Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Matthew Brendon Might, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U54OD030167 (YODER, BRADLEY K.) Sep 10, 2020 - Aug 31, 2025
    UAB Pilot Center for Precision Animal Modeling (C-PAM)
    Role: Co-Principal Investigator
  2. OT2TR003435 (BYRD, WILLIAM E) Jan 24, 2020 - Jan 23, 2022
    Doc Sherlock: An Autonomous Relay Agent for Discovering the Unknown Knowns in Precision Medicine
    Role: Co-Principal Investigator
  3. OT2TR002517 (MIGHT, MATTHEW BRENDON) Dec 29, 2017 - Dec 28, 2019
    Biomedical Data Translator Technical Feasibility Assessment of Reasoning Tool: University of Alabama at Birmingham
    Role: Principal Investigator
  4. U01HG007530 (KOHANE, ISAAC S.) Dec 20, 2013 - Jun 30, 2022
    Coordinating Center for the Undiagnosed Disease Network Phase II
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Foksinska A, Crowder CM, Crouse AB, Henrikson J, Byrd WE, Rosenblatt G, Patton MJ, He K, Tran-Nguyen TK, Zheng M, Ramsey SA, Amin N, Osborne J, Might M. The precision medicine process for treating rare disease using the artificial intelligence tool mediKanren. Front Artif Intell. 2022; 5:910216. PMID: 36248623; PMCID: PMC9562701.
  2. Kolevzon A, Levy T, Barkley S, Bedrosian-Sermone S, Davis M, Foss-Feig J, Halpern D, Keller K, Kostic A, Layton C, Lee R, Lerman B, Might M, Sandin S, Siper PM, Sloofman LG, Walker H, Zweifach J, Buxbaum JD. An open-label study evaluating the safety, behavioral, and electrophysiological outcomes of low-dose ketamine in children with ADNP syndrome. HGG Adv. 2022 Oct 13; 3(4):100138. PMID: 36119806; PMCID: PMC9471202.
  3. Might M, Crouse AB. Why rare disease needs precision medicine-and precision medicine needs rare disease. Cell Rep Med. 2022 02 15; 3(2):100530. PMID: 35243424; PMCID: PMC8861960.
    Citations: 1     Fields:    Translation:Humans
  4. Marcogliese PC, Dutta D, Ray SS, Dang NDP, Zuo Z, Wang Y, Lu D, Fazal F, Ravenscroft TA, Chung H, Kanca O, Wan J, Douine ED, Network UD, Pena LDM, Yamamoto S, Nelson SF, Might M, Meyer KC, Yeo NC, Bellen HJ. Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Sci Adv. 2022 01 21; 8(3):eabl5613. PMID: 35044823; PMCID: PMC8769555.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Long A, Crouse A, Kesterson RA, Might M, Wallis D. Functional characterization and potential therapeutic avenues for variants in the NTRK2 gene causing developmental and epileptic encephalopathies. Am J Med Genet B Neuropsychiatr Genet. 2022 01; 189(1-2):37-47. PMID: 34889524.
    Citations:    Fields:    Translation:HumansCells
  6. Pavlinov I, Farkhondeh A, Yang S, Xu M, Cheng YS, Beers J, Zou J, Liu C, Might M, Rodems S, Baumgärtel K, Zheng W. Corrigendum to "Generation of two gene corrected human isogenic iPSC lines (NCATS-CL6104 and NCATS-CL6105) from a patient line (NCATS-CL6103) carrying a homozygous p.R401X mutation in the NGLY1 gene using CRISPR/Cas9" [Stem Cell Res. 56 (2021) 102554]. Stem Cell Res. 2021 Dec; 57:102602. PMID: 34801429; PMCID: PMC9429899.
    Citations:    Fields:    
  7. Tran DT, Might M. cdev: a ground-truth based measure to evaluate RNA-seq normalization performance. PeerJ. 2021; 9:e12233. PMID: 34707933; PMCID: PMC8496462.
  8. Pavlinov I, Farkhondeh A, Yang S, Xu M, Cheng YS, Beers J, Zou J, Liu C, Might M, Rodems S, Baumgärtel K, Zheng W. Generation of two gene corrected human isogenic iPSC lines (NCATS-CL6104 and NCATS-CL6105) from a patient line (NCATS-CL6103) carrying a homozygous p.R401X mutation in the NGLY1 gene using CRISPR/Cas9. Stem Cell Res. 2021 10; 56:102554. PMID: 34619643; PMCID: PMC8647947.
    Citations:    Fields:    Translation:HumansCells
  9. Pacl HT, Tipper JL, Sevalkar RR, Crouse A, Crowder C, Ahmad S, Ahmad A, Holder GD, Kuhlman CJ, Chinta KC, Nadeem S, Green TJ, Petit CM, Steyn AJC, Might M, Harrod KS. Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase. bioRxiv. 2021 Jul 27. PMID: 34282419; PMCID: PMC8288149.
  10. Nickols NG, Goetz MB, Graber CJ, Bhattacharya D, Soo Hoo G, Might M, Goldstein DB, Wang X, Ramoni R, Myrie K, Tran S, Ghayouri L, Tsai S, Geelhoed M, Makarov D, Becker DJ, Tsay JC, Diamond M, George A, Al-Ajam M, Belligund P, Montgomery RB, Mostaghel EA, Sulpizio C, Mi Z, Dematt E, Tadalan J, Norman LE, Briones D, Clise CE, Taylor ZW, Huminik JR, Biswas K, Rettig MB. Hormonal intervention for the treatment of veterans with COVID-19 requiring hospitalization (HITCH): a multicenter, phase 2 randomized controlled trial of best supportive care vs best supportive care plus degarelix: study protocol for a randomized controlled trial. Trials. 2021 Jul 05; 22(1):431. PMID: 34225789.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  11. Mannucci I, Dang NDP, Huber H, Murry JB, Abramson J, Althoff T, Banka S, Baynam G, Bearden D, Beleza-Meireles A, Benke PJ, Berland S, Bierhals T, Bilan F, Bindoff LA, Braathen GJ, Busk ØL, Chenbhanich J, Denecke J, Escobar LF, Estes C, Fleischer J, Groepper D, Haaxma CA, Hempel M, Holler-Managan Y, Houge G, Jackson A, Kellogg L, Keren B, Kiraly-Borri C, Kraus C, Kubisch C, Le Guyader G, Ljungblad UW, Brenman LM, Martinez-Agosto JA, Might M, Miller DT, Minks KQ, Moghaddam B, Nava C, Nelson SF, Parant JM, Prescott T, Rajabi F, Randrianaivo H, Reiter SF, Schuurs-Hoeijmakers J, Shieh PB, Slavotinek A, Smithson S, Stegmann APA, Tomczak K, Tveten K, Wang J, Whitlock JH, Zweier C, McWalter K, Juusola J, Quintero-Rivera F, Fischer U, Yeo NC, Kreienkamp HJ, Lessel D. Genotype-phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders. Genome Med. 2021 05 21; 13(1):90. PMID: 34020708; PMCID: PMC8140440.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Pradhan M, Farkhondeh A, Cheng YS, Xu M, Beers J, Zou J, Liu C, Might M, Rodems S, Baumgärtel K, Zheng W. An induced pluripotent stem cell line (NCATS-CL9075) from a patient carrying compound heterozygote mutations, p.R390P and p.L318P, in the NGLY1 gene. Stem Cell Res. 2021 07; 54:102400. PMID: 34051448; PMCID: PMC8362228.
    Citations:    Fields:    Translation:HumansCells
  13. LeBlanc K, Kelley EG, Nagy A, Bater J, Berro T, McGuinness MA, Studwell C, Might M. Rare disease patient matchmaking: development and outcomes of an internet case-finding strategy in the Undiagnosed Diseases Network. Orphanet J Rare Dis. 2021 05 10; 16(1):210. PMID: 33971915; PMCID: PMC8108446.
    Citations: 1     Fields:    Translation:Humans
  14. Tao D, Xu M, Farkhondeh A, Burns AP, Rodems S, Might M, Zheng W, LeClair CA. High-throughput protein modification quantitation analysis using intact protein MRM and its application on hENGase inhibitor screening. Talanta. 2021 Aug 15; 231:122384. PMID: 33965046; PMCID: PMC8215893.
    Citations: 1     Fields:    Translation:Humans
  15. Crouse AB, Grimes T, Li P, Might M, Ovalle F, Shalev A. Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes. Front Endocrinol (Lausanne). 2020; 11:600439. PMID: 33519709; PMCID: PMC7838490.
    Citations: 57     Fields:    Translation:HumansCells
  16. Khomtchouk BB, Tran DT, Vand KA, Might M, Gozani O, Assimes TL. Cardioinformatics: the nexus of bioinformatics and precision cardiology. Brief Bioinform. 2020 12 01; 21(6):2031-2051. PMID: 31802103.
    Citations: 4     Fields:    Translation:Humans
  17. East KM, Kelley WV, Cannon A, Cochran ME, Moss IP, May T, Nakano-Okuno M, Sodeke SO, Edberg JC, Cimino JJ, Fouad M, Curry WA, Hurst ACE, Bowling KM, Thompson ML, Bebin EM, Johnson RD, Cooper GM, Might M, Barsh GS, Korf BR. A state-based approach to genomics for rare disease and population screening. Genet Med. 2021 04; 23(4):777-781. PMID: 33244164; PMCID: PMC8311654.
    Citations: 5     Fields:    Translation:Humans
  18. Rubinstein YR, Robinson PN, Gahl WA, Avillach P, Baynam G, Cederroth H, Goodwin RM, Groft SC, Hansson MG, Harris NL, Huser V, Mascalzoni D, McMurry JA, Might M, Nellaker C, Mons B, Paltoo DN, Pevsner J, Posada M, Rockett-Frase AP, Roos M, Rubinstein TB, Taruscio D, van Enckevort E, Haendel MA. The case for open science: rare diseases. JAMIA Open. 2020 Oct; 3(3):472-486. PMID: 33426479; PMCID: PMC7660964.
    Citations: 11     
  20. Tran DT, Bhaskara A, Kuberan B, Might M. A graph-based algorithm for RNA-seq data normalization. PLoS One. 2020; 15(1):e0227760. PMID: 31978105; PMCID: PMC6980396.
    Citations: 2     Fields:    
  21. Queralt-Rosinach N, Stupp GS, Li TS, Mayers M, Hoatlin ME, Might M, Good BM, Su AI. Structured reviews for data and knowledge-driven research. Database (Oxford). 2020 01 01; 2020. PMID: 32283553.
    Citations: 2     Fields:    Translation:HumansAnimals
  22. Crouse A, Nakano-Okuno M, Might M, May T. N-of-1 Precision Medicine and Research Oversight. Am J Bioeth. 2019 Aug; 19(8):36-37. PMID: 31544631.
    Citations:    Fields:    Translation:Humans
  23. Yang S, Cheng YS, Li R, Pradhan M, Hong J, Beers J, Zou J, Liu C, Might M, Rodems S, Zheng W. An induced pluripotent stem cell line (TRNDi010-C) from a patient carrying a homozygous p.R401X mutation in the NGLY1 gene. Stem Cell Res. 2019 08; 39:101496. PMID: 31326749.
    Citations: 1     Fields:    Translation:HumansCells
  24. Farkhondeh A, Li R, Gorshkov K, Chen KG, Might M, Rodems S, Lo DC, Zheng W. Induced pluripotent stem cells for neural drug discovery. Drug Discov Today. 2019 04; 24(4):992-999. PMID: 30664937; PMCID: PMC6476685.
    Citations: 22     Fields:    Translation:HumansCells
  25. Li R, Pradhan M, Xu M, Baskfield A, Farkhondeh A, Cheng YS, Beers J, Zou J, Liu C, Might M, Rodems S, Zheng W. Generation of an induced pluripotent stem cell line (TRNDi002-B) from a patient carrying compound heterozygous p.Q208X and p.G310G mutations in the NGLY1 gene. Stem Cell Res. 2019 01; 34:101362. PMID: 30612078.
    Citations: 3     Fields:    Translation:HumansCells
  26. Tran DT, Zhang T, Stutsman R, Might M, Desai UR, Kuberan B. anexVis: visual analytics framework for analysis of RNA expression. Bioinformatics. 2018 07 15; 34(14):2510-2512. PMID: 29506198; PMCID: PMC6041878.
    Citations:    Fields:    Translation:Humans
  27. Vasilevsky NA, Foster ED, Engelstad ME, Carmody L, Might M, Chambers C, Dawkins HJS, Lewis J, Della Rocca MG, Snyder M, Boerkoel CF, Rath A, Terry SF, Kent A, Searle B, Baynam G, Jones E, Gavin P, Bamshad M, Chong J, Groza T, Adams D, Resnick AC, Heath AP, Mungall C, Holm IA, Rageth K, Brownstein CA, Shefchek K, McMurry JA, Robinson PN, Köhler S, Haendel MA. Plain-language medical vocabulary for precision diagnosis. Nat Genet. 2018 04; 50(4):474-476. PMID: 29632381.
    Citations: 13     Fields:    Translation:Humans
  28. Atkin TA, Maher CM, Gerlach AC, Gay BC, Antonio BM, Santos SC, Padilla KM, Rader J, Krafte DS, Fox MA, Stewart GR, Petrovski S, Devinsky O, Might M, Petrou S, Goldstein DB. A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy. Epilepsia. 2018 04; 59(4):802-813. PMID: 29574705.
    Citations: 11     Fields:    Translation:HumansCells
  29. Owings KG, Lowry JB, Bi Y, Might M, Chow CY. Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches. Hum Mol Genet. 2018 03 15; 27(6):1055-1066. PMID: 29346549; PMCID: PMC5886220.
    Citations: 29     Fields:    Translation:AnimalsCells
  30. Bi Y, Might M, Vankayalapati H, Kuberan B. Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-ß-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease. Bioorg Med Chem Lett. 2017 07 01; 27(13):2962-2966. PMID: 28512024.
    Citations: 15     Fields:    Translation:HumansCells
  31. Might M, Might CC. What happens when N?=?1 and you want plus 1? Prenat Diagn. 2017 Jan; 37(1):70-72. PMID: 27885678.
    Citations: 6     Fields:    Translation:Humans
  32. Lambertson KF, Damiani SA, Might M, Shelton R, Terry SF. Participant-driven matchmaking in the genomic era. Hum Mutat. 2015 Oct; 36(10):965-73. PMID: 26252162.
    Citations: 18     Fields:    Translation:Humans
  33. Might M, Wilsey M. The shifting model in clinical diagnostics: how next-generation sequencing and families are altering the way rare diseases are discovered, studied, and treated. Genet Med. 2014 Oct; 16(10):736-7. PMID: 24651604.
    Citations: 37     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.