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profilePeter J Tonellato, Ph.D.

TitleResearch Associate in Biomedical Informatics
InstitutionHarvard Medical School
DepartmentBiomedical Informatics
AddressBrigham and Women's Hospital
HMS Department of Pathology, BTM 8002K
60 Fenwood Rd
Boston MA 02115
Phone617/432-7185
Fax866/771-2566
vCardDownload vCard (login for email)
Other Positions
TitleSenior Lecturer on Pathology, Part-time
InstitutionBrigham and Women's Hospital
DepartmentPathology


Collapse Mentoring 
Collapse current student opportunities
Available: 07/01/17, Expires: 06/30/21

Dr. Tonellato's Laboratory for Personalized Medicine studies the methods, use and evaluation of genetic tests and whole genome analysis (WGA) in clinical practice. Students will participate in one of the evaluations and translational methods used in the lab to identify the strengths, weaknesses and efficacy of WGA in various clinical setting including pharmacogenetics and cancer typing and treatment optimization. Contact peter_tonellato@hms.harvard.edu with questions and check out the lab website (lpm.hms.harvard.edu) for more information.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01LM011566     (TONELLATO, PETER J.)Sep 15, 2013 - Aug 31, 2017
NIH/NLM
Predictive optimal anticlotting treatment for segmented patient populations
Role: Principal Investigator

R01LM010130     (TONELLATO, PETER J.)Jul 1, 2009 - Aug 31, 2012
NIH/NLM
Method for Prediction of Efficacy of Genetic-Based Prediction Models of Personali
Role: Principal Investigator

R01HL064541     (SHIMOYAMA, MARY E)Sep 30, 1999 - Dec 31, 2018
NIH/NHLBI
Rat Genome Database
Role: Co-Principal Investigator

P50HL054998     (COWLEY, ALLEN W)Feb 1, 1996 - Jun 30, 2006
NIH/NHLBI
SCOR--MOLECULAR GENETICS OF HYPERTENSION
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chi CL, Zeng W, Oh W, Borson S, Lenskaia T, Shen X, Tonellato PJ. Personalized long-term prediction of cognitive function: Using sequential assessments to improve model performance. J Biomed Inform. 2017 Dec; 76:78-86. PMID: 29129622.
    View in: PubMed
  2. de Oliveira Taveira M, Nabavi S, Wang Y, Tonellato P, Esteva FJ, Cantley LC, Wulf GM. Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer. J Cancer Res Clin Oncol. 2017 Jul; 143(7):1255-1262. PMID: 28247034.
    View in: PubMed
  3. Elshazly H, Souilmi Y, Tonellato PJ, Wall DP, Abouelhoda M. MC-GenomeKey: a multicloud system for the detection and annotation of genomic variants. BMC Bioinformatics. 2017 Jan 20; 18(1):49. PMID: 28107819.
    View in: PubMed
  4. Ravvaz K, Weissert J, Tonellato PJ. Optimal decision support rules improve personalize warfarin treatment outcomes. Conf Proc IEEE Eng Med Biol Soc. 2016 08; 2016:2594-2597. PMID: 28268853.
    View in: PubMed
  5. Anderson DA, Walz ME, Weil E, Tonellato P, Smith MC. RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity. PeerJ. 2016; 4:e1616. PMID: 26925311; PMCID: PMC4768675.
  6. Souilmi Y, Lancaster AK, Jung JY, Rizzo E, Hawkins JB, Powles R, Amzazi S, Ghazal H, Tonellato PJ, Wall DP. Scalable and cost-effective NGS genotyping in the cloud. BMC Med Genomics. 2015 Oct 15; 8:64. PMID: 26470712; PMCID: PMC4608296.
  7. Liu Q, Spitsbergen JM, Cariou R, Huang CY, Jiang N, Goetz G, Hutz RJ, Tonellato PJ, Carvan MJ. Histopathologic alterations associated with global gene expression due to chronic dietary TCDD exposure in juvenile zebrafish. PLoS One. 2014; 9(7):e100910. PMID: 24988445; PMCID: PMC4079602.
  8. Gafni E, Luquette LJ, Lancaster AK, Hawkins JB, Jung JY, Souilmi Y, Wall DP, Tonellato PJ. COSMOS: Python library for massively parallel workflows. Bioinformatics. 2014 Oct 15; 30(20):2956-8. PMID: 24982428; PMCID: PMC4184253.
  9. Issa SA, Kienzler R, El-Kalioby M, Tonellato PJ, Wall D, Bruggmann R, Abouelhoda M. Streaming support for data intensive cloud-based sequence analysis. Biomed Res Int. 2013; 2013:791051. PMID: 23710461; PMCID: PMC3655485.
  10. Liu Q, Basu N, Goetz G, Jiang N, Hutz RJ, Tonellato PJ, Carvan MJ. Differential gene expression associated with dietary methylmercury (MeHg) exposure in rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio). Ecotoxicology. 2013 May; 22(4):740-51. PMID: 23529582; PMCID: PMC3664064.
  11. Nabavi S, Cai Z, Tonellato PJ. Analysis of sequence-based copy number variation detection tools for cancer studies. AMIA Jt Summits Transl Sci Proc. 2013; 2013:124. PMID: 24303319.
    View in: PubMed
  12. Przybytkowski E, Aguilar-Mahecha A, Nabavi S, Tonellato PJ, Basik M. Ultradense array CGH and discovery of micro-copy number alterations and gene fusions in the cancer genome. Methods Mol Biol. 2013; 973:15-38. PMID: 23412781; PMCID: PMC3692353.
  13. Fusaro VA, Patil P, Chi CL, Contant CF, Tonellato PJ. A systems approach to designing effective clinical trials using simulations. Circulation. 2013 Jan 29; 127(4):517-26. PMID: 23261867; PMCID: PMC3747989.
  14. El-Kalioby M, Abouelhoda M, Krüger J, Giegerich R, Sczyrba A, Wall DP, Tonellato P. Personalized cloud-based bioinformatics services for research and education: use cases and the elasticHPC package. BMC Bioinformatics. 2012; 13 Suppl 17:S22. PMID: 23281941; PMCID: PMC3521398.
  15. Wall DP, Tonellato PJ. The future of genomics in pathology. F1000 Med Rep. 2012; 4:14. PMID: 22802873; PMCID: PMC3391753.
  16. Suzuki S, Takai-Igarashi T, Fukuoka Y, Wall DP, Tanaka H, Tonellato PJ. Systems analysis of inflammatory bowel disease based on comprehensive gene information. BMC Med Genet. 2012 Apr 05; 13:25. PMID: 22480395; PMCID: PMC3368714.
  17. Chi CL, Fusaro VA, Patil P, Crawford MA, Content CF, Tonellato PJ. A simulation platform to examine heterogeneity influence on treatment. AMIA Jt Summits Transl Sci Proc. 2012; 2012:19-24. PMID: 22779042; PMCID: PMC3392060.
  18. Fusaro VA, Patil P, Gafni E, Wall DP, Tonellato PJ. Biomedical cloud computing with Amazon Web Services. PLoS Comput Biol. 2011 Aug; 7(8):e1002147. PMID: 21901085; PMCID: PMC3161908.
  19. Luciano JS, Andersson B, Batchelor C, Bodenreider O, Clark T, Denney CK, Domarew C, Gambet T, Harland L, Jentzsch A, Kashyap V, Kos P, Kozlovsky J, Lebo T, Marshall SM, McCusker JP, McGuinness DL, Ogbuji C, Pichler E, Powers RL, Prud'hommeaux E, Samwald M, Schriml L, Tonellato PJ, Whetzel PL, Zhao J, Stephens S, Dumontier M. The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside. J Biomed Semantics. 2011 May 17; 2 Suppl 2:S1. PMID: 21624155; PMCID: PMC3102889.
  20. Tonellato PJ, Crawford JM, Boguski MS, Saffitz JE. A national agenda for the future of pathology in personalized medicine: report of the proceedings of a meeting at the Banbury Conference Center on genome-era pathology, precision diagnostics, and preemptive care: a stakeholder summit. Am J Clin Pathol. 2011 May; 135(5):668-72. PMID: 21502420; PMCID: PMC4629248.
  21. Kudtarkar P, Deluca TF, Fusaro VA, Tonellato PJ, Wall DP. Cost-effective cloud computing: a case study using the comparative genomics tool, roundup. Evol Bioinform Online. 2010 Dec 22; 6:197-203. PMID: 21258651; PMCID: PMC3023304.
  22. Wall DP, Pivovarov R, Tong M, Jung JY, Fusaro VA, DeLuca TF, Tonellato PJ. Genotator: a disease-agnostic tool for genetic annotation of disease. BMC Med Genomics. 2010 Oct 29; 3:50. PMID: 21034472; PMCID: PMC2990725.
  23. Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A call to action: training pathology residents in genomics and personalized medicine. Am J Clin Pathol. 2010 Jun; 133(6):832-4. PMID: 20472839.
    View in: PubMed
  24. Wall DP, Kudtarkar P, Fusaro VA, Pivovarov R, Patil P, Tonellato PJ. Cloud computing for comparative genomics. BMC Bioinformatics. 2010 May 18; 11:259. PMID: 20482786; PMCID: PMC3098063.
  25. Tonellato DJ, Guse CE, Hargarten SW. Injury deaths of US citizens abroad: new data source, old travel problem. J Travel Med. 2009 Sep-Oct; 16(5):304-10. PMID: 19796099.
    View in: PubMed
  26. Yamasaki C, Murakami K, Fujii Y, Sato Y, Harada E, Takeda J, Taniya T, Sakate R, Kikugawa S, Shimada M, Tanino M, Koyanagi KO, Barrero RA, Gough C, Chun HW, Habara T, Hanaoka H, Hayakawa Y, Hilton PB, Kaneko Y, Kanno M, Kawahara Y, Kawamura T, Matsuya A, Nagata N, Nishikata K, Noda AO, Nurimoto S, Saichi N, Sakai H, Sanbonmatsu R, Shiba R, Suzuki M, Takabayashi K, Takahashi A, Tamura T, Tanaka M, Tanaka S, Todokoro F, Yamaguchi K, Yamamoto N, Okido T, Mashima J, Hashizume A, Jin L, Lee KB, Lin YC, Nozaki A, Sakai K, Tada M, Miyazaki S, Makino T, Ohyanagi H, Osato N, Tanaka N, Suzuki Y, Ikeo K, Saitou N, Sugawara H, O'Donovan C, Kulikova T, Whitfield E, Halligan B, Shimoyama M, Twigger S, Yura K, Kimura K, Yasuda T, Nishikawa T, Akiyama Y, Motono C, Mukai Y, Nagasaki H, Suwa M, Horton P, Kikuno R, Ohara O, Lancet D, Eveno E, Graudens E, Imbeaud S, Debily MA, Hayashizaki Y, Amid C, Han M, Osanger A, Endo T, Thomas MA, Hirakawa M, Makalowski W, Nakao M, Kim NS, Yoo HS, De Souza SJ, Bonaldo Mde F, Niimura Y, Kuryshev V, Schupp I, Wiemann S, Bellgard M, Shionyu M, Jia L, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Zhang Q, Go M, Minoshima S, Ohtsubo M, Hanada K, Tonellato P, Isogai T, Zhang J, Lenhard B, Kim S, Chen Z, Hinz U, Estreicher A, Nakai K, Makalowska I, Hide W, Tiffin N, Wilming L, Chakraborty R, Soares MB, Chiusano ML, Suzuki Y, Auffray C, Yamaguchi-Kabata Y, Itoh T, Hishiki T, Fukuchi S, Nishikawa K, Sugano S, Nomura N, Tateno Y, Imanishi T, Gojobori T. The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Res. 2008 Jan; 36(Database issue):D793-9. PMID: 18089548; PMCID: PMC2238988.
  27. Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA, Roman RJ, Tonellato PJ, Cowley AW. BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. Physiol Genomics. 2006 Apr 13; 25(2):303-13. PMID: 16478827.
    View in: PubMed
  28. Indap AR, Marth GT, Struble CA, Tonellato P, Olivier M. Analysis of concordance of different haplotype block partitioning algorithms. BMC Bioinformatics. 2005 Dec 15; 6:303. PMID: 16356172; PMCID: PMC1343594.
  29. Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J, dela Cruz N, Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nigam R, Petri V, Reilly D, Ruotti V, Schauberger E, Seiler K, Slyper R, Smith J, Wang W, Wu W, Zhao L, Zuniga-Meyer A, Tonellato PJ, Kwitek AE, Jacob HJ. Tools and strategies for physiological genomics: the Rat Genome Database. Physiol Genomics. 2005 Oct 17; 23(2):246-56. PMID: 16106031; PMCID: PMC4505745.
  30. Hamet P, Merlo E, Seda O, Broeckel U, Tremblay J, Kaldunski M, Gaudet D, Bouchard G, Deslauriers B, Gagnon F, Antoniol G, Pausová Z, Labuda M, Jomphe M, Gossard F, Tremblay G, Kirova R, Tonellato P, Orlov SN, Pintos J, Platko J, Hudson TJ, Rioux JD, Kotchen TA, Cowley AW. Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. Am J Hum Genet. 2005 May; 76(5):815-32. PMID: 15800845; PMCID: PMC1199371.
  31. de la Cruz N, Bromberg S, Pasko D, Shimoyama M, Twigger S, Chen J, Chen CF, Fan C, Foote C, Gopinath GR, Harris G, Hughes A, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nie J, Nigam R, Petri V, Reilly D, Wang W, Wu W, Zuniga-Meyer A, Zhao L, Kwitek A, Tonellato P, Jacob H. The Rat Genome Database (RGD): developments towards a phenome database. Nucleic Acids Res. 2005 Jan 01; 33(Database issue):D485-91. PMID: 15608243; PMCID: PMC540004.
  32. Schlicht M, Matysiak B, Brodzeller T, Wen X, Liu H, Zhou G, Dhir R, Hessner MJ, Tonellato P, Suckow M, Pollard M, Datta MW. Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium. BMC Genomics. 2004 Aug 20; 5(1):58. PMID: 15318950; PMCID: PMC516028.
  33. Halligan BD, Dratz EA, Feng X, Twigger SN, Tonellato PJ, Greene AS. Peptide identification using peptide amino acid attribute vectors. J Proteome Res. 2004 Jul-Aug; 3(4):813-20. PMID: 15359736.
    View in: PubMed
  34. Zhou G, Wen X, Liu H, Schlicht MJ, Hessner MJ, Tonellato PJ, Datta MW. B.E.A.R. GeneInfo: a tool for identifying gene-related biomedical publications through user modifiable queries. BMC Bioinformatics. 2004 Apr 29; 5:46. PMID: 15117422; PMCID: PMC419696.
  35. Etim A, Zhou G, Wen X, Liu H, Ruotti V, Twigger S, Jin W, Matysiak B, Mathis J, Tonellato PJ, Datta MW. ChromSorter PC: a database of chromosomal regions associated with human prostate cancer. BMC Genomics. 2004 Apr 28; 5(1):27. PMID: 15113398; PMCID: PMC416659.
  36. Imanishi T, Itoh T, Suzuki Y, O'Donovan C, Fukuchi S, Koyanagi KO, Barrero RA, Tamura T, Yamaguchi-Kabata Y, Tanino M, Yura K, Miyazaki S, Ikeo K, Homma K, Kasprzyk A, Nishikawa T, Hirakawa M, Thierry-Mieg J, Thierry-Mieg D, Ashurst J, Jia L, Nakao M, Thomas MA, Mulder N, Karavidopoulou Y, Jin L, Kim S, Yasuda T, Lenhard B, Eveno E, Suzuki Y, Yamasaki C, Takeda J, Gough C, Hilton P, Fujii Y, Sakai H, Tanaka S, Amid C, Bellgard M, Bonaldo Mde F, Bono H, Bromberg SK, Brookes AJ, Bruford E, Carninci P, Chelala C, Couillault C, de Souza SJ, Debily MA, Devignes MD, Dubchak I, Endo T, Estreicher A, Eyras E, Fukami-Kobayashi K, Gopinath GR, Graudens E, Hahn Y, Han M, Han ZG, Hanada K, Hanaoka H, Harada E, Hashimoto K, Hinz U, Hirai M, Hishiki T, Hopkinson I, Imbeaud S, Inoko H, Kanapin A, Kaneko Y, Kasukawa T, Kelso J, Kersey P, Kikuno R, Kimura K, Korn B, Kuryshev V, Makalowska I, Makino T, Mano S, Mariage-Samson R, Mashima J, Matsuda H, Mewes HW, Minoshima S, Nagai K, Nagasaki H, Nagata N, Nigam R, Ogasawara O, Ohara O, Ohtsubo M, Okada N, Okido T, Oota S, Ota M, Ota T, Otsuki T, Piatier-Tonneau D, Poustka A, Ren SX, Saitou N, Sakai K, Sakamoto S, Sakate R, Schupp I, Servant F, Sherry S, Shiba R, Shimizu N, Shimoyama M, Simpson AJ, Soares B, Steward C, Suwa M, Suzuki M, Takahashi A, Tamiya G, Tanaka H, Taylor T, Terwilliger JD, Unneberg P, Veeramachaneni V, Watanabe S, Wilming L, Yasuda N, Yoo HS, Stodolsky M, Makalowski W, Go M, Nakai K, Takagi T, Kanehisa M, Sakaki Y, Quackenbush J, Okazaki Y, Hayashizaki Y, Hide W, Chakraborty R, Nishikawa K, Sugawara H, Tateno Y, Chen Z, Oishi M, Tonellato P, Apweiler R, Okubo K, Wagner L, Wiemann S, Strausberg RL, Isogai T, Auffray C, Nomura N, Gojobori T, Sugano S. Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol. 2004 Jun; 2(6):e162. PMID: 15103394; PMCID: PMC393292.
  37. Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004 Apr 01; 428(6982):493-521. PMID: 15057822.
    View in: PubMed
  38. Twigger SN, Nie J, Ruotti V, Yu J, Chen D, Li D, Mathis J, Narayanasamy V, Gopinath GR, Pasko D, Shimoyama M, De La Cruz N, Bromberg S, Kwitek AE, Jacob HJ, Tonellato PJ. Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. Genome Res. 2004 Apr; 14(4):651-60. PMID: 15060006; PMCID: PMC383309.
  39. Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome Res. 2004 Apr; 14(4):750-7. PMID: 15060019; PMCID: PMC383322.
  40. Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, Richter J, Rubin GM, Blake JA, Bult C, Dolan M, Drabkin H, Eppig JT, Hill DP, Ni L, Ringwald M, Balakrishnan R, Cherry JM, Christie KR, Costanzo MC, Dwight SS, Engel S, Fisk DG, Hirschman JE, Hong EL, Nash RS, Sethuraman A, Theesfeld CL, Botstein D, Dolinski K, Feierbach B, Berardini T, Mundodi S, Rhee SY, Apweiler R, Barrell D, Camon E, Dimmer E, Lee V, Chisholm R, Gaudet P, Kibbe W, Kishore R, Schwarz EM, Sternberg P, Gwinn M, Hannick L, Wortman J, Berriman M, Wood V, de la Cruz N, Tonellato P, Jaiswal P, Seigfried T, White R. The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D258-61. PMID: 14681407; PMCID: PMC308770.
  41. Postlethwait J, Ruotti V, Carvan MJ, Tonellato PJ. Automated analysis of conserved syntenies for the zebrafish genome. Methods Cell Biol. 2004; 77:255-71. PMID: 15602916.
    View in: PubMed
  42. Wang X, Jiang N, Feng X, Xie Y, Tonellato PJ, Ghosh S, Hessner MJ. A novel approach for high-quality microarray processing using third-dye array visualization technology. IEEE Trans Nanobioscience. 2003 Dec; 2(4):193-201. PMID: 15376909.
    View in: PubMed
  43. Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics. 2003 Nov 11; 15(3):243-57. PMID: 14532335.
    View in: PubMed
  44. Tatay JW, Feng X, Sobczak N, Jiang H, Chen CF, Kirova R, Struble C, Wang NJ, Tonellato PJ. Multiple approaches to data-mining of proteomic data based on statistical and pattern classification methods. Proteomics. 2003 Sep; 3(9):1704-9. PMID: 12973729.
    View in: PubMed
  45. Thomas MA, Weston B, Joseph M, Wu W, Nekrutenko A, Tonellato PJ. Evolutionary dynamics of oncogenes and tumor suppressor genes: higher intensities of purifying selection than other genes. Mol Biol Evol. 2003 Jun; 20(6):964-8. PMID: 12716985.
    View in: PubMed
  46. Thomas MA, Chen CF, Jensen-Seaman MI, Tonellato PJ, Twigger SN. Phylogenetics of rat inbred strains. Mamm Genome. 2003 Jan; 14(1):61-4. PMID: 12532268.
    View in: PubMed
  47. Kotchen TA, Broeckel U, Grim CE, Hamet P, Jacob H, Kaldunski ML, Kotchen JM, Schork NJ, Tonellato PJ, Cowley AW. Identification of hypertension-related QTLs in African American sib pairs. Hypertension. 2002 Nov; 40(5):634-9. PMID: 12411455.
    View in: PubMed
  48. Kendziorski CM, Cowley AW, Greene AS, Salgado HC, Jacob HJ, Tonellato PJ. Mapping baroreceptor function to genome: a mathematical modeling approach. Genetics. 2002 Apr; 160(4):1687-95. PMID: 11973321; PMCID: PMC1462065.
  49. Roman RJ, Cowley AW, Greene A, Kwitek AE, Tonellato PJ, Jacob HJ. Consomic rats for the identification of genes and pathways underlying cardiovascular disease. Cold Spring Harb Symp Quant Biol. 2002; 67:309-15. PMID: 12858554.
    View in: PubMed
  50. Twigger S, Lu J, Shimoyama M, Chen D, Pasko D, Long H, Ginster J, Chen CF, Nigam R, Kwitek A, Eppig J, Maltais L, Maglott D, Schuler G, Jacob H, Tonellato PJ. Rat Genome Database (RGD): mapping disease onto the genome. Nucleic Acids Res. 2002 Jan 01; 30(1):125-8. PMID: 11752273; PMCID: PMC99132.
  51. Stoll M, Cowley AW, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. A genomic-systems biology map for cardiovascular function. Science. 2001 Nov 23; 294(5547):1723-6. PMID: 11721057.
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  52. Kwitek AE, Tonellato PJ, Chen D, Gullings-Handley J, Cheng YS, Twigger S, Scheetz TE, Casavant TL, Stoll M, Nobrega MA, Shiozawa M, Soares MB, Sheffield VC, Jacob HJ. Automated construction of high-density comparative maps between rat, human, and mouse. Genome Res. 2001 Nov; 11(11):1935-43. PMID: 11691858; PMCID: PMC311144.
  53. Gösele C, Hong L, Kreitler T, Rossmann M, Hieke B, Gross U, Kramer M, Himmelbauer H, Bihoreau MT, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC, Lindpaintner K, Ganten D, Lehrach H, Knoblauch M. High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers. Genomics. 2000 Nov 01; 69(3):287-94. PMID: 11056046.
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  54. Lombard JH, Frisbee JC, Greene AS, Hudetz AG, Roman RJ, Tonellato PJ. Microvascular flow and tissue PO(2) in skeletal muscle of chronic reduced renal mass hypertensive rats. Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5):H2295-302. PMID: 11045965.
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  55. Nora EH, Tonellato PJ, Greene AS. Quantification of the contribution of type 1 and type 2 angiotensin II receptors to the net tissue specific effect of angiotensin II. Ann Biomed Eng. 2000 Jun; 28(6):653-64. PMID: 10983711.
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  56. Cowley AW, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Schork NJ, Dumas P, Jacob HJ. Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats. Physiol Genomics. 2000 Apr 27; 2(3):107-15. PMID: 11015589.
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  57. Kendziorski CM, Bassingthwaighte JB, Tonellato PJ. Evaluating maximum likelihood estimation methods to determine the Hurst coeficient. Physica A. 1999 Nov 15; 273(3-4):439-451. PMID: 22904595.
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  58. Steen RG, Kwitek-Black AE, Glenn C, Gullings-Handley J, Van Etten W, Atkinson OS, Appel D, Twigger S, Muir M, Mull T, Granados M, Kissebah M, Russo K, Crane R, Popp M, Peden M, Matise T, Brown DM, Lu J, Kingsmore S, Tonellato PJ, Rozen S, Slonim D, Young P, Jacob HJ. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Res. 1999 Jun; 9(6):AP1-8, insert. PMID: 10400928.
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  59. Popel AS, Greene AS, Ellis CG, Ley KF, Skalak TC, Tonellato PJ. The Microcirculation Physiome Project. Ann Biomed Eng. 1998 Nov-Dec; 26(6):911-3. PMID: 9846930.
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  60. Rieder MJ, O'Drobinak DM, Tonellato PJ, Greene AS. Mathematical analysis of type-I and type-IIb muscle fiber force generation in renal hypertension. Ann Biomed Eng. 1996 Jul-Aug; 24(4):489-99. PMID: 8841724.
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  61. Greene AS, Tonellato PJ, Zhang Z, Lombard JH, Cowley AW. Effect of microvascular rarefaction on tissue oxygen delivery in hypertension. Am J Physiol. 1992 May; 262(5 Pt 2):H1486-93. PMID: 1590452.
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  62. Newton-Nash DK, Tonellato P, Swiersz M, Abramoff P. Assessment of chemokinetic behavior of inflammatory lung macrophages in a linear under-agarose assay. J Leukoc Biol. 1990 Oct; 48(4):297-305. PMID: 2394943.
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  63. Greene AS, Tonellato PJ, Lui J, Lombard JH, Cowley AW. Microvascular rarefaction and tissue vascular resistance in hypertension. Am J Physiol. 1989 Jan; 256(1 Pt 2):H126-31. PMID: 2912175.
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