Giuseppe Di Caprio, Ph.D.
Instructor in Pediatrics
Immune Disease Institute
Harvard Medical School
Warren Alpert Bldg
200 Longwood Ave
Boston MA 02115
|University of Naples Federico II, Napoli (Italy)||MS||07/2006||Physics (cum laude)|
|University of Naples Federico II, Napoli (Italy)||PhD||12/2014||Novel Technologies for Imaging (cum laude)|
2013 - 2014
Best Paper award: “Hyperspectral Microscopy of Flowing Cells” - OSA Imaging and Applied Optics
2018 - 2027
National Academic Qualification as Associate Professor of Physics applied to Biology and Medicine
My research bridges Optical Microscopy, Biology and Image Processing. I am interested in mechanistic questions addressed at a molecular level aided by fluorescence microscopy imaging acquired with high temporal and spatial resolution. During the past years I focused on problems associated with viral particles endocytosis and fusion processes, in-vitro assembly of clathrin coated pits, the shape of intracellular energy gradients in living cells, Pyrin-mediated inflammasome assembly and activation, and the mechanisms that regulates cell internalization of Transferrin-decorated DNA origami barrels. Aspects of my studies involve close collaborations with other members in the Kirchhausen group and with external collaborators. Most of the imaging is carried using minimally invasive, 3D live-cell lattice light-sheet microscopy (LLSM); I have also been responsible for implementing the construction of one of these microscopes in the Kirchhausen lab as well as developing the computational processing tools used for the quantitative analysis of the data generated by myself and by other members of our group.
My second appointment is at the Massachusetts General Hospital, in collaboration with John Higgins, MD, and David Williams MD, where my research is dedicated to the development of material technologies for mimicking the environment of the circulatory system in vitro. This method provides biomarkers promising to improve management of sickle cell patients and to optimize the development and prioritization of candidate cures, and it’s currently used to validate the efficacy of BCL11A as therapeutic target in Sickle Cell Disease, Clinical Trials Identifier: NCT03282656 (Sponsor: David Williams – Boston Children’s Hospital).
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