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Yury Popov, Ph.D., M.D.

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Biography
1999 - 2001
Young Investigator Award
2001 - 2003
Sheila Sherlock Fellowship Award
2003 - 2007
Young Investigator Travel Bursary Awards
2008
Presidential Poster of Distinction
2010
Young Investigator Travel Award
2015 - 2018
Adjunct Professor, Sun Yat-sen University
2016
Innovation in Liver Research Award
2018
Excellence in GI Research Award
2019
Visiting Professor, Lanzhou University

Overview
My laboratory's major research focus is on liver fibrosis/cirrhosis. Specifically, we are investigating the basic mechanisms of progression and regression of liver scarring. Our goal is the development of non-invasive diagnostic tools to measure these processes in the clinic, and novel therapies to prevent and reverse cirrhosis and its life-threatening complications. We are actively working on the development, validation and optimization of small animal models for novel drug target discovery and efficacy testing. Some of our current basic research projects include the investigation of a novel macrophage-mediated pathway of fibrosis reversal, a role of intestinal microbiota in chronic liver disease, and elucidating the molecular mechanisms of fibrotic matrix stabilization and collagen cross-linking which make liver scarring irreversible.

Mentoring
Available: 07/24/17, Expires: 09/01/19

Our major research focus is on liver fibrosis/cirrhosis. Specifically, we are investigating the basic mechanisms of progression and regression of liver scarring. Our goal is the development of novel therapies to prevent and reverse cirrhosis and its life-threatening complications such as cancer, portal hypertension and liver failure. We are actively working on the development, validation and optimization of small animal models for novel drug target discovery and efficacy testing. Some of our currently active basic research projects include the investigation of a role of intestinal microbiota in chronic liver disease, elucidating the molecular mechanisms of fibrotic matrix stabilization/collagen cross-linking which make liver scarring irreversible, and role of platelets in liver fibrosis and regeneration. Students will have a opportunity to conduct an independent project to elucidate the role of specific pathway listed above in mouse models of cirrhosis-associated liver cancer or alcohol-related liver disease in mice. There are also opportunities related to new, high-fidelity models of liver disease development and/or characterization. These projects will require at least 6 months part time commitment.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Feldbrügge L, Jiang ZG, Csizmadia E, Mitsuhashi S, Tran S, Yee EU, Rothweiler S, Vaid KA, Sévigny J, Schmelzle M, Popov YV, Robson SC. Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis. Purinergic Signal. 2018 03; 14(1):37-46. PMID: 29134411.
    Citations:    Fields:    Translation:Animals
  2. Peng ZW, Rothweiler S, Wei G, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Longhi MS, Kuang M, Robson SC, Popov YV. The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis. Hepatol Commun. 2017 11; 1(9):957-972. PMID: 29404503.
    Citations:    
  3. Fausther M, Pritchard MT, Popov YV, Bridle K. Contribution of Liver Nonparenchymal Cells to Hepatic Fibrosis: Interactions with the Local Microenvironment. Biomed Res Int. 2017; 2017:6824762. PMID: 28299331.
    Citations: 2     Fields:    Translation:HumansAnimals
  4. Ikenaga N, Peng ZW, Vaid KA, Liu SB, Yoshida S, Sverdlov DY, Mikels-Vigdal A, Smith V, Schuppan D, Popov YV. Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal. Gut. 2017 09; 66(9):1697-1708. PMID: 28073888.
    Citations: 14     Fields:    Translation:AnimalsCells
  5. Kim YO, Popov Y, Schuppan D. Optimized Mouse Models for Liver Fibrosis. Methods Mol Biol. 2017; 1559:279-296. PMID: 28063051.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Letter: would aspirin alleviate fibrosis in alcoholic liver disease? Authors' reply. Aliment Pharmacol Ther. 2016 07; 44(2):209-10. PMID: 27296690.
    Citations:    Fields:    Translation:Humans
  7. Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology. 2016 Mar; 63(3):965-82. PMID: 26645994.
    Citations: 14     Fields:    Translation:AnimalsCells
  8. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Aspirin use is associated with lower indices of liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 2016 Mar; 43(6):734-43. PMID: 26749582.
    Citations: 3     Fields:    Translation:Humans
  9. Liu SB, Ikenaga N, Peng ZW, Sverdlov DY, Greenstein A, Smith V, Schuppan D, Popov Y. Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice. FASEB J. 2016 Apr; 30(4):1599-609. PMID: 26700732.
    Citations: 13     Fields:    Translation:AnimalsCells
  10. Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y. Integrin avß6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis. Hepatology. 2016 Jan; 63(1):217-32. PMID: 26448099.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Jiménez Calvente C, Sehgal A, Popov Y, Kim YO, Zevallos V, Sahin U, Diken M, Schuppan D. Specific hepatic delivery of procollagen a1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis. Hepatology. 2015 Oct; 62(4):1285-97. PMID: 26096209.
    Citations: 10     Fields:    Translation:Animals
  12. Ikenaga N, Liu SB, Sverdlov DY, Yoshida S, Nasser I, Ke Q, Kang PM, Popov Y. A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer. Am J Pathol. 2015 Feb; 185(2):325-34. PMID: 25478810.
    Citations: 7     Fields:    Translation:Animals
  13. Yoshida S, Ikenaga N, Liu SB, Peng ZW, Chung J, Sverdlov DY, Miyamoto M, Kim YO, Ogawa S, Arch RH, Schuppan D, Popov Y. Extrahepatic platelet-derived growth factor-ß, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice. Gastroenterology. 2014 Dec; 147(6):1378-92. PMID: 25173753.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  14. Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology. 2014 Nov; 147(5):1073-83.e6. PMID: 25083607.
    Citations: 43     Fields:    Translation:AnimalsCells
  15. Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D, Schuppan D, Bi Y, Simonetto D, Shah VH. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014 May; 146(5):1339-50.e1. PMID: 24503129.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  16. Chowdhury S, Chen Y, Yao TW, Ajami K, Wang XM, Popov Y, Schuppan D, Bertolino P, McCaughan GW, Yu DM, Gorrell MD. Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World J Gastroenterol. 2013 May 21; 19(19):2883-93. PMID: 23704821.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto DW, Otterbein LE, Popov Y. Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation. Am J Pathol. 2013 Jul; 183(1):182-94. PMID: 23680654.
    Citations: 30     Fields:    Translation:Animals
  18. Ziogas DC, Gras-Miralles B, Mustafa S, Geiger BM, Najarian RM, Nagel JM, Flier SN, Popov Y, Tseng YH, Kokkotou E. Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2013 May 15; 304(10):G876-84. PMID: 23538494.
    Citations: 3     Fields:    Translation:AnimalsCells
  19. Popov Y. Mouse model of primary biliary cirrhosis with progressive fibrosis: are we there yet? Hepatology. 2013 Feb; 57(2):429-31. PMID: 22815060.
    Citations: 4     Fields:    Translation:Animals
  20. Kwong GA, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos IA, Sverdlov DY, Liu SB, Warren AD, Popov Y, Schuppan D, Bhatia SN. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat Biotechnol. 2013 Jan; 31(1):63-70. PMID: 23242163.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  21. Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley MA, Alatrakchi N. Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis. Hepatology. 2012 Dec; 56(6):2094-105. PMID: 22806830.
    Citations: 5     Fields:    Translation:HumansCells
  22. Martin CR, Zaman MM, Ketwaroo GA, Bhutta AQ, Coronel E, Popov Y, Schuppan D, Freedman SD. CFTR dysfunction predisposes to fibrotic liver disease in a murine model. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15; 303(4):G474-81. PMID: 22679000.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. de Meijer VE, Sverdlov DY, Le HD, Popov Y, Puder M. Tissue-specific differences in inflammatory infiltrate and matrix metalloproteinase expression in adipose tissue and liver of mice with diet-induced obesity. Hepatol Res. 2012 Jun; 42(6):601-10. PMID: 22236199.
    Citations: 8     
  24. de Meijer VE, Le HD, Meisel JA, Sharma AK, Popov Y, Puder M. Tumor necrosis factor a-converting enzyme inhibition reverses hepatic steatosis and improves insulin sensitivity markers and surgical outcome in mice. PLoS One. 2011; 6(9):e25587. PMID: 21980496.
    Citations: 5     Fields:    Translation:Animals
  25. Popov Y, Sverdlov DY, Sharma AK, Bhaskar KR, Li S, Freitag TL, Lee J, Dieterich W, Melino G, Schuppan D. Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice. Gastroenterology. 2011 May; 140(5):1642-52. PMID: 21277850.
    Citations: 28     Fields:    Translation:AnimalsCells
  26. Ruehl M, Muche M, Freise C, Erben U, Neumann U, Schuppan D, Popov Y, Dieterich W, Zeitz M, Farndale RW, Somasundaram R. Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42. Fibrogenesis Tissue Repair. 2011 Jan 06; 4(1):1. PMID: 21211003.
    Citations: 9     
  27. Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D. Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells. Hepatology. 2011 Jan; 53(1):230-42. PMID: 20979056.
    Citations: 33     Fields:    Translation:HumansCells
  28. Popov Y, Schuppan D. Epithelial-to-mesenchymal transition in liver fibrosis: dead or alive? Gastroenterology. 2010 Sep; 139(3):722-5. PMID: 20682361.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  29. de Meijer VE, Sverdlov DY, Popov Y, Le HD, Meisel JA, Nosé V, Schuppan D, Puder M. Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice. PLoS One. 2010 Jun 25; 5(6):e11256. PMID: 20593020.
    Citations: 11     Fields:    Translation:AnimalsCells
  30. Popov Y, Sverdlov DY, Bhaskar KR, Sharma AK, Millonig G, Patsenker E, Krahenbuhl S, Krahenbuhl L, Schuppan D. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Am J Physiol Gastrointest Liver Physiol. 2010 Mar; 298(3):G323-34. PMID: 20056896.
    Citations: 38     Fields:    Translation:AnimalsCells
  31. Lohwasser C, Neureiter D, Popov Y, Bauer M, Schuppan D. Role of the receptor for advanced glycation end products in hepatic fibrosis. World J Gastroenterol. 2009 Dec 14; 15(46):5789-98. PMID: 19998499.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  32. Patsenker E, Popov Y, Stickel F, Schneider V, Ledermann M, Sägesser H, Niedobitek G, Goodman SL, Schuppan D. Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. Hepatology. 2009 Nov; 50(5):1501-11. PMID: 19725105.
    Citations: 48     Fields:    Translation:AnimalsCells
  33. Popov Y, Schuppan D. CD8+ T cells drive adipose tissue inflammation--a novel clue for NASH pathogenesis? J Hepatol. 2010 Jan; 52(1):130-2. PMID: 19914729.
    Citations: 3     Fields:    
  34. Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology. 2009 Oct; 50(4):1294-306. PMID: 19711424.
    Citations: 90     Fields:    Translation:HumansAnimals
  35. Schuppan D, Popov Y. Rationale and targets for antifibrotic therapies. Gastroenterol Clin Biol. 2009 Oct-Nov; 33(10-11):949-57. PMID: 19726145.
    Citations: 8     Fields:    Translation:Humans
  36. Freitag TL, Rietdijk S, Junker Y, Popov Y, Bhan AK, Kelly CP, Terhorst C, Schuppan D. Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice. Gut. 2009 Dec; 58(12):1597-605. PMID: 19671544.
    Citations: 6     Fields:    Translation:AnimalsCells
  37. Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest. 2008 Oct; 118(10):3331-42. PMID: 18802480.
    Citations: 137     Fields:    Translation:HumansAnimalsCells
  38. Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D. Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology. 2008 Aug; 135(2):660-70. PMID: 18538673.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  39. Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan D, Diehl AM. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut. 2008 Sep; 57(9):1275-82. PMID: 18375471.
    Citations: 55     Fields:    Translation:AnimalsCells
  40. Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A, Friess H, Schuppan D. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol. 2008 Mar; 48(3):453-64. PMID: 18221819.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  41. Patsenker E, Popov Y, Wiesner M, Goodman SL, Schuppan D. Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro. J Hepatol. 2007 May; 46(5):878-87. PMID: 17258347.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  42. Popov Y, Patsenker E, Bauer M, Niedobitek E, Schulze-Krebs A, Schuppan D. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. J Biol Chem. 2006 Jun 02; 281(22):15090-8. PMID: 16489207.
    Citations: 34     Fields:    Translation:AnimalsCells
  43. Benten D, Kumaran V, Joseph B, Schattenberg J, Popov Y, Schuppan D, Gupta S. Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat. Hepatology. 2005 Nov; 42(5):1072-81. PMID: 16250034.
    Citations: 21     Fields:    Translation:AnimalsCells
  44. Popov Y, Patsenker E, Fickert P, Trauner M, Schuppan D. Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J Hepatol. 2005 Dec; 43(6):1045-54. PMID: 16223543.
    Citations: 74     Fields:    Translation:Animals
  45. Schulze-Krebs A, Preimel D, Popov Y, Bartenschlager R, Lohmann V, Pinzani M, Schuppan D. Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells. Gastroenterology. 2005 Jul; 129(1):246-58. PMID: 16012951.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  46. Dan Z, Popov Y, Patsenker E, Preimel D, Liu C, Wang XD, Seitz HK, Schuppan D, Stickel F. Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential. FASEB J. 2005 May; 19(7):845-7. PMID: 15731294.
    Citations: 18     Fields:    Translation:AnimalsCells
  47. Schuppan D, Popov Y, Porov Y. Hepatic fibrosis: from bench to bedside. J Gastroenterol Hepatol. 2002 Dec; 17 Suppl 3:S300-5. PMID: 12472954.
    Citations: 14     Fields:    Translation:HumansCells
  48. Buko VU, Lukivskaya O, Naruta E, Popov Y, Chirkin A, Chirkina I, Oettel M, Römer W, Hübler D. Antiatherogenic effects of 17 beta-estradiol and 17 alpha-estradiol and its derivative J811 in cholesterol-fed rabbits with thyroid inhibition. Climacteric. 2001 Mar; 4(1):49-57. PMID: 11379378.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.