Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Yury Popov, Ph.D., M.D.

Title
Institution
Department
Address
Phone
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Profile Picture

Biography
awards and honors
1999 - 2001
Young Investigator Award
2001 - 2003
Sheila Sherlock Fellowship Award
2003 - 2007
Young Investigator Travel Bursary Awards
2008
Presidential Poster of Distinction
2010
Young Investigator Travel Award
2015 - 2018
Adjunct Professor, Sun Yat-sen University
2016
Innovation in Liver Research Award
2018
Excellence in GI Research Award
2019 - 2021
Visiting Professor, Lanzhou University
2022
Research Innovation in Liver Disease Award

Overview
overview
My laboratory's major research focus is on liver fibrosis/cirrhosis. Specifically, we are investigating the basic mechanisms of progression and regression of liver scarring. Our goal is the development of non-invasive diagnostic tools to measure these processes in the clinic, and novel therapies to prevent and reverse cirrhosis and its life-threatening complications. We are actively working on the development, validation and optimization of small animal models for novel drug target discovery and efficacy testing. Some of our current basic research projects include the investigation of a novel macrophage-mediated pathway of fibrosis reversal, a role of intestinal microbiota in chronic liver disease, and elucidating the molecular mechanisms of fibrotic matrix stabilization and collagen cross-linking which make liver scarring irreversible.

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Beyoglu D, Huang P, Skelton-Badlani D, Zong C, Popov YV, Idle JR. Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis. Cells. 2023 02 02; 12(3). PMID: 36766828; PMCID: PMC9914390.
    Citations:    Fields:    Translation:Animals
  2. Yakah W, Shah I, Skelton-Badlani D, Freedman SD, Popov YV, Sheth SG. Circulating Mitochondrial DNA as a Diagnostic Biomarker for Predicting Disease Severity in Patients With Acute Pancreatitis. Gastroenterology. 2023 Jan 18. PMID: 36669623.
    Citations:    Fields:    
  3. Serdjebi C, Bertotti K, Huang P, Wei G, Skelton-Badlani D, Leclercq IA, Barbes D, Lepoivre B, Popov YV, Julé Y. Automated whole slide image analysis for a translational quantification of liver fibrosis. Sci Rep. 2022 11 04; 12(1):17935. PMID: 36333365; PMCID: PMC9636208.
    Citations: 1     Fields:    Translation:Animals
  4. Canesin G, Feldbrügge L, Wei G, Janovicova L, Janikova M, Csizmadia E, Ariffin J, Hedblom A, Herbert ZT, Robson SC, Celec P, Swanson KD, Nasser I, Popov YV, Wegiel B. Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells. iScience. 2022 Sep 16; 25(9):104983. PMID: 36093061; PMCID: PMC9450142.
    Citations:    
  5. Awoniyi M, Wang J, Ngo B, Meadows V, Tam J, Viswanathan A, Lai Y, Montgomery S, Farmer M, Kummen M, Thingholm L, Schramm C, Bang C, Franke A, Lu K, Zhou H, Bajaj JS, Hylemon PB, Ting J, Popov YV, Hov JR, Francis HL, Sartor RB. Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC. Gut. 2023 Apr; 72(4):671-685. PMID: 35705368; PMCID: PMC9751228.
    Citations: 4     Fields:    Translation:AnimalsCells
  6. Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG. Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis. Hepatology. 2022 04; 75(4):968-982. PMID: 34662439; PMCID: PMC9299888.
    Citations: 2     Fields:    Translation:Humans
  7. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Biermann J, Bloom-Ackermann Z, Barkas N, Ganna A, Gomez J, Melms JC, Katsyv I, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jané-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hibshoosh H, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Ellinor PT, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Izar B, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. 2021 07; 595(7865):107-113. PMID: 33915569; PMCID: PMC8919505.
    Citations: 203     Fields:    Translation:HumansCells
  8. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Bloom-Ackerman Z, Barkas N, Ganna A, Gomez J, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jane-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Gordon Jiang Z, Juric D, Babadi M, Farhi SL, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. bioRxiv. 2021 Feb 25. PMID: 33655247.
    Citations: 12     
  9. Wei G, Cao J, Huang P, An P, Badlani D, Vaid KA, Zhao S, Wang DQ, Zhuo J, Yin L, Frassetto A, Markel A, Presnyak V, Gandham S, Hua S, Lukacs C, Finn PF, Giangrande PH, Martini PGV, Popov YV. Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4-/- mouse model of PFIC3. J Hepatol. 2021 06; 74(6):1416-1428. PMID: 33340584; PMCID: PMC8188846.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  10. Schippers M, Post E, Eichhorn I, Langeland J, Beljaars L, Malo MS, Hodin RA, Millán JL, Popov Y, Schuppan D, Poelstra K. Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis. Cells. 2020 12 17; 9(12). PMID: 33348845.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Wagner WL, Föhst S, Hock J, Kim YO, Popov Y, Schuppan D, Schladitz K, Redenbach C, Ackermann M. 3D analysis of microvasculature in murine liver fibrosis models using synchrotron radiation-based microtomography. Angiogenesis. 2021 02; 24(1):57-65. PMID: 33037487; PMCID: PMC7920893.
    Citations: 4     Fields:    Translation:Animals
  12. Chen W, Yang A, Jia J, Popov YV, Schuppan D, You H. Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis. Hepatology. 2020 08; 72(2):729-741. PMID: 32176358.
    Citations: 38     Fields:    Translation:HumansAnimals
  13. An P, Wei LL, Zhao S, Sverdlov DY, Vaid KA, Miyamoto M, Kuramitsu K, Lai M, Popov YV. Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis. Nat Commun. 2020 05 12; 11(1):2362. PMID: 32398673.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  14. An P, Wei G, Huang P, Li W, Qi X, Lin Y, Vaid KA, Wang J, Zhang S, Li Y, Or YS, Jiang LJ, Popov YV. A novel non-bile acid FXR agonist EDP-305 potently suppresses liver injury and fibrosis without worsening of ductular reaction. Liver Int. 2020 07; 40(7):1655-1669. PMID: 32329946.
    Citations: 16     Fields:    Translation:Animals
  15. Tiwari-Heckler S, Jiang ZG, Popov Y, J Mukamal K. Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study. J Biomed Res. 2019 Oct 24; 34(2):139-142. PMID: 32305968; PMCID: PMC7183302.
    Citations:    
  16. Wei G, An P, Vaid KA, Nasser I, Huang P, Tan L, Zhao S, Schuppan D, Popov YV. Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer. Am J Physiol Gastrointest Liver Physiol. 2020 01 01; 318(1):G174-G188. PMID: 31630534; PMCID: PMC6985845.
    Citations: 22     Fields:    Translation:AnimalsCells
  17. Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019 09; 15(3):375-385. PMID: 31243614.
    Citations: 12     Fields:    Translation:AnimalsCells
  18. Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019 06 04; 29(6):1274-1290.e9. PMID: 30930169; PMCID: PMC6657508.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  19. Feldbrügge L, Jiang ZG, Csizmadia E, Mitsuhashi S, Tran S, Yee EU, Rothweiler S, Vaid KA, Sévigny J, Schmelzle M, Popov YV, Robson SC. Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis. Purinergic Signal. 2018 03; 14(1):37-46. PMID: 29134411.
    Citations: 9     Fields:    Translation:Animals
  20. Peng ZW, Rothweiler S, Wei G, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Longhi MS, Kuang M, Robson SC, Popov YV. The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis. Hepatol Commun. 2017 11; 1(9):957-972. PMID: 29404503; PMCID: PMC5721459.
    Citations: 18     Fields:    
  21. Fausther M, Pritchard MT, Popov YV, Bridle K. Contribution of Liver Nonparenchymal Cells to Hepatic Fibrosis: Interactions with the Local Microenvironment. Biomed Res Int. 2017; 2017:6824762. PMID: 28299331.
    Citations: 4     Fields:    Translation:HumansAnimals
  22. Ikenaga N, Peng ZW, Vaid KA, Liu SB, Yoshida S, Sverdlov DY, Mikels-Vigdal A, Smith V, Schuppan D, Popov YV. Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal. Gut. 2017 09; 66(9):1697-1708. PMID: 28073888; PMCID: PMC5561383.
    Citations: 104     Fields:    Translation:AnimalsCells
  23. Kim YO, Popov Y, Schuppan D. Optimized Mouse Models for Liver Fibrosis. Methods Mol Biol. 2017; 1559:279-296. PMID: 28063051.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  24. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Letter: would aspirin alleviate fibrosis in alcoholic liver disease? Authors' reply. Aliment Pharmacol Ther. 2016 07; 44(2):209-10. PMID: 27296690.
    Citations:    Fields:    Translation:Humans
  25. Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology. 2016 Mar; 63(3):965-82. PMID: 26645994; PMCID: PMC4764460.
    Citations: 40     Fields:    Translation:AnimalsCells
  26. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Aspirin use is associated with lower indices of liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 2016 Mar; 43(6):734-43. PMID: 26749582.
    Citations: 36     Fields:    Translation:Humans
  27. Liu SB, Ikenaga N, Peng ZW, Sverdlov DY, Greenstein A, Smith V, Schuppan D, Popov Y. Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice. FASEB J. 2016 Apr; 30(4):1599-609. PMID: 26700732.
    Citations: 86     Fields:    Translation:AnimalsCells
  28. Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y. Integrin avß6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis. Hepatology. 2016 Jan; 63(1):217-32. PMID: 26448099.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  29. Jiménez Calvente C, Sehgal A, Popov Y, Kim YO, Zevallos V, Sahin U, Diken M, Schuppan D. Specific hepatic delivery of procollagen a1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis. Hepatology. 2015 Oct; 62(4):1285-97. PMID: 26096209; PMCID: PMC4589454.
    Citations: 42     Fields:    Translation:Animals
  30. Ikenaga N, Liu SB, Sverdlov DY, Yoshida S, Nasser I, Ke Q, Kang PM, Popov Y. A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer. Am J Pathol. 2015 Feb; 185(2):325-34. PMID: 25478810.
    Citations: 33     Fields:    Translation:Animals
  31. Yoshida S, Ikenaga N, Liu SB, Peng ZW, Chung J, Sverdlov DY, Miyamoto M, Kim YO, Ogawa S, Arch RH, Schuppan D, Popov Y. Extrahepatic platelet-derived growth factor-ß, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice. Gastroenterology. 2014 Dec; 147(6):1378-92. PMID: 25173753.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  32. Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology. 2014 Nov; 147(5):1073-83.e6. PMID: 25083607; PMCID: PMC4570569.
    Citations: 118     Fields:    Translation:AnimalsCells
  33. Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D, Schuppan D, Bi Y, Simonetto D, Shah VH. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014 May; 146(5):1339-50.e1. PMID: 24503129; PMCID: PMC4001704.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  34. Chowdhury S, Chen Y, Yao TW, Ajami K, Wang XM, Popov Y, Schuppan D, Bertolino P, McCaughan GW, Yu DM, Gorrell MD. Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World J Gastroenterol. 2013 May 21; 19(19):2883-93. PMID: 23704821; PMCID: PMC3660813.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  35. Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto DW, Otterbein LE, Popov Y. Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation. Am J Pathol. 2013 Jul; 183(1):182-94. PMID: 23680654; PMCID: PMC3702745.
    Citations: 49     Fields:    Translation:Animals
  36. Ziogas DC, Gras-Miralles B, Mustafa S, Geiger BM, Najarian RM, Nagel JM, Flier SN, Popov Y, Tseng YH, Kokkotou E. Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2013 May 15; 304(10):G876-84. PMID: 23538494.
    Citations: 5     Fields:    Translation:AnimalsCells
  37. Popov Y. Mouse model of primary biliary cirrhosis with progressive fibrosis: are we there yet? Hepatology. 2013 Feb; 57(2):429-31. PMID: 22815060.
    Citations: 4     Fields:    Translation:Animals
  38. Kwong GA, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos IA, Sverdlov DY, Liu SB, Warren AD, Popov Y, Schuppan D, Bhatia SN. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat Biotechnol. 2013 Jan; 31(1):63-70. PMID: 23242163.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  39. Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley MA, Alatrakchi N. Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis. Hepatology. 2012 Dec; 56(6):2094-105. PMID: 22806830; PMCID: PMC3508175.
    Citations: 7     Fields:    Translation:HumansCells
  40. Martin CR, Zaman MM, Ketwaroo GA, Bhutta AQ, Coronel E, Popov Y, Schuppan D, Freedman SD. CFTR dysfunction predisposes to fibrotic liver disease in a murine model. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15; 303(4):G474-81. PMID: 22679000.
    Citations: 7     Fields:    Translation:AnimalsCells
  41. de Meijer VE, Sverdlov DY, Le HD, Popov Y, Puder M. Tissue-specific differences in inflammatory infiltrate and matrix metalloproteinase expression in adipose tissue and liver of mice with diet-induced obesity. Hepatol Res. 2012 Jun; 42(6):601-10. PMID: 22236199.
    Citations: 14     
  42. de Meijer VE, Le HD, Meisel JA, Sharma AK, Popov Y, Puder M. Tumor necrosis factor a-converting enzyme inhibition reverses hepatic steatosis and improves insulin sensitivity markers and surgical outcome in mice. PLoS One. 2011; 6(9):e25587. PMID: 21980496.
    Citations: 10     Fields:    Translation:Animals
  43. Popov Y, Sverdlov DY, Sharma AK, Bhaskar KR, Li S, Freitag TL, Lee J, Dieterich W, Melino G, Schuppan D. Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice. Gastroenterology. 2011 May; 140(5):1642-52. PMID: 21277850; PMCID: PMC3374132.
    Citations: 66     Fields:    Translation:AnimalsCells
  44. Ruehl M, Muche M, Freise C, Erben U, Neumann U, Schuppan D, Popov Y, Dieterich W, Zeitz M, Farndale RW, Somasundaram R. Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42. Fibrogenesis Tissue Repair. 2011 Jan 06; 4(1):1. PMID: 21211003.
    Citations: 8     
  45. Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D. Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells. Hepatology. 2011 Jan; 53(1):230-42. PMID: 20979056.
    Citations: 55     Fields:    Translation:HumansCells
  46. Popov Y, Schuppan D. Epithelial-to-mesenchymal transition in liver fibrosis: dead or alive? Gastroenterology. 2010 Sep; 139(3):722-5. PMID: 20682361.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  47. de Meijer VE, Sverdlov DY, Popov Y, Le HD, Meisel JA, Nosé V, Schuppan D, Puder M. Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice. PLoS One. 2010 Jun 25; 5(6):e11256. PMID: 20593020.
    Citations: 18     Fields:    Translation:AnimalsCells
  48. Popov Y, Sverdlov DY, Bhaskar KR, Sharma AK, Millonig G, Patsenker E, Krahenbuhl S, Krahenbuhl L, Schuppan D. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Am J Physiol Gastrointest Liver Physiol. 2010 Mar; 298(3):G323-34. PMID: 20056896; PMCID: PMC2838516.
    Citations: 58     Fields:    Translation:AnimalsCells
  49. Lohwasser C, Neureiter D, Popov Y, Bauer M, Schuppan D. Role of the receptor for advanced glycation end products in hepatic fibrosis. World J Gastroenterol. 2009 Dec 14; 15(46):5789-98. PMID: 19998499.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  50. Patsenker E, Popov Y, Stickel F, Schneider V, Ledermann M, Sägesser H, Niedobitek G, Goodman SL, Schuppan D. Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. Hepatology. 2009 Nov; 50(5):1501-11. PMID: 19725105.
    Citations: 77     Fields:    Translation:AnimalsCells
  51. Popov Y, Schuppan D. CD8+ T cells drive adipose tissue inflammation--a novel clue for NASH pathogenesis? J Hepatol. 2010 Jan; 52(1):130-2. PMID: 19914729.
    Citations: 8     Fields:    
  52. Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology. 2009 Oct; 50(4):1294-306. PMID: 19711424.
    Citations: 127     Fields:    Translation:HumansAnimals
  53. Schuppan D, Popov Y. Rationale and targets for antifibrotic therapies. Gastroenterol Clin Biol. 2009 Oct-Nov; 33(10-11):949-57. PMID: 19726145.
    Citations: 8     Fields:    Translation:Humans
  54. Freitag TL, Rietdijk S, Junker Y, Popov Y, Bhan AK, Kelly CP, Terhorst C, Schuppan D. Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice. Gut. 2009 Dec; 58(12):1597-605. PMID: 19671544; PMCID: PMC3733237.
    Citations: 14     Fields:    Translation:AnimalsCells
  55. Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest. 2008 Oct; 118(10):3331-42. PMID: 18802480; PMCID: PMC2542850.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  56. Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D. Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology. 2008 Aug; 135(2):660-70. PMID: 18538673; PMCID: PMC3505071.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  57. Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan D, Diehl AM. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut. 2008 Sep; 57(9):1275-82. PMID: 18375471.
    Citations: 68     Fields:    Translation:AnimalsCells
  58. Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A, Friess H, Schuppan D. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol. 2008 Mar; 48(3):453-64. PMID: 18221819.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  59. Patsenker E, Popov Y, Wiesner M, Goodman SL, Schuppan D. Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro. J Hepatol. 2007 May; 46(5):878-87. PMID: 17258347.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  60. Popov Y, Patsenker E, Bauer M, Niedobitek E, Schulze-Krebs A, Schuppan D. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. J Biol Chem. 2006 Jun 02; 281(22):15090-8. PMID: 16489207.
    Citations: 46     Fields:    Translation:AnimalsCells
  61. Darbinian-Sarkissian N, Darbinyan A, Otte J, Radhakrishnan S, Sawaya BE, Arzumanyan A, Chipitsyna G, Popov Y, Rappaport J, Amini S, Khalili K. p27(SJ), a novel protein in St John's Wort, that suppresses expression of HIV-1 genome. Gene Ther. 2006 Feb; 13(4):288-95. PMID: 16251997.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  62. Benten D, Kumaran V, Joseph B, Schattenberg J, Popov Y, Schuppan D, Gupta S. Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat. Hepatology. 2005 Nov; 42(5):1072-81. PMID: 16250034.
    Citations: 29     Fields:    Translation:AnimalsCells
  63. Popov Y, Patsenker E, Fickert P, Trauner M, Schuppan D. Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J Hepatol. 2005 Dec; 43(6):1045-54. PMID: 16223543.
    Citations: 113     Fields:    Translation:Animals
  64. Schulze-Krebs A, Preimel D, Popov Y, Bartenschlager R, Lohmann V, Pinzani M, Schuppan D. Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells. Gastroenterology. 2005 Jul; 129(1):246-58. PMID: 16012951.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  65. Dan Z, Popov Y, Patsenker E, Preimel D, Liu C, Wang XD, Seitz HK, Schuppan D, Stickel F. Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential. FASEB J. 2005 May; 19(7):845-7. PMID: 15731294.
    Citations: 23     Fields:    Translation:AnimalsCells
  66. Schuppan D, Popov Y, Porov Y. Hepatic fibrosis: from bench to bedside. J Gastroenterol Hepatol. 2002 Dec; 17 Suppl 3:S300-5. PMID: 12472954.
    Citations: 22     Fields:    Translation:HumansCells
  67. Buko VU, Lukivskaya O, Naruta E, Popov Y, Chirkin A, Chirkina I, Oettel M, Römer W, Hübler D. Antiatherogenic effects of 17 beta-estradiol and 17 alpha-estradiol and its derivative J811 in cholesterol-fed rabbits with thyroid inhibition. Climacteric. 2001 Mar; 4(1):49-57. PMID: 11379378.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.