Harvard Catalyst Profiles

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Navin Rath Gupta, M.D.

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Biography
awards and honors
2014
Best Internal Medicine Resident
2014 - 2015
Chief Resident
2016
Brigham Research Institute (BRI) Research Excellence Award
2017 - 2019
Harvard Stem Cell Institute (HSCI) Kidney Interlab Fellowship Award

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yoon SH, Meyer MB, Arevalo Rivas C, Tekguc M, Zhang C, Wang JS, Castro Andrade CD, Strauss KE, Sato T, Benkusky N, Lee SM, Berdeaux R, Foretz M, Sundberg TB, Xavier RJ, Adelmann CH, Brooks DJ, Anselmo A, Sadreyev RI, Rosales IA, Fisher DE, Gupta N, Morizane R, Greka A, Pike JW, Mannstadt M, Wein MN. A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis. J Clin Invest. 2023 Mar 02. PMID: 36862513.
    Citations:    Fields:    
  2. Koichiro Susa, Kenichi Kobayashi, Pierre Galichon, Takuya Matsumoto, Akitoshi Tamura, Ken Hiratsuka, Navin R. Gupta, Iman K. Yazdi, Joseph V. Bonventre, Ryuji Morizane. ATP/ADP biosensor organoids for drug nephrotoxicity assessment. Front. Cell Dev. Biol. 2023; 11 - 2023.
  3. Carrisoza-Gaytan R, Kroll KT, Hiratsuka K, Gupta NR, Morizane R, Lewis JA, Satlin LM. Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca2+ signaling. Am J Physiol Cell Physiol. 2023 Mar 01; 324(3):C757-C768. PMID: 36745528; PMCID: PMC10027089.
    Citations:    Fields:    
  4. Hiratsuka K, Miyoshi T, Kroll KT, Gupta NR, Valerius MT, Ferrante T, Yamashita M, Lewis JA, Morizane R. Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery. Sci Adv. 2022 09 23; 8(38):eabq0866. PMID: 36129975; PMCID: PMC9491724.
    Citations: 3     Fields:    Translation:Humans
  5. Rizki-Safitri A, Gupta N, Hiratsuka K, Kobayashi K, Zhang C, Ida K, Satlin LM, Morizane R. Live functional assays reveal longitudinal maturation of transepithelial transport in kidney organoids. Front Cell Dev Biol. 2022; 10:978888. PMID: 36046340; PMCID: PMC9420851.
    Citations:    
  6. Tekguc M, Gaal RCV, Uzel SGM, Gupta N, Riella LV, Lewis JA, Morizane R. Kidney organoids: a pioneering model for kidney diseases. Transl Res. 2022 12; 250:1-17. PMID: 35750295; PMCID: PMC9691572.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, Susa K, Tatsumoto N, Yamashita M, Morizane R. Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair. Science Translational Medicine. 2022; 14(634).
  8. Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, Susa K, Tatsumoto N, Yamashita M, Morizane R. Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair. Sci Transl Med. 2022 03 02; 14(634):eabj4772. PMID: 35235339; PMCID: PMC9161367.
    Citations: 13     Fields:    Translation:AnimalsCells
  9. Gupta N, Morizane R. Kidney development to kidney organoids and back again. Semin Cell Dev Biol. 2022 07; 127:68-76. PMID: 34627669; PMCID: PMC8983784.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Gupta N, Dilmen E, Morizane R. 3D kidney organoids for bench-to-bedside translation. J Mol Med (Berl). 2021 04; 99(4):477-487. PMID: 33034708; PMCID: PMC8026465.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Kishi S, Brooks CR, Taguchi K, Ichimura T, Mori Y, Akinfolarin A, Gupta N, Galichon P, Elias BC, Suzuki T, Wang Q, Gewin L, Morizane R, Bonventre JV. Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses. J Clin Invest. 2019 11 01; 129(11):4797-4816. PMID: 31589169; PMCID: PMC6819104.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  12. Homan KA, Gupta N, Kroll KT, Kolesky DB, Skylar-Scott M, Miyoshi T, Mau D, Valerius MT, Ferrante T, Bonventre JV, Lewis JA, Morizane R. Flow-enhanced vascularization and maturation of kidney organoids in vitro. Nat Methods. 2019 03; 16(3):255-262. PMID: 30742039; PMCID: PMC6488032.
    Citations: 223     Fields:    Translation:HumansCells
  13. Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS. Interleukin-1ß Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. J Am Soc Nephrol. 2018 06; 29(6):1690-1705. PMID: 29739813; PMCID: PMC6054344.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  14. Gupta N, Susa K, Yoda Y, Bonventre JV, Valerius MT, Morizane R. CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2018 05; 45(1):e50. PMID: 30040245.
    Citations: 6     Fields:    Translation:HumansCells
  15. Gupta N, Susa K, Morizane R. Regenerative Medicine, Disease Modeling, and Drug Discovery in Human Pluripotent Stem Cell-derived Kidney Tissue. Eur Med J Reprod Health. 2017 Aug; 3(1):57-67. PMID: 31157117; PMCID: PMC6544146.
    Citations: 2     
  16. Tsipotis E, Gupta NR, Raman G, Zintzaras E, Jaber BL. Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis. Am J Nephrol. 2016; 44(3):206-18. PMID: 27576318; PMCID: PMC6584577.
    Citations: 6     Fields:    Translation:Humans
  17. Sochol RD, Gupta NR, Bonventre JV. A Role for 3D Printing in Kidney-on-a-Chip Platforms. Curr Transplant Rep. 2016 Mar; 3(1):82-92. PMID: 28090431; PMCID: PMC5232415.
    Citations: 11     
  18. Navin Gupta and Bertrand Jaber, Principles and Practices of Hospital Medicine, Second Edition, Chapter 251: Kidney Stones, J Ross ed., McGraw-Hill, 2015. .
  19. Navin Gupta and Albert Q. Lam, Advances in Stem Cell Therapy, First Edition, Chapter 4: Pluripotent Stem Cells for Kidney Diseases, Springer, 2016 .
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