbial glycan microarrays define key features of host-microbial interactions. Nat Chem Biol. 2014 Jun; 10(6):470-6. PMID: 24814672; PMCID: PMC4158828.
  58. Hotaling NA, Cummings RD, Ratner DM, Babensee JE. Molecular factors in dendritic cell responses to adsorbed glycoconjugates. Biomaterials. 2014 Jul; 35(22):5862-74. PMID: 24746228; PMCID: PMC4127877.
  59. Luyai AE, Heimburg-Molinaro J, Prasanphanich NS, Mickum ML, Lasanajak Y, Song X, Nyame AK, Wilkins P, Rivera-Marrero CA, Smith DF, Van Die I, Secor WE, Cummings RD. Differential expression of anti-glycan antibodies in schistosome-infected humans, rhesus monkeys and mice. Glycobiology. 2014 Jul; 24(7):602-18. PMID: 24727442; PMCID: PMC4038252.
  60. Prasanphanich NS, Luyai AE, Song X, Heimburg-Molinaro J, Mandalasi M, Mickum M, Smith DF, Nyame AK, Cummings RD. Immunization with recombinantly expressed glycan antigens from Schistosoma mansoni induces glycan-specific antibodies against the parasite. Glycobiology. 2014 Jul; 24(7):619-37. PMID: 24727440; PMCID: PMC4038251.
  61. Wang L, Cummings RD, Smith DF, Huflejt M, Campbell CT, Gildersleeve JC, Gerlach JQ, Kilcoyne M, Joshi L, Serna S, Reichardt NC, Parera Pera N, Pieters RJ, Eng W, Mahal LK. Cross-platform comparison of glycan microarray formats. Glycobiology. 2014 Jun; 24(6):507-17. PMID: 24658466; PMCID: PMC4001710.
  62. Aryal RP, Ju T, Cummings RD. Identification of a novel protein binding motif within the T-synthase for the molecular chaperone Cosmc. J Biol Chem. 2014 Apr 25; 289(17):11630-41. PMID: 24616093; PMCID: PMC4002073.
  63. Song X, Heimburg-Molinaro J, Cummings RD, Smith DF. Chemistry of natural glycan microarrays. Curr Opin Chem Biol. 2014 Feb; 18:70-7. PMID: 24487062; PMCID: PMC3940340.
  64. Arthur CM, Cummings RD, Stowell SR. Using glycan microarrays to understand immunity. Curr Opin Chem Biol. 2014 Feb; 18:55-61. PMID: 24486647.
    View in: PubMed
  65. Halder S, Cotmore S, Heimburg-Molinaro J, Smith DF, Cummings RD, Chen X, Trollope AJ, North SJ, Haslam SM, Dell A, Tattersall P, McKenna R, Agbandje-McKenna M. Profiling of glycan receptors for minute virus of mice in permissive cell lines towards understanding the mechanism of cell recognition. PLoS One. 2014; 9(1):e86909. PMID: 24475195; PMCID: PMC3903596.
  66. Cummings RD, Pierce JM. The challenge and promise of glycomics. Chem Biol. 2014 Jan 16; 21(1):1-15. PMID: 24439204; PMCID: PMC3955176.
  67. Gulati S, Lasanajak Y, Smith DF, Cummings RD, Air GM. Glycan array analysis of influenza H1N1 binding and release. Cancer Biomark. 2014 Jan 01; 14(1):43-53. PMID: 24643041; PMCID: PMC4161021.
  68. Ju T, Aryal RP, Kudelka MR, Wang Y, Cummings RD. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 01; 14(1):63-81. PMID: 24643043.
    View in: PubMed
  69. Garapaty-Rao S, Nasveschuk C, Gagnon A, Chan EY, Sandy P, Busby J, Balasubramanian S, Campbell R, Zhao F, Bergeron L, Audia JE, Albrecht BK, Harmange JC, Cummings R, Trojer P. Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth. Chem Biol. 2013 Nov 21; 20(11):1329-39. PMID: 24183969.
    View in: PubMed
  70. Mimche SM, Nyagode BA, Merrell MD, Lee CM, Prasanphanich NS, Cummings RD, Morgan ET. Hepatic cytochrome P450s, phase II enzymes and nuclear receptors are downregulated in a Th2 environment during Schistosoma mansoni infection. Drug Metab Dispos. 2014 Jan; 42(1):134-40. PMID: 24163175; PMCID: PMC3876789.
  71. Richardson C, Chida AS, Adlowitz D, Silver L, Fox E, Jenks SA, Palmer E, Wang Y, Heimburg-Molinaro J, Li QZ, Mohan C, Cummings R, Tipton C, Sanz I. Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus. J Immunol. 2013 Nov 15; 191(10):4926-39. PMID: 24108696; PMCID: PMC3816606.
  72. Brazil JC, Liu R, Sumagin R, Kolegraff KN, Nusrat A, Cummings RD, Parkos CA, Louis NA. a3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration. J Immunol. 2013 Nov 01; 191(9):4804-17. PMID: 24068663; PMCID: PMC4047976.
  73. Song X, Johns BA, Ju H, Lasanajak Y, Zhao C, Smith DF, Cummings RD. Novel cleavage of reductively aminated glycan-tags by N-bromosuccinimide to regenerate free, reducing glycans. ACS Chem Biol. 2013 Nov 15; 8(11):2478-83. PMID: 23992636; PMCID: PMC4266466.
  74. Ju T, Wang Y, Aryal RP, Lehoux SD, Ding X, Kudelka MR, Cutler C, Zeng J, Wang J, Sun X, Heimburg-Molinaro J, Smith DF, Cummings RD. Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers. Proteomics Clin Appl. 2013 Oct; 7(9-10):618-31. PMID: 23857728.
    View in: PubMed
  75. Prasanphanich NS, Mickum ML, Heimburg-Molinaro J, Cummings RD. Glycoconjugates in host-helminth interactions. Front Immunol. 2013; 4:240. PMID: 24009607; PMCID: PMC3755266.
  76. Xia B, Zhang W, Li X, Jiang R, Harper T, Liu R, Cummings RD, He M. Serum N-glycan and O-glycan analysis by mass spectrometry for diagnosis of congenital disorders of glycosylation. Anal Biochem. 2013 Nov 15; 442(2):178-85. PMID: 23928051.
    View in: PubMed
  77. Heimburg-Molinaro J, Priest JW, Live D, Boons GJ, Song X, Cummings RD, Mead JR. Microarray analysis of the human antibody response to synthetic Cryptosporidium glycopeptides. Int J Parasitol. 2013 Oct; 43(11):901-7. PMID: 23856596; PMCID: PMC3937990.
  78. Gulati S, Smith DF, Cummings RD, Couch RB, Griesemer SB, St George K, Webster RG, Air GM. Human H3N2 Influenza Viruses Isolated from 1968 To 2012 Show Varying Preference for Receptor Substructures with No Apparent Consequences for Disease or Spread. PLoS One. 2013; 8(6):e66325. PMID: 23805213; PMCID: PMC3689742.
  79. Xia B, Asif G, Arthur L, Pervaiz MA, Li X, Liu R, Cummings RD, He M. Oligosaccharide analysis in urine by maldi-tof mass spectrometry for the diagnosis of lysosomal storage diseases. Clin Chem. 2013 Sep; 59(9):1357-68. PMID: 23676310.
    View in: PubMed
  80. Gao Y, Aryal RP, Ju T, Cummings RD, Gahlay G, Jarvis DL, Matta KL, Vlahakis JZ, Szarek WA, Brockhausen I. Acceptor specificities and selective inhibition of recombinant human Gal- and GlcNAc-transferases that synthesize core structures 1, 2, 3 and 4 of O-glycans. Biochim Biophys Acta. 2013 Aug; 1830(8):4274-81. PMID: 23578692; PMCID: PMC4002258.
  81. Mandalasi M, Dorabawila N, Smith DF, Heimburg-Molinaro J, Cummings RD, Nyame AK. Development and characterization of a specific IgG monoclonal antibody toward the Lewis x antigen using splenocytes of Schistosoma mansoni-infected mice. Glycobiology. 2013 Jul; 23(7):877-92. PMID: 23542315; PMCID: PMC3671776.
  82. Ju T, Aryal RP, Kudelka MR, Wang Y, Cummings RD. WITHDRAWN: The Cosmc connection to the Tn antigen in cancer. Dis Markers. 2013 Mar 11. PMID: 23478278.
    View in: PubMed
  83. Smith DF, Cummings RD. Application of microarrays for deciphering the structure and function of the human glycome. Mol Cell Proteomics. 2013 Apr; 12(4):902-12. PMID: 23412570; PMCID: PMC3617337.
  84. Ju T, Cummings RD. A fluorescence-based assay for Core 1 ß3galactosyltransferase (T-synthase) activity. Methods Mol Biol. 2013; 1022:15-28. PMID: 23765650.
    View in: PubMed
  85. Klaver EJ, Kuijk LM, Laan LC, Kringel H, van Vliet SJ, Bouma G, Cummings RD, Kraal G, van Die I. Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated. Int J Parasitol. 2013 Mar; 43(3-4):191-200. PMID: 23220043.
    View in: PubMed
  86. Hakomori SI, Cummings RD. Glycosylation effects on cancer development. Glycoconj J. 2012 Dec; 29(8-9):565-6. PMID: 22996057.
    View in: PubMed
  87. Yu Y, Mishra S, Song X, Lasanajak Y, Bradley KC, Tappert MM, Air GM, Steinhauer DA, Halder S, Cotmore S, Tattersall P, Agbandje-McKenna M, Cummings RD, Smith DF. Functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers. J Biol Chem. 2012 Dec 28; 287(53):44784-99. PMID: 23115247; PMCID: PMC3531791.
  88. Stowell SR, Winkler AM, Maier CL, Arthur CM, Smith NH, Girard-Pierce KR, Cummings RD, Zimring JC, Hendrickson JE. Initiation and regulation of complement during hemolytic transfusion reactions. Clin Dev Immunol. 2012; 2012:307093. PMID: 23118779; PMCID: PMC3479954.
  89. Mi R, Song L, Wang Y, Ding X, Zeng J, Lehoux S, Aryal RP, Wang J, Crew VK, van Die I, Chapman AB, Cummings RD, Ju T. Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen. J Biol Chem. 2012 Nov 30; 287(49):41523-33. PMID: 23035125; PMCID: PMC3510848.
  90. Wang Y, Jobe SM, Ding X, Choo H, Archer DR, Mi R, Ju T, Cummings RD. Platelet biogenesis and functions require correct protein O-glycosylation. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16143-8. PMID: 22988088; PMCID: PMC3479543.
  91. Cholleti SR, Agravat S, Morris T, Saltz JH, Song X, Cummings RD, Smith DF. Automated motif discovery from glycan array data. OMICS. 2012 Oct; 16(10):497-512. PMID: 22877213; PMCID: PMC3459425.
  92. Song X, Smith DF, Cummings RD. Nonenzymatic release of free reducing glycans from glycosphingolipids. Anal Biochem. 2012 Oct 01; 429(1):82-7. PMID: 22776091.
    View in: PubMed
  93. Padler-Karavani V, Song X, Yu H, Hurtado-Ziola N, Huang S, Muthana S, Chokhawala HA, Cheng J, Verhagen A, Langereis MA, Kleene R, Schachner M, de Groot RJ, Lasanajak Y, Matsuda H, Schwab R, Chen X, Smith DF, Cummings RD, Varki A. Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. J Biol Chem. 2012 Jun 29; 287(27):22593-608. PMID: 22549775; PMCID: PMC3391140.
  94. Su H, Carter CB, Fröhlich O, Cummings RD, Chen G. Glycoforms of UT-A3 urea transporter with poly-N-acetyllactosamine glycosylation have enhanced transport activity. Am J Physiol Renal Physiol. 2012 Jul 15; 303(2):F201-8. PMID: 22535801; PMCID: PMC3404584.
  95. Borgert A, Heimburg-Molinaro J, Song X, Lasanajak Y, Ju T, Liu M, Thompson P, Ragupathi G, Barany G, Smith DF, Cummings RD, Live D. Deciphering structural elements of mucin glycoprotein recognition. ACS Chem Biol. 2012 Jun 15; 7(6):1031-9. PMID: 22444368; PMCID: PMC3508731.
  96. Miwa HE, Song Y, Alvarez R, Cummings RD, Stanley P. The bisecting GlcNAc in cell growth control and tumor progression. Glycoconj J. 2012 Dec; 29(8-9):609-18. PMID: 22476631; PMCID: PMC3459286.
  97. Aryal RP, Ju T, Cummings RD. Tight complex formation between Cosmc chaperone and its specific client non-native T-synthase leads to enzyme activity and client-driven dissociation. J Biol Chem. 2012 May 04; 287(19):15317-29. PMID: 22416136; PMCID: PMC3346102.
  98. Castonguay AC, Lasanajak Y, Song X, Olson LJ, Cummings RD, Smith DF, Dahms NM. The glycan-binding properties of the cation-independent mannose 6-phosphate receptor are evolutionary conserved in vertebrates. Glycobiology. 2012 Jul; 22(7):983-96. PMID: 22369936; PMCID: PMC3355666.
  99. Heimburg-Molinaro J, Tappert M, Song X, Lasanajak Y, Air G, Smith DF, Cummings RD. Probing virus-glycan interactions using glycan microarrays. Methods Mol Biol. 2012; 808:251-67. PMID: 22057531; PMCID: PMC4930331.
  100. Song X, Heimburg-Molinaro J, Dahms NM, Smith DF, Cummings RD. Preparation of a mannose-6-phosphate glycan microarray through fluorescent derivatization, phosphorylation, and immobilization of natural high-mannose N-glycans and application in ligand identification of P-type lectins. Methods Mol Biol. 2012; 808:137-48. PMID: 22057522; PMCID: PMC4668285.
  101. Song X, Heimburg-Molinaro J, Smith DF, Cummings RD. Glycan microarrays. Methods Mol Biol. 2012; 800:163-71. PMID: 21964788.
    View in: PubMed
  102. Bradley KC, Galloway SE, Lasanajak Y, Song X, Heimburg-Molinaro J, Yu H, Chen X, Talekar GR, Smith DF, Cummings RD, Steinhauer DA. Analysis of influenza virus hemagglutinin receptor binding mutants with limited receptor recognition properties and conditional replication characteristics. J Virol. 2011 Dec; 85(23):12387-98. PMID: 21917953; PMCID: PMC3209400.
  103. Aranzamendi C, Tefsen B, Jansen M, Chiumiento L, Bruschi F, Kortbeek T, Smith DF, Cummings RD, Pinelli E, Van Die I. Glycan microarray profiling of parasite infection sera identifies the LDNF glycan as a potential antigen for serodiagnosis of trichinellosis. Exp Parasitol. 2011 Nov; 129(3):221-6. PMID: 21893057; PMCID: PMC3490624.
  104. Song X, Yu H, Chen X, Lasanajak Y, Tappert MM, Air GM, Tiwari VK, Cao H, Chokhawala HA, Zheng H, Cummings RD, Smith DF. A sialylated glycan microarray reveals novel interactions of modified sialic acids with proteins and viruses. J Biol Chem. 2011 Sep 09; 286(36):31610-22. PMID: 21757734; PMCID: PMC3173124.
  105. Heimburg-Molinaro J, Song X, Smith DF, Cummings RD. Preparation and analysis of glycan microarrays. Curr Protoc Protein Sci. 2011 Apr; Chapter 12:Unit12.10. PMID: 21488041; PMCID: PMC3097418.
  106. Song X, Heimburg-Molinaro J, Smith DF, Cummings RD. Derivatization of free natural glycans for incorporation onto glycan arrays: derivatizing glycans on the microscale for microarray and other applications (ms# CP-10-0194). Curr Protoc Chem Biol. 2011 Apr 01; 3(2):53-63. PMID: 22022660.
    View in: PubMed
  107. Bradley KC, Jones CA, Tompkins SM, Tripp RA, Russell RJ, Gramer MR, Heimburg-Molinaro J, Smith DF, Cummings RD, Steinhauer DA. Comparison of the receptor binding properties of contemporary swine isolates and early human pandemic H1N1 isolates (Novel 2009 H1N1). Virology. 2011 May 10; 413(2):169-82. PMID: 21353280.
    View in: PubMed
  108. Sun Q, Ju T, Cummings RD. The transmembrane domain of the molecular chaperone Cosmc directs its localization to the endoplasmic reticulum. J Biol Chem. 2011 Apr 01; 286(13):11529-42. PMID: 21262965; PMCID: PMC3064207.
  109. Ju T, Otto VI, Cummings RD. The Tn antigen-structural simplicity and biological complexity. Angew Chem Int Ed Engl. 2011 Feb 18; 50(8):1770-91. PMID: 21259410.
    View in: PubMed
  110. Van Damme EJ, Smith DF, Cummings R, Peumans WJ. Glycan arrays to decipher the specificity of plant lectins. Adv Exp Med Biol. 2011; 705:757-67. PMID: 21618139.
    View in: PubMed
  111. Cerliani JP, Stowell SR, Mascanfroni ID, Arthur CM, Cummings RD, Rabinovich GA. Expanding the universe of cytokines and pattern recognition receptors: galectins and glycans in innate immunity. J Clin Immunol. 2011 Feb; 31(1):10-21. PMID: 21184154.
    View in: PubMed
  112. Song X, Lasanajak Y, Xia B, Heimburg-Molinaro J, Rhea JM, Ju H, Zhao C, Molinaro RJ, Cummings RD, Smith DF. Shotgun glycomics: a microarray strategy for functional glycomics. Nat Methods. 2011 Jan; 8(1):85-90. PMID: 21131969; PMCID: PMC3074519.
  113. Ju T, Xia B, Aryal RP, Wang W, Wang Y, Ding X, Mi R, He M, Cummings RD. A novel fluorescent assay for T-synthase activity. Glycobiology. 2011 Mar; 21(3):352-62. PMID: 20959392; PMCID: PMC3033746.
  114. Huang W, Zhang X, Ju T, Cummings RD, Wang LX. Expeditious chemoenzymatic synthesis of CD52 glycopeptide antigens. Org Biomol Chem. 2010 Nov 21; 8(22):5224-33. PMID: 20848033; PMCID: PMC3717399.
  115. Lee WY, Weber DA, Laur O, Stowell SR, McCall I, Andargachew R, Cummings RD, Parkos CA. The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47. J Biol Chem. 2010 Dec 03; 285(49):37953-63. PMID: 20826801; PMCID: PMC2992229.
  116. Bolscher JG, Brevoord J, Nazmi K, Ju T, Veerman EC, van Wijk JA, Cummings RD, van Die I. Solid-phase synthesis of a pentavalent GalNAc-containing glycopeptide (Tn antigen) representing the nephropathy-associated IgA hinge region. Carbohydr Res. 2010 Sep 23; 345(14):1998-2003. PMID: 20719305; PMCID: PMC2940223.
  117. Krishnamurthy VR, Wilson JT, Cui W, Song X, Lasanajak Y, Cummings RD, Chaikof EL. Chemoselective immobilization of peptides on abiotic and cell surfaces at controlled densities. Langmuir. 2010 Jun 01; 26(11):7675-8. PMID: 20450194; PMCID: PMC2894806.
  118. Leppänen A, Parviainen V, Ahola-Iivarinen E, Kalkkinen N, Cummings RD. Human L-selectin preferentially binds synthetic glycosulfopeptides modeled after endoglycan and containing tyrosine sulfate residues and sialyl Lewis x in core 2 O-glycans. Glycobiology. 2010 Sep; 20(9):1170-85. PMID: 20507883; PMCID: PMC2948818.
  119. Krishnamurthy VR, Dougherty A, Kamat M, Song X, Cummings RD, Chaikof EL. Synthesis of an Fmoc-threonine bearing core-2 glycan: a building block for PSGL-1 via Fmoc-assisted solid-phase peptide synthesis. Carbohydr Res. 2010 Jul 19; 345(11):1541-7. PMID: 20561607; PMCID: PMC2902660.
  120. Wang Y, Ju T, Ding X, Xia B, Wang W, Xia L, He M, Cummings RD. Cosmc is an essential chaperone for correct protein O-glycosylation. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9228-33. PMID: 20439703; PMCID: PMC2889116.
  121. Stowell SR, Arthur CM, Dias-Baruffi M, Rodrigues LC, Gourdine JP, Heimburg-Molinaro J, Ju T, Molinaro RJ, Rivera-Marrero C, Xia B, Smith DF, Cummings RD. Innate immune lectins kill bacteria expressing blood group antigen. Nat Med. 2010 Mar; 16(3):295-301. PMID: 20154696; PMCID: PMC2853181.
  122. Dias-Baruffi M, Stowell SR, Song SC, Arthur CM, Cho M, Rodrigues LC, Montes MA, Rossi MA, James JA, McEver RP, Cummings RD. Differential expression of immunomodulatory galectin-1 in peripheral leukocytes and adult tissues and its cytosolic organization in striated muscle. Glycobiology. 2010 May; 20(5):507-20. PMID: 20053628; PMCID: PMC2900886.
  123. Leppänen A, Cummings RD. Fluorescence-based solid-phase assays to study glycan-binding protein interactions with glycoconjugates. Methods Enzymol. 2010; 478:241-64. PMID: 20816484.
    View in: PubMed
  124. Smith DF, Song X, Cummings RD. Use of glycan microarrays to explore specificity of glycan-binding proteins. Methods Enzymol. 2010; 480:417-44. PMID: 20816220.
    View in: PubMed
  125. Ju T, Cummings RD. Functional assays for the molecular chaperone cosmc. Methods Enzymol. 2010; 479:107-22. PMID: 20816162.
    View in: PubMed
  126. Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Marth JD, Bertozzi CR, Hart GW, Etzler ME. Symbol nomenclature for glycan representation. Proteomics. 2009 Dec; 9(24):5398-9. PMID: 19902428; PMCID: PMC2882983.
  127. Aryal RP, Ju T, Cummings RD. The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase. J Biol Chem. 2010 Jan 22; 285(4):2456-62. PMID: 19923218; PMCID: PMC2807302.
  128. Dong H, Song X, Lasanajak Y, Cummings RD, Chaikof EL. Facile construction of fluorescent peptide microarrays: One-step fluorescent derivatization of sub-microscale peptide aldehydes for selective terminal immobilization. Anal Biochem. 2010 Mar 01; 398(1):132-4. PMID: 19903446; PMCID: PMC2812691.
  129. Babu P, North SJ, Jang-Lee J, Chalabi S, Mackerness K, Stowell SR, Cummings RD, Rankin S, Dell A, Haslam SM. Structural characterisation of neutrophil glycans by ultra sensitive mass spectrometric glycomics methodology. Glycoconj J. 2009 Nov; 26(8):975-86. PMID: 18587645; PMCID: PMC2791480.
  130. Bohnsack RN, Song X, Olson LJ, Kudo M, Gotschall RR, Canfield WM, Cummings RD, Smith DF, Dahms NM. Cation-independent mannose 6-phosphate receptor: a composite of distinct phosphomannosyl binding sites. J Biol Chem. 2009 Dec 11; 284(50):35215-26. PMID: 19840944; PMCID: PMC2787381.
  131. Song X, Lasanajak Y, Olson LJ, Boonen M, Dahms NM, Kornfeld S, Cummings RD, Smith DF. Glycan microarray analysis of P-type lectins reveals distinct phosphomannose glycan recognition. J Biol Chem. 2009 Dec 11; 284(50):35201-14. PMID: 19801653; PMCID: PMC2787380.
  132. Song X, Lasanajak Y, Xia B, Smith DF, Cummings RD. Fluorescent glycosylamides produced by microscale derivatization of free glycans for natural glycan microarrays. ACS Chem Biol. 2009 Sep 18; 4(9):741-50. PMID: 19618966; PMCID: PMC2746876.
  133. van Die I, Cummings RD. Glycan gimmickry by parasitic helminths: a strategy for modulating the host immune response? Glycobiology. 2010 Jan; 20(1):2-12. PMID: 19748975.
    View in: PubMed
  134. Song X, Lasanajak Y, Rivera-Marrero C, Luyai A, Willard M, Smith DF, Cummings RD. Generation of a natural glycan microarray using 9-fluorenylmethyl chloroformate (FmocCl) as a cleavable fluorescent tag. Anal Biochem. 2009 Dec 15; 395(2):151-60. PMID: 19699706; PMCID: PMC2761097.
  135. van Stijn CM, van den Broek M, Vervelde L, Alvarez RA, Cummings RD, Tefsen B, van Die I. Vaccination-induced IgG response to Galalpha1-3GalNAc glycan epitopes in lambs protected against Haemonchus contortus challenge infection. Int J Parasitol. 2010 Feb; 40(2):215-22. PMID: 19695255; PMCID: PMC2813329.
  136. Cummings RD. The repertoire of glycan determinants in the human glycome. Mol Biosyst. 2009 Oct; 5(10):1087-104. PMID: 19756298.
    View in: PubMed
  137. Luyai A, Lasanajak Y, Smith DF, Cummings RD, Song X. Facile preparation of fluorescent neoglycoproteins using p-nitrophenyl anthranilate as a heterobifunctional linker. Bioconjug Chem. 2009 Aug 19; 20(8):1618-24. PMID: 19624117.
    View in: PubMed
  138. von Gunten S, Smith DF, Cummings RD, Riedel S, Miescher S, Schaub A, Hamilton RG, Bochner BS. Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclass. J Allergy Clin Immunol. 2009 Jun; 123(6):1268-76.e15. PMID: 19443021; PMCID: PMC2777748.
  139. Hernandez Mir G, Helin J, Skarp KP, Cummings RD, Mäkitie A, Renkonen R, Leppänen A. Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans. Blood. 2009 Jul 16; 114(3):733-41. PMID: 19359410; PMCID: PMC2713463.
  140. Xia B, Feasley CL, Sachdev GP, Smith DF, Cummings RD. Glycan reductive isotope labeling for quantitative glycomics. Anal Biochem. 2009 Apr 15; 387(2):162-70. PMID: 19454239; PMCID: PMC2706496.
  141. Song X, Xia B, Stowell SR, Lasanajak Y, Smith DF, Cummings RD. Novel fluorescent glycan microarray strategy reveals ligands for galectins. Chem Biol. 2009 Jan 30; 16(1):36-47. PMID: 19171304; PMCID: PMC2662446.
  142. Stowell SR, Karmakar S, Arthur CM, Ju T, Rodrigues LC, Riul TB, Dias-Baruffi M, Miner J, McEver RP, Cummings RD. Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane. Mol Biol Cell. 2009 Mar; 20(5):1408-18. PMID: 19116313; PMCID: PMC2649277.
  143. Stowell SR, Cho M, Feasley CL, Arthur CM, Song X, Colucci JK, Karmakar S, Mehta P, Dias-Baruffi M, McEver RP, Cummings RD. Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation. J Biol Chem. 2009 Feb 20; 284(8):4989-99. PMID: 19103599; PMCID: PMC2643495.
  144. Mitoma J, Miyazaki T, Sutton-Smith M, Suzuki M, Saito H, Yeh JC, Kawano T, Hindsgaul O, Seeberger PH, Panico M, Haslam SM, Morris HR, Cummings RD, Dell A, Fukuda M. The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells. Glycoconj J. 2009 Jul; 26(5):511-23. PMID: 19089612; PMCID: PMC2743473.
  145. Perrine C, Ju T, Cummings RD, Gerken TA. Systematic determination of the peptide acceptor preferences for the human UDP-Gal:glycoprotein-alpha-GalNAc beta 3 galactosyltransferase (T-synthase). Glycobiology. 2009 Mar; 19(3):321-8. PMID: 19073881; PMCID: PMC2733779.
  146. Fu J, Gerhardt H, McDaniel JM, Xia B, Liu X, Ivanciu L, Ny A, Hermans K, Silasi-Mansat R, McGee S, Nye E, Ju T, Ramirez MI, Carmeliet P, Cummings RD, Lupu F, Xia L. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest. 2008 Nov; 118(11):3725-37. PMID: 18924607.
    View in: PubMed
  147. Lawrence R, Olson SK, Steele RE, Wang L, Warrior R, Cummings RD, Esko JD. Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling. J Biol Chem. 2008 Nov 28; 283(48):33674-84. PMID: 18818196; PMCID: PMC2586254.
  148. Cerri DG, Rodrigues LC, Stowell SR, Araujo DD, Coelho MC, Oliveira SR, Bizario JC, Cummings RD, Dias-Baruffi M, Costa MC. Degeneration of dystrophic or injured skeletal muscles induces high expression of Galectin-1. Glycobiology. 2008 Nov; 18(11):842-50. PMID: 18723690.
    View in: PubMed
  149. Ju T, Aryal RP, Stowell CJ, Cummings RD. Regulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc. J Cell Biol. 2008 Aug 11; 182(3):531-42. PMID: 18695044; PMCID: PMC2500138.
  150. Karmakar S, Stowell SR, Cummings RD, McEver RP. Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans. Glycobiology. 2008 Oct; 18(10):770-8. PMID: 18633135; PMCID: PMC2733774.
  151. Varki AP, Baum LG, Bellis SL, Cummings RD, Esko JD, Hart GW, Linhardt RJ, Lowe JB, McEver RP, Srivastava A, Sarkar R. Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology. 2008 Oct; 18(10):747-9. PMID: 18621991.
    View in: PubMed
  152. Farrand S, Hotze E, Friese P, Hollingshead SK, Smith DF, Cummings RD, Dale GL, Tweten RK. Characterization of a streptococcal cholesterol-dependent cytolysin with a lewis y and b specific lectin domain. Biochemistry. 2008 Jul 08; 47(27):7097-107. PMID: 18553932; PMCID: PMC2622431.
  153. Stowell SR, Arthur CM, Slanina KA, Horton JR, Smith DF, Cummings RD. Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain. J Biol Chem. 2008 Jul 18; 283(29):20547-59. PMID: 18456665; PMCID: PMC2459286.
  154. Zupancic ML, Frieman M, Smith D, Alvarez RA, Cummings RD, Cormack BP. Glycan microarray analysis of Candida glabrata adhesin ligand specificity. Mol Microbiol. 2008 May; 68(3):547-59. PMID: 18394144.
    View in: PubMed
  155. Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia JY, Zuna RE, Laszik Z, Benbrook DM, Hanigan MH, Cummings RD. Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc. Cancer Res. 2008 Mar 15; 68(6):1636-46. PMID: 18339842.
    View in: PubMed
  156. Stowell SR, Qian Y, Karmakar S, Koyama NS, Dias-Baruffi M, Leffler H, McEver RP, Cummings RD. Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol. 2008 Mar 01; 180(5):3091-102. PMID: 18292532.
    View in: PubMed
  157. Kawar ZS, Johnson TK, Natunen S, Lowe JB, Cummings RD. PSGL-1 from the murine leukocytic cell line WEHI-3 is enriched for core 2-based O-glycans with sialyl Lewis x antigen. Glycobiology. 2008 Jun; 18(6):441-6. PMID: 18310305; PMCID: PMC2727551.
  158. Zheng Q, Van Die I, Cummings RD. A novel alpha1,2-fucosyltransferase (CE2FT-2) in Caenorhabditis elegans generates H-type 3 glycan structures. Glycobiology. 2008 Apr; 18(4):290-302. PMID: 18252778.
    View in: PubMed
  159. Klopocki AG, Yago T, Mehta P, Yang J, Wu T, Leppänen A, Bovin NV, Cummings RD, Zhu C, McEver RP. Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis x. J Biol Chem. 2008 Apr 25; 283(17):11493-500. PMID: 18250165; PMCID: PMC2431087.
  160. Stowell SR, Arthur CM, Mehta P, Slanina KA, Blixt O, Leffler H, Smith DF, Cummings RD. Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem. 2008 Apr 11; 283(15):10109-23. PMID: 18216021; PMCID: PMC2442294.
  161. Parthasarathy G, Cummings R, Becker JW, Soisson SM. Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae. Acta Crystallogr D Biol Crystallogr. 2008 Feb; 64(Pt 2):141-8. PMID: 18219113.
    View in: PubMed
  162. Song X, Xia B, Lasanajak Y, Smith DF, Cummings RD. Quantifiable fluorescent glycan microarrays. Glycoconj J. 2008 Jan; 25(1):15-25. PMID: 17763939.
    View in: PubMed
  163. Castillo MG, Wu XJ, Dinguirard N, Nyame AK, Cummings RD, Yoshino TP. Surface membrane proteins of Biomphalaria glabrata embryonic cells bind fucosyl determinants on the tegumental surface of Schistosoma mansoni primary sporocysts. J Parasitol. 2007 Aug; 93(4):832-40. PMID: 17918362.
    View in: PubMed
  164. Amonsen M, Smith DF, Cummings RD, Air GM. Human parainfluenza viruses hPIV1 and hPIV3 bind oligosaccharides with alpha2-3-linked sialic acids that are distinct from those bound by H5 avian influenza virus hemagglutinin. J Virol. 2007 Aug; 81(15):8341-5. PMID: 17522226; PMCID: PMC1951310.
  165. An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L. Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med. 2007 Jun 11; 204(6):1417-29. PMID: 17517967; PMCID: PMC2118614.
  166. Condac E, Silasi-Mansat R, Kosanke S, Schoeb T, Towner R, Lupu F, Cummings RD, Hinsdale ME. Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9416-21. PMID: 17517600; PMCID: PMC1890509.
  167. Kumari K, Gulati S, Smith DF, Gulati U, Cummings RD, Air GM. Receptor binding specificity of recent human H3N2 influenza viruses. Virol J. 2007 May 09; 4:42. PMID: 17490484; PMCID: PMC1876801.
  168. Williams SA, Xia L, Cummings RD, McEver RP, Stanley P. Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans. J Cell Sci. 2007 Apr 15; 120(Pt 8):1341-9. PMID: 17374637.
    View in: PubMed
  169. Nguyen K, van Die I, Grundahl KM, Kawar ZS, Cummings RD. Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family. Glycobiology. 2007 Jun; 17(6):586-99. PMID: 17369288.
    View in: PubMed
  170. Carlsson S, Oberg CT, Carlsson MC, Sundin A, Nilsson UJ, Smith D, Cummings RD, Almkvist J, Karlsson A, Leffler H. Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. Glycobiology. 2007 Jun; 17(6):663-76. PMID: 17339281.
    View in: PubMed
  171. Xia B, Sachdev GP, Cummings RD. Pseudomonas aeruginosa mucoid strain 8830 binds glycans containing the sialyl-Lewis x epitope. Glycoconj J. 2007 Jan; 24(1):87-95. PMID: 17139557.
    View in: PubMed
  172. Jayasuriya H, Herath KB, Zhang C, Zink DL, Basilio A, Genilloud O, Diez MT, Vicente F, Gonzalez I, Salazar O, Pelaez F, Cummings R, Ha S, Wang J, Singh SB. Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity. Angew Chem Int Ed Engl. 2007; 46(25):4684-8. PMID: 17487925.
    View in: PubMed
  173. van Liempt E, Bank CM, Mehta P, Garciá-Vallejo JJ, Kawar ZS, Geyer R, Alvarez RA, Cummings RD, Kooyk Yv, van Die I. Specificity of DC-SIGN for mannose- and fucose-containing glycans. FEBS Lett. 2006 Nov 13; 580(26):6123-31. PMID: 17055489.
    View in: PubMed
  174. Rychak JJ, Li B, Acton ST, Leppänen A, Cummings RD, Ley K, Klibanov AL. Selectin ligands promote ultrasound contrast agent adhesion under shear flow. Mol Pharm. 2006 Sep-Oct; 3(5):516-24. PMID: 17009850.
    View in: PubMed
  175. Stowell SR, Karmakar S, Stowell CJ, Dias-Baruffi M, McEver RP, Cummings RD. Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells. Blood. 2007 Jan 01; 109(1):219-27. PMID: 16940423; PMCID: PMC1785076.
  176. Reneer DV, Kearns SA, Yago T, Sims J, Cummings RD, McEver RP, Carlyon JA. Characterization of a sialic acid- and P-selectin glycoprotein ligand-1-independent adhesin activity in the granulocytotropic bacterium Anaplasma phagocytophilum. Cell Microbiol. 2006 Dec; 8(12):1972-84. PMID: 16869829.
    View in: PubMed
  177. Marková V, Smetana K, Jeníková G, Láchová J, Krejciríková V, Poplstein M, Fábry M, Brynda J, Alvarez RA, Cummings RD, Maly P. Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues. Int J Mol Med. 2006 Jul; 18(1):65-76. PMID: 16786157.
    View in: PubMed
  178. Kim YM, Park KI, Choi KS, Alvarez RA, Cummings RD, Cho M. Lectin from the Manila clam Ruditapes philippinarum is induced upon infection with the protozoan parasite Perkinsus olseni. J Biol Chem. 2006 Sep 15; 281(37):26854-64. PMID: 16785239.
    View in: PubMed
  179. Ju T, Zheng Q, Cummings RD. Identification of core 1 O-glycan T-synthase from Caenorhabditis elegans. Glycobiology. 2006 Oct; 16(10):947-58. PMID: 16762980.
    View in: PubMed
  180. Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature. 2006 May 18; 441(7091):358-61. PMID: 16710421.
    View in: PubMed
  181. van Die I, Cummings RD. Glycans modulate immune responses in helminth infections and allergy. Chem Immunol Allergy. 2006; 90:91-112. PMID: 16210905.
    View in: PubMed
  182. Xia B, Kawar ZS, Ju T, Alvarez RA, Sachdev GP, Cummings RD. Versatile fluorescent derivatization of glycans for glycomic analysis. Nat Methods. 2005 Nov; 2(11):845-50. PMID: 16278655.
    View in: PubMed
  183. Ju T, Cummings RD. Protein glycosylation: chaperone mutation in Tn syndrome. Nature. 2005 Oct 27; 437(7063):1252. PMID: 16251947.
    View in: PubMed
  184. Karmakar S, Cummings RD, McEver RP. Contributions of Ca2+ to galectin-1-induced exposure of phosphatidylserine on activated neutrophils. J Biol Chem. 2005 Aug 05; 280(31):28623-31. PMID: 15929990.
    View in: PubMed
  185. Xia B, Royall JA, Damera G, Sachdev GP, Cummings RD. Altered O-glycosylation and sulfation of airway mucins associated with cystic fibrosis. Glycobiology. 2005 Aug; 15(8):747-75. PMID: 15994837.
    View in: PubMed
  186. Kawar ZS, Haslam SM, Morris HR, Dell A, Cummings RD. Novel poly-GalNAcbeta1-4GlcNAc (LacdiNAc) and fucosylated poly-LacdiNAc N-glycans from mammalian cells expressing beta1,4-N-acetylgalactosaminyltransferase and alpha1,3-fucosyltransferase. J Biol Chem. 2005 Apr 01; 280(13):12810-9. PMID: 15653684.
    View in: PubMed
  187. Geldhof P, Newlands GF, Nyame K, Cummings R, Smith WD, Knox DP. Presence of the LDNF glycan on the host-protective H-gal-GP fraction from Haemonchus contortus. Parasite Immunol. 2005 Jan-Feb; 27(1-2):55-60. PMID: 15813723.
    View in: PubMed
  188. Blixt O, Head S, Mondala T, Scanlan C, Huflejt ME, Alvarez R, Bryan MC, Fazio F, Calarese D, Stevens J, Razi N, Stevens DJ, Skehel JJ, van Die I, Burton DR, Wilson IA, Cummings R, Bovin N, Wong CH, Paulson JC. Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17033-8. PMID: 15563589; PMCID: PMC534418.
  189. Leppänen A, Stowell S, Blixt O, Cummings RD. Dimeric galectin-1 binds with high affinity to alpha2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans. J Biol Chem. 2005 Feb 18; 280(7):5549-62. PMID: 15556936.
    View in: PubMed
  190. van den Berg TK, Honing H, Franke N, van Remoortere A, Schiphorst WE, Liu FT, Deelder AM, Cummings RD, Hokke CH, van Die I. LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition. J Immunol. 2004 Aug 01; 173(3):1902-7. PMID: 15265923.
    View in: PubMed
  191. Otto VI, Schürpf T, Folkers G, Cummings RD. Sialylated complex-type N-glycans enhance the signaling activity of soluble intercellular adhesion molecule-1 in mouse astrocytes. J Biol Chem. 2004 Aug 20; 279(34):35201-9. PMID: 15201278.
    View in: PubMed
  192. Nyame AK, Kawar ZS, Cummings RD. Antigenic glycans in parasitic infections: implications for vaccines and diagnostics. Arch Biochem Biophys. 2004 Jun 15; 426(2):182-200. PMID: 15158669.
    View in: PubMed
  193. Xia L, Ju T, Westmuckett A, An G, Ivanciu L, McDaniel JM, Lupu F, Cummings RD, McEver RP. Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. J Cell Biol. 2004 Feb 02; 164(3):451-9. PMID: 14745002; PMCID: PMC2172228.
  194. Stowell SR, Dias-Baruffi M, Penttilä L, Renkonen O, Nyame AK, Cummings RD. Human galectin-1 recognition of poly-N-acetyllactosamine and chimeric polysaccharides. Glycobiology. 2004 Feb; 14(2):157-67. PMID: 14576172.
    View in: PubMed
  195. Vervelde L, Bakker N, Kooyman FN, Cornelissen AW, Bank CM, Nyame AK, Cummings RD, van Die I. Vaccination-induced protection of lambs against the parasitic nematode Haemonchus contortus correlates with high IgG antibody responses to the LDNF glycan antigen. Glycobiology. 2003 Nov; 13(11):795-804. PMID: 12907692.
    View in: PubMed
  196. Carlyon JA, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings RD, McEver RP, Fikrig E. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood. 2003 Nov 01; 102(9):3387-95. PMID: 12869507.
    View in: PubMed
  197. Dias-Baruffi M, Zhu H, Cho M, Karmakar S, McEver RP, Cummings RD. Dimeric galectin-1 induces surface exposure of phosphatidylserine and phagocytic recognition of leukocytes without inducing apoptosis. J Biol Chem. 2003 Oct 17; 278(42):41282-93. PMID: 12853445.
    View in: PubMed
  198. Yago T, Leppänen A, Carlyon JA, Akkoyunlu M, Karmakar S, Fikrig E, Cummings RD, McEver RP. Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. J Biol Chem. 2003 Sep 26; 278(39):37987-97. PMID: 12847092.
    View in: PubMed
  199. Leppänen A, Yago T, Otto VI, McEver RP, Cummings RD. Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. J Biol Chem. 2003 Jul 18; 278(29):26391-400. PMID: 12736247.
    View in: PubMed
  200. Nyame AK, Lewis FA, Doughty BL, Correa-Oliveira R, Cummings RD. Immunity to schistosomiasis: glycans are potential antigenic targets for immune intervention. Exp Parasitol. 2003 May-Jun; 104(1-2):1-13. PMID: 12932753.
    View in: PubMed
  201. van Die I, van Vliet SJ, Nyame AK, Cummings RD, Bank CM, Appelmelk B, Geijtenbeek TB, van Kooyk Y. The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x. Glycobiology. 2003 Jun; 13(6):471-8. PMID: 12626400.
    View in: PubMed
  202. van Remoortere A, Bank CM, Nyame AK, Cummings RD, Deelder AM, van Die I. Schistosoma mansoni-infected mice produce antibodies that cross-react with plant, insect, and mammalian glycoproteins and recognize the truncated biantennaryN-glycan Man3GlcNAc2-R. Glycobiology. 2003 Mar; 13(3):217-25. PMID: 12626421.
    View in: PubMed
  203. Ju T, Cummings RD. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16613-8. PMID: 12464682; PMCID: PMC139192.
  204. Nyame AK, Yoshino TP, Cummings RD. Differential expression of LacdiNAc, fucosylated LacdiNAc, and Lewis x glycan antigens in intramolluscan stages of Schistosoma mansoni. J Parasitol. 2002 Oct; 88(5):890-7. PMID: 12435126.
    View in: PubMed
  205. Xia L, Ramachandran V, McDaniel JM, Nguyen KN, Cummings RD, McEver RP. N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. Blood. 2003 Jan 15; 101(2):552-9. PMID: 12393631.
    View in: PubMed
  206. Kobzdej MM, Leppänen A, Ramachandran V, Cummings RD, McEver RP. Discordant expression of selectin ligands and sialyl Lewis x-related epitopes on murine myeloid cells. Blood. 2002 Dec 15; 100(13):4485-94. PMID: 12393554.
    View in: PubMed
  207. Yago T, Leppänen A, Qiu H, Marcus WD, Nollert MU, Zhu C, Cummings RD, McEver RP. Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow. J Cell Biol. 2002 Aug 19; 158(4):787-99. PMID: 12177042; PMCID: PMC2174028.
  208. Zheng Q, Van Die I, Cummings RD. Molecular cloning and characterization of a novel alpha 1,2-fucosyltransferase (CE2FT-1) from Caenorhabditis elegans. J Biol Chem. 2002 Oct 18; 277(42):39823-32. PMID: 12163507.
    View in: PubMed
  209. Leppanen A, Penttila L, Renkonen O, McEver RP, Cummings RD. Glycosulfopeptides with O-glycans containing sialylated and polyfucosylated polylactosamine bind with low affinity to P-selectin. J Biol Chem. 2002 Oct 18; 277(42):39749-59. PMID: 12145302.
    View in: PubMed
  210. Kawar ZS, Van Die I, Cummings RD. Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans. J Biol Chem. 2002 Sep 20; 277(38):34924-32. PMID: 12167666.
    View in: PubMed
  211. Hicks AE, Leppänen A, Cummings RD, McEver RP, Hellewell PG, Norman KE. Glycosulfopeptides modeled on P-selectin glycoprotein ligand 1 inhibit P-selectin-dependent leukocyte rolling in vivo. FASEB J. 2002 Sep; 16(11):1461-2. PMID: 12205048.
    View in: PubMed
  212. Walcheck B, Leppanen A, Cummings RD, Knibbs RN, Stoolman LM, Alexander SR, Mattila PE, McEver RP. The monoclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialyl-Lewis x, which is a functional glycan ligand for P-selectin. Blood. 2002 Jun 01; 99(11):4063-9. PMID: 12010808.
    View in: PubMed
  213. Xia L, Sperandio M, Yago T, McDaniel JM, Cummings RD, Pearson-White S, Ley K, McEver RP. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest. 2002 Apr; 109(7):939-50. PMID: 11927621; PMCID: PMC150926.
  214. Rivera-Marrero CA, Ritzenthaler JD, Newburn SA, Roman J, Cummings RD. Molecular cloning and expression of a novel glycolipid sulfotransferase in Mycobacterium tuberculosis. Microbiology. 2002 Mar; 148(Pt 3):783-92. PMID: 11882713.
    View in: PubMed
  215. Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM. Cloning and expression of human core 1 beta1,3-galactosyltransferase. J Biol Chem. 2002 Jan 04; 277(1):178-86. PMID: 11677243.
    View in: PubMed
  216. Ju T, Cummings RD, Canfield WM. Purification, characterization, and subunit structure of rat core 1 Beta1,3-galactosyltransferase. J Biol Chem. 2002 Jan 04; 277(1):169-77. PMID: 11673471.
    View in: PubMed
  217. Ramachandran V, Yago T, Epperson TK, Kobzdej MM, Nollert MU, Cummings RD, Zhu C, McEver RP. Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10166-71. PMID: 11481445; PMCID: PMC56933.
  218. Eberl M, Langermans JA, Vervenne RA, Nyame AK, Cummings RD, Thomas AW, Coulson PS, Wilson RA. Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive? J Infect Dis. 2001 Apr 15; 183(8):1238-47. PMID: 11262206.
    View in: PubMed
  219. Kelder B, Erney R, Kopchick J, Cummings R, Prieto P. Glycoconjugates in human and transgenic animal milk. Adv Exp Med Biol. 2001; 501:269-78. PMID: 11787690.
    View in: PubMed
  220. Leppänen A, White SP, Helin J, McEver RP, Cummings RD. Binding of glycosulfopeptides to P-selectin requires stereospecific contributions of individual tyrosine sulfate and sugar residues. J Biol Chem. 2000 Dec 15; 275(50):39569-78. PMID: 10978329.
    View in: PubMed
  221. Nyame AK, Leppänen AM, Bogitsh BJ, Cummings RD. Antibody responses to the fucosylated LacdiNAc glycan antigen in Schistosoma mansoni-infected mice and expression of the glycan among schistosomes. Exp Parasitol. 2000 Dec; 96(4):202-12. PMID: 11162373.
    View in: PubMed
  222. Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU. Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids. J Biol Chem. 2000 Aug 18; 275(33):25308-14. PMID: 10854427.
    View in: PubMed
  223. Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU. Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals. J Biol Chem. 2000 Aug 18; 275(33):25315-21. PMID: 10854428.
    View in: PubMed
  224. Stray SJ, Cummings RD, Air GM. Influenza virus infection of desialylated cells. Glycobiology. 2000 Jul; 10(7):649-58. PMID: 10910970.
    View in: PubMed
  225. Epperson TK, Patel KD, McEver RP, Cummings RD. Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin. J Biol Chem. 2000 Mar 17; 275(11):7839-53. PMID: 10713099.
    View in: PubMed
  226. van Die I, Cummings RD, van Tetering A, Hokke CH, Koeleman CA, van den Eijnden DH. Identification of a novel UDP-Glc:GlcNAc beta1-->4-glucosyltransferase in Lymnaea stagnalis that may be involved in the synthesis of complex-type oligosaccharide chains. Glycobiology. 2000 Mar; 10(3):263-71. PMID: 10704525.
    View in: PubMed
  227. van Die I, Gomord V, Kooyman FN, van den Berg TK, Cummings RD, Vervelde L. Core alpha1-->3-fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep. FEBS Lett. 1999 Dec 10; 463(1-2):189-93. PMID: 10601665.
    View in: PubMed
  228. Ramachandran V, Nollert MU, Qiu H, Liu WJ, Cummings RD, Zhu C, McEver RP. Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13771-6. PMID: 10570148; PMCID: PMC24140.
  229. Luo Y, Wen J, Luo C, Cummings RD, Cooper DK. Pig xenogeneic antigen modification with green coffee bean alpha-galactosidase. Xenotransplantation. 1999 Nov; 6(4):238-48. PMID: 10704067.
    View in: PubMed
  230. Cummings RD, Nyame AK. Schistosome glysoconjugates. Biochim Biophys Acta. 1999 Oct 08; 1455(2-3):363-74. PMID: 10571025.
    View in: PubMed
  231. Nyame AK, Leppanen AM, DeBose-Boyd R, Cummings RD. Mice infected with Schistosoma mansoni generate antibodies to LacdiNAc (GalNAc beta 1-->4GlcNAc) determinants. Glycobiology. 1999 Oct; 9(10):1029-35. PMID: 10521539.
    View in: PubMed
  232. Leppänen A, Mehta P, Ouyang YB, Ju T, Helin J, Moore KL, van Die I, Canfield WM, McEver RP, Cummings RD. A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to P-selectin. J Biol Chem. 1999 Aug 27; 274(35):24838-48. PMID: 10455156.
    View in: PubMed
  233. Cummings RD. Structure and function of the selectin ligand PSGL-1. Braz J Med Biol Res. 1999 May; 32(5):519-28. PMID: 10412562.
    View in: PubMed
  234. Mehta P, Cummings RD, McEver RP. Affinity and kinetic analysis of P-selectin binding to P-selectin glycoprotein ligand-1. J Biol Chem. 1998 Dec 04; 273(49):32506-13. PMID: 9829984.
    View in: PubMed
  235. Zhou G, Cummings R, Li Y, Mitra S, Wilkinson HA, Elbrecht A, Hermes JD, Schaeffer JM, Smith RG, Moller DE. Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer. Mol Endocrinol. 1998 Oct; 12(10):1594-604. PMID: 9773982.
    View in: PubMed
  236. DeBose-Boyd RA, Nyame AK, Cummings RD. Molecular cloning and characterization of an alpha1,3 fucosyltransferase, CEFT-1, from Caenorhabditis elegans. Glycobiology. 1998 Sep; 8(9):905-17. PMID: 9675224.
    View in: PubMed
  237. DeBose-Boyd RA, Nyame AK, Jasmer DP, Cummings RD. The ruminant parasite Haemonchus contortus expresses an alpha1,3-fucosyltransferase capable of synthesizing the Lewis x and sialyl Lewis x antigens. Glycoconj J. 1998 Aug; 15(8):789-98. PMID: 9870355.
    View in: PubMed
  238. Nyame AK, Debose-Boyd R, Long TD, Tsang VC, Cummings RD. Expression of Lex antigen in Schistosoma japonicum and S.haematobium and immune responses to Lex in infected animals: lack of Lex expression in other trematodes and nematodes. Glycobiology. 1998 Jun; 8(6):615-24. PMID: 9592128.
    View in: PubMed
  239. Hall IH, Taylor K, Izydore RA, Coleman DE, Mitchell JA, Cummings R. The cytotoxic action of 1,3,5-triazabicyclo[3.1.0]hexane-2,4-diones and 1,3,5-triazine-4,6-(1 H,5 H)-diones in murine and human tumor cells. Pharmazie. 1998 Jun; 53(6):398-405. PMID: 9675770.
    View in: PubMed
  240. Liu W, Ramachandran V, Kang J, Kishimoto TK, Cummings RD, McEver RP. Identification of N-terminal residues on P-selectin glycoprotein ligand-1 required for binding to P-selectin. J Biol Chem. 1998 Mar 20; 273(12):7078-87. PMID: 9507018.
    View in: PubMed
  241. McEver RP, Cummings RD. Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest. 1997 Dec 01; 100(11 Suppl):S97-103. PMID: 9413410.
    View in: PubMed
  242. Cho SK, Yeh JC, Cummings RD. Secretion of alpha1,3-galactosyltransferase by cultured cells and presence of enzyme in animal sera. Glycoconj J. 1997 Nov; 14(7):809-19. PMID: 9511986.
    View in: PubMed
  243. Zheng Z, Cummings RD, Pummill PE, Kincade PW. Growth as a solid tumor or reduced glucose concentrations in culture reversibly induce CD44-mediated hyaluronan recognition by Chinese hamster ovary cells. J Clin Invest. 1997 Sep 01; 100(5):1217-29. PMID: 9276740; PMCID: PMC508299.
  244. McEver RP, Cummings RD. Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest. 1997 Aug 01; 100(3):485-91. PMID: 9239393; PMCID: PMC508213.
  245. Cho SK, Cummings RD. A soluble form of alpha1,3-galactosyltransferase functions within cells to galactosylate glycoproteins. J Biol Chem. 1997 May 23; 272(21):13622-8. PMID: 9153211.
    View in: PubMed
  246. Yeh J, Cummings RD. Differential recognition of glycoprotein acceptors by terminal glycosyltransferases. Glycobiology. 1997 Mar; 7(2):241-51. PMID: 9134431.
    View in: PubMed
  247. Do KY, Do SI, Cummings RD. Differential expression of LacdiNAc sequences (GalNAc beta 1-4GlcNAc-R) in glycoproteins synthesized by Chinese hamster ovary and human 293 cells. Glycobiology. 1997 Mar; 7(2):183-94. PMID: 9134425.
    View in: PubMed
  248. Nyame AK, Pilcher JB, Tsang VC, Cummings RD. Rodents infected with Schistosoma mansoni produce cytolytic IgG and IgM antibodies to the Lewis x antigen. Glycobiology. 1997 Mar; 7(2):207-15. PMID: 9134427.
    View in: PubMed
  249. Prieto PA, Larsen RD, Cho M, Rivera HN, Shilatifard A, Lowe JB, Cummings RD, Smith DF. Expression of human H-type alpha1,2-fucosyltransferase encoding for blood group H(O) antigen in Chinese hamster ovary cells. Evidence for preferential fucosylation and truncation of polylactosamine sequences. J Biol Chem. 1997 Jan 24; 272(4):2089-97. PMID: 8999907.
    View in: PubMed
  250. Yan L, Wilkins PP, Alvarez-Manilla G, Do SI, Smith DF, Cummings RD. Immobilized Lotus tetragonolobus agglutinin binds oligosaccharides containing the Le(x) determinant. Glycoconj J. 1997 Jan; 14(1):45-55. PMID: 9076513.
    View in: PubMed
  251. White KD, Cummings RD, Waxman FJ. Ig N-glycan orientation can influence interactions with the complement system. J Immunol. 1997 Jan 01; 158(1):426-35. PMID: 8977219.
    View in: PubMed
  252. Gupta D, Cho M, Cummings RD, Brewer CF. Thermodynamics of carbohydrate binding to galectin-1 from Chinese hamster ovary cells and two mutants. A comparison with four galactose-specific plant lectins. Biochemistry. 1996 Dec 03; 35(48):15236-43. PMID: 8952472.
    View in: PubMed
  253. Wicker LS, Chen SL, Nepom GT, Elliott JF, Freed DC, Bansal A, Zheng S, Herman A, Lernmark A, Zaller DM, Peterson LB, Rothbard JB, Cummings R, Whiteley PJ. Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. J Clin Invest. 1996 Dec 01; 98(11):2597-603. PMID: 8958223; PMCID: PMC507718.
  254. Li SF, Neethling FA, Taniguchi S, Yeh JC, Kobayashi T, Ye Y, Koren E, Cummings RD, Cooper DK. Glycans derived from porcine stomach mucin are effective inhibitors of natural anti-alpha-galactosyl antibodies in vitro and after intravenous infusion in baboons. Transplantation. 1996 Nov 15; 62(9):1324-31. PMID: 8932280.
    View in: PubMed
  255. DeBose-Boyd RA, Nyame AK, Smith DF, Cummings RD. alpha1,4-Fucosyltransferase activity in human serum and saliva. Arch Biochem Biophys. 1996 Nov 01; 335(1):109-17. PMID: 8914840.
    View in: PubMed
  256. Laszik Z, Jansen PJ, Cummings RD, Tedder TF, McEver RP, Moore KL. P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. Blood. 1996 Oct 15; 88(8):3010-21. PMID: 8874199.
    View in: PubMed
  257. Cho M, Cummings RD. Characterization of monomeric forms of galectin-1 generated by site-directed mutagenesis. Biochemistry. 1996 Oct 08; 35(40):13081-8. PMID: 8855944.
    View in: PubMed
  258. Wilkins PP, McEver RP, Cummings RD. Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells. J Biol Chem. 1996 Aug 02; 271(31):18732-42. PMID: 8702529.
    View in: PubMed
  259. Cummings RD, Nyame AK. Glycobiology of schistosomiasis. FASEB J. 1996 Jun; 10(8):838-48. PMID: 8666160.
    View in: PubMed
  260. Yeh JC, Cummings RD. Absorbance- and light-based solid-phase assays for CMPNeuAc:Galbeta1-4GlcNAc-R alpha-2,3-sialyltransferase. Anal Biochem. 1996 Apr 05; 236(1):126-33. PMID: 8619476.
    View in: PubMed
  261. Li S, Neethling FA, Yeh JC, Cooper DK, Cummings RD. Potent inhibition of human and baboon anti-alpha Gal antibodies by a subfraction of oligosaccharides derived from porcine stomach mucin. Transplant Proc. 1996 Apr; 28(2):558. PMID: 8623268.
    View in: PubMed
  262. Li F, Erickson HP, James JA, Moore KL, Cummings RD, McEver RP. Visualization of P-selectin glycoprotein ligand-1 as a highly extended molecule and mapping of protein epitopes for monoclonal antibodies. J Biol Chem. 1996 Mar 15; 271(11):6342-8. PMID: 8626430.
    View in: PubMed
  263. Nyame AK, Pilcher JB, Tsang VC, Cummings RD. Schistosoma mansoni infection in humans and primates induces cytolytic antibodies to surface Le(x) determinants on myeloid cells. Exp Parasitol. 1996 Mar; 82(2):191-200. PMID: 8617346.
    View in: PubMed
  264. Cho SK, Yeh J, Cho M, Cummings RD. Transcriptional regulation of alpha1,3-galactosyltransferase in embryonal carcinoma cells by retinoic acid. Masking of Lewis X antigens by alpha-galactosylation. J Biol Chem. 1996 Feb 09; 271(6):3238-46. PMID: 8621726.
    View in: PubMed
  265. Li F, Wilkins PP, Crawley S, Weinstein J, Cummings RD, McEver RP. Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin. J Biol Chem. 1996 Feb 09; 271(6):3255-64. PMID: 8621728.
    View in: PubMed
  266. DeBose-Boyd R, Nyame AK, Cummings RD. Schistosoma mansoni: characterization of an alpha 1-3 fucosyltransferase in adult parasites. Exp Parasitol. 1996 Jan; 82(1):1-10. PMID: 8617325.
    View in: PubMed
  267. Wilkins PP, Moore KL, McEver RP, Cummings RD. Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. J Biol Chem. 1995 Sep 29; 270(39):22677-80. PMID: 7559387.
    View in: PubMed
  268. Wang CS, Dashti A, Jackson KW, Yeh JC, Cummings RD, Tang J. Isolation and characterization of human milk bile salt-activated lipase C-tail fragment. Biochemistry. 1995 Aug 22; 34(33):10639-44. PMID: 7654718.
    View in: PubMed
  269. Do KY, Do SI, Cummings RD. Alpha-lactalbumin induces bovine milk beta 1,4-galactosyltransferase to utilize UDP-GalNAc. J Biol Chem. 1995 Aug 04; 270(31):18447-51. PMID: 7629170.
    View in: PubMed
  270. McEver RP, Moore KL, Cummings RD. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J Biol Chem. 1995 May 12; 270(19):11025-8. PMID: 7538108.
    View in: PubMed
  271. Shilatifard A, Cummings RD. Sulphate release from keratan sulphate and heparan sulphate by bovine N-acetylglucosamine-6-sulphate sulphatase. Glycobiology. 1995 May; 5(3):291-7. PMID: 7655166.
    View in: PubMed
  272. Cho M, Cummings RD. Galectin-1, a beta-galactoside-binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization. J Biol Chem. 1995 Mar 10; 270(10):5198-206. PMID: 7890630.
    View in: PubMed
  273. Cho M, Cummings RD. Galectin-1, a beta-galactoside-binding lectin in Chinese hamster ovary cells. II. Localization and biosynthesis. J Biol Chem. 1995 Mar 10; 270(10):5207-12. PMID: 7890631.
    View in: PubMed
  274. Moore KL, Patel KD, Bruehl RE, Li F, Johnson DA, Lichenstein HS, Cummings RD, Bainton DF, McEver RP. P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. J Cell Biol. 1995 Feb; 128(4):661-71. PMID: 7532174; PMCID: PMC2199883.
  275. Srivatsan J, Smith DF, Cummings RD. Demonstration of a novel UDPGalNAc:GlcNAc beta 1-4 N-acetylgalactosaminyltransferase in extracts of Schistosoma mansoni. J Parasitol. 1994 Dec; 80(6):884-90. PMID: 7799159.
    View in: PubMed
  276. Yan L, Smith DF, Cummings RD. Determination of GDP-Fuc:Gal beta 1-4GlcNAc-R (Fuc to GlcNAc) alpha 1,3 fucosyltransferase activity by a solid-phase method. Anal Biochem. 1994 Nov 15; 223(1):111-8. PMID: 7695085.
    View in: PubMed
  277. Do KY, Fregien N, Pierce M, Cummings RD. Modification of glycoproteins by N-acetylglucosaminyltransferase V is greatly influenced by accessibility of the enzyme to oligosaccharide acceptors. J Biol Chem. 1994 Sep 23; 269(38):23456-64. PMID: 7522229.
    View in: PubMed
  278. Moore KL, Eaton SF, Lyons DE, Lichenstein HS, Cummings RD, McEver RP. The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine. J Biol Chem. 1994 Sep 16; 269(37):23318-27. PMID: 7521878.
    View in: PubMed
  279. Woods A, Chen HY, Trumbauer ME, Sirotina A, Cummings R, Zaller DM. Human major histocompatibility complex class II-restricted T cell responses in transgenic mice. J Exp Med. 1994 Jul 01; 180(1):173-81. PMID: 8006581; PMCID: PMC2191575.
  280. Cho MJ, Cummings RD. Structure and biosynthesis of carbohydrate ligands for animal lectins involved in cell adhesion. Biochem Soc Trans. 1994 May; 22(2):378-81. PMID: 7958329.
    View in: PubMed
  281. Shilatifard A, Cummings RD. Purification and characterization of N-acetylglucosamine-6-sulfate sulfatase from bovine kidney: evidence for the presence of a novel endosulfatase activity. Biochemistry. 1994 Apr 12; 33(14):4273-82. PMID: 8155645.
    View in: PubMed
  282. Barondes SH, Castronovo V, Cooper DN, Cummings RD, Drickamer K, Feizi T, Gitt MA, Hirabayashi J, Hughes C, Kasai K, et al. Galectins: a family of animal beta-galactoside-binding lectins. Cell. 1994 Feb 25; 76(4):597-8. PMID: 8124704.
    View in: PubMed
  283. Cummings RD. Use of lectins in analysis of glycoconjugates. Methods Enzymol. 1994; 230:66-86. PMID: 8139516.
    View in: PubMed
  284. Kang S, Cummings RD, McCall JW. Characterization of the N-linked oligosaccharides in glycoproteins synthesized by microfilariae of Dirofilaria immitis. J Parasitol. 1993 Dec; 79(6):815-28. PMID: 8277373.
    View in: PubMed
  285. Stults NL, Cummings RD. O-linked fucose in glycoproteins from Chinese hamster ovary cells. Glycobiology. 1993 Dec; 3(6):589-96. PMID: 8130391.
    View in: PubMed
  286. Yeh JC, Seals JR, Murphy CI, van Halbeek H, Cummings RD. Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system. Biochemistry. 1993 Oct 19; 32(41):11087-99. PMID: 8218172.
    View in: PubMed
  287. Do KY, Cummings RD. 2,6-branched mannose and the regulation of poly-N-acetyllactosamine biosynthesis in N-linked oligosaccharides of Chinese hamster ovary cells. J Biol Chem. 1993 Oct 15; 268(29):22028-35. PMID: 8408060.
    View in: PubMed
  288. Norgard KE, Moore KL, Diaz S, Stults NL, Ushiyama S, McEver RP, Cummings RD, Varki A. Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides. J Biol Chem. 1993 Jun 15; 268(17):12764-74. PMID: 7685350.
    View in: PubMed
  289. Shilatifard A, Merkle RK, Helland DE, Welles JL, Haseltine WA, Cummings RD. Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine. J Virol. 1993 Feb; 67(2):943-52. PMID: 8419650; PMCID: PMC237448.
  290. Zhou Q, Cummings RD. L-14 lectin recognition of laminin and its promotion of in vitro cell adhesion. Arch Biochem Biophys. 1993 Jan; 300(1):6-17. PMID: 8380972.
    View in: PubMed
  291. Cummings RD, Smith DF. The selectin family of carbohydrate-binding proteins: structure and importance of carbohydrate ligands for cell adhesion. Bioessays. 1992 Dec; 14(12):849-56. PMID: 1285423.
    View in: PubMed
  292. Mattox S, Walrath K, Ceiler D, Smith DF, Cummings RD. A solid-phase assay for the activity of CMPNeuAc:Gal beta 1-4GlcNAc-R alpha-2,6-sialyltransferase. Anal Biochem. 1992 Nov 01; 206(2):430-6. PMID: 1280007.
    View in: PubMed
  293. Srivatsan J, Smith DF, Cummings RD. The human blood fluke Schistosoma mansoni synthesizes glycoproteins containing the Lewis X antigen. J Biol Chem. 1992 Oct 05; 267(28):20196-203. PMID: 1356976.
    View in: PubMed
  294. Srivatsan J, Smith DF, Cummings RD. Schistosoma mansoni synthesizes novel biantennary Asn-linked oligosaccharides containing terminal beta-linked N-acetylgalactosamine. Glycobiology. 1992 Oct; 2(5):445-52. PMID: 1457973.
    View in: PubMed
  295. Do SI, Cummings RD. Presence of O-linked oligosaccharide on a threonine residue in the human transferrin receptor. Glycobiology. 1992 Aug; 2(4):345-53. PMID: 1421756.
    View in: PubMed
  296. Moore KL, Stults NL, Diaz S, Smith DF, Cummings RD, Varki A, McEver RP. Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J Cell Biol. 1992 Jul; 118(2):445-56. PMID: 1378449; PMCID: PMC2290037.
  297. Do SI, Cummings RD. The hamster transferrin receptor contains Ser/Thr-linked oligosaccharides: use of a lectin-resistant CHO cell line to identify glycoproteins containing these linkages. J Biochem Biophys Methods. 1992 Jun; 24(3-4):153-65. PMID: 1640050.
    View in: PubMed
  298. Stults NL, Stocks NF, Rivera H, Gray J, McCann RO, O'Kane D, Cummings RD, Cormier MJ, Smith DF. Use of recombinant biotinylated aequorin in microtiter and membrane-based assays: purification of recombinant apoaequorin from Escherichia coli. Biochemistry. 1992 Feb 11; 31(5):1433-42. PMID: 1737001.
    View in: PubMed
  299. Makaaru CK, Damian RT, Smith DF, Cummings RD. The human blood fluke Schistosoma mansoni synthesizes a novel type of glycosphingolipid. J Biol Chem. 1992 Feb 05; 267(4):2251-7. PMID: 1733932.
    View in: PubMed
  300. Zhou Q, Moore KL, Smith DF, Varki A, McEver RP, Cummings RD. The selectin GMP-140 binds to sialylated, fucosylated lactosaminoglycans on both myeloid and nonmyeloid cells. J Cell Biol. 1991 Oct; 115(2):557-64. PMID: 1717488; PMCID: PMC2289144.
  301. Merkle RK, Helland DE, Welles JL, Shilatifard A, Haseltine WA, Cummings RD. gp160 of HIV-I synthesized by persistently infected Molt-3 cells is terminally glycosylated: evidence that cleavage of gp160 occurs subsequent to oligosaccharide processing. Arch Biochem Biophys. 1991 Oct; 290(1):248-57. PMID: 1898096.
    View in: PubMed
  302. Clark GF, Gorbea CM, Cummings RD, Mattox S, Smith DF. Decreased biosynthesis of Forssman glycolipid after retinoic acid-induced differentiation of mouse F9 teratocarcinoma cells. Lectin-affinity chromatography of the glycolipid-derived oligosaccharide. Carbohydr Res. 1991 Jun 25; 213:155-68. PMID: 1933935.
    View in: PubMed
  303. Zatta PF, Nyame K, Cormier MJ, Mattox SA, Prieto PA, Smith DF, Cummings RD. A solid-phase assay for beta-1,4-galactosyltransferase activity in human serum using recombinant aequorin. Anal Biochem. 1991 Apr; 194(1):185-91. PMID: 1907813.
    View in: PubMed
  304. Seguchi T, Merkle RK, Ono M, Kuwano M, Cummings RD. The dysfunctional LDL receptor in a monensin-resistant mutant of Chinese hamster ovary cells lacks selected O-linked oligosaccharides. Arch Biochem Biophys. 1991 Feb 01; 284(2):245-56. PMID: 1899178.
    View in: PubMed
  305. Do KY, Smith DF, Cummings RD. LAMP-1 in CHO cells is a primary carrier of poly-N-acetyllactosamine chains and is bound preferentially by a mammalian S-type lectin. Biochem Biophys Res Commun. 1990 Dec 31; 173(3):1123-8. PMID: 2268316.
    View in: PubMed
  306. Rivera-Marrero CA, Cummings RD. Schistosoma mansoni contains a galactosyltransferase activity distinct from that typically found in mammalian cells. Mol Biochem Parasitol. 1990 Nov; 43(1):59-67. PMID: 2127077.
    View in: PubMed
  307. Zhou Q, Cummings RD. The S-type lectin from calf heart tissue binds selectively to the carbohydrate chains of laminin. Arch Biochem Biophys. 1990 Aug 15; 281(1):27-35. PMID: 1696449.
    View in: PubMed
  308. Larsen RD, Rivera-Marrero CA, Ernst LK, Cummings RD, Lowe JB. Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA. J Biol Chem. 1990 Apr 25; 265(12):7055-61. PMID: 2108966.
    View in: PubMed
  309. Smith DF, Larsen RD, Mattox S, Lowe JB, Cummings RD. Transfer and expression of a murine UDP-Gal:beta-D-Gal-alpha 1,3-galactosyltransferase gene in transfected Chinese hamster ovary cells. Competition reactions between the alpha 1,3-galactosyltransferase and the endogenous alpha 2,3-sialyltransferase. J Biol Chem. 1990 Apr 15; 265(11):6225-34. PMID: 2108155.
    View in: PubMed
  310. Do SI, Enns C, Cummings RD. Human transferrin receptor contains O-linked oligosaccharides. J Biol Chem. 1990 Jan 05; 265(1):114-25. PMID: 2403553.
    View in: PubMed
  311. Stults NL, Fechheimer M, Cummings RD. Relationship between Golgi architecture and glycoprotein biosynthesis and transport in Chinese hamster ovary cells. J Biol Chem. 1989 Nov 25; 264(33):19956-66. PMID: 2684964.
    View in: PubMed
  312. Merkle RK, Zhou Q, Schultz TK, Harper WB, Cummings RD. Characterization of an S-type lectin purified from porcine heart. Arch Biochem Biophys. 1989 Nov 01; 274(2):404-16. PMID: 2802618.
    View in: PubMed
  313. Larsen RD, Rajan VP, Ruff MM, Kukowska-Latallo J, Cummings RD, Lowe JB. Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8227-31. PMID: 2510162; PMCID: PMC298253.
  314. Nyame K, Smith DF, Damian RT, Cummings RD. Complex-type asparagine-linked oligosaccharides in glycoproteins synthesized by Schistosoma mansoni adult males contain terminal beta-linked N-acetylgalactosamine. J Biol Chem. 1989 Feb 25; 264(6):3235-43. PMID: 2914950.
    View in: PubMed
  315. Cummings RD, Merkle RK, Stults NL. Separation and analysis of glycoprotein oligosaccharides. Methods Cell Biol. 1989; 32:141-83. PMID: 2691849.
    View in: PubMed
  316. Wang WC, Clark GF, Smith DF, Cummings RD. Separation of oligosaccharides containing terminal alpha-linked galactose residues by affinity chromatography on Griffonia simplicifolia I bound to concanavalin A-sepharose. Anal Biochem. 1988 Dec; 175(2):390-6. PMID: 3239769.
    View in: PubMed
  317. Merkle RK, Cummings RD. Asparagine-linked oligosaccharides containing poly-N-acetyllactosamine chains are preferentially bound by immobilized calf heart agglutinin. J Biol Chem. 1988 Nov 05; 263(31):16143-9. PMID: 3182789.
    View in: PubMed
  318. Cummings RD, Teleb ZA. Alterations in the metabolism of [6-H3] galactose in Chinese hamster ovary cells at 20 degrees C compared to 37 degrees C. J Pharm Belg. 1988 Nov-Dec; 43(6):445-9. PMID: 3246628.
    View in: PubMed
  319. Nyame K, Cummings RD, Damian RT. Characterization of the N- and O-linked oligosaccharides in glycoproteins synthesized by Schistosoma mansoni schistosomula. J Parasitol. 1988 Aug; 74(4):562-72. PMID: 3397817.
    View in: PubMed
  320. Pathak RK, Merkle RK, Cummings RD, Goldstein JL, Brown MS, Anderson RG. Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex. J Cell Biol. 1988 Jun; 106(6):1831-41. PMID: 2898477; PMCID: PMC2115130.
  321. Wang WC, Cummings RD. The immobilized leukoagglutinin from the seeds of Maackia amurensis binds with high affinity to complex-type Asn-linked oligosaccharides containing terminal sialic acid-linked alpha-2,3 to penultimate galactose residues. J Biol Chem. 1988 Apr 05; 263(10):4576-85. PMID: 3350806.
    View in: PubMed
  322. Nyame K, Cummings RD, Damian RT. Characterization of the high mannose asparagine-linked oligosaccharides synthesized by Schistosoma mansoni adult male worms. Mol Biochem Parasitol. 1988 Apr; 28(3):265-74. PMID: 3386683.
    View in: PubMed
  323. Cummings RD, Mattox SA. Retinoic acid-induced differentiation of the mouse teratocarcinoma cell line F9 is accompanied by an increase in the activity of UDP-galactose: beta-D-galactosyl-alpha 1,3-galactosyltransferase. J Biol Chem. 1988 Jan 05; 263(1):511-9. PMID: 3121614.
    View in: PubMed
  324. Merkle RK, Cummings RD. Relationship of the terminal sequences to the length of poly-N-acetyllactosamine chains in asparagine-linked oligosaccharides from the mouse lymphoma cell line BW5147. Immobilized tomato lectin interacts with high affinity with glycopeptides containing long poly-N-acetyllactosamine chains. J Biol Chem. 1987 Jun 15; 262(17):8179-89. PMID: 3597368.
    View in: PubMed
  325. Nyame K, Cummings RD, Damian RT. Schistosoma mansoni synthesizes glycoproteins containing terminal O-linked N-acetylglucosamine residues. J Biol Chem. 1987 Jun 15; 262(17):7990-5. PMID: 3597358.
    View in: PubMed
  326. Wang WC, Cummings RD. An assay for leukoagglutinating lectins using suspension cultured mouse lymphoma cells (BW5147) stained with neutral red. Anal Biochem. 1987 Feb 15; 161(1):80-4. PMID: 3578790.
    View in: PubMed
  327. Merkle RK, Cummings RD. Lectin affinity chromatography of glycopeptides. Methods Enzymol. 1987; 138:232-59. PMID: 3600324.
    View in: PubMed
  328. Cummings RD, Soderquist AM, Carpenter G. The oligosaccharide moieties of the epidermal growth factor receptor in A-431 cells. Presence of complex-type N-linked chains that contain terminal N-acetylgalactosamine residues. J Biol Chem. 1985 Oct 05; 260(22):11944-52. PMID: 2995354.
    View in: PubMed
  329. Cowan EP, Cummings RD, Lee DR, Schwartz BD, Cullen SE. Structural characterization of murine Ia antigen N-linked oligosaccharides and localization of specific structures to two unique alpha-chain glycosylation sites. Mol Immunol. 1985 Feb; 22(2):135-43. PMID: 3856097.
    View in: PubMed
  330. Cummings RD, Kornfeld S. The distribution of repeating [Gal beta 1,4GlcNAc beta 1,3] sequences in asparagine-linked oligosaccharides of the mouse lymphoma cell lines BW5147 and PHAR 2.1. J Biol Chem. 1984 May 25; 259(10):6253-60. PMID: 6725252.
    View in: PubMed
  331. Cummings RD, Kornfeld S, Schneider WJ, Hobgood KK, Tolleshaug H, Brown MS, Goldstein JL. Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor. J Biol Chem. 1983 Dec 25; 258(24):15261-73. PMID: 6317691.
    View in: PubMed
  332. Liscum L, Cummings RD, Anderson RG, DeMartino GN, Goldstein JL, Brown MS. 3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides. Proc Natl Acad Sci U S A. 1983 Dec; 80(23):7165-9. PMID: 6580634; PMCID: PMC390014.
  333. Cummings RD, Trowbridge IS, Kornfeld S. A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase. J Biol Chem. 1982 Nov 25; 257(22):13421-7. PMID: 6216250.
    View in: PubMed
  334. Cowan EP, Cummings RD, Schwartz BD, Cullen SE. Analysis of murine Ia antigen glycosylation by lectin affinity chromatography. I-Ak alpha chain subspecies and beta chains are each glycosylated differently. J Biol Chem. 1982 Oct 10; 257(19):11241-8. PMID: 6956576.
    View in: PubMed
  335. Cummings RD, Kornfeld S. Fractionation of asparagine-linked oligosaccharides by serial lectin-Agarose affinity chromatography. A rapid, sensitive, and specific technique. J Biol Chem. 1982 Oct 10; 257(19):11235-40. PMID: 7118881.
    View in: PubMed
  336. Cummings RD, Kornfeld S. Characterization of the structural determinants required for the high affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins. J Biol Chem. 1982 Oct 10; 257(19):11230-4. PMID: 7118880.
    View in: PubMed
  337. Cummings RD, Roth S. The discovery of a lipid-linked glucuronide and its synthesis by chicken liver. J Biol Chem. 1982 Feb 25; 257(4):1755-64. PMID: 6799514.
    View in: PubMed
  338. Pierce M, Cummings RD, Roth S. The localization of galactosyltransferases in polyacrylamide gels by a coupled enzyme assay. Anal Biochem. 1980 Mar 01; 102(2):441-9. PMID: 6775556.
    View in: PubMed
  339. Pierce M, Cummings RD, Cebula TA, Roth S. Galactosyltransferase from commerical preparations of fetuin. Biochim Biophys Acta. 1979 Nov 09; 571(1):166-70. PMID: 91386.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Cummings's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description