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Nathan Hutzel Raines, M.D.

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Department
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Biography
Icahn School of Medicine at Mount Sinai, New York, NYMD05/2015Medicine
Mount Sinai School of Medicine, New York, NYMPH05/2013Epidemiology and Biostatistics
Dartmouth College, Hanover NHBA06/2007Ecology and Evolutionary Biology
Beth Israel Deaconess Medical Center, Boston, MA06/2018Internal Medicine Residency
Beth Israel Deaconess Medical Center, Boston, MANephrology Fellowship
2015
Distinction in Research
2014
George James Epidemiology Award
2013
Outstanding MPH Thesis
2005 - 2006
Presidential Scholar

Overview
My research interests revolve around exploring the pathophysiology underlying emerging novel kidney diseases, and using these physiologic understandings to develop and apply improved prevention and treatment regimens. Much of my work to date has revolved around Chronic Kidney Disease of Nontraditional Cause (CKDnT), alternatively called Mesoamerican Nephropathy (MeN). The underlying pathophysiology of CKDnT remains unknown, as do its specific causes, although emerging consensus is that it is linked at least in part to heat exposure. I have served principal investigator and first author for one of the early prevalence studies on CKDnT in a hotspot region in Central America while a medical student, and am currently engaged in investigations into variance in biomarker-based kidney function between CKDnT populations and other traditional CKD populations. I currently serve as chairman the board of directors of La Isla Network, a nonprofit devoted to CKDnT research which is responsible for the creation and study of the first intervention protocols designed to prevent the onset of CKDnT. I am a founding member and ongoing participant in the Consortium on the Epidemic of Nephropathy in Central America and Mexico (CENCAM), the principal international collaboration of researchers focused on the disease. I’m pursuing fellowship training in Nephrology to expand my specialist knowledge of renal diseases and their pathophysiology, and have already completed my MPH in epidemiology and biostatistics. My current work focuses on use of novel metabolomic techniques to provide new insights into the pathophysiology of CKDnt.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32DK007199 (POLLAK, MARTIN R.) Jul 1, 1977 - Jun 30, 2023
    NIH
    Research Training in Nephrology
    Role: Co-Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Raines NH, Cheung MD, Wilson LS, Edberg JC, Erdmann NB, Schmaier AA, Berryhill TF, Manickas-Hill Z, Li JZ, Yu XG, Agarwal A, Barnes S, Parikh SM. NAD+ biosynthetic impairment and urinary metabolomic alterations observed in hospitalized adults with COVID-19-related acute kidney injury. Kidney Int Rep. 2021 Sep 14. PMID: 34541422.
    Citations:    
  2. Raines, N. H., S. Ganatra, P. Nissaisorakarn, A. Pandit, A. Morales, A. Asnani, M. Sadrolashrafi, R. Maheshwari, R. Patel, V. Bang, K. Shreyder, S. Brar, A. Singh, S. S. Dani, S. Knapp, A. Poyan Mehr, R. S. Brown, M. L. Zeidel, R. Bhargava, J. Schlondorff, T. I. Steinman, K. J. Mukamal and S. M. Parikh. Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study. Kidney360. 2021; 2(1):33-41. View Publication.
  3. Olsen MH, Møller M, Romano S, Andersson J, Mlodzinski E, Raines NH, Sherak R, Jeppesen AN. Association Between ICU-Acquired Hypernatremia and In-Hospital Mortality: Data From the Medical Information Mart for Intensive Care III and the Electronic ICU Collaborative Research Database. Crit Care Explor. 2020 Dec; 2(12):e0304. PMID: 33354677.
    Citations: 2     
  4. Kimura S, de la Hoz MAA, Raines NH, Celi LA. Association of Chloride Ion and Sodium-Chloride Difference With Acute Kidney Injury and Mortality in Critically Ill Patients. Crit Care Explor. 2020 Dec; 2(12):e0247. PMID: 33251513.
    Citations: 1     
  5. Gubatan J, Raines N, Khosravi H, Challies TL, Berzin TM. Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa. Case Rep Gastrointest Med. 2016; 2016:4325302. PMID: 27830096.
    Citations:    
  6. Buser MC, Ingber SZ, Raines N, Fowler DA, Scinicariello F. Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012. Int J Hyg Environ Health. 2016 May; 219(3):261-7. PMID: 26852280.
    Citations: 31     Fields:    Translation:HumansPHPublic Health
  7. Soeters HM, McNamara LA, Whaley M, Wang X, Alexander-Scott N, Kanadanian KV, Kelleher CM, MacNeil J, Martin SW, Raines N, Sears S, Vanner C, Vuong J, Bandy U, Sicard K, Patel M. Serogroup B Meningococcal Disease Outbreak and Carriage Evaluation at a College - Rhode Island, 2015. MMWR Morb Mortal Wkly Rep. 2015 Jun 12; 64(22):606-7. PMID: 26068563.
    Citations: 21     Fields:    Translation:HumansCellsPHPublic Health
  8. Raines N, González M, Wyatt C, Kurzrok M, Pool C, Lemma T, Weiss I, Marín C, Prado V, Marcas E, Mayorga K, Morales JF, Aragón A, Sheffield P. Risk factors for reduced glomerular filtration rate in a Nicaraguan community affected by Mesoamerican nephropathy. MEDICC Rev. 2014 04; 16(2):16-22. PMID: 24878645.
    Citations: 34     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.