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Heng-Jia Liu, Ph.D.

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  1. (Heng-Jia Liu) Jan 14, 2021 - Jan 15, 2024
    The LAM Foundation
    Targeting the Immune Checkpoint Molecule B7-H3 in the Therapy of LAM
    Role: PI
  2. (Heng-Jia Liu) Dec 1, 2016 - Nov 30, 2018
    Tuberous Sclerosis Alliance
    T Cell Dysfunction in TSC: Mechanisms and Targeted Therapy
    Role: PI

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Srijakotre N, Liu HJ, Nobis M, Man J, Yip HYK, Papa A, Abud HE, Anderson KI, Welch HCE, Tiganis T, Timpson P, McLean CA, Ooms LM, Mitchell CA. PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28056-28067. PMID: 33097662.
    Citations:    Fields:    Translation:Animals
  2. Zarei M, Giannikou K, Du H, Liu HJ, Duarte M, Johnson S, Nassar AH, Widlund HR, Henske EP, Long HW, Kwiatkowski DJ. MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61. Oncogene. 2021 01; 40(1):112-126. PMID: 33082558.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Liu HJ, Krymskaya VP, Henske EP. Immunotherapy for Lymphangioleiomyomatosis and Tuberous Sclerosis: Progress and Future Directions. Chest. 2019 12; 156(6):1062-1067. PMID: 31437431.
    Citations: 2     Fields:    Translation:HumansAnimals
  4. Liu HJ, Lam HC, Baglini CV, Nijmeh J, Cottrill AA, Chan SY, Henske EP. Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor ß (RARß). Oncogene. 2019 12; 38(49):7367-7383. PMID: 31420607.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  5. Liu HJ, Henske EP. Vitamin D binding protein: a new biomarker of disease severity in lymphangioleiomyomatosis. Eur Respir J. 2018 11; 52(5). PMID: 30385604.
    Citations:    Fields:    Translation:Humans
  6. Ogórek B, Lam HC, Khabibullin D, Liu HJ, Nijmeh J, Triboulet R, Kwiatkowski DJ, Gregory RI, Henske EP. TSC2 regulates microRNA biogenesis via mTORC1 and GSK3ß. Hum Mol Genet. 2018 05 01; 27(9):1654-1663. PMID: 29509898.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  7. Liu HJ, Lizotte PH, Du H, Speranza MC, Lam HC, Vaughan S, Alesi N, Wong KK, Freeman GJ, Sharpe AH, Henske EP. TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy. JCI Insight. 2018 04 19; 3(8). PMID: 29669930.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, Henske EP. Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells. Oncotarget. 2017 Sep 12; 8(39):64714-64727. PMID: 29029388.
    Citations: 7     Fields:    
  9. Lam HC, Baglini CV, Lope AL, Parkhitko AA, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh J, Kavanagh T, Handen A, Chan SY, Asara JM, Oldham WM, Diaz-Meco MT, Moscat J, Sahin M, Priolo C, Henske EP. p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer Res. 2017 06 15; 77(12):3255-3267. PMID: 28512249.
    Citations: 17     Fields:    Translation:AnimalsCells
  10. Liu HJ, Ooms LM, Srijakotre N, Man J, Vieusseux J, Waters JE, Feng Y, Bailey CG, Rasko JE, Price JT, Mitchell CA. PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling. J Biol Chem. 2016 08 12; 291(33):17258-70. PMID: 27358402.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  11. Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM. The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J Biol Chem. 2015 Aug 21; 290(34):20827-20840. PMID: 26112412.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  12. Rynkiewicz NK, Liu HJ, Balamatsias D, Mitchell CA. INPP4A/INPP4B and P-Rex proteins: related but different? Adv Biol Regul. 2012 Jan; 52(1):265-79. PMID: 21925199.
    Citations: 7     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.