Harvard Catalyst Profiles

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Alec Andrew Schmaier, M.D.,Ph.D.

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Princeton University, Princeton, NJAB06/2004Molecular Biology
University of Pennsylvania, Philadelphia, PAPhD05/2010Pharmacology
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PAMD05/2012Medicine
Hospital of the University of Pennsylvania, Philadelphia, PA06/2015Resident, Internal Medicine
Brigham and Women’s Hospital, Boston, MA06/2019Fellow, Cardiovascular Medicine
Brigham and Women's Hospital, Boston, MA06/2018Vascular Medicine
Edward Holmes Award for Bench Research - Perelman School of Medicine
Young Investigator Award - International Society on Thrombosis and Haemostasis (ISTH)
Young Investigator Award - Gordon Research Conference in Hemostasis
Alpha Omega Alpha Honor Medical
Penn Pearl Award for Excellence in Clinical Teaching - Perelman School of Medicine
Jay D. Coffman Young Investigator Award

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Eleanor and Miles Shore Family Award (Schmaier, Alec) Jun 1, 2022 - May 31, 2023
    Harvard Medical School
    The role of TMEM16 proteins in prothrombotic endothelial extracellular vesicles.
    Role: PI
  2. Career Development Grant 937800 (Schmaier, Alec) May 1, 2022 - Apr 30, 2025
    American Heart Association
    Regulation of endothelial cell procoagulant activity by TMEM16 scramblases
    Role: PI
  3. 1K08HL161259 (Schmaier, Alec) Jan 1, 2022 - Dec 31, 2027
    Regulation of endothelial cell phosphatidylserine in thrombosis
    Role: PI
  4. COVID-19 Response Award (Flaumenhaft, Robert) May 1, 2020 - Oct 30, 2022
    Massachusetts Consortium on Pathogen Readiness
    Endothelial-targeted therapy for COVID-19 acute respiratory distress syndrome
    Role: PI
  5. Cardiovascular Research Award (Schmaier, Alec) Jul 1, 2019 - Jan 1, 2022
    John S. LaDue Memorial Fellowship, HMS
    Regulation of phosphatidylserine modulates endothelial cell thrombotic potential

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Flaumenhaft R, Enjyoji K, Schmaier AA. Vasculopathy in COVID-19. Blood. 2022 07 21; 140(3):222-235. PMID: 34986238; PMCID: PMC8736280.
    Citations: 4     Fields:    Translation:HumansCells
  2. Katz DH, Tahir UA, Bick AG, Pampana A, Ngo D, Benson MD, Yu Z, Robbins JM, Chen ZZ, Cruz DE, Deng S, Farrell L, Sinha S, Schmaier AA, Shen D, Gao Y, Hall ME, Correa A, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Yao J, Ida Chen YD, Manichaikul AW, Jain D, Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Natarajan P, Gerszten RE. Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease. Circulation. 2022 02; 145(5):357-370. PMID: 34814699; PMCID: PMC9158509.
    Citations: 4     Fields:    Translation:Humans
  3. Pribish AM, Secemsky EA, Schmaier AA. Venous Thromboembolism for the Practicing Cardiologist. Cardiol Clin. 2021 Nov; 39(4):551-566. PMID: 34686267.
    Citations:    Fields:    Translation:Humans
  4. Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu XG, Peters KG, Flaumenhaft R, Parikh SM. Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19. JCI Insight. 2021 10 22; 6(20). PMID: 34506304; PMCID: PMC8564889.
    Citations: 10     Fields:    Translation:HumansCells
  5. Raines NH, Cheung MD, Wilson LS, Edberg JC, Erdmann NB, Schmaier AA, Berryhill TF, Manickas-Hill Z, Li JZ, Yu XG, Agarwal A, Barnes S, Parikh SM. Nicotinamide Adenine Dinucleotide Biosynthetic Impairment and Urinary Metabolomic Alterations Observed in Hospitalized Adults With COVID-19-Related Acute Kidney Injury. Kidney Int Rep. 2021 Dec; 6(12):3002-3013. PMID: 34541422; PMCID: PMC8439094.
    Citations: 3     
  6. Schmaier AA, Schmaier AH. Vascular Disease Patient Information Page: COVID-19-related thrombosis. Vasc Med. 2020 12; 25(6):604-607. PMID: 33044129.
    Citations:    Fields:    Translation:HumansCells
  7. Weinberg I, Weinberg M, Secemsky E, Schmaier A. 2019 Fellows Course and Advanced Practice Provider Course. Vasc Med. 2020 04; 25(2):200-201. PMID: 32186251.
    Citations:    Fields:    
  8. Schmaier AA, Ambesh P, Campia U. Venous Thromboembolism and Cancer. Curr Cardiol Rep. 2018 08 20; 20(10):89. PMID: 30128839.
    Citations: 5     Fields:    Translation:Humans
  9. Schmaier AA, Taqueti VR. A Lack of Reserve: Recognizing the Large Impact of Small Vessels in the Heart. Circulation. 2018 07 24; 138(4):424-428. PMID: 30546157; PMCID: PMC6287614.
    Citations: 4     Fields:    Translation:Humans
  10. Schmaier AA, Bhatt DL. Are Patients Getting Their Aspirin's Worth in Ischemic Stroke? J Am Heart Assoc. 2018 06 01; 7(11). PMID: 29858359.
    Citations: 1     Fields:    Translation:Humans
  11. Basu SS, Deutsch EC, Schmaier AA, Lynch DR, Blair IA. Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and LC-MS. Bioanalysis. 2013 Dec; 5(24):3009-21. PMID: 24320127.
    Citations: 10     Fields:    Translation:HumansCells
  12. Fang C, Stavrou E, Schmaier AA, Grobe N, Morris M, Chen A, Nieman MT, Adams GN, LaRusch G, Zhou Y, Bilodeau ML, Mahdi F, Warnock M, Schmaier AH. Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2-/- mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation. Blood. 2013 Apr 11; 121(15):3023-32. PMID: 23386129; PMCID: PMC3624945.
    Citations: 42     Fields:    Translation:AnimalsCells
  13. Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliché S, Gariépy C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML. Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease. Blood. 2011 Sep 29; 118(13):3661-9. PMID: 21816834; PMCID: PMC3186337.
    Citations: 16     Fields:    Translation:HumansAnimals
  14. Opalinska JB, Bersenev A, Zhang Z, Schmaier AA, Choi J, Yao Y, D'Souza J, Tong W, Weiss MJ. MicroRNA expression in maturing murine megakaryocytes. Blood. 2010 Dec 02; 116(23):e128-38. PMID: 20720187; PMCID: PMC3012601.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  15. Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen CY, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Jul 29; 116(4):661-70. PMID: 20363774; PMCID: PMC3324297.
    Citations: 172     Fields:    Translation:HumansAnimalsCells
  16. Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML. Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21167-72. PMID: 19940238.
    Citations: 30     Fields:    Translation:AnimalsCells
  17. Schmaier AA, Kahn ML. Platelet integrin signaling: wherefore art thou? Blood. 2009 Sep 24; 114(13):2571-2. PMID: 19779046.
    Citations:    Fields:    
  18. Schmaier AA, Schmaier AH. Thrombosis in flowing blood. Blood. 2009 Jul 23; 114(4):754-6. PMID: 19628716.
    Citations: 1     Fields:    
  19. Zou Z, Schmaier AA, Cheng L, Mericko P, Dickeson SK, Stricker TP, Santoro SA, Kahn ML. Negative regulation of activated alpha-2 integrins during thrombopoiesis. Blood. 2009 Jun 18; 113(25):6428-39. PMID: 19258597.
    Citations: 11     Fields:    Translation:AnimalsCells
  20. Neeves KB, Maloney SF, Fong KP, Schmaier AA, Kahn ML, Brass LF, Diamond SL. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thromb Haemost. 2008 Dec; 6(12):2193-201. PMID: 18983510.
    Citations: 72     Fields:    Translation:AnimalsCells
  21. Zou Z, Chen H, Schmaier AA, Hynes RO, Kahn ML. Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets. Blood. 2007 Apr 15; 109(8):3284-90. PMID: 17170121.
    Citations: 25     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.