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Michael Ned Margolies, M.D.

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  1. R01HL047415 (MARGOLIES, MICHAEL N) Aug 1, 1992 - Jul 31, 2001
    NIH/NHLBI
    ENGINEERING OF ANTIDIGOXIN ANTIBODY COMBINING SITES
    Role: Principal Investigator
  2. R01CA024432 (MARGOLIES, MICHAEL N) May 1, 1978 - Jun 30, 1996
    NIH/NCI
    SEQUENCE, SHAPE AND SPECIFICITY OF ANTIBODIES
    Role: Principal Investigator
  3. P01HL019259 (MARGOLIES, MICHAEL N) Jun 1, 1976 - May 31, 1992
    NIH/NHLBI
    ANTIBODIES AS TOOLS IN CARDIOVASCULAR RESEARCH
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Krykbaev RA, Tsantili P, Jeffrey PD, Margolies MN. Modifying specificity of antidigoxin antibodies using insertional mutagenesis. Protein Sci. 2002 Dec; 11(12):2899-908. PMID: 12441388.
    Citations:    Fields:    Translation:AnimalsCells
  2. Parhami-Seren B, Haberly R, Margolies MN, Haupert GT. Ouabain-binding protein(s) from human plasma. Hypertension. 2002 Aug; 40(2):220-8. PMID: 12154117.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  3. Short MK, Krykbaev RA, Jeffrey PD, Margolies MN. Complementary combining site contact residue mutations of the anti-digoxin Fab 26-10 permit high affinity wild-type binding. J Biol Chem. 2002 May 10; 277(19):16365-70. PMID: 11854275.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Parhami-Seren B, Viswanathan M, Margolies MN. Selection of high affinity p-azophenyarsonate Fabs from heavy-chain CDR2 insertion libraries. J Immunol Methods. 2002 Jan 01; 259(1-2):43-53. PMID: 11730840.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Parhami-Seren B, Viswanathan M, Strong RK, Margolies MN. Structural analysis of mutants of high-affinity and low-affinity p-azophenylarsonate-specific antibodies generated by alanine scanning of heavy chain complementarity-determining region 2. J Immunol. 2001 Nov 01; 167(9):5129-35. PMID: 11673524.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Short MK, Jeffrey PD, Demirjian A, Margolies MN. A single H:CDR3 residue in the anti-digoxin antibody 26-10 modulates specificity for C16-substituted digoxin analogs. Protein Eng. 2001 Apr; 14(4):287-96. PMID: 11391021.
    Citations: 3     Fields:    Translation:HumansCells
  7. Krykbaev RA, Liu WR, Jeffrey PD, Margolies MN. Phage display-selected sequences of the heavy-chain CDR3 loop of the anti-digoxin antibody 26-10 define a high affinity binding site for position 16-substituted analogs of digoxin. J Biol Chem. 2001 Mar 16; 276(11):8149-58. PMID: 11060305.
    Citations: 2     Fields:    Translation:Cells
  8. Ball WJ, Wang Z, Malik B, Kasturi R, Dey P, Short MK, Margolies MN. Selection of peptidic mimics of digoxin from phage-displayed peptide libraries by anti-digoxin antibodies. J Mol Biol. 2000 Aug 04; 301(1):101-15. PMID: 10926495.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Roy P, Roth CM, Margolies MN, Yarmush ML. Aromatic residues mediate the pressure-induced association of digoxigenin and antibody 26-10. Biophys Chem. 2000 Jan 24; 83(3):171-7. PMID: 10647847.
    Citations:    Fields:    
  10. Kim SH, Titlow CC, Margolies MN. An approach for preventing recombination-deletion of the 40-50 anti-digoxin antibody V(H) gene from the phage display vector pComb3. Gene. 2000 Jan 04; 241(1):19-25. PMID: 10607894.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Roy P, Roth CM, Margolies MN, Yarmush ML. Effect of pressure on antigen-antibody complexes: modulation by temperature and ionic strength. Mol Immunol. 1999 Dec; 36(17):1149-58. PMID: 10698317.
    Citations: 1     Fields:    Translation:Animals
  12. Parhami-Seren B, Bell C, Margolies MN, Haupert GT. Monoclonal antibodies that distinguish between two related digitalis glycosides, ouabain and digoxin. J Immunol. 1999 Oct 15; 163(8):4360-6. PMID: 10510376.
    Citations:    Fields:    Translation:AnimalsCells
  13. Wong YW, Gill DS, Parhami-Seren B, Short MK, Sompuram SR, Margolies MN. Structural requirements for a specificity switch and for maintenance of affinity using mutational analysis of a phage-displayed anti-arsonate antibody of Fab heavy chain first complementarity-determining region. J Immunol. 1998 Jun 15; 160(12):5990-7. PMID: 9637513.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Kasturi R, Yuan J, McLean LR, Margolies MN, Ball WJ. Identification of a model cardiac glycoside receptor: comparisons with Na+,K+-ATPase. Biochemistry. 1998 May 12; 37(19):6658-66. PMID: 9578549.
    Citations:    Fields:    Translation:AnimalsCells
  15. Kasturi R, McLean LR, Margolies MN, Ball WJ. High affinity anti-digoxin antibodies as model receptors for cardiac glycosides. Comparisons with Na+,K(+)-ATPase. Ann N Y Acad Sci. 1997 Nov 03; 834:634-6. PMID: 9405877.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Gill DS, Wong YW, Margolies MN. Differences in sequence-specific expression of two anti-arsonate Fabs in E. coli. Biotechnol Prog. 1997 Sep-Oct; 13(5):692-4. PMID: 9336990.
    Citations: 1     Fields:    Translation:Cells
  17. Parhami-Seren B, Margolies MN. Contribution of heavy chain junctional amino acid diversity to antibody affinity among p-azophenylarsonate-specific antibodies. J Immunol. 1996 Sep 01; 157(5):2066-72. PMID: 8757328.
    Citations: 1     Fields:    Translation:AnimalsCells
  18. Huston JS, Margolies MN, Haber E. Antibody binding sites. Adv Protein Chem. 1996; 49:329-450. PMID: 8908302.
    Citations: 3     Fields:    Translation:Cells
  19. Short MK, Jeffrey PD, Kwong RF, Margolies MN. Contribution of antibody heavy chain CDR1 to digoxin binding analyzed by random mutagenesis of phage-displayed Fab 26-10. J Biol Chem. 1995 Dec 01; 270(48):28541-50. PMID: 7499368.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Jeffrey PD, Schildbach JF, Chang CY, Kussie PH, Margolies MN, Sheriff S. Structure and specificity of the anti-digoxin antibody 40-50. J Mol Biol. 1995 Apr 28; 248(2):344-60. PMID: 7739045.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Wong YW, Kussie PH, Parhami-Seren B, Margolies MN. Modulation of antibody affinity by an engineered amino acid substitution. J Immunol. 1995 Apr 01; 154(7):3351-8. PMID: 7897218.
    Citations:    Fields:    Translation:AnimalsCells
  22. Chang CY, Shih H, Jeffrey PD, Margolies MN, Sheriff S. Crystallization and preliminary X-ray analysis of anti-digoxin antibodies. Acta Crystallogr D Biol Crystallogr. 1994 Nov 01; 50(Pt 6):915-7. PMID: 15299362.
    Citations:    Fields:    
  23. Kussie PH, Parhami-Seren B, Wysocki LJ, Margolies MN. A single engineered amino acid substitution changes antibody fine specificity. J Immunol. 1994 Jan 01; 152(1):146-52. PMID: 8254187.
    Citations: 8     Fields:    Translation:AnimalsCells
  24. Ping J, Schildbach JF, Shaw SY, Quertermous T, Novotny J, Bruccoleri R, Margolies MN. Effect of heavy chain signal peptide mutations and NH2-terminal chain length on binding of anti-digoxin antibodies. J Biol Chem. 1993 Nov 05; 268(31):23000-7. PMID: 8226814.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Jeffrey PD, Strong RK, Sieker LC, Chang CY, Campbell RL, Petsko GA, Haber E, Margolies MN, Sheriff S. 26-10 Fab-digoxin complex: affinity and specificity due to surface complementarity. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):10310-4. PMID: 8234291.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  26. Schildbach JF, Near RI, Bruccoleri RE, Haber E, Jeffrey PD, Ng SC, Novotny J, Sheriff S, Margolies MN. Heavy chain position 50 is a determinant of affinity and specificity for the anti-digoxin antibody 26-10. J Biol Chem. 1993 Oct 15; 268(29):21739-47. PMID: 7691815.
    Citations: 5     Fields:    Translation:AnimalsCells
  27. Panka DJ, Very DL, Jacobson BA, Kussie PH, Parhami-Seren B, Margolies MN, Marshak-Rothstein A. Defining the structural correlates responsible for loss of arsonate affinity in an IDCR antibody isolated from an autoimmune mouse. Mol Immunol. 1993 Aug; 30(11):1013-20. PMID: 8350871.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Parhami-Seren B, Kussie PH, Strong RK, Margolies MN. Conservation of binding site geometry among p-azophenylarsonate-specific antibodies. J Immunol. 1993 Mar 01; 150(5):1829-37. PMID: 8436818.
    Citations: 3     Fields:    Translation:HumansCells
  29. Schillbach JF, Near RI, Bruccoleri RE, Haber E, Jeffrey PD, Novotny J, Sheriff S, Margolies MN. Modulation of antibody affinity by a non-contact residue. Protein Sci. 1993 Feb; 2(2):206-14. PMID: 8443598.
    Citations: 7     Fields:    Translation:AnimalsCells
  30. Shaw SY, Margolies MN. A spontaneous variant of an antidigoxin hybridoma antibody with increased affinity arises from a heavy chain signal peptide mutation. Mol Immunol. 1992 Apr; 29(4):525-9. PMID: 1565100.
    Citations: 1     Fields:    Translation:AnimalsCells
  31. Strong RK, Petsko GA, Sharon J, Margolies MN. Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 2. Structural basis of hapten binding and idiotypy. Biochemistry. 1991 Apr 16; 30(15):3749-57. PMID: 2015230.
    Citations: 7     Fields:    Translation:AnimalsCells
  32. Strong RK, Campbell R, Rose DR, Petsko GA, Sharon J, Margolies MN. Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten. Biochemistry. 1991 Apr 16; 30(15):3739-48. PMID: 2015229.
    Citations: 16     Fields:    Translation:Cells
  33. Schildbach JF, Panka DJ, Parks DR, Jager GC, Novotny J, Herzenberg LA, Mudgett-Hunter M, Bruccoleri RE, Haber E, Margolies MN. Altered hapten recognition by two anti-digoxin hybridoma variants due to variable region point mutations. J Biol Chem. 1991 Mar 05; 266(7):4640-7. PMID: 1999439.
    Citations: 9     Fields:    Translation:Cells
  34. Wildey GM, Fischman AJ, Margolies MN, Graham RM, Homcy CJ. Phosphorylation state of pro-atrial natriuretic factor in rat atrial secretory granules. Endocrinology. 1990 Dec; 127(6):2839-48. PMID: 2174336.
    Citations:    Fields:    Translation:AnimalsCells
  35. Hudson NW, Bruccoleri RE, Steinrauf LK, Hamilton JA, Mudgett-Hunter M, Margolies MN. A V kappa-J kappa junctional change in an antidigoxin recombinant antibody destroys digoxin-binding activity. J Immunol. 1990 Oct 15; 145(8):2718-24. PMID: 2120338.
    Citations: 3     Fields:    Translation:AnimalsCells
  36. Parhami-Seren B, Wysocki LJ, Margolies MN, Sharon J. Clustered H chain somatic mutations shared by anti-p-azophenylarsonate antibodies confer enhanced affinity and ablate the cross-reactive idiotype. J Immunol. 1990 Oct 01; 145(7):2340-6. PMID: 2118935.
    Citations: 7     Fields:    Translation:AnimalsCells
  37. Near RI, Ng SC, Mudgett-Hunter M, Hudson NW, Margolies MN, Seidman JG, Haber E, Jacobson MA. Heavy and light chain contributions to antigen binding in an anti-digoxin chain recombinant antibody produced by transfection of cloned anti-digoxin antibody genes. Mol Immunol. 1990 Sep; 27(9):901-9. PMID: 2120577.
    Citations: 5     Fields:    Translation:AnimalsCells
  38. Wysocki LJ, Gefter ML, Margolies MN. Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversion. J Exp Med. 1990 Jul 01; 172(1):315-23. PMID: 2358780.
    Citations: 7     Fields:    Translation:AnimalsCells
  39. Parhami-Seren B, Sharon J, Margolies MN. Structural characterization of H chain-associated idiotopes of anti-p-azophenylarsonate monoclonal antibodies. J Immunol. 1990 Jun 01; 144(11):4426-33. PMID: 2111347.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Rose DR, Strong RK, Margolies MN, Gefter ML, Petsko GA. Crystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):338-42. PMID: 2296590.
    Citations: 5     Fields:    Translation:Cells
  41. Parhami-Seren B, Wysocki L, Margolies MN. The amino acid residues at the VH-D-JH junctions affect the affinity of anti-p-azophenylarsonate antibodies. J Immunol. 1989 Dec 15; 143(12):4090-7. PMID: 2512349.
    Citations: 5     Fields:    Translation:AnimalsCells
  42. Becker ML, Near R, Mudgett-Hunter M, Margolies MN, Kubo RT, Kaye J, Hedrick SM. Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell. 1989 Sep 08; 58(5):911-21. PMID: 2528411.
    Citations: 37     Fields:    Translation:AnimalsCells
  43. Lin SF, Coll M, Gefter ML, Margolies MN, Wang AH. Preliminary crystallographic studies of the Fab fragment of an anti-azophenylarsonate antibody. J Mol Biol. 1989 Apr 20; 206(4):789-90. PMID: 2738920.
    Citations:    Fields:    Translation:AnimalsCells
  44. Sharon J, Gefter ML, Wysocki LJ, Margolies MN. Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten. J Immunol. 1989 Jan 15; 142(2):596-601. PMID: 2911012.
    Citations: 21     Fields:    Translation:AnimalsCells
  45. Fischman AJ, Wildey GM, Matsueda GR, Margolies MN, Zisfein JB, Homcy CJ, Graham RM. Specificity of serine proteases for cleavage sites on proatrial natriuretic factor. Peptides. 1988 Nov-Dec; 9(6):1275-83. PMID: 2977643.
    Citations: 1     Fields:    Translation:AnimalsCells
  46. Huston JS, Levinson D, Mudgett-Hunter M, Tai MS, Novotný J, Margolies MN, Ridge RJ, Bruccoleri RE, Haber E, Crea R, et al. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):5879-83. PMID: 3045807.
    Citations: 253     Fields:    Translation:Cells
  47. Mikoryak CA, Margolies MN, Steiner LA. J chain in Rana catesbeiana high molecular weight Ig. J Immunol. 1988 Jun 15; 140(12):4279-85. PMID: 3131430.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  48. Panka DJ, Mudgett-Hunter M, Parks DR, Peterson LL, Herzenberg LA, Haber E, Margolies MN. Variable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies. Proc Natl Acad Sci U S A. 1988 May; 85(9):3080-4. PMID: 3129726.
    Citations: 12     Fields:    Translation:AnimalsCells
  49. Manser T, Parhami-Seren B, Margolies MN, Gefter ML. Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response? J Exp Med. 1987 Nov 01; 166(5):1456-63. PMID: 3681190.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  50. Hudson NW, Mudgett-Hunter M, Panka DJ, Margolies MN. Immunoglobulin chain recombination among antidigoxin antibodies by hybridoma-hybridoma fusion. J Immunol. 1987 Oct 15; 139(8):2715-23. PMID: 3655369.
    Citations: 3     Fields:    Translation:Cells
  51. Panka DJ, Margolies MN. Complete variable region sequences of five homologous high affinity anti-digoxin antibodies. J Immunol. 1987 Oct 01; 139(7):2385-91. PMID: 3655367.
    Citations: 4     Fields:    Translation:AnimalsCells
  52. Manser T, Wysocki LJ, Margolies MN, Gefter ML. Evolution of antibody variable region structure during the immune response. Immunol Rev. 1987 Apr; 96:141-62. PMID: 3298006.
    Citations: 37     Fields:    Translation:AnimalsCells
  53. Smith JA, Margolies MN. Complete amino acid sequences of the heavy and light chain variable regions from two A/J mouse antigen nonbinding monoclonal antibodies bearing the predominant p-azophenyl arsonate idiotype. Biochemistry. 1987 Jan 27; 26(2):604-12. PMID: 3103682.
    Citations: 5     Fields:    Translation:AnimalsCells
  54. Bloch KD, Zisfein JB, Margolies MN, Homcy CJ, Seidman JG, Graham RM. A serum protease cleaves proANF into a 14-kilodalton peptide and ANF. Am J Physiol. 1987 Jan; 252(1 Pt 1):E147-51. PMID: 2949627.
    Citations: 4     Fields:    Translation:AnimalsCells
  55. Matsueda GR, Margolies MN. Structural basis for the species selectivity of a fibrin-specific monoclonal antibody. Biochemistry. 1986 Mar 25; 25(6):1451-5. PMID: 2421767.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  56. Bloch KD, Scott JA, Zisfein JB, Fallon JT, Margolies MN, Seidman CE, Matsueda GR, Homcy CJ, Graham RM, Seidman JG. Biosynthesis and secretion of proatrial natriuretic factor by cultured rat cardiocytes. Science. 1985 Dec 06; 230(4730):1168-71. PMID: 2933808.
    Citations: 17     Fields:    Translation:AnimalsCells
  57. Gross J, Carlson RI, Brauer AW, Margolies MN, Warshaw AL, Wands JR. Isolation, characterization, and distribution of an unusual pancreatic human secretory protein. J Clin Invest. 1985 Dec; 76(6):2115-26. PMID: 3908481.
    Citations: 32     Fields:    Translation:HumansCells
  58. Gross J, Brauer AW, Bringhurst RF, Corbett C, Margolies MN. An unusual bovine pancreatic protein exhibiting pH-dependent globule-fibril transformation and unique amino acid sequence. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5627-31. PMID: 3862086.
    Citations: 12     Fields:    Translation:AnimalsCells
  59. Mudgett-Hunter M, Anderson W, Haber E, Margolies MN. Binding and structural diversity among high-affinity monoclonal anti-digoxin antibodies. Mol Immunol. 1985 Apr; 22(4):477-88. PMID: 4033667.
    Citations: 14     Fields:    Translation:AnimalsCells
  60. Wysocki LJ, Margolies MN, Huang B, Nemazee DA, Wechsler DS, Sato VL, Smith JA, Gefter ML. Combinational diversity within variable regions bearing the predominant anti-p-azophenylarsonate idiotype of strain A mice. J Immunol. 1985 Apr; 134(4):2740-7. PMID: 2982953.
    Citations: 5     Fields:    Translation:AnimalsCells
  61. Gridley T, Margolies MN, Gefter ML. The association of various D elements with a single-immunoglobulin VH gene segment: influence on the expression of a major cross-reactive idiotype. J Immunol. 1985 Feb; 134(2):1236-44. PMID: 3917472.
    Citations: 12     Fields:    Translation:AnimalsCells
  62. Juszczak E, Near RI, Gefter ML, Margolies MN. Complete heavy and light chain variable region sequence of anti-arsonate monoclonal antibodies from BALB/c and A/J mice sharing the 36-60 idiotype are highly homologous. J Immunol. 1984 Nov; 133(5):2603-9. PMID: 6207237.
    Citations: 8     Fields:    Translation:AnimalsCells
  63. Smith JA, Margolies MN. Complete amino acid sequence of the heavy-chain variable region from an A/J mouse antigen-nonbinding monoclonal antibody bearing the predominant arsonate idiotype. Biochemistry. 1984 Sep 25; 23(20):4726-32. PMID: 6437441.
    Citations: 7     Fields:    Translation:AnimalsCells
  64. Lechat P, Mudgett-Hunter M, Margolies MN, Haber E, Smith TW. Reversal of lethal digoxin toxicity in guinea pigs using monoclonal antibodies and Fab fragments. J Pharmacol Exp Ther. 1984 Apr; 229(1):210-3. PMID: 6707937.
    Citations: 5     Fields:    Translation:Animals
  65. Near RI, Juszczak EC, Huang SY, Sicari SA, Margolies MN, Gefter ML. Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2167-71. PMID: 6326109.
    Citations: 28     Fields:    Translation:AnimalsCells
  66. Brauer AW, Oman CL, Margolies MN. Use of o-phthalaldehyde to reduce background during automated Edman degradation. Anal Biochem. 1984 Feb; 137(1):134-42. PMID: 6428262.
    Citations: 36     Fields:    Translation:Cells
  67. Gefter ML, Margolies MN, Near RI, Wysocki LJ. Analysis of the anti-azobenzenearsonate response at the molecular level. Ann Immunol (Paris). 1984 Jan-Feb; 135C(1):17-30. PMID: 6712160.
    Citations: 1     Fields:    Translation:AnimalsCells
  68. Juszczak EC, Margolies MN. Amino acid sequence of the heavy chain variable region from the A/J mouse anti-arsonate monoclonal antibody 36-60 bearing a minor idiotype. Biochemistry. 1983 Aug 30; 22(18):4291-6. PMID: 6414509.
    Citations: 1     Fields:    Translation:AnimalsCells
  69. Rose DR, Seaton BA, Petsko GA, Novotný J, Margolies MN, Locke E, Haber E. Crystallization of the Fab fragment of a monoclonal anti-digoxin antibody and its complex with digoxin. J Mol Biol. 1983 Mar 25; 165(1):203-6. PMID: 6842605.
    Citations: 4     Fields:    Translation:Cells
  70. Novotn? J, Margolies MN. Amino acid sequence of the light chain variable region from a mouse anti-digoxin hybridoma antibody. Biochemistry. 1983 Mar 01; 22(5):1153-8. PMID: 6404298.
    Citations: 5     Fields:    Translation:AnimalsCells
  71. Rothstein TL, Margolies MN, Gefter ML, Marshak-Rothstein A. Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response. J Exp Med. 1983 Feb 01; 157(2):795-800. PMID: 6185619.
    Citations: 5     Fields:    Translation:AnimalsCells
  72. Margolies MN, Wysocki LJ, Sato VL. Immunoglobulin idiotype and anti-anti-idiotype utilize the same variable region genes irrespective of antigen specificity. J Immunol. 1983 Feb; 130(2):515-7. PMID: 6184395.
    Citations: 8     Fields:    Translation:AnimalsCells
  73. Mudgett-Hunter M, Budzik GP, Donahoe PK, Khaw BA, Margolies MN, Ridgeway EC, Haber E. Monoclonal antibodies as physiologic probes. Basic Life Sci. 1983; 25:101-28. PMID: 6190474.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  74. Margolies MN, Juszczak EC, Near R, Marshak-Rothstein A, Rothstein TL, Sato VL, Siekevitz M, Smith JA, Wysocki LJ, Gefter ML. Structural correlates of idiotypy in the arsonate system. Ann N Y Acad Sci. 1983; 418:48-64. PMID: 6424532.
    Citations: 8     Fields:    Translation:AnimalsCells
  75. Hunter MM, Margolies MN, Ju A, Haber E. High-affinity monoclonal antibodies to the cardiac glycoside, digoxin. J Immunol. 1982 Sep; 129(3):1165-72. PMID: 6179995.
    Citations: 20     Fields:    Translation:Animals
  76. Cambria RP, Margolies MN. Hepatic portal venous gas in diverticulitis: survival in a steroid-treated patient. Arch Surg. 1982 Jun; 117(6):834-5. PMID: 7082173.
    Citations: 7     Fields:    Translation:Humans
  77. Huang SY, Margolies MN, Rothstein AM, Siekevitz M, Gefter ML. Analysis of immune response at the molecular level. Pharmacol Rev. 1982 Mar; 34(1):43-9. PMID: 7071124.
    Citations: 1     Fields:    Translation:AnimalsCells
  78. Margolies MN, Marshak-Rothstein A, Gefter ML. Structural diversity among anti-p-azophenylarsonate monoclonal antibodies from A/J mice; comparison of Id- and Id+ sequences. Mol Immunol. 1981 Dec; 18(12):1065-77. PMID: 6801478.
    Citations: 19     Fields:    Translation:AnimalsCells
  79. Marshak-Rothstein A, Margolies MN, Benedetto JD, Gefter ML. Two structurally distinct and independently regulated idiotypic families associated with the A/J response to azophenylarsonate. Eur J Immunol. 1981 Jul; 11(7):565-72. PMID: 7286063.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  80. Matsueda GR, Haber E, Margolies MN. Quantitative solid-phase Edman degradation for evaluation of extended solid-phase peptide synthesis. Biochemistry. 1981 Apr 28; 20(9):2571-80. PMID: 6786336.
    Citations: 2     Fields:    Translation:AnimalsCells
  81. Akins CW, Thurer RL, Waltman AC, Margolies MN, Schneider RC. A misplaced caval filter: its removal from the heart without cardiopulmonary bypass. Arch Surg. 1980 Sep; 115(9):1133. PMID: 7416963.
    Citations:    Fields:    Translation:HumansCells
  82. Ehrlich PH, Matsueda GR, Margolies MN, Husain SS, Haber E. Isolation of an active heavy-chain variable domain from a homogeneous rabbit antibody by cathepsin B digestion of the aminoethylated heavy chain. Biochemistry. 1980 Aug 19; 19(17):4091-6. PMID: 6157405.
    Citations:    Fields:    Translation:AnimalsCells
  83. Marshak-Rothstein A, Siekevitz M, Margolies MN, Mudgett-Hunter M, Gefter ML. Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice. Proc Natl Acad Sci U S A. 1980 Feb; 77(2):1120-4. PMID: 6767242.
    Citations: 46     Fields:    Translation:AnimalsCells
  84. Matalon TS, Athanasoulis CA, Margolies MN, Waltman AC, Novelline RA, Greenfield AJ, Miller SE. Hemorrhage with pelvic fractures: efficacy of transcatheter embolization. AJR Am J Roentgenol. 1979 Nov; 133(5):859-64. PMID: 115274.
    Citations: 10     Fields:    Translation:Humans
  85. Ehrlich PH, Matsueda GR, Haber E, Margolies MN. Isolation and characterization of an active variable domain from a homogeneous rabbit antibody light chain. Biochemistry. 1979 Oct 02; 18(20):4411-8. PMID: 114216.
    Citations: 1     Fields:    Translation:AnimalsCells
  86. Matsueda GR, Margolies MN. Increased efficiency in solid-phase Edman degradation of synthetic peptidyl-resins using an oxymethylphenylacetamidomethyl-linkage. FEBS Lett. 1979 Oct 01; 106(1):89-92. PMID: 499506.
    Citations:    Fields:    Translation:Cells
  87. Steiner LA, Pardo AG, Margolies MN. Amino acid sequence of the heavy-chain variable region of the crystallizable human myeloma protein Dob. Biochemistry. 1979 Sep 18; 18(19):4068-80. PMID: 114209.
    Citations: 7     Fields:    Translation:HumansCells
  88. Ferrucci JT, Wittenberg J, Margolies MN, Carey RW. Malignant seeding of the tract after thin-needle aspiration biopsy. Radiology. 1979 Feb; 130(2):345-6. PMID: 760147.
    Citations: 41     Fields:    Translation:Humans
  89. Ehrlich PH, Matsueda GR, Margolies MN, Haber E. Preparation of an active Fd fragment by cyanogen bromide cleavage of an IgG heavy chain from a homogeneous rabbit antibody. Immunochemistry. 1978 Dec; 15(12):937-40. PMID: 35462.
    Citations: 1     Fields:    Translation:AnimalsCells
  90. Cannon LE, Margolies MN, Haber E. Light chain variable region sequence of rabbit antipneumococcal type III polysaccharide antibody 3368. Biochemistry. 1978 Jul 25; 17(15):3101-9. PMID: 100133.
    Citations: 1     Fields:    Translation:AnimalsCells
  91. Zurawski VR, Novotný J, Haber E, Margolies MN. Antibodies of restricted heterogeneity directed against the cardiac glycoside digoxin. J Immunol. 1978 Jul; 121(1):122-9. PMID: 27558.
    Citations: 1     Fields:    Translation:AnimalsCells
  92. Novotný J, Franek F, Margolies MN, Haber E. Amino acid sequence of normal (microheterogeneous) porcine immunoglobulin lambda chains. Biochemistry. 1977 Aug 23; 16(17):3765-72. PMID: 409425.
    Citations: 3     Fields:    Translation:AnimalsCells
  93. Margolies MN, Cannon LE, Kindt TJ, Fraser B. The structural basis of rabbit VH allotypes: serologic studies on a1 H chains with defined amino acid sequence. J Immunol. 1977 Jul; 119(1):287-94. PMID: 406325.
    Citations: 6     Fields:    Translation:AnimalsCells
  94. Haber E, Margolies MN, Cannon LE. Origins of antibody diversity: insight gained from amino acid sequence studies of elicited antibodies. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 2:647-59. PMID: 19193.
    Citations: 2     Fields:    Translation:AnimalsCells
  95. Wittenberg J, Maturi RA, Ferrucci JT, Margolies MN. Computerized tomography of in vitro abdominal organs--effect of preservation methods on attenuation coefficient. Comput Tomogr. 1977; 1(1):95-101. PMID: 565690.
    Citations:    Fields:    Translation:AnimalsCells
  96. Chen FW, Cannon LE, Margolies MN, Strosberg AD, Haber E. Purification, specificity, and hypervariable region sequence of anti-pneumococcal polysaccharide antibodies elicited in a single rabbit. J Immunol. 1976 Sep; 117(3):807-13. PMID: 8570.
    Citations: 1     Fields:    Translation:AnimalsCells
  97. Cannon LE, Margolies MN, Strosberg AD, Chen FW, Newell J, Haber E. Diversity among rabbit antibody light chain amino terminal sequences. J Immunol. 1976 Jul; 117(1):160-7. PMID: 819580.
    Citations: 1     Fields:    Translation:AnimalsCells
  98. Strosberg AD, Margolies MN, Haber E. The interdomain disulfide bond of a homogeneous rabbit pneumococcal antibody light chain. J Immunol. 1975 Nov; 115(5):1422-4. PMID: 240892.
    Citations: 5     Fields:    Translation:AnimalsCells
  99. Brauer AW, Margolies MN, Haber E. The application of 0.1 M quadrol to the microsequence of proteins and the sequence of tryptic peptides. Biochemistry. 1975 Jul; 14(13):3029-35. PMID: 1148190.
    Citations: 84     Fields:    Translation:Cells
  100. Margolies MN, Cannon LE, Strosberg AD, Haber E. Diversity of light chain variable region sequences among rabbit antibodies elicited by the same antigens. Proc Natl Acad Sci U S A. 1975 Jun; 72(6):2180-4. PMID: 1094456.
    Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
  101. Rosemblatt MS, Margolies MN, Cannon LE, Haber E. Peptides: an analytical method for their resolution by polyacrylamide gel electrophoresis applicable to a wide range of sizes and solubilities. Anal Biochem. 1975 May 12; 65(1-2):321-30. PMID: 236694.
    Citations: 6     Fields:    
  102. Selden R, Margolies MN, Smith TW. Renal and gastrointestinal excretion of ouabain in dog and man. J Pharmacol Exp Ther. 1974 Mar; 188(3):615-23. PMID: 4816328.
    Citations: 9     Fields:    Translation:HumansAnimals
  103. Ring EJ, Athanasoulis C, Waltman AC, Margolies MN, Baum S. Arteriographic management of hemorrhage following pelvic fracture. Radiology. 1973 Oct; 109(1):65-70. PMID: 4783129.
    Citations: 16     Fields:    Translation:Humans
  104. Kerr WS, Margolies MN, Ring EJ, Waltman AC, Baum SN. Arteriography in pelvic fractures with massive hemorrhage. J Urol. 1973 Mar; 109(3):479-82. PMID: 4692385.
    Citations: 1     Fields:    Translation:Humans
  105. Strosberg AD, Fraser KJ, Margolies MN, Haber E. Amino acid sequence of rabbit pneumococcal antibody. I. Light-chain cysteine-containing peptides. Biochemistry. 1972 Dec 19; 11(26):4978-85. PMID: 4118103.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  106. Margolies MN, Ring EJ, Waltman AC, Kerr WS, Baum S. Arteriography in the management of hemorrhage from pelvic fractures. N Engl J Med. 1972 Aug 17; 287(7):317-21. PMID: 5041699.
    Citations: 22     Fields:    Translation:Humans
  107. Kerr WS, Margolies MN, Ring EJ, Waltman AC, Baum SN. Arteriography in pelvic fractures with massive hemorrhage. Trans Am Assoc Genitourin Surg. 1972; 64:14-7. PMID: 4654520.
    Citations:    Fields:    Translation:Humans
  108. Jaton JC, Waterfield MD, Margolies MN, Bloch KJ, Haber E. Variation in the primary structure of antibodies during the course of immunization. Biochemistry. 1971 Apr 27; 10(9):1583-7. PMID: 4103273.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  109. Jaton JC, Waterfield MD, Margolies MN, Haber E. Isolation and characterization of structurally homogeneous antibodies from antipneumococcal sera. Proc Natl Acad Sci U S A. 1970 Jul; 66(3):959-66. PMID: 4393268.
    Citations: 8     Fields:    Translation:AnimalsCells
  110. Whitfield HJ, Gutnick DL, Margolies MN, Martin RG, Rechler MM, Voll MJ. Relative translation frequencies of the cistrons of the histidine operon. J Mol Biol. 1970 Apr 14; 49(1):245-9. PMID: 4915861.
    Citations: 5     Fields:    Translation:Cells
  111. Margolies MN, Goldberger RF. Correlation between mutation type and the production of cross-reacting material in mutants of the A gene of the histidine operon in Salmonella typhimurium. J Bacteriol. 1968 Feb; 95(2):507-19. PMID: 4966548.
    Citations: 6     Fields:    Translation:Cells
  112. Margolies MN, Goldberger RF. Physical and chemical characterization of the isomerase of histidine biosynthesis in Salmonella typhimurium. J Biol Chem. 1967 Jan 25; 242(2):256-64. PMID: 4959618.
    Citations: 8     Fields:    Translation:Cells
  113. Margolies MN, Goldberger RF. Isolation of the fourth (isomerase) of histidine biosynthesis from Salmonella typhimurium. J Biol Chem. 1966 Jul 25; 241(14):3262-9. PMID: 5330429.
    Citations: 10     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.