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Nathan Hutzel Raines, M.D.


Icahn School of Medicine at Mount Sinai, New York, NYMD05/2015Medicine
Mount Sinai School of Medicine, New York, NYMPH05/2013Epidemiology and Biostatistics
Dartmouth College, Hanover NHBA06/2007Ecology and Evolutionary Biology
Beth Israel Deaconess Medical Center, Boston, MA06/2018Internal Medicine Residency
Beth Israel Deaconess Medical Center, Boston, MA12/2021Nephrology Fellowship
Doris Duke Physician Scientist Fellowship Recipient
Distinction in Research
George James Epidemiology Award
Outstanding MPH Thesis
2005 - 2006
Presidential Scholar

My research is focused on exploring the pathophysiology underlying emerging novel kidney diseases, and using these physiologic understandings to develop and apply improved prevention and treatment regimens. I hold a master’s degree in public health in epidemiology and biostatistics, and more recent training in metabolomics research techniques. Much of my work to date has revolved around Chronic Kidney Disease of Nontraditional Cause (CKDnt), alternatively called Mesoamerican Nephropathy (MeN). I was principal investigator and first author for one of the early prevalence studies on CKDnT in a hotspot region in Central America, and am currently engaged in investigations into metabolic features of CKDnt supported by a Doris Duke Physician Scientist Fellowship award as well as additional research on alterations in biomarker-based kidney function equations in CKDnt populations. I am chairperson of the board of directors of La Isla Network, a nonprofit devoted to CKDnt research which is responsible for the creation and study of the first protocols designed to prevent the onset of CKDnt and has a well-established field presence in CKDnt-endemic regions, as well as a founding member current board co-chairperson for the Consortium on the Epidemic of Nephropathy in Central America and Mexico (CENCAM), the principal international society of researchers focused on the disease. More recently, I have studied what metabolic alterations arise in patients with COVID-19 and acute kidney injury (AKI), and whether interventions targeted at these metabolic derangements may mitigate the consequences of AKI. My current work focuses on use of novel metabolomic techniques to provide new insights into the pathophysiology of CKDnt.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32DK007199 (POLLAK, MARTIN R.) Jul 1, 1977 - Jun 30, 2023
    Research Training in Nephrology
    Role: Co-Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Raines NH, Inker LA, Seegmiller JC, Brooks DR, Gonzalez-Quiroz M, Friedman DJ. Estimated Versus Measured Glomerular Filtration Rate in Men at Risk for Mesoamerican Nephropathy. Am J Kidney Dis. 2022 Oct 31. PMID: 36328101.
    Citations:    Fields:    
  2. Thorsness R, Raines NH, White EM, Santostefano CM, Parikh SM, Riester MR, Feifer RA, Mor V, Zullo AR. Association of Kidney Function With 30-Day Mortality Following SARS-CoV-2 Infection in Nursing Home Residents: A Retrospective Cohort Study. Am J Kidney Dis. 2022 02; 79(2):305-307. PMID: 34656641; PMCID: PMC8516437.
    Citations: 1     Fields:    Translation:HumansCells
  3. Raines NH, Cheung MD, Wilson LS, Edberg JC, Erdmann NB, Schmaier AA, Berryhill TF, Manickas-Hill Z, Li JZ, Yu XG, Agarwal A, Barnes S, Parikh SM. Nicotinamide Adenine Dinucleotide Biosynthetic Impairment and Urinary Metabolomic Alterations Observed in Hospitalized Adults With COVID-19-Related Acute Kidney Injury. Kidney Int Rep. 2021 Dec; 6(12):3002-3013. PMID: 34541422; PMCID: PMC8439094.
    Citations: 3     
  4. Raines, N. H., S. Ganatra, P. Nissaisorakarn, A. Pandit, A. Morales, A. Asnani, M. Sadrolashrafi, R. Maheshwari, R. Patel, V. Bang, K. Shreyder, S. Brar, A. Singh, S. S. Dani, S. Knapp, A. Poyan Mehr, R. S. Brown, M. L. Zeidel, R. Bhargava, J. Schlondorff, T. I. Steinman, K. J. Mukamal and S. M. Parikh. Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study. Kidney360. 2021; 2(1):33-41. View Publication.
  5. Olsen MH, Møller M, Romano S, Andersson J, Mlodzinski E, Raines NH, Sherak R, Jeppesen AN. Association Between ICU-Acquired Hypernatremia and In-Hospital Mortality: Data From the Medical Information Mart for Intensive Care III and the Electronic ICU Collaborative Research Database. Crit Care Explor. 2020 Dec; 2(12):e0304. PMID: 33354677; PMCID: PMC7746205.
    Citations: 4     
  6. Kimura S, de la Hoz MAA, Raines NH, Celi LA. Association of Chloride Ion and Sodium-Chloride Difference With Acute Kidney Injury and Mortality in Critically Ill Patients. Crit Care Explor. 2020 Dec; 2(12):e0247. PMID: 33251513; PMCID: PMC7688253.
    Citations: 1     
  7. Raines NH, Ganatra S, Nissaisorakarn P, Pandit A, Morales A, Asnani A, Sadrolashrafi M, Maheshwari R, Patel R, Bang V, Shreyder K, Brar S, Singh A, Dani SS, Knapp S, Poyan Mehr A, Brown RS, Zeidel ML, Bhargava R, Schlondorff J, Steinman TI, Mukamal KJ, Parikh SM. Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study. Kidney360. 2021 01 28; 2(1):33-41. PMID: 35368823; PMCID: PMC8785722.
    Citations:    Translation:Humans
  8. Gubatan J, Raines N, Khosravi H, Challies TL, Berzin TM. Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa. Case Rep Gastrointest Med. 2016; 2016:4325302. PMID: 27830096; PMCID: PMC5088272.
  9. Buser MC, Ingber SZ, Raines N, Fowler DA, Scinicariello F. Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012. Int J Hyg Environ Health. 2016 May; 219(3):261-7. PMID: 26852280.
    Citations: 43     Fields:    Translation:HumansPHPublic Health
  10. Soeters HM, McNamara LA, Whaley M, Wang X, Alexander-Scott N, Kanadanian KV, Kelleher CM, MacNeil J, Martin SW, Raines N, Sears S, Vanner C, Vuong J, Bandy U, Sicard K, Patel M. Serogroup B Meningococcal Disease Outbreak and Carriage Evaluation at a College - Rhode Island, 2015. MMWR Morb Mortal Wkly Rep. 2015 Jun 12; 64(22):606-7. PMID: 26068563; PMCID: PMC4584922.
    Citations: 28     Fields:    Translation:HumansCellsPHPublic Health
  11. Raines N, González M, Wyatt C, Kurzrok M, Pool C, Lemma T, Weiss I, Marín C, Prado V, Marcas E, Mayorga K, Morales JF, Aragón A, Sheffield P. Risk factors for reduced glomerular filtration rate in a Nicaraguan community affected by Mesoamerican nephropathy. MEDICC Rev. 2014 04; 16(2):16-22. PMID: 24878645.
    Citations: 43     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.