Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Sangeeta Bhatia, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI132413 (SAILOR, MICHAEL J) Jul 1, 2017 - Jun 30, 2022
    Infection-homing nanosystems as antibacterial therapeutics-delivery platforms
    Role: Co-Principal Investigator
  2. R01DK085713 (RICE, CHARLES M) Sep 30, 2009 - Aug 31, 2015
    Modeling human hepatotropic infections in complex tissue organoids
    Role: Co-Principal Investigator
  3. R01EB008396 (CHEN, CHRISTOPHER S) Jun 15, 2009 - Nov 30, 2020
    Engineering Multicellular Tissue Structure, Function, and Vascularization
    Role: Co-Principal Investigator
  4. R21HL091331 (MAHADEVAN, LAKSHMINARAYANAN) Dec 1, 2007 - Nov 30, 2010
    Experimental and theoretical multiscale model of sickle cell vaso-occlusion in a
    Role: Co-Principal Investigator
  5. R01CA124427 (BHATIA, SANGEETA N.) Sep 28, 2006 - Jul 31, 2011
    Engineering Multifunctional Nanoparticles
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Werling K, Shaw WR, Itoe MA, Westervelt KA, Marcenac P, Paton DG, Peng D, Singh N, Smidler AL, South A, Deik AA, Mancio-Silva L, Demas AR, March S, Calvo E, Bhatia SN, Clish CB, Catteruccia F. Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles. Cell. 2019 04 04; 177(2):315-325.e14. PMID: 30929905; PMCID: PMC6450776.
    Citations: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  2. Mancio-Silva L, Fleming HE, Miller AB, Milstein S, Liebow A, Haslett P, Sepp-Lorenzino L, Bhatia SN. Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers. Cell Metab. 2019 03 05; 29(3):727-735.e3. PMID: 30840913; PMCID: PMC6408324.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  3. Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB. Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes. Cancer Res. 2019 04 15; 79(8):1952-1966. PMID: 30755444; PMCID: PMC6467770.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  4. Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W. Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 2019 05; 156(6):1788-1804.e13. PMID: 30641053; PMCID: PMC6532055.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  5. Buss CG, Dudani JS, Akana RTK, Fleming HE, Bhatia SN. Protease activity sensors noninvasively classify bacterial infections and antibiotic responses. EBioMedicine. 2018 Dec; 38:248-256. PMID: 30503861; PMCID: PMC6306379.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  6. Dudani JS, Ibrahim M, Kirkpatrick J, Warren AD, Bhatia SN. Classification of prostate cancer using a protease activity nanosensor library. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):8954-8959. PMID: 30126988; PMCID: PMC6130343.
    Citations: 18     Fields:    Translation:HumansAnimals
  7. Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Mol Cancer Ther. 2018 11; 17(11):2377-2388. PMID: 30097486; PMCID: PMC6298224.
    Citations: 23     Fields:    Translation:AnimalsCells
  8. Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, Lage K, Carr SA, Schenone M, Bhatia SN, Vazquez F, Tsherniak A, Hahn WC, Meyerson M. Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet. 2018 07; 50(7):937-943. PMID: 29955178; PMCID: PMC6143899.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  9. Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA. A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nat Med. 2018 05; 24(4):408-416. PMID: 29554083; PMCID: PMC5893371.
    Citations: 99     Fields:    Translation:HumansAnimals
  10. Gural N, Mancio-Silva L, Miller AB, Galstian A, Butty VL, Levine SS, Patrapuvich R, Desai SP, Mikolajczak SA, Kappe SHI, Fleming HE, March S, Sattabongkot J, Bhatia SN. In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites. Cell Host Microbe. 2018 Mar 14; 23(3):395-406.e4. PMID: 29478773; PMCID: PMC8048090.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  11. Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ. Personalized RNA Medicine for Pancreatic Cancer. Clin Cancer Res. 2018 04 01; 24(7):1734-1747. PMID: 29330203.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  12. Kato N, March S, Bhatia SN, Marti M. Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages. Methods Mol Biol. 2018; 1787:41-52. PMID: 29736708.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Michailidis E, Pabon J, Xiang K, Park P, Ramanan V, Hoffmann HH, Schneider WM, Bhatia SN, de Jong YP, Shlomai A, Rice CM. A robust cell culture system supporting the complete life cycle of hepatitis B virus. Sci Rep. 2017 11 30; 7(1):16616. PMID: 29192196.
    Citations: 30     Fields:    Translation:HumansCells
  14. Gural N, Mancio-Silva L, He J, Bhatia SN. Engineered Livers for Infectious Diseases. Cell Mol Gastroenterol Hepatol. 2018; 5(2):131-144. PMID: 29322086; PMCID: PMC5756057.
    Citations: 21     Fields:    
  15. Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Bluestone JA, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, DePinho RA, Diasio RB, Draetta G, Frazier AL, Futreal A, Gambhir SS, Ganz PA, Garraway L, Gerson S, Gupta S, Heath J, Hoffman RI, Hudis C, Hughes-Halbert C, Ibrahim R, Jadvar H, Kavanagh B, Kittles R, Le QT, Lippman SM, Mankoff D, Mardis ER, Mayer DK, McMasters K, Meropol NJ, Mitchell B, Naredi P, Ornish D, Pawlik TM, Peppercorn J, Pomper MG, Raghavan D, Ritchie C, Schwarz SW, Sullivan R, Wahl R, Wolchok JD, Wong SL, Yung A. Future cancer research priorities in the USA: a Lancet Oncology Commission. Lancet Oncol. 2017 11; 18(11):e653-e706. PMID: 29208398; PMCID: PMC6178838.
    Citations: 52     Fields:    Translation:Humans
  16. Ren Y, Sagers JE, Landegger LD, Bhatia SN, Stankovic KM. Tumor-Penetrating Delivery of siRNA against TNFa to Human Vestibular Schwannomas. Sci Rep. 2017 10 10; 7(1):12922. PMID: 29018206.
    Citations: 7     Fields:    Translation:HumansCells
  17. Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 09 15; 357(6356):1156-1160. PMID: 28912244.
    Citations: 349     Fields:    Translation:HumansAnimalsCells
  18. Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE. Depolarization signatures map gold nanorods within biological tissue. Nat Photonics. 2017; 11:583-588. PMID: 29201136; PMCID: PMC5703429.
    Citations: 15     
  19. Stevens KR, Scull MA, Ramanan V, Fortin CL, Chaturvedi RR, Knouse KA, Xiao JW, Fung C, Mirabella T, Chen AX, McCue MG, Yang MT, Fleming HE, Chung K, de Jong YP, Chen CS, Rice CM, Bhatia SN. In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Sci Transl Med. 2017 07 19; 9(399). PMID: 28724577; PMCID: PMC5896001.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  20. Kwon EJ, Skalak M, Bertucci A, Braun G, Ricci F, Ruoslahti E, Sailor MJ, Bhatia SN. Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections. Adv Mater. 2017 Sep; 29(35). PMID: 28699173; PMCID: PMC5765747.
    Citations: 21     Fields:    Translation:AnimalsCells
  21. Kwon EJ, Dudani JS, Bhatia SN. Ultrasensitive tumour-penetrating nanosensors of protease activity. Nat Biomed Eng. 2017; 1. PMID: 28970963; PMCID: PMC5621765.
    Citations: 28     Fields:    
  22. Ng S, March S, Galstian A, Gural N, Stevens KR, Mota MM, Bhatia SN. Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers. Sci Rep. 2017 03 31; 7:45424. PMID: 28361899.
    Citations: 8     Fields:    Translation:HumansAnimals
  23. Lo JH, Kwon EJ, Zhang AQ, Singhal P, Bhatia SN. Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide-siRNA Nanocomplexes. Bioconjug Chem. 2016 10 19; 27(10):2323-2331. PMID: 27583545; PMCID: PMC5410868.
    Citations: 6     Fields:    Translation:HumansAnimals
  24. Schuerle S, Dudani JS, Christiansen MG, Anikeeva P, Bhatia SN. Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling. Nano Lett. 2016 Oct 12; 16(10):6303-6310. PMID: 27622711; PMCID: PMC5344125.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  25. Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016 Oct 20; 538(7625):344-349. PMID: 27602946.
    Citations: 86     Fields:    Translation:AnimalsCells
  26. Ruivo MTG, Vera IM, Sales-Dias J, Meireles P, Gural N, Bhatia SN, Mota MM, Mancio-Silva L. Host AMPK Is a Modulator of Plasmodium Liver Infection. Cell Rep. 2016 09 06; 16(10):2539-2545. PMID: 27568570.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  27. Jain PK, Ramanan V, Schepers AG, Dalvie NS, Panda A, Fleming HE, Bhatia SN. Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors. Angew Chem Int Ed Engl. 2016 09 26; 55(40):12440-4. PMID: 27554600; PMCID: PMC5864249.
    Citations: 42     Fields:    Translation:HumansCells
  28. Shan J, Logan DJ, Root DE, Carpenter AE, Bhatia SN. High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro. J Biomol Screen. 2016 Oct; 21(9):897-911. PMID: 27650791; PMCID: PMC6352718.
    Citations: 4     Fields:    Translation:HumansCells
  29. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 07; 12(7):e1005763. PMID: 27467575; PMCID: PMC4965013.
    Citations: 112     Fields:    Translation:Humans
  30. Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT. Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. Int J Parasitol. 2016 10; 46(11):679-83. PMID: 27456552; PMCID: PMC5028309.
    Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
  31. Kwon EJ, Skalak M, Lo Bu R, Bhatia SN. Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries. ACS Nano. 2016 08 23; 10(8):7926-33. PMID: 27429164; PMCID: PMC5896006.
    Citations: 37     Fields:    Translation:AnimalsCells
  32. Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring LS, Bhatia SN, Hasty J. Synchronized cycles of bacterial lysis for in vivo delivery. Nature. 2016 08 04; 536(7614):81-85. PMID: 27437587.
    Citations: 131     Fields:    Translation:AnimalsCells
  33. Kang J, Joo J, Kwon EJ, Skalak M, Hussain S, She ZG, Ruoslahti E, Bhatia SN, Sailor MJ. Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain. Adv Mater. 2016 Sep; 28(36):7962-7969. PMID: 27383373; PMCID: PMC6274592.
    Citations: 34     Fields:    Translation:AnimalsCells
  34. Schepers A, Li C, Chhabra A, Seney BT, Bhatia S. Engineering a perfusable 3D human liver platform from iPS cells. Lab Chip. 2016 07 05; 16(14):2644-53. PMID: 27296616; PMCID: PMC5318999.
    Citations: 48     Fields:    Translation:HumansCells
  35. Mann AP, Scodeller P, Hussain S, Joo J, Kwon E, Braun GB, Mölder T, She ZG, Kotamraju VR, Ranscht B, Krajewski S, Teesalu T, Bhatia S, Sailor MJ, Ruoslahti E. A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries. Nat Commun. 2016 06 28; 7:11980. PMID: 27351915.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  36. Joo J, Kwon EJ, Kang J, Skalak M, Anglin EJ, Mann AP, Ruoslahti E, Bhatia SN, Sailor MJ. Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain. Nanoscale Horiz. 2016 Sep 01; 1(5):407-414. PMID: 29732165; PMCID: PMC5935492.
    Citations: 16     
  37. Ramanan V, Trehan K, Ong ML, Luna JM, Hoffmann HH, Espiritu C, Sheahan TP, Chandrasekar H, Schwartz RE, Christine KS, Rice CM, van Oudenaarden A, Bhatia SN. Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies. Virology. 2016 07; 494:236-47. PMID: 27128351; PMCID: PMC5366982.
    Citations: 9     Fields:    Translation:HumansCells
  38. Dudani JS, Buss CG, Akana RTK, Kwong GA, Bhatia SN. Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts. Adv Funct Mater. 2016 May 03; 26(17):2919-2928. PMID: 29706854; PMCID: PMC5914179.
    Citations: 10     
  39. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T. Voices of biotech. Nat Biotechnol. 2016 Mar; 34(3):270-5. PMID: 26963549.
    Citations: 2     Fields:    Translation:Humans
  40. Malta DFB, Reticker-Flynn NE, da Silva CL, Cabral JMS, Fleming HE, Zaret KS, Bhatia SN, Underhill GH. Extracellular matrix microarrays to study inductive signaling for endoderm specification. Acta Biomater. 2016 Apr 01; 34:30-40. PMID: 26883775; PMCID: PMC5588684.
    Citations: 9     Fields:    Translation:AnimalsCells
  41. Logan DJ, Shan J, Bhatia SN, Carpenter AE. Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification. Methods. 2016 Mar 01; 96:6-11. PMID: 26687239.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  42. Kwon EJ, Lo JH, Bhatia SN. Smart nanosystems: Bio-inspired technologies that interact with the host environment. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14460-6. PMID: 26598694; PMCID: PMC4664363.
    Citations: 17     Fields:    Translation:HumansCells
  43. March S, Ramanan V, Trehan K, Ng S, Galstian A, Gural N, Scull MA, Shlomai A, Mota MM, Fleming HE, Khetani SR, Rice CM, Bhatia SN. Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens. Nat Protoc. 2015 Dec; 10(12):2027-53. PMID: 26584444; PMCID: PMC5867906.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  44. Dudani JS, Jain PK, Kwong GA, Stevens KR, Bhatia SN. Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity. ACS Nano. 2015 Dec 22; 9(12):11708-17. PMID: 26565752.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  45. Kwong GA, Dudani JS, Carrodeguas E, Mazumdar EV, Zekavat SM, Bhatia SN. Mathematical framework for activity-based cancer biomarkers. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12627-32. PMID: 26417077; PMCID: PMC4611621.
    Citations: 25     Fields:    Translation:HumansAnimals
  46. Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med. 2015 Jul 15; 7(296):296ra111. PMID: 26180101.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  47. Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN. Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors. Cancer Res. 2015 Aug 15; 75(16):3255-67. PMID: 26122846; PMCID: PMC4833008.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  48. Ramanan V, Shlomai A, Cox DB, Schwartz RE, Michailidis E, Bhatta A, Scott DA, Zhang F, Rice CM, Bhatia SN. CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus. Sci Rep. 2015 Jun 02; 5:10833. PMID: 26035283.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  49. Danino T, Prindle A, Kwong GA, Skalak M, Li H, Allen K, Hasty J, Bhatia SN. Programmable probiotics for detection of cancer in urine. Sci Transl Med. 2015 May 27; 7(289):289ra84. PMID: 26019220.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  50. Stevens KR, Miller JS, Blakely BL, Chen CS, Bhatia SN. Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering. J Biomed Mater Res A. 2015 Oct; 103(10):3331-8. PMID: 25851120.
    Citations: 11     Fields:    Translation:AnimalsCells
  51. Chaturvedi RR, Stevens KR, Solorzano RD, Schwartz RE, Eyckmans J, Baranski JD, Stapleton SC, Bhatia SN, Chen CS. Patterning vascular networks in vivo for tissue engineering applications. Tissue Eng Part C Methods. 2015 May; 21(5):509-17. PMID: 25390971.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  52. Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, Bhatia SN. Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro. Stem Cell Reports. 2015 Mar 10; 4(3):348-59. PMID: 25660406.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  53. Itoe MA, Sampaio JL, Cabal GG, Real E, Zuzarte-Luis V, March S, Bhatia SN, Frischknecht F, Thiele C, Shevchenko A, Mota MM. Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection. Cell Host Microbe. 2014 Dec 10; 16(6):778-86. PMID: 25498345; PMCID: PMC4271766.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  54. Reticker-Flynn NE, Bhatia SN. Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche. Cancer Discov. 2015 Feb; 5(2):168-81. PMID: 25421439; PMCID: PMC4367955.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  55. Hanson KK, March S, Ng S, Bhatia SN, Mota MM. In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection. Eukaryot Cell. 2015 Jan; 14(1):96-103. PMID: 25416236; PMCID: PMC4279013.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  56. Ramanan V, Scull MA, Sheahan TP, Rice CM, Bhatia SN. New Methods in Tissue Engineering: Improved Models for Viral Infection. Annu Rev Virol. 2014 Nov; 1:475-499. PMID: 25893203.
    Citations: 11     Fields:    
  57. Warren AD, Gaylord ST, Ngan KC, Dumont Milutinovic M, Kwong GA, Bhatia SN, Walt DR. Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers. J Am Chem Soc. 2014 Oct 01; 136(39):13709-14. PMID: 25198059.
    Citations: 20     Fields:    Translation:Animals
  58. Lin KY, Kwon EJ, Lo JH, Bhatia SN. Drug-induced amplification of nanoparticle targeting to tumors. Nano Today. 2014 Oct; 9(5):550-559. PMID: 29731806; PMCID: PMC5935498.
    Citations: 8     
  59. Ghosh D, Bagley AF, Na YJ, Birrer MJ, Bhatia SN, Belcher AM. Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13948-53. PMID: 25214538.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  60. Lin KY, Lo JH, Consul N, Kwong GA, Bhatia SN. Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade. ACS Nano. 2014 Sep 23; 8(9):8776-85. PMID: 25119520.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  61. Shlomai A, Schwartz RE, Ramanan V, Bhatta A, de Jong YP, Bhatia SN, Rice CM. Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):12193-8. PMID: 25092305.
    Citations: 124     Fields:    Translation:HumansCells
  62. Bhatia SN, Ingber DE. Microfluidic organs-on-chips. Nat Biotechnol. 2014 Aug; 32(8):760-72. PMID: 25093883.
    Citations: 826     Fields:    Translation:HumansCells
  63. Hauert S, Bhatia SN. Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology. Trends Biotechnol. 2014 Sep; 32(9):448-55. PMID: 25086728; PMCID: PMC4295824.
    Citations: 11     Fields:    Translation:Humans
  64. Bhatia SN, Underhill GH, Zaret KS, Fox IJ. Cell and tissue engineering for liver disease. Sci Transl Med. 2014 Jul 16; 6(245):245sr2. PMID: 25031271; PMCID: PMC4374645.
    Citations: 95     Fields:    Translation:HumansAnimals
  65. Li CY, Stevens KR, Schwartz RE, Alejandro BS, Huang JH, Bhatia SN. Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue Eng Part A. 2014 Aug; 20(15-16):2200-12. PMID: 24498910.
    Citations: 42     Fields:    Translation:AnimalsCells
  66. Hui EE, Li C, Agrawal A, Bhatia SN. A Macro-to-Micro Interface for the Control of Cellular Organization. J Microelectromech Syst. 2014 Apr; 23(2):391-397. PMID: 26167106.
  67. Warren AD, Kwong GA, Wood DK, Lin KY, Bhatia SN. Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3671-6. PMID: 24567404.
    Citations: 60     Fields:    Translation:HumansAnimals
  68. Schwartz RE, Fleming HE, Khetani SR, Bhatia SN. Pluripotent stem cell-derived hepatocyte-like cells. Biotechnol Adv. 2014 Mar-Apr; 32(2):504-13. PMID: 24440487; PMCID: PMC4043206.
    Citations: 103     Fields:    Translation:HumansCells
  69. Olcum S, Cermak N, Wasserman SC, Christine KS, Atsumi H, Payer KR, Shen W, Lee J, Belcher AM, Bhatia SN, Manalis SR. Weighing nanoparticles in solution at the attogram scale. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1310-5. PMID: 24474753.
    Citations: 24     Fields:    Translation:Cells
  70. Vunjak-Novakovic G, Bhatia S, Chen C, Hirschi K. HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Res Ther. 2013; 4 Suppl 1:S8. PMID: 24565063.
    Citations: 35     Fields:    Translation:HumansCells
  71. Hauert S, Berman S, Nagpal R, Bhatia SN. A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors. Nano Today. 2013 Dec 01; 8(6):566-576. PMID: 25009578; PMCID: PMC4084751.
    Citations: 14     
  72. Ng S, March S, Galstian A, Hanson K, Carvalho T, Mota MM, Bhatia SN. Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro. Dis Model Mech. 2014 Feb; 7(2):215-24. PMID: 24291761.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  73. Wong IY, Bhatia SN, Toner M. Nanotechnology: emerging tools for biology and medicine. Genes Dev. 2013 Nov 15; 27(22):2397-408. PMID: 24240230.
    Citations: 26     Fields:    Translation:Humans
  74. Lin KY, Kwong GA, Warren AD, Wood DK, Bhatia SN. Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis. ACS Nano. 2013 Oct 22; 7(10):9001-9. PMID: 24015809.
    Citations: 39     Fields:    Translation:Animals
  75. Bagley AF, Hill S, Rogers GS, Bhatia SN. Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source. ACS Nano. 2013 Sep 24; 7(9):8089-97. PMID: 23961973.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  76. March S, Ng S, Velmurugan S, Galstian A, Shan J, Logan DJ, Carpenter AE, Thomas D, Sim BK, Mota MM, Hoffman SL, Bhatia SN. A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell Host Microbe. 2013 Jul 17; 14(1):104-15. PMID: 23870318; PMCID: PMC3780791.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  77. Danino T, Prindle A, Hasty J, Bhatia S. Measuring growth and gene expression dynamics of tumor-targeted S. typhimurium bacteria. J Vis Exp. 2013 Jul 06; (77):e50540. PMID: 23851642.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  78. Lo JH, von Maltzahn G, Douglass J, Park JH, Sailor MJ, Ruoslahti E, Bhatia SN. Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites. J Mater Chem B. 2013 Oct 21; 1(39):5235-5240. PMID: 24177171; PMCID: PMC3809612.
    Citations: 3     Fields:    
  79. Shan J, Schwartz RE, Ross NT, Logan DJ, Thomas D, Duncan SA, North TE, Goessling W, Carpenter AE, Bhatia SN. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug; 9(8):514-20. PMID: 23728495; PMCID: PMC3720805.
    Citations: 115     Fields:    Translation:HumansCells
  80. Desai SP, Bhatia SN, Toner M, Irimia D. Mitochondrial localization and the persistent migration of epithelial cancer cells. Biophys J. 2013 May 07; 104(9):2077-88. PMID: 23663851.
    Citations: 99     Fields:    Translation:HumansCells
  81. Baranski JD, Chaturvedi RR, Stevens KR, Eyckmans J, Carvalho B, Solorzano RD, Yang MT, Miller JS, Bhatia SN, Chen CS. Geometric control of vascular networks to enhance engineered tissue integration and function. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7586-91. PMID: 23610423; PMCID: PMC3651499.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  82. Li CY, Wood DK, Huang JH, Bhatia SN. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab Chip. 2013 May 21; 13(10):1969-78. PMID: 23563587; PMCID: PMC3812960.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  83. Stevens KR, Ungrin MD, Schwartz RE, Ng S, Carvalho B, Christine KS, Chaturvedi RR, Li CY, Zandstra PW, Chen CS, Bhatia SN. InVERT molding for scalable control of tissue microarchitecture. Nat Commun. 2013; 4:1847. PMID: 23673632; PMCID: PMC3660041.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  84. Kwong GA, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos IA, Sverdlov DY, Liu SB, Warren AD, Popov Y, Schuppan D, Bhatia SN. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat Biotechnol. 2013 Jan; 31(1):63-70. PMID: 23242163.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  85. Prestwich GD, Bhatia S, Breuer CK, Dahl SL, Mason C, McFarland R, McQuillan DJ, Sackner-Bernstein J, Schox J, Tente WE, Trounson A. What is the greatest regulatory challenge in the translation of biomaterials to the clinic? Sci Transl Med. 2012 Nov 14; 4(160):160cm14. PMID: 23152323.
    Citations: 13     Fields:    Translation:HumansAnimals
  86. El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, Csizmadia E, Mariani O, Zhu C, Campagne A, Toner M, Bhatia SN, Irimia D, Vincent-Salomon A, Karnoub AE. Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17460-5. PMID: 23033492.
    Citations: 100     Fields:    Translation:HumansCells
  87. Danino T, Lo J, Prindle A, Hasty J, Bhatia SN. In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria. ACS Synth Biol. 2012 Oct 19; 1(10):465-470. PMID: 23097750.
    Citations: 21     Fields:    
  88. Ren Y, Hauert S, Lo JH, Bhatia SN. Identification and characterization of receptor-specific peptides for siRNA delivery. ACS Nano. 2012 Oct 23; 6(10):8620-31. PMID: 22909216.
    Citations: 28     Fields:    Translation:HumansCells
  89. Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, Bhatia SN, Beroukhim R, Hahn WC. Cancer vulnerabilities unveiled by genomic loss. Cell. 2012 Aug 17; 150(4):842-54. PMID: 22901813.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  90. Ren Y, Cheung HW, von Maltzhan G, Agrawal A, Cowley GS, Weir BA, Boehm JS, Tamayo P, Karst AM, Liu JF, Hirsch MS, Mesirov JP, Drapkin R, Root DE, Lo J, Fogal V, Ruoslahti E, Hahn WC, Bhatia SN. Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci Transl Med. 2012 Aug 15; 4(147):147ra112. PMID: 22896676; PMCID: PMC3633234.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  91. Bhatia S, Frangioni JV, Hoffman RM, Iafrate AJ, Polyak K. The challenges posed by cancer heterogeneity. Nat Biotechnol. 2012 Jul 10; 30(7):604-10. PMID: 22781679.
    Citations: 36     Fields:    Translation:HumansCells
  92. Miller JS, Stevens KR, Yang MT, Baker BM, Nguyen DH, Cohen DM, Toro E, Chen AA, Galie PA, Yu X, Chaturvedi R, Bhatia SN, Chen CS. Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nat Mater. 2012 Sep; 11(9):768-74. PMID: 22751181.
    Citations: 538     Fields:    Translation:HumansAnimalsCells
  93. Wood DK, Soriano A, Mahadevan L, Higgins JM, Bhatia SN. A biophysical indicator of vaso-occlusive risk in sickle cell disease. Sci Transl Med. 2012 Feb 29; 4(123):123ra26. PMID: 22378926; PMCID: PMC3633235.
    Citations: 51     Fields:    Translation:Humans
  94. Schwartz RE, Trehan K, Andrus L, Sheahan TP, Ploss A, Duncan SA, Rice CM, Bhatia SN. Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2544-8. PMID: 22308485.
    Citations: 107     Fields:    Translation:HumansCells
  95. Reticker-Flynn NE, Malta DF, Winslow MM, Lamar JM, Xu MJ, Underhill GH, Hynes RO, Jacks TE, Bhatia SN. A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nat Commun. 2012; 3:1122. PMID: 23047680; PMCID: PMC3794716.
    Citations: 86     Fields:    Translation:AnimalsCells
  96. Underhill GH, Galie P, Chen CS, Bhatia SN. Bioengineering methods for analysis of cells in vitro. Annu Rev Cell Dev Biol. 2012; 28:385-410. PMID: 23057744.
    Citations: 13     Fields:    Translation:Humans
  97. Andrus L, Marukian S, Jones CT, Catanese MT, Sheahan TP, Schoggins JW, Barry WT, Dustin LB, Trehan K, Ploss A, Bhatia SN, Rice CM. Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells. Hepatology. 2011 Dec; 54(6):1901-12. PMID: 22144107.
    Citations: 49     Fields:    Translation:HumansCells
  98. Singh N, Karambelkar A, Gu L, Lin K, Miller JS, Chen CS, Sailor MJ, Bhatia SN. Bioresponsive mesoporous silica nanoparticles for triggered drug release. J Am Chem Soc. 2011 Dec 14; 133(49):19582-5. PMID: 21981330.
    Citations: 59     Fields:    Translation:HumansCells
  99. Li CY, Wood DK, Hsu CM, Bhatia SN. DNA-templated assembly of droplet-derived PEG microtissues. Lab Chip. 2011 Sep 07; 11(17):2967-75. PMID: 21776518; PMCID: PMC3399244.
    Citations: 20     Fields:    Translation:AnimalsCells
  100. Chen AA, Thomas DK, Ong LL, Schwartz RE, Golub TR, Bhatia SN. Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11842-7. PMID: 21746904.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  101. Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, Gopal S, Tamayo P, Gould J, Tsherniak A, Stransky N, Luo B, Ren Y, Drapkin R, Bhatia SN, Mesirov JP, Garraway LA, Meyerson M, Lander ES, Root DE, Hahn WC. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12372-7. PMID: 21746896.
    Citations: 245     Fields:    Translation:HumansCells
  102. von Maltzahn G, Park JH, Lin KY, Singh N, Schwöppe C, Mesters R, Berdel WE, Ruoslahti E, Sailor MJ, Bhatia SN. Nanoparticles that communicate in vivo to amplify tumour targeting. Nat Mater. 2011 Jun 19; 10(7):545-52. PMID: 21685903; PMCID: PMC3361766.
    Citations: 133     Fields:    Translation:HumansAnimalsCells
  103. Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA. Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):745-50. PMID: 21187397.
    Citations: 34     Fields:    Translation:HumansAnimals
  104. Poon Z, Chen S, Engler AC, Lee HI, Atas E, von Maltzahn G, Bhatia SN, Hammond PT. Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting. Angew Chem Int Ed Engl. 2010 Sep 24; 49(40):7266-70. PMID: 20740515.
    Citations: 33     Fields:    Translation:HumansCells
  105. Chen AA, Underhill GH, Bhatia SN. Multiplexed, high-throughput analysis of 3D microtissue suspensions. Integr Biol (Camb). 2010 Oct; 2(10):517-27. PMID: 20820630; PMCID: PMC4124885.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  106. Singh N, Agrawal A, Leung AK, Sharp PA, Bhatia SN. Effect of nanoparticle conjugation on gene silencing by RNA interference. J Am Chem Soc. 2010 Jun 23; 132(24):8241-3. PMID: 20518524.
    Citations: 32     Fields:    Translation:HumansCells
  107. Wood DK, Weingeist DM, Bhatia SN, Engelward BP. Single cell trapping and DNA damage analysis using microwell arrays. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10008-13. PMID: 20534572.
    Citations: 86     Fields:    Translation:HumansCells
  108. Albrecht DR, Underhill GH, Resnikoff J, Mendelson A, Bhatia SN, Shah JV. Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integr Biol (Camb). 2010 Jun; 2(5-6):278-87. PMID: 20532320.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  109. Ruoslahti E, Bhatia SN, Sailor MJ. Targeting of drugs and nanoparticles to tumors. J Cell Biol. 2010 Mar 22; 188(6):759-68. PMID: 20231381; PMCID: PMC2845077.
    Citations: 275     Fields:    Translation:HumansAnimals
  110. Park JH, von Maltzahn G, Ong LL, Centrone A, Hatton TA, Ruoslahti E, Bhatia SN, Sailor MJ. Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery. Adv Mater. 2010 Feb 23; 22(8):880-5. PMID: 20217810; PMCID: PMC3057607.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  111. Ploss A, Khetani SR, Jones CT, Syder AJ, Trehan K, Gaysinskaya VA, Mu K, Ritola K, Rice CM, Bhatia SN. Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3141-5. PMID: 20133632.
    Citations: 98     Fields:    Translation:HumansCells
  112. Jones CT, Catanese MT, Law LM, Khetani SR, Syder AJ, Ploss A, Oh TS, Schoggins JW, MacDonald MR, Bhatia SN, Rice CM. Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nat Biotechnol. 2010 Feb; 28(2):167-71. PMID: 20118917; PMCID: PMC2828266.
    Citations: 132     Fields:    Translation:Cells
  113. Park JH, von Maltzahn G, Xu MJ, Fogal V, Kotamraju VR, Ruoslahti E, Bhatia SN, Sailor MJ. Cooperative nanomaterial system to sensitize, target, and treat tumors. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):981-6. PMID: 20080556.
    Citations: 89     Fields:    Translation:HumansCells
  114. Aptekar JW, Cassidy MC, Johnson AC, Barton RA, Lee M, Ogier AC, Vo C, Anahtar MN, Ren Y, Bhatia SN, Ramanathan C, Cory DG, Hill AL, Mair RW, Rosen MS, Walsworth RL, Marcus CM. Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. ACS Nano. 2009 Dec 22; 3(12):4003-8. PMID: 19950973; PMCID: PMC4083556.
    Citations: 14     Fields:    Translation:Cells
  115. Harris TJ, Green JJ, Fung PW, Langer R, Anderson DG, Bhatia SN. Tissue-specific gene delivery via nanoparticle coating. Biomaterials. 2010 Feb; 31(5):998-1006. PMID: 19850333.
    Citations: 35     Fields:    Translation:Animals
  116. Agrawal A, Min DH, Singh N, Zhu H, Birjiniuk A, von Maltzahn G, Harris TJ, Xing D, Woolfenden SD, Sharp PA, Charest A, Bhatia S. Functional delivery of siRNA in mice using dendriworms. ACS Nano. 2009 Sep 22; 3(9):2495-504. PMID: 19673534.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  117. March S, Hui EE, Underhill GH, Khetani S, Bhatia SN. Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology. 2009 Sep; 50(3):920-8. PMID: 19585615.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  118. Simberg D, Park JH, Karmali PP, Zhang WM, Merkulov S, McCrae K, Bhatia SN, Sailor M, Ruoslahti E. Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. Biomaterials. 2009 Aug; 30(23-24):3926-33. PMID: 19394687.
    Citations: 41     Fields:    Translation:AnimalsCells
  119. von Maltzahn G, Centrone A, Park JH, Ramanathan R, Sailor MJ, Hatton TA, Bhatia SN. SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating. Adv Mater. 2009 Apr 20; 21(31):3175-3180. PMID: 20174478.
    Citations: 73     Fields:    
  120. von Maltzahn G, Park JH, Agrawal A, Bandaru NK, Das SK, Sailor MJ, Bhatia SN. Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res. 2009 May 01; 69(9):3892-900. PMID: 19366797.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  121. Park JH, von Maltzahn G, Zhang L, Derfus AM, Simberg D, Harris TJ, Ruoslahti E, Bhatia SN, Sailor MJ. Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting. Small. 2009 Mar; 5(6):694-700. PMID: 19263431.
    Citations: 94     Fields:    Translation:HumansCells
  122. Park JH, Gu L, von Maltzahn G, Ruoslahti E, Bhatia SN, Sailor MJ. Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mater. 2009 Apr; 8(4):331-6. PMID: 19234444; PMCID: PMC3058936.
    Citations: 295     Fields:    Translation:HumansAnimalsCells
  123. Higgins JM, Eddington DT, Bhatia SN, Mahadevan L. Statistical dynamics of flowing red blood cells by morphological image processing. PLoS Comput Biol. 2009 Feb; 5(2):e1000288. PMID: 19214200.
    Citations: 20     Fields:    Translation:HumansCells
  124. Chen AA, Khetani SR, Lee S, Bhatia SN, Van Vliet KJ. Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers. Biomaterials. 2009 Feb; 30(6):1113-20. PMID: 19046762.
    Citations: 24     Fields:    Translation:AnimalsCells
  125. Alvarez SD, Derfus AM, Schwartz MP, Bhatia SN, Sailor MJ. The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors. Biomaterials. 2009 Jan; 30(1):26-34. PMID: 18845334.
    Citations: 15     Fields:    Translation:AnimalsCells
  126. Harris TJ, von Maltzahn G, Lord ME, Park JH, Agrawal A, Min DH, Sailor MJ, Bhatia SN. Protease-triggered unveiling of bioactive nanoparticles. Small. 2008 Sep; 4(9):1307-12. PMID: 18690639.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  127. Khetani SR, Chen AA, Ranscht B, Bhatia SN. T-cadherin modulates hepatocyte functions in vitro. FASEB J. 2008 Nov; 22(11):3768-75. PMID: 18635739.
    Citations: 24     Fields:    Translation:AnimalsCells
  128. von Maltzahn G, Ren Y, Park JH, Min DH, Kotamraju VR, Jayakumar J, Fogal V, Sailor MJ, Ruoslahti E, Bhatia SN. In vivo tumor cell targeting with "click" nanoparticles. Bioconjug Chem. 2008 Aug; 19(8):1570-8. PMID: 18611045; PMCID: PMC2538627.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  129. Higgins JM, Eddington DT, Bhatia SN, Mahadevan L. Review of an in vitro microfluidic model of sickle cell vaso-occlusion. Transfus Clin Biol. 2008 Feb-Mar; 15(1-2):12-3. PMID: 18495515.
    Citations:    Fields:    Translation:Humans
  130. Park JH, von Maltzahn G, Zhang L, Schwartz MP, Ruoslahti E, Bhatia SN, Sailor MJ. Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging. Adv Mater. 2008 May 05; 20(9):1630-1635. PMID: 21687830.
    Citations: 131     Fields:    
  131. Park JH, von Maltzahn G, Ruoslahti E, Bhatia SN, Sailor MJ. Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery. Angew Chem Int Ed Engl. 2008; 47(38):7284-8. PMID: 18696519.
    Citations: 58     Fields:    Translation:HumansCells
  132. Higgins JM, Eddington DT, Bhatia SN, Mahadevan L. Sickle cell vasoocclusion and rescue in a microfluidic device. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20496-500. PMID: 18077341.
    Citations: 66     Fields:    Translation:Humans
  133. Khetani SR, Bhatia SN. Microscale culture of human liver cells for drug development. Nat Biotechnol. 2008 Jan; 26(1):120-6. PMID: 18026090.
    Citations: 366     Fields:    Translation:HumansCells
  134. Evans AR, Euteneuer S, Chavez E, Mullen LM, Hui EE, Bhatia SN, Ryan AF. Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. Dev Neurobiol. 2007 Nov; 67(13):1721-30. PMID: 17600813.
    Citations: 30     Fields:    Translation:AnimalsCells
  135. Hui EE, Bhatia SN. Silicon microchips for manipulating cell-cell interaction. J Vis Exp. 2007; (7):268. PMID: 18989439.
    Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  136. Underhill GH, Bhatia SN. High-throughput analysis of signals regulating stem cell fate and function. Curr Opin Chem Biol. 2007 Aug; 11(4):357-66. PMID: 17656147.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  137. Derfus AM, Chen AA, Min DH, Ruoslahti E, Bhatia SN. Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem. 2007 Sep-Oct; 18(5):1391-6. PMID: 17630789.
    Citations: 104     Fields:    Translation:HumansCells
  138. von Maltzahn G, Harris TJ, Park JH, Min DH, Schmidt AJ, Sailor MJ, Bhatia SN. Nanoparticle self-assembly gated by logical proteolytic triggers. J Am Chem Soc. 2007 May 16; 129(19):6064-5. PMID: 17447766; PMCID: PMC2759670.
    Citations: 28     Fields:    
  139. Albrecht DR, Underhill GH, Mendelson A, Bhatia SN. Multiphase electropatterning of cells and biomaterials. Lab Chip. 2007 Jun; 7(6):702-9. PMID: 17538711.
    Citations: 22     Fields:    Translation:AnimalsCells
  140. Hui EE, Bhatia SN. Micromechanical control of cell-cell interactions. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5722-6. PMID: 17389399; PMCID: PMC1851558.
    Citations: 126     Fields:    Translation:AnimalsCells
  141. Hui EE, Bhatia SN. Microscale control of cell contact and spacing via three-component surface patterning. Langmuir. 2007 Apr 10; 23(8):4103-7. PMID: 17243746.
    Citations: 18     Fields:    Translation:AnimalsCells
  142. Simberg D, Duza T, Park JH, Essler M, Pilch J, Zhang L, Derfus AM, Yang M, Hoffman RM, Bhatia S, Sailor MJ, Ruoslahti E. Biomimetic amplification of nanoparticle homing to tumors. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):932-6. PMID: 17215365; PMCID: PMC1783417.
    Citations: 152     Fields:    Translation:AnimalsCells
  143. Liu Tsang V, Chen AA, Cho LM, Jadin KD, Sah RL, DeLong S, West JL, Bhatia SN. Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J. 2007 Mar; 21(3):790-801. PMID: 17197384.
    Citations: 130     Fields:    Translation:AnimalsCells
  144. Allen JW, Khetani SR, Johnson RS, Bhatia SN. In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression. Tissue Eng. 2006 Nov; 12(11):3135-47. PMID: 17518628.
    Citations: 5     Fields:    Translation:AnimalsCells
  145. Underhill GH, Chen AA, Albrecht DR, Bhatia SN. Assessment of hepatocellular function within PEG hydrogels. Biomaterials. 2007 Jan; 28(2):256-70. PMID: 16979755.
    Citations: 41     Fields:    Translation:AnimalsCells
  146. Khetani SR, Bhatia SN. Engineering tissues for in vitro applications. Curr Opin Biotechnol. 2006 Oct; 17(5):524-31. PMID: 16978857.
    Citations: 26     Fields:    Translation:HumansAnimals
  147. Schwartz MP, Derfus AM, Alvarez SD, Bhatia SN, Sailor MJ. The smart Petri dish: a nanostructured photonic crystal for real-time monitoring of living cells. Langmuir. 2006 Aug 01; 22(16):7084-90. PMID: 16863264.
    Citations: 16     Fields:    Translation:AnimalsCells
  148. Park JH, Derfus AM, Segal E, Vecchio KS, Bhatia SN, Sailor MJ. Local heating of discrete droplets using magnetic porous silicon-based photonic crystals. J Am Chem Soc. 2006 Jun 21; 128(24):7938-46. PMID: 16771508; PMCID: PMC3505692.
    Citations: 8     Fields:    Translation:Cells
  149. Harris TJ, von Maltzahn G, Derfus AM, Ruoslahti E, Bhatia SN. Proteolytic actuation of nanoparticle self-assembly. Angew Chem Int Ed Engl. 2006 May 05; 45(19):3161-5. PMID: 16642514.
    Citations: 32     Fields:    Translation:HumansCells
  150. Albrecht DR, Underhill GH, Wassermann TB, Sah RL, Bhatia SN. Probing the role of multicellular organization in three-dimensional microenvironments. Nat Methods. 2006 May; 3(5):369-75. PMID: 16628207.
    Citations: 150     Fields:    Translation:AnimalsCells
  151. Chen AA, Derfus AM, Khetani SR, Bhatia SN. Quantum dots to monitor RNAi delivery and improve gene silencing. Nucleic Acids Res. 2005 Dec 13; 33(22):e190. PMID: 16352864; PMCID: PMC1312364.
    Citations: 42     Fields:    Translation:Animals
  152. Flaim CJ, Chien S, Bhatia SN. An extracellular matrix microarray for probing cellular differentiation. Nat Methods. 2005 Feb; 2(2):119-25. PMID: 15782209.
    Citations: 253     Fields:    Translation:AnimalsCells
  153. Allen JW, Johnson RS, Bhatia SN. Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha. Toxicol Lett. 2005 Jan 15; 155(1):151-9. PMID: 15585370.
    Citations: 12     Fields:    Translation:AnimalsCells
  154. Allen JW, Khetani SR, Bhatia SN. In vitro zonation and toxicity in a hepatocyte bioreactor. Toxicol Sci. 2005 Mar; 84(1):110-9. PMID: 15590888.
    Citations: 63     Fields:    Translation:AnimalsCells
  155. Albrecht DR, Tsang VL, Sah RL, Bhatia SN. Photo- and electropatterning of hydrogel-encapsulated living cell arrays. Lab Chip. 2005 Jan; 5(1):111-8. PMID: 15616749.
    Citations: 60     Fields:    Translation:AnimalsCells
  156. Dorvee JR, Derfus AM, Bhatia SN, Sailor MJ. Manipulation of liquid droplets using amphiphilic, magnetic one-dimensional photonic crystal chaperones. Nat Mater. 2004 Dec; 3(12):896-9. PMID: 15531887.
    Citations: 20     Fields:    Translation:Cells
  157. Albrecht DR, Sah RL, Bhatia SN. Geometric and material determinants of patterning efficiency by dielectrophoresis. Biophys J. 2004 Oct; 87(4):2131-47. PMID: 15454417; PMCID: PMC1304640.
    Citations: 12     Fields:    
  158. Tsang VL, Bhatia SN. Three-dimensional tissue fabrication. Adv Drug Deliv Rev. 2004 Sep 22; 56(11):1635-47. PMID: 15350293.
    Citations: 78     Fields:    
  159. Khetani SR, Szulgit G, Del Rio JA, Barlow C, Bhatia SN. Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling. Hepatology. 2004 Sep; 40(3):545-54. PMID: 15349892.
    Citations: 52     Fields:    Translation:AnimalsCells
  160. Lin P, Chan WC, Badylak SF, Bhatia SN. Assessing porcine liver-derived biomatrix for hepatic tissue engineering. Tissue Eng. 2004 Jul-Aug; 10(7-8):1046-53. PMID: 15363162.
    Citations: 55     Fields:    Translation:AnimalsCells
  161. Derfus AM, Chan WCW, Bhatia SN. Probing the Cytotoxicity Of Semiconductor Quantum Dots. Nano Lett. 2004 Jan 01; 4(1):11-18. PMID: 28890669; PMCID: PMC5588688.
    Citations: 435     Fields:    
  162. Vozzi G, Flaim C, Ahluwalia A, Bhatia S. Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials. 2003 Jun; 24(14):2533-40. PMID: 12695080.
    Citations: 31     Fields:    
  163. Allen JW, Bhatia SN. Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol Bioeng. 2003 May 05; 82(3):253-62. PMID: 12599251.
    Citations: 85     Fields:    Translation:AnimalsCells
  164. Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN, Sailor MJ. Polymer replicas of photonic porous silicon for sensing and drug delivery applications. Science. 2003 Mar 28; 299(5615):2045-7. PMID: 12663921.
    Citations: 31     Fields:    Translation:HumansCells
  165. Allen JW, Bhatia SN. Improving the next generation of bioartificial liver devices. Semin Cell Dev Biol. 2002 Dec; 13(6):447-54. PMID: 12468246.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  166. Allen JW, Bhatia SN. Engineering liver therapies for the future. Tissue Eng. 2002 Oct; 8(5):725-37. PMID: 12459052.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  167. Akerman ME, Chan WC, Laakkonen P, Bhatia SN, Ruoslahti E. Nanocrystal targeting in vivo. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12617-21. PMID: 12235356; PMCID: PMC130509.
    Citations: 247     Fields:    Translation:HumansAnimalsCells
  168. Cunin F, Schmedake TA, Link JR, Li YY, Koh J, Bhatia SN, Sailor MJ. Biomolecular screening with encoded porous-silicon photonic crystals. Nat Mater. 2002 Sep; 1(1):39-41. PMID: 12618846.
    Citations: 44     Fields:    Translation:AnimalsCells
  169. Liu VA, Jastromb WE, Bhatia SN. Engineering protein and cell adhesivity using PEO-terminated triblock polymers. J Biomed Mater Res. 2002 Apr; 60(1):126-34. PMID: 11835168.
    Citations: 32     Fields:    Translation:AnimalsCells
  170. Allen JW, Hassanein T, Bhatia SN. Advances in bioartificial liver devices. Hepatology. 2001 Sep; 34(3):447-55. PMID: 11526528.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  171. Bhatia SN, Balis UJ, Yarmush ML, Toner M. Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J. 1999 Nov; 13(14):1883-900. PMID: 10544172.
    Citations: 232     Fields:    Translation:HumansAnimals
  172. Ledezma GA, Folch A, Bhatia SN, Balis UJ, Yarmush ML, Toner M. Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes. J Biomech Eng. 1999 Feb; 121(1):58-64. PMID: 10080090.
    Citations: 13     Fields:    Translation:AnimalsCells
  173. Balis UJ, Behnia K, Dwarakanath B, Bhatia SN, Sullivan SJ, Yarmush ML, Toner M. Oxygen consumption characteristics of porcine hepatocytes. Metab Eng. 1999 Jan; 1(1):49-62. PMID: 10935754.
    Citations: 21     Fields:    Translation:AnimalsCells
  174. Bhatia SN, Yarmush ML, Toner M. Micropatterning cells in tissue engineering. Methods Mol Med. 1999; 18:349-63. PMID: 21370189.
    Citations: 1     Fields:    
  175. Bhatia SN, Balis UJ, Yarmush ML, Toner M. Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions. Biotechnol Prog. 1998 May-Jun; 14(3):378-87. PMID: 9622518.
    Citations: 60     Fields:    Translation:AnimalsCells
  176. Bhatia SN, Balis UJ, Yarmush ML, Toner M. Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures. J Biomater Sci Polym Ed. 1998; 9(11):1137-60. PMID: 9860177.
    Citations: 35     Fields:    Translation:AnimalsCells
  177. Bhatia SN, Yarmush ML, Toner M. Controlling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts. J Biomed Mater Res. 1997 Feb; 34(2):189-99. PMID: 9029299.
    Citations: 92     Fields:    Translation:AnimalsCells
  178. Bhatia SN, Toner M, Tompkins RG, Yarmush ML. Selective adhesion of hepatocytes on patterned surfaces. Ann N Y Acad Sci. 1994 Nov 30; 745:187-209. PMID: 7832508.
    Citations: 14     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Bhatia's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (652)
Co-Authors (73)
Similar People (60)
Same Department 
Physical Neighbors