Camila Miranda Lopes-Ramos, Ph.D.
Title Instructor in Medicine Institution Brigham and Women's Hospital Address Brigham and Women's Hospital
75 Francis St
Boston MA 02115
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Institution
Harvard T.H. Chan School of Public Health
Research
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K01HL166376
(Camila Lopes-Ramos)
May 1, 2023 - Feb 29, 2028
Sex chromosome gene regulatory networks and COPD
Role Description: There are significant sex differences in COPD epidemiology and clinical manifestations, however sex-based analyses of genomic data have been limited, neglecting an essential biological variable for advancing precision medicine for lung diseases. We propose integrating X chromosome multi-omic data, X chromosome inactivation patterns, and network analysis to better understand sex-biased regulation of X chromosome genes in COPD susceptibility and heterogeneity. Understanding the X chromosome genetic, epigenetic, and regulatory network features associated with COPD will provide insights into the molecular mechanisms underlying sex differences in COPD susceptibility, emphysema, and lung function, and facilitate future development of sex-aware diagnostics and therapeutics.
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R01HG011393
(DEMEO, DAWN L ;QUACKENBUSH, JOHN)
Sep 1, 2021 - Jun 30, 2025
Networks Tools to Understand Sex- and Gender-Specific Drivers of Disease
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LCD-821824
(Camila Lopes-Ramos)
Jul 1, 2021 - Jun 30, 2022
American Lung Association
Identifying therapeutic targets through sex-specific regulatory networks in lung cancer
Bibliographic
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