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profileGuillermo Garcia-Cardena, PH.D.

TitleAssociate Professor of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressHarvard Medical School
Center for Excellence in Vascular Biology, NRB-730C
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-4302
Fax617/525-4330
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
Control of Endothelial and Graft Function by the Mechano-activated Gene KLF2 during Organ Transplantation
Summer, 06/04/07 - 08/24/07
The Role of Ephrin-B2 in Tumor Angiogenesis
Full Time, 01/03/05 - 06/01/05
Role of Transcription Factor KLF2 in Lineage Specification of hiPSC-derived Hematopoietic Stem Cell Progenitors
Part Time, 02/01/12 - 12/31/12
Atheroprotective Effects of Statins on Vascular Endothelium
Summer, 06/01/05 - 08/31/05

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL130624     (GARCIA-CARDENA, GUILLERMO)Sep 15, 2015 - Jun 30, 2019
NIH/NHLBI
Vascular Dysfunction in the Pathogenesis of Severe Malaria
Role: Principal Investigator

R44HL118826     (ADAMS, WILLIAM JAMES)Aug 15, 2013 - May 31, 2019
NIH/NHLBI
Therapeutic Reversal of Endothelial Dysfunction in Atherogenesis
Role: Co-Principal Investigator

R41HL118826     (ADAMS, WILLIAM JAMES)Aug 15, 2013 - Jul 31, 2015
NIH/NHLBI
Pharmacological Targeting of Endothelial Dysfunction in Atherogenesis
Role: Co-Principal Investigator

R21GM103435     (BORENSTEIN, JEFFREY T)Aug 1, 2010 - Sep 30, 2013
NIH/NIGMS
A High-Throughput Flow System to Probe Biomechanics of Pathophysiology
Role: Co-Principal Investigator

R21RR031253     (BORENSTEIN, JEFFREY T)Aug 1, 2010 - Apr 30, 2013
NIH/NCRR
A High-Throughput Flow System to Probe Biomechanics of Pathophysiology
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Malaspinas O, Turjman A, Ribeiro de Sousa D, Garcia-Cardena G, Raes M, Nguyen PT, Zhang Y, Courbebaisse G, Lelubre C, Zouaoui Boudjeltia K, Chopard B. A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. J Theor Biol. 2016 Apr 7; 394:68-76. PMID: 26802480.
    View in: PubMed
  2. Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13. PMID: 24052946; PMCID: PMC3757754.
  3. Koo A, Nordsletten D, Umeton R, Yankama B, Ayyadurai S, García-Cardeña G, Dewey CF. In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology. Biophys J. 2013 May 21; 104(10):2295-306. PMID: 23708369; PMCID: PMC3660651.
  4. Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37. PMID: 23623383; PMCID: PMC3760474.
  5. Timsit MO, Adams WJ, Laguna-Fernandez A, Ichimura T, Bonventre JV, García-Cardeña G, Tullius SG. Flow is critical for maintaining a protective phenotype in renal proximal tubular cells. Am J Transplant. 2013 Jun; 13(6):1617-8. PMID: 23617882; PMCID: PMC4625983.
  6. Giantsos-Adams KM, Koo AJ, Song S, Sakai J, Sankaran J, Shin JH, Garcia-Cardena G, Dewey CF. Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation. Cell Mol Bioeng. 2013 Jun; 6(2):160-174. PMID: 23805169.
    View in: PubMed
  7. Koo A, Dewey CF, García-Cardeña G. Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells. Am J Physiol Cell Physiol. 2013 Jan 15; 304(2):C137-46. PMID: 23114962; PMCID: PMC3546807.
  8. Marrone G, Russo L, Rosado E, Hide D, García-Cardeña G, García-Pagán JC, Bosch J, Gracia-Sancho J. The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins. J Hepatol. 2013 Jan; 58(1):98-103. PMID: 22989565.
    View in: PubMed
  9. Adams WJ, García-Cardeña G. Novel stem cell-based drug discovery platforms for cardiovascular disease. J Biomol Screen. 2012 Oct; 17(9):1117-27. PMID: 22853930.
    View in: PubMed
  10. Gimbrone MA, García-Cardeña G. Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovasc Pathol. 2013 Jan-Feb; 22(1):9-15. PMID: 22818581; PMCID: PMC4564111.
  11. Timsit MO, García-Cardeña G. Flow-dependent endothelial function and kidney dysfunction. Semin Nephrol. 2012 Mar; 32(2):185-91. PMID: 22617767.
    View in: PubMed
  12. Russo L, Gracia-Sancho J, García-Calderó H, Marrone G, García-Pagán JC, García-Cardeña G, Bosch J. Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers. Hepatology. 2012 Mar; 55(3):921-30. PMID: 22031447.
    View in: PubMed
  13. Adamo L, García-Cardeña G. The vascular origin of hematopoietic cells. Dev Biol. 2012 Feb 1; 362(1):1-10. PMID: 21945862.
    View in: PubMed
  14. Wu W, Xiao H, Laguna-Fernandez A, Villarreal G, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy JY. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 2011 Aug 2; 124(5):633-41. PMID: 21768538; PMCID: PMC3511909.
  15. Gracia-Sancho J, Russo L, García-Calderó H, García-Pagán JC, García-Cardeña G, Bosch J. Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver. Gut. 2011 Apr; 60(4):517-24. PMID: 21112949.
    View in: PubMed
  16. Gracia-Sancho J, Villarreal G, Zhang Y, Yu JX, Liu Y, Tullius SG, García-Cardeña G. Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention. Transplantation. 2010 Jul 27; 90(2):142-9. PMID: 20606606; PMCID: PMC4522158.
  17. Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, Aikawa M, García-Cardeña G, Lichtman AH. Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses. J Clin Invest. 2010 Jun; 120(6):1961-70. PMID: 20440076; PMCID: PMC2877947.
  18. Borenstein JT, Tupper MM, Mack PJ, Weinberg EJ, Khalil AS, Hsiao J, García-Cardeña G. Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate. Biomed Microdevices. 2010 Feb; 12(1):71-9. PMID: 19787455.
    View in: PubMed
  19. Yuan X, Theruvath AJ, Ge X, Floerchinger B, Jurisch A, García-Cardeña G, Tullius SG. Machine perfusion or cold storage in organ transplantation: indication, mechanisms, and future perspectives. Transpl Int. 2010 Jun; 23(6):561-70. PMID: 20074082.
    View in: PubMed
  20. Villarreal G, Zhang Y, Larman HB, Gracia-Sancho J, Koo A, García-Cardeña G. Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells. Biochem Biophys Res Commun. 2010 Jan 1; 391(1):984-9. PMID: 19968965; PMCID: PMC4165389.
  21. Gracia-Sancho J, Villarreal G, Zhang Y, García-Cardeña G. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res. 2010 Feb 1; 85(3):514-9. PMID: 19815564; PMCID: PMC2802207.
  22. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. PMID: 19696400; PMCID: PMC2766008.
  23. Adamo L, Naveiras O, Wenzel PL, McKinney-Freeman S, Mack PJ, Gracia-Sancho J, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, García-Cardeña G, Daley GQ. Biomechanical forces promote embryonic haematopoiesis. Nature. 2009 Jun 25; 459(7250):1131-5. PMID: 19440194; PMCID: PMC2782763.
  24. Adamo L, Zhang Y, García-Cardeña G. AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts. BMC Pharmacol. 2009; 9:2. PMID: 19216758; PMCID: PMC2651871.
  25. Tullius SG, García-Cardeña G. Organ procurement and perfusion before transplantation. N Engl J Med. 2009 Jan 1; 360(1):78-80. PMID: 19118308.
    View in: PubMed
  26. Mack PJ, Zhang Y, Chung S, Vickerman V, Kamm RD, García-Cardeña G. Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling. J Biol Chem. 2009 Mar 27; 284(13):8412-20. PMID: 19047056; PMCID: PMC2659199.
  27. Liu M, Kluger MS, D'Alessio A, García-Cardeña G, Pober JS. Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context. Am J Pathol. 2008 Apr; 172(4):1088-99. PMID: 18292233; PMCID: PMC2276407.
  28. Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res. 2007 Aug 3; 101(3):234-47. PMID: 17673684.
    View in: PubMed
  29. Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ Res. 2007 Sep 28; 101(7):723-33. PMID: 17673673.
    View in: PubMed
  30. Abeles D, Kwei S, Stavrakis G, Zhang Y, Wang ET, García-Cardeña G. Gene expression changes evoked in a venous segment exposed to arterial flow. J Vasc Surg. 2006 Oct; 44(4):863-70. PMID: 17012009.
    View in: PubMed
  31. García-Cardeña G, Gimbrone MA. Biomechanical modulation of endothelial phenotype: implications for health and disease. Handb Exp Pharmacol. 2006; (176 Pt 2):79-95. PMID: 16999225.
    View in: PubMed
  32. Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA, García-Cardeña G. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest. 2006 Jan; 116(1):49-58. PMID: 16341264; PMCID: PMC1307560.
  33. Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA, García-Cardeña G. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem. 2005 Jul 22; 280(29):26714-9. PMID: 15878865.
    View in: PubMed
  34. Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MA, Balasubramanian V, García-Cardeña G, Jain MK. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res. 2005 Mar 18; 96(5):e48-57. PMID: 15718498.
    View in: PubMed
  35. Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, García-Cardeña G, Gimbrone MA. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14871-6. PMID: 15466704; PMCID: PMC522013.
  36. Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ. Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site. J Thorac Cardiovasc Surg. 2004 Oct; 128(4):552-61. PMID: 15457156.
    View in: PubMed
  37. Chang LK, Garcia-Cardeña G, Farnebo F, Fannon M, Chen EJ, Butterfield C, Moses MA, Mulligan RC, Folkman J, Kaipainen A. Dose-dependent response of FGF-2 for lymphangiogenesis. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11658-63. PMID: 15289610; PMCID: PMC511009.
  38. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17; 199(10):1305-15. PMID: 15136591; PMCID: PMC2211816.
  39. Comander J, Natarajan S, Gimbrone MA, García-Cardeña G. Improving the statistical detection of regulated genes from microarray data using intensity-based variance estimation. BMC Genomics. 2004 Feb 27; 5(1):17. PMID: 15113402; PMCID: PMC400250.
  40. Papapetropoulos A, Fulton D, Lin MI, Fontana J, McCabe TJ, Zoellner S, García-Cardeña G, Zhou Z, Gratton JP, Sessa WC. Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein. Mol Pharmacol. 2004 Feb; 65(2):407-15. PMID: 14742683.
    View in: PubMed
  41. Kwei S, Stavrakis G, Takahas M, Taylor G, Folkman MJ, Gimbrone MA, García-Cardeña G. Early adaptive responses of the vascular wall during venous arterialization in mice. Am J Pathol. 2004 Jan; 164(1):81-9. PMID: 14695322; PMCID: PMC1602233.
  42. Kiely JM, Hu Y, García-Cardeña G, Gimbrone MA. Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma. J Immunol. 2003 Sep 15; 171(6):3216-24. PMID: 12960351.
    View in: PubMed
  43. Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA, Luscinskas FW. Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol. 2003 May; 162(5):1591-601. PMID: 12707043; PMCID: PMC1851196.
  44. Takayama K, García-Cardena G, Sukhova GK, Comander J, Gimbrone MA, Libby P. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem. 2002 Nov 15; 277(46):44147-54. PMID: 12215436.
    View in: PubMed
  45. Blackman BR, García-Cardeña G, Gimbrone MA. A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms. J Biomech Eng. 2002 Aug; 124(4):397-407. PMID: 12188206.
    View in: PubMed
  46. García-Cardeña G, Comander JI, Blackman BR, Anderson KR, Gimbrone MA. Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis? Ann N Y Acad Sci. 2001 Dec; 947:1-6. PMID: 11795257.
    View in: PubMed
  47. Comander J, Weber GM, Gimbrone MA, García-Cardeña G. Argus--a new database system for Web-based analysis of multiple microarray data sets. Genome Res. 2001 Sep; 11(9):1603-10. PMID: 11544205; PMCID: PMC311087.
  48. Garcia-Cardeña G, Comander J, Anderson KR, Blackman BR, Gimbrone MA. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4478-85. PMID: 11296290; PMCID: PMC31860.
  49. Kuo CJ, LaMontagne KR, Garcia-Cardeña G, Ackley BD, Kalman D, Park S, Christofferson R, Kamihara J, Ding YH, Lo KM, Gillies S, Folkman J, Mulligan RC, Javaherian K. Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain. J Cell Biol. 2001 Mar 19; 152(6):1233-46. PMID: 11257123; PMCID: PMC2199214.
  50. Shin D, Garcia-Cardena G, Hayashi S, Gerety S, Asahara T, Stavrakis G, Isner J, Folkman J, Gimbrone MA, Anderson DJ. Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 2001 Feb 15; 230(2):139-50. PMID: 11161568.
    View in: PubMed
  51. Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem. 2000 Jul 21; 275(29):22268-72. PMID: 10781589.
    View in: PubMed
  52. Gimbrone MA, Topper JN, Nagel T, Anderson KR, Garcia-Cardeña G. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci. 2000 May; 902:230-9; discussion 239-40. PMID: 10865843.
    View in: PubMed
  53. García-Cardeña G, Anderson KR, Mauri L, Gimbrone MA. Distinct mechanical stimuli differentially regulate the PI3K/Akt survival pathway in endothelial cells. Ann N Y Acad Sci. 2000 May; 902:294-7. PMID: 10865850.
    View in: PubMed
  54. Shah V, Wiest R, Garcia-Cardena G, Cadelina G, Groszmann RJ, Sessa WC. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. Am J Physiol. 1999 Aug; 277(2 Pt 1):G463-8. PMID: 10444461.
    View in: PubMed
  55. Papapetropoulos A, García-Cardeña G, Dengler TJ, Maisonpierre PC, Yancopoulos GD, Sessa WC. Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab Invest. 1999 Feb; 79(2):213-23. PMID: 10068209.
    View in: PubMed
  56. Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science. 1998 Sep 11; 281(5383):1683-6. PMID: 9733517.
    View in: PubMed
  57. García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998 Apr 23; 392(6678):821-4. PMID: 9580552.
    View in: PubMed
  58. García-Cardeña G, Folkman J. Is there a role for nitric oxide in tumor angiogenesis? J Natl Cancer Inst. 1998 Apr 15; 90(8):560-1. PMID: 9580259.
    View in: PubMed
  59. Woodard AS, García-Cardeña G, Leong M, Madri JA, Sessa WC, Languino LR. The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration. J Cell Sci. 1998 Feb; 111 ( Pt 4):469-78. PMID: 9443896.
    View in: PubMed
  60. Shah V, García-Cardeña G, Sessa WC, Groszmann RJ. The hepatic circulation in health and disease: report of a single-topic symposium. Hepatology. 1998 Jan; 27(1):279-88. PMID: 9425948.
    View in: PubMed
  61. Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest. 1997 Dec 15; 100(12):3131-9. PMID: 9399960; PMCID: PMC508526.
  62. Shah V, Haddad FG, Garcia-Cardena G, Frangos JA, Mennone A, Groszmann RJ, Sessa WC. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest. 1997 Dec 1; 100(11):2923-30. PMID: 9389760; PMCID: PMC508500.
  63. Caulin-Glaser T, García-Cardeña G, Sarrel P, Sessa WC, Bender JR. 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res. 1997 Nov; 81(5):885-92. PMID: 9351464.
    View in: PubMed
  64. García-Cardeña G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem. 1997 Oct 10; 272(41):25437-40. PMID: 9325253.
    View in: PubMed
  65. Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. Am J Pathol. 1997 May; 150(5):1835-44. PMID: 9137106; PMCID: PMC1858220.
  66. Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest. 1997 Jan 1; 99(1):110-6. PMID: 9011564; PMCID: PMC507774.
  67. Atucha NM, Shah V, García-Cardeña G, Sessa WE, Groszmann RJ. Role of endothelium in the abnormal response of mesenteric vessels in rats with portal hypertension and liver cirrhosis. Gastroenterology. 1996 Dec; 111(6):1627-32. PMID: 8942743.
    View in: PubMed
  68. García-Cardeña G, Fan R, Stern DF, Liu J, Sessa WC. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem. 1996 Nov 1; 271(44):27237-40. PMID: 8910295.
    View in: PubMed
  69. Liu J, García-Cardeña G, Sessa WC. Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization. Biochemistry. 1996 Oct 15; 35(41):13277-81. PMID: 8873592.
    View in: PubMed
  70. García-Cardeña G, Oh P, Liu J, Schnitzer JE, Sessa WC. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6448-53. PMID: 8692835; PMCID: PMC39043.
  71. Liu J, García-Cardeña G, Sessa WC. Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme. Biochemistry. 1995 Sep 26; 34(38):12333-40. PMID: 7547976.
    View in: PubMed
  72. Sessa WC, García-Cardeña G, Liu J, Keh A, Pollock JS, Bradley J, Thiru S, Braverman IM, Desai KM. The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J Biol Chem. 1995 Jul 28; 270(30):17641-4. PMID: 7543089.
    View in: PubMed
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