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Spencer Philips Hey, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hey SP, Gerlach CV, Dunlap G, Prasad V, Kesselheim AS. The evidence landscape in precision medicine. Sci Transl Med. 2020 Apr 22; 12(540). PMID: 32321867.
    Citations:    
  2. Hey SP, Weijer C, Taljaard M, Kesselheim AS. Research ethics for emerging trial designs: does equipoise need to adapt? BMJ. 2018 01 25; 360:k226. PMID: 29371211.
    Citations:    Fields:    
  3. Hey SP, London AJ, Weijer C, Rid A, Miller F. Is the concept of clinical equipoise still relevant to research? BMJ. 2017 12 28; 359:j5787. PMID: 29284666.
    Citations: 2     Fields:    Translation:Humans
  4. Hey SP. Ethical Challenges in Biomarker-Driven Drug Development. Clin Pharmacol Ther. 2018 Jan; 103(1):23-25. PMID: 28944956.
    Citations:    Fields:    Translation:Humans
  5. Hey SP, Cohen IG, Adashi EY, Kesselheim AS. Influence, integrity, and the FDA: An ethical framework. Science. 2017 Sep 01; 357(6354):876-877. PMID: 28860375.
    Citations:    Fields:    
  6. Hey SP, Franklin JM, Avorn J, Kesselheim AS. Success, Failure, and Transparency in Biomarker-Based Drug Development: A Case Study of Cholesteryl Ester Transfer Protein Inhibitors. Circ Cardiovasc Qual Outcomes. 2017 Jun; 10(6). PMID: 28611186.
    Citations:    Fields:    Translation:Humans
  7. Hey SP, Kesselheim AS. Reprioritizing Research Activity for the Post-Antibiotic Era: Ethical, Legal, and Social Considerations. Hastings Cent Rep. 2017 Mar; 47(2):16-20. PMID: 28301705.
    Citations: 1     Fields:    Translation:Humans
  8. Hey SP. Priority, prediction and the ethical research enterprise. J Med Ethics. 2017 12; 43(12):812-813. PMID: 28167632.
    Citations:    
  9. Barsanti-Innes B, Hey SP, Kimmelman J. The Challenges of Validating in Precision Medicine: The Case of Excision Repair Cross-Complement Group 1 Diagnostic Testing. Oncologist. 2017 01; 22(1):89-96. PMID: 28126916.
    Citations: 1     Fields:    Translation:HumansCells
  10. Hey SP, Kesselheim AS. The FDA, Juno Therapeutics, and the ethical imperative of transparency. BMJ. 2016 Aug 15; 354:i4435. PMID: 27526698.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  11. Hey SP, Kesselheim AS. BIOMEDICAL RESEARCH. Countering imprecision in precision medicine. Science. 2016 Jul 29; 353(6298):448-9. PMID: 27471295.
    Citations: 2     Fields:    Translation:Humans
  12. Hey SP, Kimmelman J. Do We Know Whether Researchers and Reviewers are Estimating Risk and Benefit Accurately? Bioethics. 2016 10; 30(8):609-17. PMID: 27197044.
    Citations:    Fields:    Translation:Humans
  13. Hey SP, Kesselheim AS. An Uninformative Truth: The Logic of Amarin's Off-Label Promotion. PLoS Med. 2016 Mar; 13(3):e1001978. PMID: 26978686.
    Citations:    Fields:    Translation:Humans
  14. Hey SP, Weijer C. What questions can a placebo answer? Monash Bioeth Rev. 2016 Mar; 34(1):23-36. PMID: 27188301.
    Citations:    Fields:    Translation:Humans
  15. Hey SP, Barsanti-Innes B. Epistemology, Ethics, and Progress in Precision Medicine. Perspect Biol Med. 2016; 59(3):293-310. PMID: 28479573.
    Citations:    Fields:    Translation:Humans
  16. Hey SP. What Theories Are Tested in Clinical Trials?. Philosophy of Science. 2015; 82(5):1318-1329.
  17. Hey SP, Truog RD. The Question of Clinical Equipoise and Patients' Best Interests. AMA J Ethics. 2015 Dec 01; 17(12):1108-15. PMID: 26698583.
    Citations: 5     Fields:    Translation:Humans
  18. Carlisle B, Demko N, Freeman G, Hakala A, MacKinnon N, Ramsay T, Hey S, London AJ, Kimmelman J. Benefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib. J Natl Cancer Inst. 2016 Jan; 108(1). PMID: 26547927.
    Citations: 8     Fields:    Translation:Humans
  19. Hey SP. Judging Quality and Coordination in Biomarker Diagnostic Development. THEORIA: An International Journal for Theory, History and Foundations of Science. 2015; 30(2):207-27. View Publication.
  20. Hey SP, Kimmelman J. Rejoinder. Clin Trials. 2015 Apr; 12(2):125-7. PMID: 25649107.
    Citations: 1     Fields:    Translation:Humans
  21. Hey SP, Kimmelman J. Are outcome-adaptive allocation trials ethical? Clin Trials. 2015 Apr; 12(2):102-6. PMID: 25649106.
    Citations: 14     Fields:    Translation:Humans
  22. Hey SP. Robust and Discordant Evidence: Methodological Lessons from Clinical Research. Philosophy of Science. 2015; 82(1):55-75. View Publication.
  23. Hey SP. Heuristics and Meta-heuristics in Scientific Judgment. The British Journal for the Philosophy of Science. 2014; doi:10.1093/bjps/axu045. View Publication.
  24. Hey SP. Ethics and epistemology of accurate prediction in clinical research. J Med Ethics. 2015 Jul; 41(7):559-62. PMID: 25249375.
    Citations:    Fields:    Translation:Humans
  25. Hey SP, Kimmelman J. The risk-escalation model: a principled design strategy for early-phase trials. Kennedy Inst Ethics J. 2014 Jun; 24(2):121-39. PMID: 25109092.
    Citations: 4     Fields:    Translation:Humans
  26. Kimmelman J, Hey SP. Handbook of Neuroethics, eds. J Clausen, N Levy. Clinical Translation in Central Nervous System Diseases: Ethical and Social Challenges. 2014; 1107-24. View Publication.
  27. Hey SP, Kimmelman J. The questionable use of unequal allocation in confirmatory trials. Neurology. 2014 Jan 07; 82(1):77-9. PMID: 24306005.
    Citations: 11     Fields:    Translation:HumansAnimals
  28. Hey SP, Heilig CM, Weijer C. Accumulating Evidence and Research Organization (AERO) model: a new tool for representing, analyzing, and planning a translational research program. Trials. 2013 May 30; 14:159. PMID: 23721523.
    Citations: 2     Fields:    Translation:HumansAnimals
  29. Hey SP, Kimmelman J. Ethics, error, and initial trials of efficacy. Sci Transl Med. 2013 May 08; 5(184):184fs16. PMID: 23658242.
    Citations:    Fields:    
  30. Hey SP, Weijer C. Assay sensitivity and the epistemic contexts of clinical trials. Perspect Biol Med. 2013; 56(1):1-17. PMID: 23748523.
    Citations: 4     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.