Harvard Catalyst Profiles

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Camila Miranda Lopes-Ramos, Ph.D.

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  1. K01HL166376 (Camila Lopes-Ramos) May 1, 2023 - Feb 29, 2028
    NIH/NHLBI
    Sex chromosome gene regulatory networks and COPD
    Role Description: There are significant sex differences in COPD epidemiology and clinical manifestations, however sex-based analyses of genomic data have been limited, neglecting an essential biological variable for advancing precision medicine for lung diseases. We propose integrating X chromosome multi-omic data, X chromosome inactivation patterns, and network analysis to better understand sex-biased regulation of X chromosome genes in COPD susceptibility and heterogeneity. Understanding the X chromosome genetic, epigenetic, and regulatory network features associated with COPD will provide insights into the molecular mechanisms underlying sex differences in COPD susceptibility, emphysema, and lung function, and facilitate future development of sex-aware diagnostics and therapeutics.
    Role: PI
  2. R01HG011393 (DEMEO, DAWN L) Sep 1, 2021 - Jun 30, 2025
    NIH
    Networks Tools to Understand Sex- and Gender-Specific Drivers of Disease
    Role: Co-Investigator
  3. LCD-821824 (Camila Lopes-Ramos) Jul 1, 2021 - Jun 30, 2022
    American Lung Association
    Identifying therapeutic targets through sex-specific regulatory networks in lung cancer

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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.