Harvard Catalyst Profiles

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Yury Popov, M.D., Ph.D.

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Biography
awards and honors
1999 - 2001
Young Investigator Award
2001 - 2003
Sheila Sherlock Fellowship Award
2003 - 2007
Young Investigator Travel Bursary Awards
2008
Presidential Poster of Distinction
2010
Young Investigator Travel Award
2015 - 2018
Adjunct Professor, Sun Yat-sen University
2016
Innovation in Liver Research Award
2018
Excellence in GI Research Award
2019 - 2021
Visiting Professor, Lanzhou University
2022
Research Innovation in Liver Disease Award

Overview
overview
My laboratory's major research focus is on liver fibrosis/cirrhosis. Specifically, we are investigating the basic mechanisms of progression and regression of liver scarring. Our goal is the development of non-invasive diagnostic tools to measure these processes in the clinic, and novel therapies to prevent and reverse cirrhosis and its life-threatening complications. We are actively working on the development, validation and optimization of small animal models for novel drug target discovery and efficacy testing. Some of our current basic research projects include the investigation of a novel macrophage-mediated pathway of fibrosis reversal, a role of intestinal microbiota in chronic liver disease, and elucidating the molecular mechanisms of fibrotic matrix stabilization and collagen cross-linking which make liver scarring irreversible.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.