Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Lerner Hepner, M.D.

Title
Institution
Department
Address
Phone
Fax

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Volcheck GW, Hepner DL. Identification and Management of Perioperative Anaphylaxis (Grand Rounds Review Article). J Allergy Clin Immunol Pract. 2019 May 30. PMID: 31154032.
    Citations:    
  2. Garvey LH, Dewachter P, Hepner DL, Mertes PM, Voltolini S, Clarke R, Cooke P, Garcez T, Guttormsen AB, Ebo DG, Hopkins PM, Khan DA, Kopac P, Krøigaard M, Laguna JJ, Marshall S, Platt P, Rose M, Sabato V, Sadleir P, Savic L, Savic S, Scherer K, Takazawa T, Volcheck GW, Kolawole H. Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations. Br J Anaesth. 2019 Jul; 123(1):e50-e64. PMID: 31130272.
    Citations:    
  3. Hopkins PM, Cooke PJ, Clarke RC, Guttormsen AB, Platt PR, Dewachter P, Ebo DG, Garcez T, Garvey LH, Hepner DL, Khan DA, Kolawole H, Kopac P, Krøigaard M, Laguna JJ, Marshall SD, Mertes PM, Rose MA, Sabato V, Savic LC, Savic S, Takazawa T, Volcheck GW, Voltolini S, Sadleir PHM. Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions. Br J Anaesth. 2019 Jul; 123(1):e29-e37. PMID: 31029409.
    Citations:    
  4. Garvey LH, Ebo DG, Krøigaard M, Savic S, Clarke R, Cooke P, Dewachter P, Garcez T, Guttormsen AB, Hopkins PM, Hepner DL, Khan DA, Kolawole H, Kopac P, Marshall S, Mertes PM, Platt P, Rose M, Sabato V, Sadleir P, Savic L, Scherer K, Takazawa T, Volcheck GW, Voltolini S, Laguna JJ. The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status. Br J Anaesth. 2019 Jul; 123(1):e126-e134. PMID: 31027914.
    Citations:    
  5. Kolawole H, Guttormsen AB, Hepner DL, Kroigaard M, Marshall S. Use of simulation to improve management of perioperative anaphylaxis: a narrative review. Br J Anaesth. 2019 Jul; 123(1):e104-e109. PMID: 30916025.
    Citations:    
  6. Savic LC, Khan DA, Kopac P, Clarke RC, Cooke PJ, Dewachter P, Ebo DG, Garcez T, Garvey LH, Guttormsen AB, Hopkins PM, Hepner DL, Kolawole H, Krøigaard M, Laguna JJ, Marshall SD, Mertes PM, Platt PR, Rose MA, Sabato V, Sadleir PHM, Savic S, Takazawa T, Voltolini S, Volcheck GW. Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations. Br J Anaesth. 2019 Jul; 123(1):e82-e94. PMID: 30916014.
    Citations:    
  7. Mertes PM, Ebo DG, Garcez T, Rose M, Sabato V, Takazawa T, Cooke PJ, Clarke RC, Dewachter P, Garvey LH, Guttormsen AB, Hepner DL, Hopkins PM, Khan DA, Kolawole H, Kopac P, Krøigaard M, Laguna JJ, Marshall SD, Platt PR, Sadleir PHM, Savic LC, Savic S, Volcheck GW, Voltolini S. Comparative epidemiology of suspected perioperative hypersensitivity reactions. Br J Anaesth. 2019 07; 123(1):e16-e28. PMID: 30916015.
    Citations:    
  8. Weinstein AS, Bader AM, Urman RD, Hepner DL, Fox JA. Preoperative Cardiac Stress Tests Ordered in the Preoperative Evaluation Clinic: A Retrospective Review of Ordering Patterns. Cardiol Res. 2019 Feb; 10(1):1-8. PMID: 30834053.
    Citations:    
  9. Sherman JB, Chatterjee A, Urman RD, Culley DJ, Crosby GJ, Cooper Z, Javedan H, Hepner DL, Bader AM. Implementation of Routine Cognitive Screening in the Preoperative Assessment Clinic. A A Pract. 2019 Feb 15; 12(4):125-127. PMID: 30234511.
    Citations:    
  10. Alidina S, Goldhaber-Fiebert SN, Hannenberg AA, Hepner DL, Singer SJ, Neville BA, Sachetta JR, Lipsitz SR, Berry WR. Factors associated with the use of cognitive aids in operating room crises: a cross-sectional study of US hospitals and ambulatory surgical centers. Implement Sci. 2018 03 26; 13(1):50. PMID: 29580243.
    Citations:    Fields:    Translation:Humans
  11. Urman RD, Lilley EJ, Changala M, Lindvall C, Hepner DL, Bader AM. A Pilot Study to Evaluate Compliance with Guidelines for Preprocedural Reconsideration of Code Status Limitations. J Palliat Med. 2018 Aug; 21(8):1152-1156. PMID: 29480756.
    Citations:    Fields:    
  12. Arriaga AF, Hepner DL, Bader AM. "However Beautiful the Strategy, You Should Occasionally Look at the Results": Sir Winston Churchill and Medical Checklists. Anesth Analg. 2018 01; 126(1):16-18. PMID: 29252477.
    Citations:    Fields:    Translation:Humans
  13. Hepner DL, Arriaga AF, Cooper JB, Goldhaber-Fiebert SN, Gaba DM, Berry WR, Boorman DJ, Bader AM. Operating Room Crisis Checklists and Emergency Manuals. Anesthesiology. 2017 Aug; 127(2):384-392. PMID: 28604405.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  14. Hsu Blatman KS, Hepner DL. Current Knowledge and Management of Hypersensitivity to Perioperative Drugs and Radiocontrast Media. J Allergy Clin Immunol Pract. 2017 May - Jun; 5(3):587-592. PMID: 28483312.
    Citations:    Fields:    Translation:HumansAnimals
  15. Chow VW, Hepner DL, Bader AM. Electronic Care Coordination From the Preoperative Clinic. Anesth Analg. 2016 12; 123(6):1458-1462. PMID: 27861445.
    Citations:    Fields:    Translation:Humans
  16. Murthy S, Hepner DL, Cooper Z, Javedan H, Gleason LJ, Chi JH, Bader AM. Leveraging the Preoperative Clinic to Engage Older Patients in Shared Decision Making About Complex Surgery: An Illustrative Case. A A Case Rep. 2016 Jul 15; 7(2):30-2. PMID: 27258175.
    Citations:    Fields:    Translation:Humans
  17. Hickey TR, Cooper Z, Urman RD, Hepner DL, Bader AM. An Agenda for Improving Perioperative Code Status Discussion. A A Case Rep. 2016 Jun 15; 6(12):411-5. PMID: 27301059.
    Citations: 1     Fields:    Translation:Humans
  18. Nelson O, Quinn TD, Arriaga AF, Hepner DL, Lipsitz SR, Cooper Z, Gawande AA, Bader AM. A Model for Better Leveraging the Point of Preoperative Assessment: Patients and Providers Look Beyond Operative Indications When Making Decisions. A A Case Rep. 2016 Apr 15; 6(8):241-8. PMID: 26669650.
    Citations:    Fields:    Translation:Humans
  19. Hepner DL, Bader AM. If I Had a Hammer: Building Alignment and Accountability. Anesthesiology. 2016 Apr; 124(4):755-7. PMID: 26825152.
    Citations: 1     Fields:    Translation:Humans
  20. Bock M, Fritsch G, Hepner DL. Preoperative Laboratory Testing. Anesthesiol Clin. 2016 Mar; 34(1):43-58. PMID: 26927738.
    Citations: 2     Fields:    Translation:Humans
  21. Murthy S, Hepner DL, Cooper Z, Bader AM, Neuman MD. Controversies in anaesthesia for noncardiac surgery in older adults. Br J Anaesth. 2015 Dec; 115 Suppl 2:ii15-25. PMID: 26658197.
    Citations: 4     Fields:    Translation:Humans
  22. Bader AM, Fox JA, Hepner DL. Channeling Phaedrus: How Do the 2007 and 2014 ACC/AHA Guidelines Compare on the Horns of a Dilemma? J Cardiothorac Vasc Anesth. 2015 Dec; 29(6):1408-9. PMID: 26456272.
    Citations:    Fields:    Translation:Humans
  23. Dewachter P, Mouton-Faivre C, Hepner DL. Perioperative anaphylaxis: what should be known? Curr Allergy Asthma Rep. 2015 May; 15(5):21. PMID: 26139330.
    Citations:    
  24. Gabriel RA, Skowron M, Carrubba D, Hepner DL, Bader AM. Impact of information technology on preoperative scheduling systems: a pilot study modeling scheduling systems in the preoperative clinic. J Med Pract Manage. 2015 Mar-Apr; 30(6 Spec No):2-7. PMID: 26062309.
    Citations:    Fields:    Translation:Humans
  25. Dewachter P, Castells MC, Hepner DL, Mouton-Faivre C. Perioperative management of patients with mastocytosis. Anesthesiology. 2014 Mar; 120(3):753-9. PMID: 24135579.
    Citations: 2     Fields:    Translation:Humans
  26. Ankuda CK, Block SD, Cooper Z, Correll DJ, Hepner DL, Lasic M, Gawande AA, Bader AM. Measuring critical deficits in shared decision making before elective surgery. Patient Educ Couns. 2014 Mar; 94(3):328-33. PMID: 24382399.
    Citations: 6     Fields:    Translation:Humans
  27. Hepner DL, Castells M, Mouton-Faivre C, Dewachter P. Anaphylaxis in the clinical setting of obstetric anesthesia: a literature review. Anesth Analg. 2013 Dec; 117(6):1357-67. PMID: 24257386.
    Citations: 2     Fields:    Translation:Humans
  28. Barnet CS, Arriaga AF, Hepner DL, Correll DJ, Gawande AA, Bader AM. Surgery at the end of life: a pilot study comparing decedents and survivors at a tertiary care center. Anesthesiology. 2013 Oct; 119(4):796-801. PMID: 23838711.
    Citations: 3     Fields:    Translation:Humans
  29. Arriaga AF, Bader AM, Wong JM, Lipsitz SR, Berry WR, Ziewacz JE, Hepner DL, Boorman DJ, Pozner CN, Smink DS, Gawande AA. Simulation-based trial of surgical-crisis checklists. N Engl J Med. 2013 Jan 17; 368(3):246-53. PMID: 23323901.
    Citations: 47     Fields:    Translation:Humans
  30. Fritsch G, Flamm M, Hepner DL, Panisch S, Seer J, Soennichsen A. Abnormal pre-operative tests, pathologic findings of medical history, and their predictive value for perioperative complications. Acta Anaesthesiol Scand. 2012 Mar; 56(3):339-50. PMID: 22188223.
    Citations: 8     Fields:    Translation:Humans
  31. Ziewacz JE, Arriaga AF, Bader AM, Berry WR, Edmondson L, Wong JM, Lipsitz SR, Hepner DL, Peyre S, Nelson S, Boorman DJ, Smink DS, Ashley SW, Gawande AA. Crisis checklists for the operating room: development and pilot testing. J Am Coll Surg. 2011 Aug; 213(2):212-217.e10. PMID: 21658974.
    Citations: 25     Fields:    Translation:HumansPHPublic Health
  32. Dewachter P, Mouton-Faivre C, Castells MC, Hepner DL. Anesthesia in the patient with multiple drug allergies: are all allergies the same? Curr Opin Anaesthesiol. 2011 Jun; 24(3):320-5. PMID: 21494128.
    Citations: 10     Fields:    Translation:HumansAnimals
  33. Hepner DL. Follow your heart? Adherence to guidelines during preoperative cardiac evaluation. J Clin Anesth. 2010 Sep; 22(6):399-401. PMID: 20868958.
    Citations:    Fields:    Translation:Humans
  34. Racine SX, Solis A, Hamou NA, Letoumelin P, Hepner DL, Beloucif S, Baillard C. Face mask ventilation in edentulous patients: a comparison of mandibular groove and lower lip placement. Anesthesiology. 2010 May; 112(5):1190-3. PMID: 20395823.
    Citations: 6     Fields:    Translation:Humans
  35. Harnett MJ, Correll DJ, Hurwitz S, Bader AM, Hepner DL. Improving efficiency and patient satisfaction in a tertiary teaching hospital preoperative clinic. Anesthesiology. 2010 Jan; 112(1):66-72. PMID: 19996948.
    Citations: 7     Fields:    Translation:Humans
  36. Hepner DL. The role of testing in the preoperative evaluation. Cleve Clin J Med. 2009 Nov; 76 Suppl 4:S22-7. PMID: 19880831.
    Citations: 4     Fields:    Translation:Humans
  37. Correll DJ, Hepner DL, Chang C, Tsen L, Hevelone ND, Bader AM. Preoperative electrocardiograms: patient factors predictive of abnormalities. Anesthesiology. 2009 Jun; 110(6):1217-22. PMID: 19417620.
    Citations: 3     Fields:    Translation:Humans
  38. Zhang B, Hepner DL, Tran MH, Friedman M, Korn JR, Menzin J. Neuromuscular blockade, reversal agent use, and operating room time: retrospective analysis of US inpatient surgeries. Curr Med Res Opin. 2009 Apr; 25(4):943-50. PMID: 19257799.
    Citations: 3     Fields:    Translation:Humans
  39. Bader A, Hepner DL. The role of the preoperative clinic in perioperative risk reduction. Int Anesthesiol Clin. 2009; 47(4):151-60. PMID: 19820484.
    Citations:    Fields:    Translation:Humans
  40. Hepner DL, Correll DJ, Beckman JA, Klickovich RJ, Park KH, Govindarajulu U, Bader AM. Needs analysis for the development of a preoperative clinic protocol for perioperative beta-blocker therapy. J Clin Anesth. 2008 Dec; 20(8):580-8. PMID: 19100930.
    Citations: 1     Fields:    Translation:Humans
  41. Palanisamy A, Hepner DL, Segal S. Fever, epidurals, and inflammation: a burning issue. J Clin Anesth. 2007 May; 19(3):165-7. PMID: 17531722.
    Citations:    Fields:    Translation:Humans
  42. Correll DJ, Bader AM, Hull MW, Hsu C, Tsen LC, Hepner DL. Value of preoperative clinic visits in identifying issues with potential impact on operating room efficiency. Anesthesiology. 2006 Dec; 105(6):1254-9; discussion 6A. PMID: 17122589.
    Citations: 9     Fields:    Translation:Humans
  43. Hepner DL. Gloved and masked--will gowns be next? The role of asepsis during neuraxial instrumentation. Anesthesiology. 2006 Aug; 105(2):241-3. PMID: 16871056.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  44. Tsen LC, Hepner DL. Needles used for spinal anesthesia. Expert Rev Med Devices. 2006 Jul; 3(4):499-508. PMID: 16866646.
    Citations: 3     Fields:    Translation:Humans
  45. Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF, Bock SA, Branum A, Brown SG, Camargo CA, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor AD, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O'Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW. Second symposium on the definition and management of anaphylaxis: summary report--second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. Ann Emerg Med. 2006 Apr; 47(4):373-80. PMID: 16546624.
    Citations: 71     Fields:    
  46. Grady SP, Nishino S, Czeisler CA, Hepner D, Scammell TE. Diurnal variation in CSF orexin-A in healthy male subjects. Sleep. 2006 Mar; 29(3):295-7. PMID: 16553014.
    Citations: 13     Fields:    Translation:Humans
  47. Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF, Bock SA, Branum A, Brown SG, Camargo CA, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor AD, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O'Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW. Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006 Feb; 117(2):391-7. PMID: 16461139.
    Citations: 231     Fields:    Translation:Humans
  48. Harnett MJ, Hepner DL, Datta S, Kodali BS. Effect of amniotic fluid on coagulation and platelet function in pregnancy: an evaluation using thromboelastography. Anaesthesia. 2005 Nov; 60(11):1068-72. PMID: 16229690.
    Citations: 6     Fields:    Translation:HumansCells
  49. Hepner DL. From the laboratory to the bedside: searching for an understanding of anaphylaxis. Anesthesiology. 2005 Jul; 103(1):1-2. PMID: 15983446.
    Citations:    Fields:    Translation:Humans
  50. Sampson HA, Muñoz-Furlong A, Bock SA, Schmitt C, Bass R, Chowdhury BA, Decker WW, Furlong TJ, Galli SJ, Golden DB, Gruchalla RS, Harlor AD, Hepner DL, Howarth M, Kaplan AP, Levy JH, Lewis LM, Lieberman PL, Metcalfe DD, Murphy R, Pollart SM, Pumphrey RS, Rosenwasser LJ, Simons FE, Wood JP, Camargo CA. Symposium on the definition and management of anaphylaxis: summary report. J Allergy Clin Immunol. 2005 Mar; 115(3):584-91. PMID: 15753908.
    Citations: 54     Fields:    Translation:Humans
  51. Hepner DL, Tsen LC. Severe thrombocytopenia, type 2B von Willebrand disease and pregnancy. Anesthesiology. 2004 Dec; 101(6):1465-7. PMID: 15564956.
    Citations: 1     Fields:    Translation:Humans
  52. Hepner DL, Bader AM, Hurwitz S, Gustafson M, Tsen LC. Patient satisfaction with preoperative assessment in a preoperative assessment testing clinic. Anesth Analg. 2004 Apr; 98(4):1099-105, table of contents. PMID: 15041606.
    Citations: 9     Fields:    Translation:Humans
  53. Williams JH, Hepner DL. Risperidone and exaggerated hypotension during a spinal anesthetic. Anesth Analg. 2004 Jan; 98(1):240-1, table of contents. PMID: 14693627.
    Citations:    Fields:    Translation:Humans
  54. Hepner DL, Castells MC, Tsen LC. Should local anesthetic allergy testing be routinely performed during pregnancy? Anesth Analg. 2003 Dec; 97(6):1853-4; author reply 1854. PMID: 14633575.
    Citations:    Fields:    Translation:Humans
  55. Hepner DL, Castells MC. Anaphylaxis during the perioperative period. Anesth Analg. 2003 Nov; 97(5):1381-95. PMID: 14570656.
    Citations: 42     Fields:    Translation:Humans
  56. Hepner DL. Latex-free pulmonary artery catheters. Anesth Analg. 2003 Sep; 97(3):925. PMID: 12933443.
    Citations:    Fields:    Translation:Humans
  57. Hepner DL, Castells MC. Latex allergy: an update. Anesth Analg. 2003 Apr; 96(4):1219-29. PMID: 12651689.
    Citations: 6     Fields:    Translation:Humans
  58. Hepner DL, Harnett MJ, Segal S, Camann W, Bader M, Tsen LC. Herbal medicinal products during pregnancy: are they safe? BJOG. 2002 Dec; 109(12):1425-6. PMID: 12504999.
    Citations: 1     Fields:    Translation:HumansAnimals
  59. Hepner DL, Concepcion M, Bhavani-Shankar K. Coagulation status using thromboelastography in patients receiving warfarin prophylaxis and epidural analgesia. J Clin Anesth. 2002 Sep; 14(6):405-10. PMID: 12393106.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  60. Hepner DL. Propofol-induced bronchoconstriction: asthma or allergy? Anesth Analg. 2002 Apr; 94(4):1045. PMID: 11916829.
    Citations: 1     Fields:    Translation:Humans
  61. Hepner DL, Harnett M, Segal S, Camann W, Bader AM, Tsen LC. Herbal medicine use in parturients. Anesth Analg. 2002 Mar; 94(3):690-3; table of contents. PMID: 11867399.
    Citations: 12     Fields:    Translation:Humans
  62. Hepner DL, Bader AM. The perioperative physician and professionalism: the two must go together! Anesth Analg. 2001 Nov; 93(5):1088-90. PMID: 11682372.
    Citations: 1     Fields:    Translation:Humans
  63. Hepner DL. Low-dose spinal anesthesia for cesarean delivery: Have we gone too far? Reg Anesth Pain Med. 2001 Mar-Apr; 26(2):180-2. PMID: 11251150.
    Citations:    Fields:    Translation:Humans
  64. Hepner DL. Neuraxial opioids and respiratory depression. Anesth Analg. 2000 Dec; 91(6):1560-1. PMID: 11094019.
    Citations:    Fields:    Translation:Humans
  65. Hepner DL. Preemptive analgesia: what does it really mean? Anesthesiology. 2000 Nov; 93(5):1368. PMID: 11184769.
    Citations: 1     Fields:    Translation:Humans
  66. Hepner DL. Anesthetic implications of a new implantable device: the loop recorder system. Anesthesiology. 2000 Oct; 93(4):1161. PMID: 11020784.
    Citations:    Fields:    Translation:Humans
  67. Hepner DL, Bader AM. Preoperative cardiac assessment has to take into account the type of surgery. Anesthesiology. 2000 Jul; 93(1):271-2. PMID: 10861172.
    Citations:    Fields:    Translation:Humans
  68. Hepner DL. Sudden bronchospasm on intubation: latex anaphylaxis? J Clin Anesth. 2000 Mar; 12(2):162-6. PMID: 10818333.
    Citations:    Fields:    Translation:Humans
  69. Hepner DL, Gaiser RR, Cheek TG, Gutsche BB. Comparison of combined spinal-epidural and low dose epidural for labour analgesia. Can J Anaesth. 2000 Mar; 47(3):232-6. PMID: 10730733.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  70. Hepner DL, Gaiser RR, Cheek TG, Gutsche BB. The Zavanelli maneuver does not preclude regional anesthesia. Anesth Analg. 1997 May; 84(5):1145-6. PMID: 9141949.
    Citations:    Fields:    Translation:Humans
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Hepner's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (281)
Explore
_
Co-Authors (30)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.