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Seth M. Bloom, Ph.D., M.D.

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Biography
education and training
Washington University, St. Louis, MO, USABA05/2004Biology
Washington University School of Medicine, St. Louis, MO, USAMD, PhD05/2012Medicine and Microbiology
Barnes-Jewish Hospital & Washington University, St. Louis, MO, USA06/2015Internal Medicine (residency)
Massachusetts General Hospital and Brigham & Women's Hospital, Boston, MA, USA07/2017Infectious Diseases (fellowship)

Overview
overview
I am an Infectious Disease physician-scientist at Massachusetts General Hospital and Instructor in Medicine at HMS doing research at the Ragon Institute of MGH, MIT, and Harvard. I study how the cervicovaginal microbiota and metabolome influence genital tract health, mucosal immunity, and risk for diseases such as HIV and bacterial vaginosis. I seek to elucidate basic mechanisms of disease and identify new therapies to modify microbiota composition. This research is broadly relevant for genital tract health but holds particular importance for southern and eastern African populations, where the burden of key microbiota-associated diseases is highest.
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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yockey LJ, Hussain FA, Bergerat A, Reissis A, Worrall D, Xu J, Gomez I, Bloom SM, Mafunda NA, Kelly J, Kwon DS, Mitchell CM. Screening and characterization of vaginal fluid donations for vaginal microbiota transplantation. Sci Rep. 2022 10 26; 12(1):17948. PMID: 36289360; PMCID: PMC9606370.
    Citations:    Fields:    Translation:HumansCells
  2. Li JC, Siglin J, Marshall MS, Stemmer-Rachamimov A, Bloom SM, Blumenthal KG. Successful Treatment of Delayed Localized Necrotizing Inflammatory Myositis After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccine: A Case Report. Open Forum Infect Dis. 2022 Oct; 9(10):ofac499. PMID: 36267257.
    Citations:    
  3. Tazinkeng NN, Teuwafeu DG, Asombang AW, Agbor VN, Bloom SM, Nkhoma AN, Mohareb AM, Luma HN. Factors associated with hepatitis B and C among adults in Buea, Cameroon: A community-based cross-sectional study. Liver Int. 2022 11; 42(11):2396-2402. PMID: 35946051.
    Citations:    Fields:    Translation:HumansCells
  4. Bloom SM, Mafunda NA, Woolston BM, Hayward MR, Frempong JF, Abai AB, Xu J, Mitchell AJ, Westergaard X, Hussain FA, Xulu N, Dong M, Dong KL, Gumbi T, Ceasar FX, Rice JK, Choksi N, Ismail N, Ndung'u T, Ghebremichael MS, Relman DA, Balskus EP, Mitchell CM, Kwon DS. Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation. Nat Microbiol. 2022 03; 7(3):434-450. PMID: 35241796.
    Citations: 1     Fields:    Translation:HumansCells
  5. Byrne EH, Farcasanu M, Bloom SM, Xulu N, Xu J, Hykes BL, Mafunda NA, Hayward MR, Dong M, Dong KL, Gumbi T, Ceasar FX, Ismail N, Ndung'u T, Gosmann C, Ghebremichael MS, Handley SA, Mitchell CM, Villani AC, Kwon DS. Antigen Presenting Cells Link the Female Genital Tract Microbiome to Mucosal Inflammation, With Hormonal Contraception as an Additional Modulator of Inflammatory Signatures. Front Cell Infect Microbiol. 2021; 11:733619. PMID: 34604114.
    Citations:    Fields:    Translation:HumansCells
  6. Munoz A, Hayward MR, Bloom SM, Rocafort M, Ngcapu S, Mafunda NA, Xu J, Xulu N, Dong M, Dong KL, Ismail N, Ndung'u T, Ghebremichael MS, Kwon DS. Modeling the temporal dynamics of cervicovaginal microbiota identifies targets that may promote reproductive health. Microbiome. 2021 07 26; 9(1):163. PMID: 34311774.
    Citations: 4     Fields:    Translation:HumansCells
  7. Mohareb AM, Rosenberg JM, Bhattacharyya RP, Kotton CN, Chu JT, Jilg N, Hysell KM, Albin JS, Sen P, Bloom SM, Schiff AE, Zachary KC, Letourneau AR, Kim AY, Hurtado RM. Preventing Infectious Complications of Immunomodulation in COVID-19 in Foreign-Born Patients. J Immigr Minor Health. 2021 Dec; 23(6):1343-1347. PMID: 34159495; PMCID: PMC8218971.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  8. Hoang T, Toler E, DeLong K, Mafunda NA, Bloom SM, Zierden HC, Moench TR, Coleman JS, Hanes J, Kwon DS, Lai SK, Cone RA, Ensign LM. The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis. PLoS Pathog. 2020 01; 16(1):e1008236. PMID: 31971984.
    Citations: 23     Fields:    Translation:HumansCells
  9. Lathrop SK, Bloom SM, Rao SM, Nutsch K, Lio CW, Santacruz N, Peterson DA, Stappenbeck TS, Hsieh CS. Peripheral education of the immune system by colonic commensal microbiota. Nature. 2011 Sep 21; 478(7368):250-4. PMID: 21937990.
    Citations: 491     Fields:    Translation:AnimalsCells
  10. Bloom SM, Bijanki VN, Nava GM, Sun L, Malvin NP, Donermeyer DL, Dunne WM, Allen PM, Stappenbeck TS. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe. 2011 May 19; 9(5):390-403. PMID: 21575910.
    Citations: 214     Fields:    Translation:AnimalsCells
  11. Kang SS, Bloom SM, Norian LA, Geske MJ, Flavell RA, Stappenbeck TS, Allen PM. An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med. 2008 Mar 04; 5(3):e41. PMID: 18318596; PMCID: PMC2270287.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  12. Slawson EE, Shaffer CD, Malone CD, Leung W, Kellmann E, Shevchek RB, Craig CA, Bloom SM, Bogenpohl J, Dee J, Morimoto ET, Myoung J, Nett AS, Ozsolak F, Tittiger ME, Zeug A, Pardue ML, Buhler J, Mardis ER, Elgin SC. Comparison of dot chromosome sequences from D. melanogaster and D. virilis reveals an enrichment of DNA transposon sequences in heterochromatic domains. Genome Biol. 2006; 7(2):R15. PMID: 16507169; PMCID: PMC1431729.
    Citations: 34     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.