Harvard Catalyst Profiles

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Naoka Murakami, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08DK120868 (MURAKAMI, NAOKA) Jul 1, 2019 - Apr 30, 2024
    Protection of kidney from autoimmunity by modulating co-stimlatory signaling
    Role: Principal Investigator
  2. Carl W. Gottschalk Research Scholar Grant (MURAKAMI, NAOKA) Jul 1, 2019 - Jun 30, 2021
    ASN Foundation of Kidney Research
    Roles of immune checkpoint signaling in autoimmune kidney diseases
    Role Description: The goal of this study is to develop precise methods to monitor and characterize autoantigen-specific immune response by combining novel transgenic mouse models and tetramer-tracking technique
    Role: Primary Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wongboonsin J, Shah SI, Marty FM, Mount DB, Rennke HG, Murakami N. Osmotic tubulopathy in a patient with COVID-19 treated with remdesivir. Kidney Int Rep. 2021 May 12. PMID: 33997535.
  2. Win TS, Crisler WJ, Dyring-Andersen B, Lopdrup R, Teague JE, Zhan Q, Barrera V, Ho Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius SG, Pomahac B, Riella LV, Clark RA. Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. J Clin Invest. 2021 Apr 15; 131(8). PMID: 33667197.
    Citations:    Fields:    
  3. Murakami N, Mulvaney P, Danesh M, Abudayyeh A, Diab A, Abdel-Wahab N, Abdelrahim M, Khairallah P, Shirazian S, Kukla A, Owoyemi IO, Alhamad T, Husami S, Menon M, Santeusanio A, Blosser CD, Zuniga SC, Soler MJ, Moreso F, Mithani Z, Ortiz-Melo D, Jaimes EA, Gutgarts V, Lum E, Danovitch GM, Cardarelli F, Drews RE, Bassil C, Swank JL, Westphal S, Mannon RB, Shirai K, Kitchlu A, Ong S, Machado SM, Mothi SS, Ott PA, Rahma O, Hodi FS, Sise ME, Gupta S, Leaf DE, Devoe CE, Wanchoo R, Nair VV, Schmults CD, Hanna GJ, Sprangers B, Riella LV, Jhaveri KD. A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant. Kidney Int. 2020 Dec 24. PMID: 33359528.
    Citations: 1     Fields:    
  4. Danesh MJ, Mulvaney PM, Murakami N, Riella LV, Silk AW, Hanna GJ, Schmults CD. Impact of corticosteroids on allograft protection in renal transplant patients receiving anti-PD-1 immunotherapy. Cancer Immunol Immunother. 2020 09; 69(9):1937-1941. PMID: 32588077.
    Citations:    Fields:    Translation:Humans
  5. Murakami N, Riella LV. Response by Murakami and Riella to Letter Regarding Article, "Notch-1 Inhibition Promoted Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms". Circulation. 2020 01 21; 141(3):e37-e38. PMID: 31958243.
    Citations:    Fields:    Translation:Cells
  6. Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan AD, Ortiz-Melo DI, Rangarajan S, Malik AB, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol. 2020 02; 31(2):435-446. PMID: 31896554.
    Citations: 31     Fields:    Translation:Humans
  7. Murakami N, Riella LV. Not transplanting kidney donors with acute kidney injury: a missed opportunity? J Bras Nefrol. 2019 Oct-Dec; 41(4):448-450. PMID: 31904762.
    Citations:    Fields:    Translation:Humans
  8. Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Circulation. 2019 09 09; 140(10):846-863. PMID: 31266349.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Uffing A, Hidalgo LG, McMullan C, Perry J, Milford EL, Murakami N, Yeung MY, Guleria I, Wood IG, Akalin E, Azzi J, Chandraker AK, Riella LV. Preformed Donor-specific Antibodies Against HLA Class II and Graft Outcomes in Deceased-donor Kidney Transplantation. Transplant Direct. 2019 May; 5(5):e446. PMID: 31165081.
    Citations: 1     
  10. Pérez-Sáez MJ, Yu B, Uffing A, Murakami N, Borges TJ, Azzi J, El Haji S, Gabardi S, Riella LV. Conversion from tacrolimus to belatacept improves renal function in kidney transplant patients with chronic vascular lesions in allograft biopsy. Clin Kidney J. 2019 Aug; 12(4):586-591. PMID: 31384452.
    Citations: 1     
  11. Borges TJ, Murakami N, Machado FD, Murshid A, Lang BJ, Lopes RL, Bellan LM, Uehara M, Antunes KH, Pérez-Saéz MJ, Birrane G, Vianna P, Gonçalves JIB, Zanin RF, Azzi J, Abdi R, Ishido S, Shin JS, Souza APD, Calderwood SK, Riella LV, Bonorino C. March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity. Nat Commun. 2018 08 28; 9(1):3482. PMID: 30154416.
    Citations: 9     Fields:    Translation:AnimalsCells
  12. Murakami N, Ding Y, Cohen DJ, Chandraker AK, Rennke HG. Recurrent membranous nephropathy and acute cellular rejection in a patient treated with direct anti-HCV therapy (ledipasvir/sofosbuvir). Transpl Infect Dis. 2018 Oct; 20(5):e12959. PMID: 29968947.
    Citations:    Fields:    Translation:HumansCells
  13. Kawano Y, Zavidij O, Park J, Moschetta M, Kokubun K, Mouhieddine TH, Manier S, Mishima Y, Murakami N, Bustoros M, Pistofidis RS, Reidy M, Shen YJ, Rahmat M, Lukyanchykov P, Karreci ES, Tsukamoto S, Shi J, Takagi S, Huynh D, Sacco A, Tai YT, Chesi M, Bergsagel PL, Roccaro AM, Azzi J, Ghobrial IM. Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression. J Clin Invest. 2018 06 01; 128(6):2487-2499. PMID: 29558366.
    Citations: 20     Fields:    Translation:AnimalsCells
  14. Leon J, Pérez-Sáez MJ, Uffing A, Murakami N, Watanabe A, Cureton P, Kenyon V, Keating L, Yee K, Fernandes Satiro CA, Yu B, Bonventre JV, Fasano A, Riella LV. Effect of Combined Gluten-Free, Dairy-Free Diet in Children With Steroid-Resistant Nephrotic Syndrome: An Open Pilot Trial. Kidney Int Rep. 2018 Jul; 3(4):851-860. PMID: 30116795.
    Citations: 2     
  15. Kishi S, Minato M, Saijo A, Murakami N, Tamaki M, Matsuura M, Murakami T, Nagai K, Abe H, Nishioka Y, Doi T. IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma. Intern Med. 2018 May 01; 57(9):1259-1263. PMID: 29279511.
    Citations: 15     Fields:    Translation:Humans
  16. Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G. Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nat Commun. 2017 11 22; 8(1):1692. PMID: 29167449.
    Citations: 13     Fields:    Translation:HumansCells
  17. Win TS, Murakami N, Borges TJ, Chandraker A, Murphy G, Lian C, Barrera V, Ho Sui S, Schoenfeld D, Teague J, Bueno E, Tullius SG, Pomahac B, Clark RA, Riella LV. Longitudinal immunological characterization of the first presensitized recipient of a face transplant. JCI Insight. 2017 Jul 06; 2(13). PMID: 28679959.
    Citations: 2     Fields:    
  18. Murakami N, Motwani S, Riella LV. Renal complications of immune checkpoint blockade. Curr Probl Cancer. 2017 Mar - Apr; 41(2):100-110. PMID: 28189263.
    Citations: 25     Fields:    Translation:HumansAnimals
  19. Borges TJ, Murakami N, Riella LV. Current status of alloimmunity. Curr Opin Nephrol Hypertens. 2016 11; 25(6):556-562. PMID: 27584931.
    Citations: 1     Fields:    Translation:Humans
  20. Murakami N, Maillard I, Riella LV. Notch Signaling and Immune Regulation in Alloimmunity. Curr Transplant Rep. 2016 Dec; 3(4):294-302. PMID: 29977738.
  21. Krezdorn N, Murakami N, Pomahac B, Riella LV. Immunological Characteristics of a Patient With Belatacept-Resistant Acute Rejection After Face Transplantation. Am J Transplant. 2016 11; 16(11):3305-3307. PMID: 27457067.
    Citations: 5     Fields:    Translation:HumansCells
  22. Murakami N, Borges TJ, Yamashita M, Riella LV. Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma. Clin Kidney J. 2016 Jun; 9(3):411-7. PMID: 27274826.
    Citations: 29     
  23. Borges TJ, O'Malley JT, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane JD, Bueno EM, Clark RA, Tullius SG, Chandraker A, Lian CG, Murphy GF, Strom TB, Pomahac B, Najafian N, Riella LV. Codominant Role of Interferon-?- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients. Am J Transplant. 2016 07; 16(7):2158-71. PMID: 26749226.
    Citations: 9     Fields:    Translation:HumansCells
  24. Murakami N, Riella LV. CD4+ CD28-Negative Cells: Armed and Dangerous. Am J Transplant. 2016 Apr; 16(4):1045-6. PMID: 26613671.
    Citations: 1     Fields:    Translation:HumansCells
  25. Murakami N, Siktel HB, Lucido D, Winchester JF, Harbord NB. Disaster Preparedness and Awareness of Patients on Hemodialysis after Hurricane Sandy. Clin J Am Soc Nephrol. 2015 Aug 07; 10(8):1389-96. PMID: 26220814.
    Citations: 9     Fields:    Translation:Humans
  26. Murakami N, Yoshida N, Hamano K, Suzuki H, Miyakawa M, Takeshita A, Takeuchi Y. Primary aldosteronism presenting with an atypical aldosterone-renin ratio in the acute phase of cerebral hemorrhage. Intern Med. 2015; 54(4):415-20. PMID: 25748959.
    Citations:    Fields:    Translation:Humans
  27. Yuki K, Murakami N. Sepsis pathophysiology and anesthetic consideration. Cardiovasc Hematol Disord Drug Targets. 2015; 15(1):57-69. PMID: 25567335.
    Citations: 10     Fields:    Translation:HumansAnimals
  28. Murakami N, Riella LV, Funakoshi T. Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: a systematic review and meta-analysis. Am J Transplant. 2014 Oct; 14(10):2317-27. PMID: 25146383.
    Citations: 26     Fields:    Translation:Humans
  29. Grafals M, Smith B, Murakami N, Trabucco A, Hamill K, Marangos E, Gilligan H, Pomfret EA, Pomposelli JJ, Simpson MA, Azzi J, Najafian N, Riella LV. Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. PLoS One. 2014; 9(8):e104408. PMID: 25111080.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  30. Murakami N, Riella LV. Co-inhibitory pathways and their importance in immune regulation. Transplantation. 2014 Jul 15; 98(1):3-14. PMID: 24978034.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  31. Lan W, Yamaguchi S, Yamamoto T, Yamahira S, Tan M, Murakami N, Zhang J, Nakamura M, Nagamune T. Visualization of the pH-dependent dynamic distribution of G2A in living cells. FASEB J. 2014 Sep; 28(9):3965-74. PMID: 24891524.
    Citations: 2     Fields:    Translation:HumansCells
  32. Murakami N, Takeshita A, Suzuki H, Iizuka T, Kikuchi D, Matsui A, Kaise M, Miura D, Kinowaki K, Ohashi K, Takeuchi Y. Hidden culprit of primary hyperparathyroidism. J Clin Endocrinol Metab. 2012 Oct; 97(10):3410-1. PMID: 22767637.
    Citations:    Fields:    Translation:Humans
  33. Hashidate T, Murakami N, Nakagawa M, Ichikawa M, Kurokawa M, Shimizu T, Nakamura M. AML1 enhances the expression of leukotriene B4 type-1 receptor in leukocytes. FASEB J. 2010 Sep; 24(9):3500-10. PMID: 20395453.
    Citations: 3     Fields:    Translation:HumansCells
  34. Murakami N, Hashidate T, Harayama T, Yokomizo T, Shimizu T, Nakamura M. Transcriptional regulation of human G2A in monocytes/ macrophages: involvement of c/EBPs, Runx and Pu.1. Genes Cells. 2009 Dec; 14(12):1441-55. PMID: 19930466.
    Citations: 3     Fields:    Translation:HumansCells
  35. Murakami N, Yokomizo T, Okuno T, Shimizu T. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. J Biol Chem. 2004 Oct 08; 279(41):42484-91. PMID: 15280385.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.