Harvard Catalyst Profiles

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Matthew Brendon Might, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. OT2TR003435 (BYRD, WILLIAM E) Jan 24, 2020 - May 31, 2020
    Doc Sherlock: An Autonomous Relay Agent for Discovering the Unknown Knowns in Precision Medicine
    Role: Co-Principal Investigator
  2. OT2TR002517 (MIGHT, MATTHEW BRENDON) Dec 29, 2017 - Jan 31, 2018
    Biomedical Data Translator Technical Feasibility Assessment of Reasoning Tool: University of Alabama at Birmingham
    Role: Principal Investigator
  3. U01HG007530 (KOHANE, ISAAC S.) Apr 1, 2015 - Nov 30, 2017
    Coordinating Center for the Undiagnosed Disease Network Phase II
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tran DT, Bhaskara A, Kuberan B, Might M. A graph-based algorithm for RNA-seq data normalization. PLoS One. 2020; 15(1):e0227760. PMID: 31978105.
  2. Queralt-Rosinach N, Stupp GS, Li TS, Mayers M, Hoatlin ME, Might M, Good BM, Su AI. Structured reviews for data and knowledge-driven research. Database (Oxford). 2020 01 01; 2020. PMID: 32283553.
  3. Khomtchouk BB, Tran DT, Vand KA, Might M, Gozani O, Assimes TL. Cardioinformatics: the nexus of bioinformatics and precision cardiology. Brief Bioinform. 2019 Dec 04. PMID: 31802103.
  4. Crouse A, Nakano-Okuno M, Might M, May T. N-of-1 Precision Medicine and Research Oversight. Am J Bioeth. 2019 Aug; 19(8):36-37. PMID: 31544631.
  5. Yang S, Cheng YS, Li R, Pradhan M, Hong J, Beers J, Zou J, Liu C, Might M, Rodems S, Zheng W. An induced pluripotent stem cell line (TRNDi010-C) from a patient carrying a homozygous p.R401X mutation in the NGLY1 gene. Stem Cell Res. 2019 08; 39:101496. PMID: 31326749.
  6. Farkhondeh A, Li R, Gorshkov K, Chen KG, Might M, Rodems S, Lo DC, Zheng W. Induced pluripotent stem cells for neural drug discovery. Drug Discov Today. 2019 04; 24(4):992-999. PMID: 30664937.
    Citations:    Fields:    
  7. Li R, Pradhan M, Xu M, Baskfield A, Farkhondeh A, Cheng YS, Beers J, Zou J, Liu C, Might M, Rodems S, Zheng W. Generation of an induced pluripotent stem cell line (TRNDi002-B) from a patient carrying compound heterozygous p.Q208X and p.G310G mutations in the NGLY1 gene. Stem Cell Res. 2019 01; 34:101362. PMID: 30612078.
    Citations:    Fields:    
  8. Tran DT, Zhang T, Stutsman R, Might M, Desai UR, Kuberan B. anexVis: visual analytics framework for analysis of RNA expression. Bioinformatics. 2018 07 15; 34(14):2510-2512. PMID: 29506198.
    Citations:    Fields:    
  9. Vasilevsky NA, Foster ED, Engelstad ME, Carmody L, Might M, Chambers C, Dawkins HJS, Lewis J, Della Rocca MG, Snyder M, Boerkoel CF, Rath A, Terry SF, Kent A, Searle B, Baynam G, Jones E, Gavin P, Bamshad M, Chong J, Groza T, Adams D, Resnick AC, Heath AP, Mungall C, Holm IA, Rageth K, Brownstein CA, Shefchek K, McMurry JA, Robinson PN, Köhler S, Haendel MA. Plain-language medical vocabulary for precision diagnosis. Nat Genet. 2018 04; 50(4):474-476. PMID: 29632381.
    Citations: 3     Fields:    
  10. Atkin TA, Maher CM, Gerlach AC, Gay BC, Antonio BM, Santos SC, Padilla KM, Rader J, Krafte DS, Fox MA, Stewart GR, Petrovski S, Devinsky O, Might M, Petrou S, Goldstein DB. A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy. Epilepsia. 2018 04; 59(4):802-813. PMID: 29574705.
    Citations:    Fields:    Translation:HumansCells
  11. Owings KG, Lowry JB, Bi Y, Might M, Chow CY. Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches. Hum Mol Genet. 2018 03 15; 27(6):1055-1066. PMID: 29346549.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Bi Y, Might M, Vankayalapati H, Kuberan B. Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-ß-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease. Bioorg Med Chem Lett. 2017 07 01; 27(13):2962-2966. PMID: 28512024.
    Citations: 1     Fields:    Translation:HumansCells
  13. Might M, Might CC. What happens when N?=?1 and you want plus 1? Prenat Diagn. 2017 Jan; 37(1):70-72. PMID: 27885678.
    Citations: 1     Fields:    Translation:Humans
  14. Lambertson KF, Damiani SA, Might M, Shelton R, Terry SF. Participant-driven matchmaking in the genomic era. Hum Mutat. 2015 Oct; 36(10):965-73. PMID: 26252162.
    Citations: 7     Fields:    Translation:Humans
  15. Might M, Wilsey M. The shifting model in clinical diagnostics: how next-generation sequencing and families are altering the way rare diseases are discovered, studied, and treated. Genet Med. 2014 Oct; 16(10):736-7. PMID: 24651604.
    Citations: 20     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.