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Shadmehr Demehri, M.D.,Ph.D.

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The research in Demehri laboratory is focused on identifying the immune mechanisms that drive an immune recognition of early malignant cells to prevent cancer formation from pre-cancerous lesions. This approach raises a great opportunity to discover novel immune pathways that can be leveraged in cancer prevention and therapy.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA251755 (DEMEHRI, SHADMEHR) May 1, 2021 - Apr 30, 2026
    Immunity to commensal papillomaviruses for cancer therapy
    Role: Principal Investigator
  2. R01AR076013 (DEMEHRI, SHADMEHR) Jul 5, 2019 - May 31, 2024
    Immunotherapy for Skin Cancer Precursors to Prevent Skin Cancer
    Role: Principal Investigator
  3. U01CA233097 (DEMEHRI, SHADMEHR) Sep 30, 2018 - Aug 31, 2023
    Epithelium-derived alarmins role in breast cancer immunoprevention
    Role: Principal Investigator
  4. DP5OD021353 (DEMEHRI, SHADMEHR) Sep 25, 2015 - Aug 31, 2021
    Role: Principal Investigator
  5. K08AR068619 (DEMEHRI, SHADMEHR) Aug 1, 2015 - Jan 31, 2021
    The Role of Allergic Contact Dermatitis in Skin Carcinogenesis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kim J, Savory SA, Demehri S, Gill JG. Prevention of Skin Cancers With Topical Calcipotriol and Fluorouracil in Patients With Xeroderma Pigmentosum. JAMA Dermatol. 2022 Dec 21. PMID: 36542363.
    Citations:    Fields:    
  2. Boieri M, Marchese E, Pham QM, Azin M, Steidl LE, Malishkevich A, Demehri S. Thymic stromal lymphopoietin-stimulated CD4+ T cells induce senescence in advanced breast cancer. Front Cell Dev Biol. 2022; 10:1002692. PMID: 36467403; PMCID: PMC9714463.
  3. Johnson L, Ha DT, Hall MB, Shoemaker G, Bevins PA, Strickley J, Demehri S, Redman RA, Joh J. Trending Anti-E7 Serology Predicts Mortality and Recurrence of HPV-Associated Cancers of the Oropharynx. J Oncol. 2022; 2022:3107990. PMID: 36199787; PMCID: PMC9529406.
  4. Vyas M, Peigney D, Demehri S. Extracellular matrix-natural killer cell interactome: an uncharted territory in health and disease. Curr Opin Immunol. 2022 Oct; 78:102246. PMID: 36174410.
    Citations:    Fields:    Translation:HumansCells
  5. Azin M, Ameri AH, Foreman RK, Neel VA, Lorenzo ME, Demehri S. Lethal Dermal Sarcoma in Immunosuppressed Patients. Oncologist. 2022 09 02; 27(9):e759-e761. PMID: 35867136; PMCID: PMC9438906.
    Citations:    Fields:    
  6. Boieri M, Malishkevich A, Guennoun R, Marchese E, Kroon S, Trerice KE, Awad M, Park JH, Iyer S, Kreuzer J, Haas W, Rivera MN, Demehri S. CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation. J Exp Med. 2022 07 04; 219(7). PMID: 35657353; PMCID: PMC9170526.
    Citations:    Fields:    Translation:HumansCells
  7. Choi YS, Erlich TH, von Franque M, Rachmin I, Flesher JL, Schiferle EB, Zhang Y, Pereira da Silva M, Jiang A, Dobry AS, Su M, Germana S, Lacher S, Freund O, Feder E, Cortez JL, Ryu S, Babila Propp T, Samuels YL, Zakka LR, Azin M, Burd CE, Sharpless NE, Liu XS, Meyer C, Austen WG, Bojovic B, Cetrulo CL, Mihm MC, Hoon DS, Demehri S, Hawryluk EB, Fisher DE. Topical therapy for regression and melanoma prevention of congenital giant nevi. Cell. 2022 06 09; 185(12):2071-2085.e12. PMID: 35561684; PMCID: PMC9237838.
    Citations: 1     Fields:    Translation:HumansAnimals
  8. Vyas M, Demehri S. The extracellular matrix and immunity: breaking the old barrier in cancer. Trends Immunol. 2022 06; 43(6):423-425. PMID: 35527181.
    Citations:    Fields:    Translation:HumansCells
  9. Guennoun R, Hojanazarova J, Trerice KE, Azin M, McGoldrick MT, Schiferle EB, Stover MP, Demehri S. Thymic Stromal Lymphopoietin Induction Suppresses Lung Cancer Development. Cancers (Basel). 2022 Apr 27; 14(9). PMID: 35565302; PMCID: PMC9104311.
  10. Hasegawa T, Oka T, Demehri S. Alarmin Cytokines as Central Regulators of Cutaneous Immunity. Front Immunol. 2022; 13:876515. PMID: 35432341; PMCID: PMC9005840.
    Citations:    Fields:    Translation:HumansCells
  11. Cheon SY, Park JH, Ameri AH, Lee RT, Nazarian RM, Demehri S. IL-33/Regulatory T-Cell Axis Suppresses Skin Fibrosis. J Invest Dermatol. 2022 10; 142(10):2668-2676.e4. PMID: 35341735; PMCID: PMC9511765.
    Citations:    Fields:    
  12. Bunting MD, Vyas M, Requesens M, Langenbucher A, Schiferle EB, Manguso RT, Lawrence MS, Demehri S. Extracellular matrix proteins regulate NK cell function in peripheral tissues. Sci Adv. 2022 03 18; 8(11):eabk3327. PMID: 35294229; PMCID: PMC8926340.
    Citations:    Fields:    Translation:HumansCells
  13. Azin M, Demehri S. STK11 Loss: A Novel Mechanism for Melanoma Metastasis with Therapeutic Implications. J Invest Dermatol. 2022 04; 142(4):1007-1009. PMID: 35131083.
    Citations:    Fields:    Translation:HumansCells
  14. Azin M, Mahon AB, Isaacman S, Seaman JE, Allen IE, Szarek M, Cornelius LA, Demehri S. Topical Calcipotriol Plus 5-Fluorouracil Immunotherapy for Actinic Keratosis Treatment. JID Innov. 2022 May; 2(3):100104. PMID: 35310879; PMCID: PMC8927816.
  15. Chang MS, Azin M, Demehri S. Cutaneous Squamous Cell Carcinoma: The Frontier of Cancer Immunoprevention. Annu Rev Pathol. 2022 01 24; 17:101-119. PMID: 35073167.
    Citations:    Fields:    Translation:Humans
  16. Azin M, Demehri S. Innate Lymphoid Cells: New Targets for Cutaneous Squamous Cell Carcinoma Immunotherapy. J Invest Dermatol. 2021 10; 141(10):2320-2322. PMID: 34560914.
    Citations:    Fields:    Translation:HumansCells
  17. Alspach E, Chow RD, Demehri S, Guerriero JL, Gujar S, Hartmann FJ, Helmink BA, Hudson WH, Ho WJ, Ma L, Maier BB, Maltez VI, Miller BC, Moran AE, Parry EM, Pillai PS, Rafiq S, Reina-Campos M, Rosato PC, Rudqvist NP, Ruhland MK, Sagiv-Barfi I, Sahu AD, Samstein RM, Schürch CM, Sen DR, Thommen DS, Wolf Y, Zappasodi R. Supporting the Next Generation of Scientists to Lead Cancer Immunology Research. Cancer Immunol Res. 2021 11; 9(11):1245-1251. PMID: 34544686; PMCID: PMC9644410.
    Citations:    Fields:    Translation:Humans
  18. Schiferle EB, Cheon SY, Ham S, Son HG, Messerschmidt JL, Lawrence DP, Cohen JV, Flaherty KT, Moon JJ, Lian CG, Sullivan RJ, Demehri S. Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells. Sci Adv. 2021 Jun; 7(26). PMID: 34162549.
    Citations: 2     Fields:    
  19. Li K, Li T, Feng Z, Huang M, Wei L, Yan Z, Long M, Hu Q, Wang J, Liu S, Sgroi DC, Demehri S. CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer. Sci Adv. 2021 06; 7(25). PMID: 34144976; PMCID: PMC8213232.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  20. Miller MS, Allen PJ, Brown PH, Chan AT, Clapper ML, Dashwood RH, Demehri S, Disis ML, DuBois RN, Glynn RJ, Kensler TW, Khan SA, Johnson BD, Liby KT, Lipkin SM, Mallery SR, Meuillet EJ, Roden RBS, Schoen RE, Sharp ZD, Shirwan H, Siegfried JM, Rao CV, You M, Vilar E, Szabo E, Mohammed A. Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting. J Cancer Prev. 2021 Mar 30; 26(1):71-82. PMID: 33842408.
    Citations: 1     
  21. Park JH, Ameri AH, Dempsey KE, Conrad DN, Kem M, Mino-Kenudson M, Demehri S. Nuclear IL-33/SMAD signaling axis promotes cancer development in chronic inflammation. EMBO J. 2021 04 01; 40(7):e106151. PMID: 33616251; PMCID: PMC8013835.
    Citations: 4     Fields:    Translation:AnimalsCells
  22. Strickley JD, Messerschmidt JL, Jenson AB, Joh J, Demehri S. Reply to: Beta human papillomaviruses and skin cancer. Nature. 2020 12; 588(7838):E22-E23. PMID: 33328662.
    Citations: 1     Fields:    Translation:HumansCells
  23. Khanal S, Strickley JD, Ha T, Demehri S, Ghim SJ, Jenson AB, Redman RA, Joh JJ. Human papillomavirus-positivity is associated with EREG down-regulation and promoter hypermethylation in head and neck squamous cell carcinoma. Exp Mol Pathol. 2020 12; 117:104549. PMID: 33007298.
    Citations: 1     Fields:    Translation:HumansCells
  24. Annapragada A, Sikora A, Bollard C, Conejo-Garcia J, Cruz CR, Demehri S, Demetriou M, Demirdjian L, Fong L, Horowitz M, Hutson A, Kadash-Edmondson K, Kufe D, Lipkin S, Liu S, McCarthy C, Morgan M, Morris Z, Pan Y, Pasquini M, Schoenberger S, Van Allen E, Vilar E, Xing Y, Zha W, Odunsi A. Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer. J Immunother Cancer. 2020 06; 8(1). PMID: 32554617.
    Citations: 2     Fields:    Translation:Humans
  25. Herbosa CM, Hodges W, Mann C, Demehri S, Cornelius LA, Semenov YR. Risk of cancer in psoriasis: study of a nationally representative sample of the US population with comparison to a single-institution cohort. J Eur Acad Dermatol Venereol. 2020 Sep; 34(9):e529-e531. PMID: 32277504.
    Citations: 1     Fields:    Translation:Humans
  26. Messerschmidt JL, Dempsey KE, Dillon KS, Demehri S. Divergent Roles of Epithelium-Derived Alarmins in Notch Signaling-Deficient Skin. J Invest Dermatol. 2020 10; 140(10):2089-2092. PMID: 32147504; PMCID: PMC8085680.
    Citations:    Fields:    Translation:AnimalsCells
  27. Ameri AH, Foreman RK, Vedak P, Chen S, Miller DM, Demehri S. Hypertrophic Lichen Planus with Histological Features of Squamous Cell Carcinoma Associated with Immune Checkpoint Blockade Therapy. Oncologist. 2020 05; 25(5):366-368. PMID: 32073194; PMCID: PMC7216465.
    Citations:    Fields:    Translation:Humans
  28. Weintraub GS, Su KA, Demehri S, Asgari MM. Enhancing the process for care delivery in a dermatology specialty clinic. J Am Acad Dermatol. 2020 Oct; 83(4):1181-1184. PMID: 32068037.
    Citations:    Fields:    Translation:Humans
  29. Nguyen ED, Xue YK, Danesh M, Ameri A, Weng CQ, Klebanov N, Foreman RK, Nazarian RM, Demehri S, Tsao H, Kroshinsky D. A Case of Nivolumab-Induced Cutaneous Toxicity with Multiple Morphologies. Dermatopathology (Basel). 2019 Oct-Dec; 6(4):255-259. PMID: 32232031; PMCID: PMC7098352.
    Citations: 1     
  30. Hasegawa T, Feng Z, Yan Z, Ngo KH, Hosoi J, Demehri S. Reduction in Human Epidermal Langerhans Cells with Age Is Associated with Decline in CXCL14-Mediated Recruitment of CD14+ Monocytes. J Invest Dermatol. 2020 07; 140(7):1327-1334. PMID: 31881212.
    Citations: 5     Fields:    Translation:HumansCells
  31. Strickley JD, Messerschmidt JL, Awad ME, Li T, Hasegawa T, Ha DT, Nabeta HW, Bevins PA, Ngo KH, Asgari MM, Nazarian RM, Neel VA, Jenson AB, Joh J, Demehri S. Immunity to commensal papillomaviruses protects against skin cancer. Nature. 2019 11; 575(7783):519-522. PMID: 31666702; PMCID: PMC6872936.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  32. Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, Wakimoto H, Curry WT, Carter BS, Maus MV. CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity. Nat Biotechnol. 2019 09; 37(9):1049-1058. PMID: 31332324.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  33. Molina GE, Khalifian S, Mull JL, Chen L, Rosman IS, Faulkner-Jones BE, Ngo KH, Demehri S, Cornelius LA, Wu PA. Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease. JAMA Dermatol. 2019 May 01; 155(5):599-603. PMID: 30785593; PMCID: PMC6506893.
    Citations: 4     Fields:    Translation:Humans
  34. Rosenberg AR, Tabacchi M, Ngo KH, Wallendorf M, Rosman IS, Cornelius LA, Demehri S. Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. JCI Insight. 2019 03 21; 4(6). PMID: 30895944.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  35. Boroughs AC, Larson RC, Choi BD, Bouffard AA, Riley LS, Schiferle E, Kulkarni AS, Cetrulo CL, Ting D, Blazar BR, Demehri S, Maus MV. Chimeric antigen receptor costimulation domains modulate human regulatory T cell function. JCI Insight. 2019 03 14; 5. PMID: 30869654.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  36. Ameri AH, Moradi Tuchayi S, Zaalberg A, Park JH, Ngo KH, Li T, Lopez E, Colonna M, Lee RT, Mino-Kenudson M, Demehri S. IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation. Proc Natl Acad Sci U S A. 2019 02 12; 116(7):2646-2651. PMID: 30696763; PMCID: PMC6377481.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  37. Zaalberg A, Moradi Tuchayi S, Ameri AH, Ngo KH, Cunningham TJ, Eliane JP, Livneh M, Horn TD, Rosman IS, Musiek A, Anadkat MJ, Demehri S. Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus. J Invest Dermatol. 2019 01; 139(1):62-70. PMID: 30030152.
    Citations: 7     Fields:    Translation:HumansAnimals
  38. Wang W, Ollila HM, Whittemore AS, Demehri S, Ioannidis NM, Jorgenson E, Mignot E, Asgari MM. Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma. Cancer Immunol Immunother. 2018 Jul; 67(7):1123-1133. PMID: 29754218; PMCID: PMC7081741.
    Citations: 4     Fields:    Translation:Humans
  39. Kawakubo M, Cunningham TJ, Demehri S, Manstein D. Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity. Sci Rep. 2017 10 06; 7(1):12751. PMID: 28986576.
    Citations: 4     Fields:    Translation:AnimalsCells
  40. Kawakubo M, Demehri S, Manstein D. Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response. PLoS One. 2017; 12(9):e0184852. PMID: 28922374.
    Citations: 5     Fields:    Translation:AnimalsCells
  41. Yesantharao P, Wang W, Ioannidis NM, Demehri S, Whittemore AS, Asgari MM. Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system. Hum Immunol. 2017 Apr; 78(4):327-335. PMID: 28185865; PMCID: PMC5428079.
    Citations: 11     Fields:    Translation:HumansCells
  42. Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest. 2017 01 03; 127(1):106-116. PMID: 27869649; PMCID: PMC5199703.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  43. Demehri S, Cunningham TJ, Manivasagam S, Ngo KH, Moradi Tuchayi S, Reddy R, Meyers MA, DeNardo DG, Yokoyama WM. Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis. J Clin Invest. 2016 Apr 01; 126(4):1458-70. PMID: 26927668; PMCID: PMC4811115.
    Citations: 35     Fields:    Translation:AnimalsCells
  44. Demehri S, Cunningham TJ, Hurst EA, Schaffer A, Sheinbein DM, Yokoyama WM. Chronic allergic contact dermatitis promotes skin cancer. J Clin Invest. 2014 Nov; 124(11):5037-41. PMID: 25295539; PMCID: PMC4347218.
    Citations: 4     Fields:    Translation:HumansAnimals
  45. Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey JF, Zhong J, Chen ZF. Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest. 2013 Nov; 123(11):4769-80. PMID: 24216512; PMCID: PMC3809799.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  46. Yockey LJ, Demehri S, Turkoz M, Turkoz A, Ahern PP, Jassim O, Manivasagam S, Kearney JF, Gordon JI, Kopan R. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol. 2013 Dec; 133(12):2714-2721. PMID: 23698100.
    Citations: 11     Fields:    Translation:AnimalsCells
  47. Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell. 2012 Oct 16; 22(4):494-505. PMID: 23079659.
    Citations: 63     Fields:    Translation:AnimalsCells
  48. Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One. 2010 Feb 18; 5(2):e9258. PMID: 20174635.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  49. Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation. 2009 Dec; 78(5):292-300. PMID: 19683850.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  50. Demehri S, Turkoz A, Kopan R. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell. 2009 Jul 07; 16(1):55-66. PMID: 19573812.
    Citations: 138     Fields:    Translation:AnimalsCells
  51. Demehri S, Morimoto M, Holtzman MJ, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol. 2009 May 19; 7(5):e1000067. PMID: 19557146.
    Citations: 92     Fields:    Translation:Animals
  52. Demehri S, Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development. 2009 Mar; 136(6):891-6. PMID: 19211676.
    Citations: 43     Fields:    Translation:AnimalsCells
  53. Pazolli E, Luo X, Brehm S, Carbery K, Chung JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res. 2009 Feb 01; 69(3):1230-9. PMID: 19155301.
    Citations: 63     Fields:    Translation:HumansCells
  54. Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol. 2008 May 27; 6(5):e123. PMID: 18507503.
    Citations: 104     Fields:    Translation:AnimalsCells
  55. Lee J, Basak JM, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development. 2007 Aug; 134(15):2795-806. PMID: 17611229.
    Citations: 41     Fields:    Translation:AnimalsCells
  56. Demehri S, Corbin A, Loriaux M, Druker BJ, Deininger MW. Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia. Exp Hematol. 2006 Mar; 34(3):284-8. PMID: 16543062.
    Citations: 7     Fields:    Translation:AnimalsCells
  57. Willis SG, Lange T, Demehri S, Otto S, Crossman L, Niederwieser D, Stoffregen EP, McWeeney S, Kovacs I, Park B, Druker BJ, Deininger MW. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood. 2005 Sep 15; 106(6):2128-37. PMID: 15914554.
    Citations: 90     Fields:    Translation:HumansCells
  58. Corbin AS, Demehri S, Griswold IJ, Wang Y, Metcalf CA, Sundaramoorthi R, Shakespeare WC, Snodgrass J, Wardwell S, Dalgarno D, Iuliucci J, Sawyer TK, Heinrich MC, Druker BJ, Deininger MW. In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Blood. 2005 Jul 01; 106(1):227-34. PMID: 15746079.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  59. Griswold IJ, Shen LJ, La Rosée P, Demehri S, Heinrich MC, Braziel RM, McGreevey L, Haley AD, Giese N, Druker BJ, Deininger MW. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood. 2004 Nov 01; 104(9):2912-8. PMID: 15242881.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.