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Shadmehr Demehri, M.D.,Ph.D.

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Overview
The research in Demehri laboratory is focused on identifying the immune mechanisms that drive an immune recognition of early malignant cells to prevent cancer formation from pre-cancerous lesions. This approach raises a great opportunity to discover novel immune pathways that can be leveraged in cancer prevention and therapy.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR076013 (DEMEHRI, SHADMEHR) Jul 5, 2019 - May 31, 2024
    NIH/NIAMS
    Immunotherapy for Skin Cancer Precursors to Prevent Skin Cancer
    Role: Principal Investigator
  2. U01CA233097 (DEMEHRI, SHADMEHR) Sep 30, 2018 - Aug 31, 2023
    NIH/NCI
    Epithelium-derived alarmins role in breast cancer immunoprevention
    Role: Principal Investigator
  3. DP5OD021353 (DEMEHRI, SHADMEHR) Sep 25, 2015 - Aug 31, 2020
    NIH
    THE MECHANISM OF TSLP ANTI-TUMOR EFFECTS IN THE SKIN
    Role: Principal Investigator
  4. K08AR068619 (DEMEHRI, SHADMEHR) Aug 1, 2015 - Jul 31, 2020
    NIH/NIAMS
    The Role of Allergic Contact Dermatitis in Skin Carcinogenesis
    Role: Principal Investigator
  5. F30HL095244 (DEMEHRI, SHADMEHR) Apr 1, 2009 - May 21, 2010
    NIH/NHLBI
    The mechanism of thymic stromal lymphopoietin overexpression by epithelial cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Annapragada A, Sikora A, Bollard C, Conejo-Garcia J, Cruz CR, Demehri S, Demetriou M, Demirdjian L, Fong L, Horowitz M, Hutson A, Kadash-Edmondson K, Kufe D, Lipkin S, Liu S, McCarthy C, Morgan M, Morris Z, Pan Y, Pasquini M, Schoenberger S, Van Allen E, Vilar E, Xing Y, Zha W, Odunsi A. Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer. J Immunother Cancer. 2020 Jun; 8(1). PMID: 32554617.
    Citations:    
  2. Herbosa CM, Hodges W, Mann C, Demehri S, Cornelius LA, Semenov YR. Risk of cancer in psoriasis: study of a nationally representative sample of the US population with comparison to a single-institution cohort. J Eur Acad Dermatol Venereol. 2020 Apr 10. PMID: 32277504.
    Citations:    
  3. Messerschmidt JL, Dempsey KE, Dillon KS, Demehri S. Divergent Roles of Epithelium-Derived Alarmins in Notch Signaling-Deficient Skin. J Invest Dermatol. 2020 Mar 06. PMID: 32147504.
    Citations:    
  4. Ameri AH, Foreman RK, Vedak P, Chen S, Miller DM, Demehri S. Hypertrophic Lichen Planus with Histological Features of Squamous Cell Carcinoma Associated with Immune Checkpoint Blockade Therapy. Oncologist. 2020 May; 25(5):366-368. PMID: 32073194.
    Citations:    
  5. Weintraub GS, Su KA, Demehri S, Asgari MM. Enhancing the process for care delivery in a dermatology specialty clinic. J Am Acad Dermatol. 2020 Feb 14. PMID: 32068037.
    Citations:    
  6. Nguyen ED, Xue YK, Danesh M, Ameri A, Weng CQ, Klebanov N, Foreman RK, Nazarian RM, Demehri S, Tsao H, Kroshinsky D. A Case of Nivolumab-Induced Cutaneous Toxicity with Multiple Morphologies. Dermatopathology (Basel). 2019 Oct-Dec; 6(4):255-259. PMID: 32232031.
    Citations:    
  7. Hasegawa T, Feng Z, Yan Z, Ngo KH, Hosoi J, Demehri S. Reduction in Human Epidermal Langerhans Cells with Age Is Associated with Decline in CXCL14-Mediated Recruitment of CD14+ Monocytes. J Invest Dermatol. 2020 Jul; 140(7):1327-1334. PMID: 31881212.
    Citations:    
  8. Strickley JD, Messerschmidt JL, Awad ME, Li T, Hasegawa T, Ha DT, Nabeta HW, Bevins PA, Ngo KH, Asgari MM, Nazarian RM, Neel VA, Jenson AB, Joh J, Demehri S. Immunity to commensal papillomaviruses protects against skin cancer. Nature. 2019 11; 575(7783):519-522. PMID: 31666702.
    Citations:    
  9. Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, Wakimoto H, Curry WT, Carter BS, Maus MV. CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity. Nat Biotechnol. 2019 09; 37(9):1049-1058. PMID: 31332324.
    Citations:    
  10. Molina GE, Khalifian S, Mull JL, Chen L, Rosman IS, Faulkner-Jones BE, Ngo KH, Demehri S, Cornelius LA, Wu PA. Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease. JAMA Dermatol. 2019 May 01; 155(5):599-603. PMID: 30785593.
    Citations:    
  11. Rosenberg AR, Tabacchi M, Ngo KH, Wallendorf M, Rosman IS, Cornelius LA, Demehri S. Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. JCI Insight. 2019 03 21; 4(6). PMID: 30895944.
    Citations:    
  12. Boroughs AC, Larson RC, Choi BD, Bouffard AA, Riley LS, Schiferle E, Kulkarni AS, Cetrulo CL, Ting D, Blazar BR, Demehri S, Maus MV. Chimeric antigen receptor costimulation domains modulate human regulatory T cell function. JCI Insight. 2019 03 14; 5. PMID: 30869654.
    Citations:    
  13. Ameri AH, Moradi Tuchayi S, Zaalberg A, Park JH, Ngo KH, Li T, Lopez E, Colonna M, Lee RT, Mino-Kenudson M, Demehri S. IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation. Proc Natl Acad Sci U S A. 2019 02 12; 116(7):2646-2651. PMID: 30696763.
    Citations:    Fields:    
  14. Zaalberg A, Moradi Tuchayi S, Ameri AH, Ngo KH, Cunningham TJ, Eliane JP, Livneh M, Horn TD, Rosman IS, Musiek A, Anadkat MJ, Demehri S. Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus. J Invest Dermatol. 2019 01; 139(1):62-70. PMID: 30030152.
    Citations:    Fields:    
  15. Wang W, Ollila HM, Whittemore AS, Demehri S, Ioannidis NM, Jorgenson E, Mignot E, Asgari MM. Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma. Cancer Immunol Immunother. 2018 Jul; 67(7):1123-1133. PMID: 29754218.
    Citations:    Fields:    
  16. Kawakubo M, Cunningham TJ, Demehri S, Manstein D. Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity. Sci Rep. 2017 10 06; 7(1):12751. PMID: 28986576.
    Citations:    Fields:    
  17. Kawakubo M, Demehri S, Manstein D. Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response. PLoS One. 2017; 12(9):e0184852. PMID: 28922374.
    Citations:    Fields:    Translation:AnimalsCells
  18. Yesantharao P, Wang W, Ioannidis NM, Demehri S, Whittemore AS, Asgari MM. Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system. Hum Immunol. 2017 Apr; 78(4):327-335. PMID: 28185865.
    Citations: 2     Fields:    Translation:HumansCells
  19. Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest. 2017 01 03; 127(1):106-116. PMID: 27869649.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  20. Demehri S, Cunningham TJ, Manivasagam S, Ngo KH, Moradi Tuchayi S, Reddy R, Meyers MA, DeNardo DG, Yokoyama WM. Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis. J Clin Invest. 2016 Apr 01; 126(4):1458-70. PMID: 26927668.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Demehri S, Cunningham TJ, Hurst EA, Schaffer A, Sheinbein DM, Yokoyama WM. Chronic allergic contact dermatitis promotes skin cancer. J Clin Invest. 2014 Nov; 124(11):5037-41. PMID: 25295539.
    Citations: 2     Fields:    Translation:HumansAnimals
  22. Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey JF, Zhong J, Chen ZF. Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest. 2013 Nov; 123(11):4769-80. PMID: 24216512.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  23. Yockey LJ, Demehri S, Turkoz M, Turkoz A, Ahern PP, Jassim O, Manivasagam S, Kearney JF, Gordon JI, Kopan R. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol. 2013 Dec; 133(12):2714-2721. PMID: 23698100.
    Citations: 8     Fields:    Translation:AnimalsCells
  24. Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell. 2012 Oct 16; 22(4):494-505. PMID: 23079659.
    Citations: 38     Fields:    Translation:AnimalsCells
  25. Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One. 2010 Feb 18; 5(2):e9258. PMID: 20174635.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  26. Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation. 2009 Dec; 78(5):292-300. PMID: 19683850.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  27. Demehri S, Turkoz A, Kopan R. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell. 2009 Jul 07; 16(1):55-66. PMID: 19573812.
    Citations: 99     Fields:    Translation:AnimalsCells
  28. Demehri S, Morimoto M, Holtzman MJ, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol. 2009 May 19; 7(5):e1000067. PMID: 19557146.
    Citations: 68     Fields:    Translation:Animals
  29. Demehri S, Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development. 2009 Mar; 136(6):891-6. PMID: 19211676.
    Citations: 25     Fields:    Translation:AnimalsCells
  30. Pazolli E, Luo X, Brehm S, Carbery K, Chung JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res. 2009 Feb 01; 69(3):1230-9. PMID: 19155301.
    Citations: 50     Fields:    Translation:HumansCells
  31. Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol. 2008 May 27; 6(5):e123. PMID: 18507503.
    Citations: 87     Fields:    Translation:AnimalsCells
  32. Lee J, Basak JM, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development. 2007 Aug; 134(15):2795-806. PMID: 17611229.
    Citations: 34     Fields:    Translation:AnimalsCells
  33. Demehri S, Corbin A, Loriaux M, Druker BJ, Deininger MW. Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia. Exp Hematol. 2006 Mar; 34(3):284-8. PMID: 16543062.
    Citations: 5     Fields:    Translation:AnimalsCells
  34. Willis SG, Lange T, Demehri S, Otto S, Crossman L, Niederwieser D, Stoffregen EP, McWeeney S, Kovacs I, Park B, Druker BJ, Deininger MW. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood. 2005 Sep 15; 106(6):2128-37. PMID: 15914554.
    Citations: 72     Fields:    Translation:HumansCells
  35. Corbin AS, Demehri S, Griswold IJ, Wang Y, Metcalf CA, Sundaramoorthi R, Shakespeare WC, Snodgrass J, Wardwell S, Dalgarno D, Iuliucci J, Sawyer TK, Heinrich MC, Druker BJ, Deininger MW. In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Blood. 2005 Jul 01; 106(1):227-34. PMID: 15746079.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  36. Griswold IJ, Shen LJ, La Rosée P, Demehri S, Heinrich MC, Braziel RM, McGreevey L, Haley AD, Giese N, Druker BJ, Deininger MW. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood. 2004 Nov 01; 104(9):2912-8. PMID: 15242881.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.