Harvard Catalyst Profiles

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Kathleen Michelle Leahy, M.D.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Roberts DA, Faig J, Bodio-Downey K, Shpilsky J, Leahy K, Wischhusen J, Giordano S, Acharya U, Drews R, Dougherty D, Lathan C, Rangachari D. Training Hematologists/Oncologists for the Academic-Community Hybrid: Creating a Fellowship Framework for the Future. JCO Oncol Pract. 2022 Dec 19; OP2200671. PMID: 36534931.
    Citations:    Fields:    
  2. Avraham O, Le J, Leahy K, Li T, Zhao G, Cavalli V. Analysis of neuronal injury transcriptional response identifies CTCF and YY1 as co-operating factors regulating axon regeneration. Front Mol Neurosci. 2022; 15:967472. PMID: 36081575; PMCID: PMC9446241.
    Citations:    
  3. Tahir Z, Peters J, Leahy K, Batalini F. Double-hit monomorphic B-cell lymphoma after liver transplantation. BMJ Case Rep. 2020 Jan 02; 13(1). PMID: 31900295.
    Citations:    Fields:    Translation:Humans
  4. Oh YM, Mahar M, Ewan EE, Leahy KM, Zhao G, Cavalli V. Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12417-E12426. PMID: 30530687; PMCID: PMC6310844.
    Citations: 27     Fields:    Translation:AnimalsCells
  5. Murali B, Ren Q, Luo X, Faget DV, Wang C, Johnson RM, Gruosso T, Flanagan KC, Fu Y, Leahy K, Alspach E, Su X, Ross MH, Burnette B, Weilbaecher KN, Park M, Mbalaviele G, Monahan JB, Stewart SA. Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss. Cancer Res. 2018 10 01; 78(19):5618-5630. PMID: 30093561; PMCID: PMC6168362.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  6. Ruhland MK, Loza AJ, Capietto AH, Luo X, Knolhoff BL, Flanagan KC, Belt BA, Alspach E, Leahy K, Luo J, Schaffer A, Edwards JR, Longmore G, Faccio R, DeNardo DG, Stewart SA. Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Nat Commun. 2016 06 08; 7:11762. PMID: 27272654; PMCID: PMC4899869.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  7. Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA. Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development. Cell Rep. 2016 Jan 05; 14(1):82-92. PMID: 26725121.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  8. Schleicher SM, Thotala DK, Linkous AG, Hu R, Leahy KM, Yazlovitskaya EM, Hallahan DE. Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature. PLoS One. 2011; 6(7):e22182. PMID: 21799791.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  9. Amrein PC, Attar EC, Takvorian T, Hochberg EP, Ballen KK, Leahy KM, Fisher DC, Lacasce AS, Jacobsen ED, Armand P, Hasserjian RP, Werner L, Neuberg D, Brown JR. Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia. Clin Cancer Res. 2011 May 01; 17(9):2977-86. PMID: 21402714.
    Citations: 56     Fields:    Translation:HumansCTClinical Trials
  10. Dickey A, Schleicher S, Leahy K, Hu R, Hallahan D, Thotala DK. GSK-3ß inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line. J Neurooncol. 2011 Aug; 104(1):145-53. PMID: 21161565.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  11. Gierse J, Nickols M, Leahy K, Warner J, Zhang Y, Cortes-Burgos L, Carter J, Seibert K, Masferrer J. Evaluation of COX-1/COX-2 selectivity and potency of a new class of COX-2 inhibitors. Eur J Pharmacol. 2008 Jun 24; 588(1):93-8. PMID: 18457826.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  12. Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM, Kronenberg HM, Scadden DT. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell. 2008 Mar 06; 2(3):274-83. PMID: 18371452.
    Citations: 218     Fields:    Translation:AnimalsCells
  13. Leahy KM, Ornberg RL, Wang Y, Zhu Y, Gidday JM, Connor JR, Wax MB. Quantitative ex vivo detection of rodent retinal ganglion cells by immunolabeling Brn-3b. Exp Eye Res. 2004 Jul; 79(1):131-40. PMID: 15183108.
    Citations: 12     Fields:    Translation:AnimalsCells
  14. Patel N, Sun L, Moshinsky D, Chen H, Leahy KM, Le P, Moss KG, Wang X, Rice A, Tam D, Laird AD, Yu X, Zhang Q, Tang C, McMahon G, Howlett A. A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability. J Pharmacol Exp Ther. 2003 Sep; 306(3):838-45. PMID: 12766257.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  15. Ciceri P, Zhang Y, Shaffer AF, Leahy KM, Woerner MB, Smith WG, Seibert K, Isakson PC. Pharmacology of celecoxib in rat brain after kainate administration. J Pharmacol Exp Ther. 2002 Sep; 302(3):846-52. PMID: 12183639.
    Citations: 16     Fields:    Translation:Animals
  16. Leahy KM, Ornberg RL, Wang Y, Zweifel BS, Koki AT, Masferrer JL. Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res. 2002 Feb 01; 62(3):625-31. PMID: 11830509.
    Citations: 116     Fields:    Translation:HumansAnimals
  17. Leahy KM, Koki AT, Masferrer JL. Role of cyclooxygenases in angiogenesis. Curr Med Chem. 2000 Nov; 7(11):1163-70. PMID: 11032965.
    Citations: 39     Fields:    Translation:HumansAnimals
  18. Grubbs CJ, Lubet RA, Koki AT, Leahy KM, Masferrer JL, Steele VE, Kelloff GJ, Hill DL, Seibert K. Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats. Cancer Res. 2000 Oct 15; 60(20):5599-602. PMID: 11059745.
    Citations: 62     Fields:    Translation:Animals
  19. Masferrer JL, Leahy KM, Koki AT, Zweifel BS, Settle SL, Woerner BM, Edwards DA, Flickinger AG, Moore RJ, Seibert K. Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res. 2000 Mar 01; 60(5):1306-11. PMID: 10728691.
    Citations: 284     Fields:    Translation:HumansAnimals
  20. Yang X, Ma N, Szabolcs MJ, Zhong J, Athan E, Sciacca RR, Michler RE, Anderson GD, Wiese JF, Leahy KM, Gregory S, Cannon PJ. Upregulation of COX-2 during cardiac allograft rejection. Circulation. 2000 Feb 01; 101(4):430-8. PMID: 10653836.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Isakson P. Distribution of COX-1 and COX-2 in normal and inflamed tissues. Adv Exp Med Biol. 1997; 400A:167-70. PMID: 9547553.
    Citations: 27     Fields:    Translation:AnimalsCells
  22. Seibert K, Masferrer J, Zhang Y, Gregory S, Olson G, Hauser S, Leahy K, Perkins W, Isakson P. Mediation of inflammation by cyclooxygenase-2. Agents Actions Suppl. 1995; 46:41-50. PMID: 7610990.
    Citations: 39     Fields:    Translation:HumansAnimals
  23. Seibert K, Masferrer J, Zhang Y, Leahy K, Hauser S, Gierse J, Koboldt C, Anderson G, Bremer M, Gregory S, et al. Expression and selective inhibition of constitutive and inducible forms of cyclooxygenase. Adv Prostaglandin Thromboxane Leukot Res. 1995; 23:125-7. PMID: 7794421.
    Citations: 5     Fields:    Translation:Animals
  24. Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Perkins W, Lee L, Isakson P. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12013-7. PMID: 7991575; PMCID: PMC45366.
    Citations: 258     Fields:    Translation:Animals
  25. Isakson P, Hauser S, Zhang Y, Leahy K, Masferrer J, Seibert K. Cytokine regulation of eicosanoid generation. Ann N Y Acad Sci. 1994 Nov 15; 744:181-3. PMID: 7825839.
    Citations:    Fields:    Translation:Animals
  26. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, Isakson PC, Seibert K. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3228-32. PMID: 8159730; PMCID: PMC43549.
    Citations: 213     Fields:    Translation:AnimalsCells
  27. Saper CB, Hurley KM, Moga MM, Holmes HR, Adams SA, Leahy KM, Needleman P. Brain natriuretic peptides: differential localization of a new family of neuropeptides. Neurosci Lett. 1989 Jan 02; 96(1):29-34. PMID: 2522605.
    Citations: 13     Fields:    Translation:Animals
  28. Stockmann PT, Will DH, Sides SD, Brunnert SR, Wilner GD, Leahy KM, Wiegand RC, Needleman P. Reversible induction of right ventricular atriopeptin synthesis in hypertrophy due to hypoxia. Circ Res. 1988 Jul; 63(1):207-13. PMID: 2968194.
    Citations: 7     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.