Harvard Catalyst Profiles

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Daniel Thomas Claiborne, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K22AI150373 (CLAIBORNE, DANIEL THOMAS) Sep 1, 2021 - Aug 31, 2023
    NIH
    Overcoming the hurdles to successful CAR T cell therapy for a functional HIV cure
    Role: Principal Investigator
  2. F32AI136750 (CLAIBORNE, DANIEL THOMAS) Mar 1, 2018 - Feb 28, 2021
    NIH
    Interrogating mechanisms of HIV pathogenesis in the humanized BLT mouse model
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Garcia-Beltran WF, Claiborne DT, Maldini CR, Phelps M, Vrbanac V, Karpel ME, Krupp KL, Power KA, Boutwell CL, Balazs AB, Tager AM, Altfeld M, Allen TM. Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection. Front Immunol. 2021; 12:667393. PMID: 34122425.
    Citations: 1     Fields:    
  2. Maldini CR, Claiborne DT, Okawa K, Chen T, Dopkin DL, Shan X, Power KA, Trifonova RT, Krupp K, Phelps M, Vrbanac VD, Tanno S, Bateson T, Leslie GJ, Hoxie JA, Boutwell CL, Riley JL, Allen TM. Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo. Nat Med. 2020 11; 26(11):1776-1787. PMID: 32868878.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  3. El-Badry E, Macharia G, Claiborne D, Brooks K, Dilernia DA, Goepfert P, Kilembe W, Allen S, Gilmour J, Hunter E. Better Viral Control despite Higher CD4+ T Cell Activation during Acute HIV-1 Infection in Zambian Women Is Linked to the Sex Hormone Estradiol. J Virol. 2020 07 30; 94(16). PMID: 32461316.
    Citations:    Fields:    Translation:HumansCells
  4. Brooks K, Jones BR, Dilernia DA, Wilkins DJ, Claiborne DT, McInally S, Gilmour J, Kilembe W, Joy JB, Allen SA, Brumme ZL, Hunter E. HIV-1 variants are archived throughout infection and persist in the reservoir. PLoS Pathog. 2020 06; 16(6):e1008378. PMID: 32492044.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  5. Claiborne DT, Dudek TE, Maldini CR, Power KA, Ghebremichael M, Seung E, Mellors EF, Vrbanac VD, Krupp K, Bisesi A, Tager AM, Knipe DM, Boutwell CL, Allen TM. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. J Virol. 2019 10 15; 93(20). PMID: 31375576.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Claiborne DT, Scully EP, Palmer CD, Prince JL, Macharia GN, Kopycinski J, Michelo CM, Wiener HW, Parker R, Nganou-Makamdop K, Douek D, Altfeld M, Gilmour J, Price MA, Tang J, Kilembe W, Allen SA, Hunter E. Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis. PLoS Pathog. 2019 08; 15(8):e1007981. PMID: 31449552.
    Citations: 3     Fields:    Translation:HumansCells
  7. Ende Z, Deymier MJ, Claiborne DT, Prince JL, Mónaco DC, Kilembe W, Allen SA, Hunter E. HLA Class I Downregulation by HIV-1 Variants from Subtype C Transmission Pairs. J Virol. 2018 04 01; 92(7). PMID: 29321314.
    Citations: 5     Fields:    Translation:HumansCells
  8. Tully DC, Claiborne DT, Allen TM. Interferon-I: The Pièce de Résistance of HIV-1 Transmission? Trends Microbiol. 2017 05; 25(5):332-334. PMID: 28285909.
    Citations:    Fields:    Translation:HumansCells
  9. Sutherland KA, Collier DA, Claiborne DT, Prince JL, Deymier MJ, Goldstein RA, Hunter E, Gupta RK. Wide variation in susceptibility of transmitted/founder HIV-1 subtype C Isolates to protease inhibitors and association with in vitro replication efficiency. Sci Rep. 2016 11 30; 6:38153. PMID: 27901085.
    Citations: 7     Fields:    Translation:HumansCells
  10. Mónaco DC, Dilernia DA, Fiore-Gartland A, Yu T, Prince JL, Dennis KK, Qin K, Schaefer M, Claiborne DT, Kilembe W, Tang J, Price MA, Farmer P, Gilmour J, Bansal A, Allen S, Goepfert P, Hunter E. Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression. J Exp Med. 2016 09 19; 213(10):2049-63. PMID: 27551154.
    Citations: 19     Fields:    Translation:HumansCells
  11. Claiborne DT, Prince JL, Scully E, Macharia G, Micci L, Lawson B, Kopycinski J, Deymier MJ, Vanderford TH, Nganou-Makamdop K, Ende Z, Brooks K, Tang J, Yu T, Lakhi S, Kilembe W, Silvestri G, Douek D, Goepfert PA, Price MA, Allen SA, Paiardini M, Altfeld M, Gilmour J, Hunter E. Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):E1480-9. PMID: 25730868.
    Citations: 48     Fields:    Translation:HumansCells
  12. Yue L, Pfafferott KJ, Baalwa J, Conrod K, Dong CC, Chui C, Rong R, Claiborne DT, Prince JL, Tang J, Ribeiro RM, Cormier E, Hahn BH, Perelson AS, Shaw GM, Karita E, Gilmour J, Goepfert P, Derdeyn CA, Allen SA, Borrow P, Hunter E. Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients. PLoS Pathog. 2015 Jan; 11(1):e1004565. PMID: 25569444.
    Citations: 32     Fields:    Translation:HumansCells
  13. Deymier MJ, Claiborne DT, Ende Z, Ratner HK, Kilembe W, Allen S, Hunter E. Particle infectivity of HIV-1 full-length genome infectious molecular clones in a subtype C heterosexual transmission pair following high fidelity amplification and unbiased cloning. Virology. 2014 Nov; 468-470:454-461. PMID: 25243334.
    Citations: 10     Fields:    Translation:HumansCells
  14. Claiborne DT, Prince JL, Hunter E. A restriction enzyme based cloning method to assess the in vitro replication capacity of HIV-1 subtype C Gag-MJ4 chimeric viruses. J Vis Exp. 2014 Aug 31; (90). PMID: 25225725.
    Citations: 9     Fields:    Translation:HumansCells
  15. Carlson JM, Schaefer M, Monaco DC, Batorsky R, Claiborne DT, Prince J, Deymier MJ, Ende ZS, Klatt NR, DeZiel CE, Lin TH, Peng J, Seese AM, Shapiro R, Frater J, Ndung'u T, Tang J, Goepfert P, Gilmour J, Price MA, Kilembe W, Heckerman D, Goulder PJ, Allen TM, Allen S, Hunter E. HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck. Science. 2014 Jul 11; 345(6193):1254031. PMID: 25013080.
    Citations: 130     Fields:    Translation:HumansCells
  16. Prince JL, Claiborne DT, Carlson JM, Schaefer M, Yu T, Lahki S, Prentice HA, Yue L, Vishwanathan SA, Kilembe W, Goepfert P, Price MA, Gilmour J, Mulenga J, Farmer P, Derdeyn CA, Tang J, Heckerman D, Kaslow RA, Allen SA, Hunter E. Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis. PLoS Pathog. 2012; 8(11):e1003041. PMID: 23209412.
    Citations: 62     Fields:    Translation:HumansCellsCTClinical Trials
  17. Wright JK, Naidoo VL, Brumme ZL, Prince JL, Claiborne DT, Goulder PJ, Brockman MA, Hunter E, Ndung'u T. Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity. J Virol. 2012 Mar; 86(6):3193-9. PMID: 22238317.
    Citations: 42     Fields:    Translation:HumansCells
  18. Bhakta SJ, Shang L, Prince JL, Claiborne DT, Hunter E. Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity. Retrovirology. 2011 May 14; 8:37. PMID: 21569545.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.