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Siavash Raigani, M.D.

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Case Western Reserve University, Cleveland, OHMD
Massachusetts General Hospital, Boston, MAGeneral surgery residency
Center for Engineering in Medicine, Boston, MALiver transplantation, machine perfusion

I'm interested in using ex vivo machine perfusion technology to resuscitate and rehabilitate discarded donor organs for transplantation. Currently, we are exploring normothermic machine perfusion as a platform for modulating discarded human livers that are inadequate for transplantation. My interests are in exploring mechanisms that underlie the deficits these "marginal" organs face during perfusion as a means of improving their function prior to transplantation. We are exploring this through multi-omics methods, including metabolomics, lipidomics, transcriptomics, and proteomics.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xu K, Raigani S, Shih A, Baptista SG, Rosales I, Parry NM, Shroff SG, Misdraji J, Uygun K, Yeh H, Fairchild K, Anne Dageforde L. A Novel Digital Algorithm for Identifying Liver Steatosis Using Smartphone-Captured Images. Transplant Direct. 2022 Sep; 8(9):e1361. PMID: 35935028.
  2. Raigani S, Santiago J, Ohman A, Heaney M, Baptista S, Coe TM, de Vries RJ, Rosales I, Shih A, Markmann JF, Gruppuso P, Uygun K, Sanders J, Yeh H. Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses. Front Immunol. 2022; 13:940094. PMID: 35958587.
    Citations:    Fields:    Translation:Humans
  3. Tessier SN, de Vries RJ, Pendexter CA, Cronin SEJ, Ozer S, Hafiz EOA, Raigani S, Oliveira-Costa JP, Wilks BT, Lopera Higuita M, van Gulik TM, Usta OB, Stott SL, Yeh H, Yarmush ML, Uygun K, Toner M. Partial freezing of rat livers extends preservation time by 5-fold. Nat Commun. 2022 07 15; 13(1):4008. PMID: 35840553; PMCID: PMC9287450.
    Citations:    Fields:    Translation:AnimalsCells
  4. Ohman A, Raigani S, Santiago JC, Heaney MG, Boylan JM, Parry N, Carroll C, Baptista SG, Uygun K, Gruppuso PA, Sanders JA, Yeh H. Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function. Am J Physiol Gastrointest Liver Physiol. 2022 01 01; 322(1):G21-G33. PMID: 34730028; PMCID: PMC8698515.
    Citations:    Fields:    Translation:Humans
  5. de Vries RJ, Cronin SEJ, Romfh P, Pendexter CA, Jain R, Wilks BT, Raigani S, van Gulik TM, Chen P, Yeh H, Uygun K, Tessier SN. Non-invasive quantification of the mitochondrial redox state in livers during machine perfusion. PLoS One. 2021; 16(10):e0258833. PMID: 34705828; PMCID: PMC8550443.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Haque O, Raigani S, Rosales I, Carroll C, Coe TM, Baptista S, Yeh H, Uygun K, Delmonico FL, Markmann JF. Thrombolytic Therapy During ex-vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury. Front Surg. 2021; 8:644859. PMID: 34222314.
    Citations: 1     
  7. Bashyam A, Frangieh CJ, Raigani S, Sogo J, Bronson RT, Uygun K, Yeh H, Ausiello DA, Cima MJ. A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis. Nat Biomed Eng. 2021 03; 5(3):240-251. PMID: 33257853.
    Citations: 1     Fields:    Translation:HumansAnimals
  8. Haque O, Pendexter CA, Cronin SEJ, Raigani S, de Vries RJ, Yeh H, Markmann JF, Uygun K. Twenty-four hour ex-vivo normothermic machine perfusion in rat livers. Technology (Singap World Sci). 2020 Mar-Jun; 8(1-2):27-36. PMID: 34307768.
    Citations: 1     
  9. Raigani S, De Vries RJ, Carroll C, Chen YW, Chang DC, Shroff SG, Uygun K, Yeh H. Viability testing of discarded livers with normothermic machine perfusion: Alleviating the organ shortage outweighs the cost. Clin Transplant. 2020 11; 34(11):e14069. PMID: 32860634.
    Citations: 3     Fields:    Translation:Humans
  10. Zhang A, Carroll C, Raigani S, Karimian N, Huang V, Nagpal S, Beijert I, Porte RJ, Yarmush M, Uygun K, Yeh H. Tryptophan Metabolism via the Kynurenine Pathway: Implications for Graft Optimization during Machine Perfusion. J Clin Med. 2020 Jun 15; 9(6). PMID: 32549246; PMCID: PMC7355886.
    Citations: 2     
  11. Raigani S, Carroll C, Griffith S, Pendexter C, Rosales I, Deirawan H, Beydoun R, Yarmush M, Uygun K, Yeh H. Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content. PLoS One. 2020; 15(5):e0232886. PMID: 32396553; PMCID: PMC7217452.
    Citations: 6     Fields:    Translation:HumansAnimals
  12. Raigani S, Karimian N, Huang V, Zhang AM, Beijert I, Geerts S, Nagpal S, Hafiz EOA, Fontan FM, Aburawi MM, Mahboub P, Markmann JF, Porte RJ, Uygun K, Yarmush M, Yeh H. Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies. PLoS One. 2020; 15(1):e0228011. PMID: 31978172.
    Citations: 5     Fields:    Translation:HumansCells
  13. Huang V, Karimian N, Detelich D, Raigani S, Geerts S, Beijert I, Fontan FM, Aburawi MM, Ozer S, Banik P, Lin F, Karabacak M, Hafiz EOA, Porte RJ, Uygun K, Markmann JF, Yeh H. Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions. J Clin Med. 2020 Jan 18; 9(1). PMID: 31963739; PMCID: PMC7019984.
    Citations: 8     
  14. Chin LY, Carroll C, Raigani S, Detelich DM, Tessier SN, Wojtkiewicz GR, Schmidt SP, Weissleder R, Yeh H, Uygun K, Parekkadan B. Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs. PLoS One. 2019; 14(12):e0225222. PMID: 31790444.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Raigani S, De Vries RJ, Uygun K, Yeh H. Pumping new life into old ideas: Preservation and rehabilitation of the liver using ex situ machine perfusion. Artif Organs. 2020 Feb; 44(2):123-128. PMID: 31691326.
    Citations: 3     Fields:    Translation:HumansAnimals
  16. Karimian N, Raigani S, Huang V, Nagpal S, Hafiz EOA, Beijert I, Mahboub P, Porte RJ, Uygun K, Yarmush M, Yeh H. Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion. Metabolites. 2019 Oct 24; 9(11). PMID: 31652927; PMCID: PMC6918199.
    Citations: 5     
  17. Raigani S, Markmann JF, Yeh H. Rehabilitation of Discarded Steatotic Livers Using Ex Situ Normothermic Machine Perfusion: A Future Source of Livers for Transplantation. Liver Transpl. 2019 07; 25(7):991-992. PMID: 31077626.
    Citations: 5     Fields:    Translation:Humans
  18. Raigani S, Cohen S, Boland GM. The Role of Surgery for Melanoma in an Era of Effective Systemic Therapy. Curr Oncol Rep. 2017 Mar; 19(3):17. PMID: 28251494.
    Citations: 10     Fields:    Translation:Humans
  19. Strohl MP, Raigani S, Ammori JB, Hardacre JM, Kim JA. Surgery for Localized Pancreatic Cancer: The Trend Is Not Improving. Pancreas. 2016 May-Jun; 45(5):687-93. PMID: 26491905.
    Citations: 5     Fields:    Translation:Humans
  20. Petro CC, Raigani S, Fayezizadeh M, Rowbottom JR, Klick JC, Prabhu AS, Novitsky YW, Rosen MJ. Reply: Permissive Intraabdominal Hypertension following Complex Abdominal Wall Reconstruction. Plast Reconstr Surg. 2016 Apr; 137(4):764e. PMID: 26761511.
    Citations:    Fields:    Translation:Humans
  21. Petro CC, Raigani S, Fayezizadeh M, Rowbottom JR, Klick JC, Prabhu AS, Novitsky YW, Rosen MJ. Permissible Intraabdominal Hypertension following Complex Abdominal Wall Reconstruction. Plast Reconstr Surg. 2015 Oct; 136(4):868-881. PMID: 26090761.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  22. Hardacre JM, Raigani S, Dumot J. Starting a High-Quality Pancreatic Surgery Program at a Community Hospital. J Gastrointest Surg. 2015 Dec; 19(12):2178-82. PMID: 26358277.
    Citations: 3     Fields:    Translation:Humans
  23. Petro CC, O'Rourke CP, Posielski NM, Criss CN, Raigani S, Prabhu AS, Rosen MJ. Designing a ventral hernia staging system. Hernia. 2016 Feb; 20(1):111-7. PMID: 26342924.
    Citations: 11     Fields:    Translation:Humans
  24. Petro CC, Posielski NM, Raigani S, Criss CN, Orenstein SB, Novitsky YW. Risk factors for wound morbidity after open retromuscular (sublay) hernia repair. Surgery. 2015 Dec; 158(6):1658-68. PMID: 26100569.
    Citations: 13     Fields:    Translation:Humans
  25. Orenstein SB, Raigani S, Wu YV, Pauli EM, Phillips MS, Ponsky JL, Marks JM. Peroral endoscopic myotomy (POEM) leads to similar results in patients with and without prior endoscopic or surgical therapy. Surg Endosc. 2015 May; 29(5):1064-70. PMID: 25249143.
    Citations: 29     Fields:    Translation:Humans
  26. Raigani S, Numanoglu A, Schwachter M, Ponsky TA. Online resources in pediatric surgery: the new era of medical information. Eur J Pediatr Surg. 2014 Aug; 24(4):308-12. PMID: 25111279.
    Citations: 3     Fields:    Translation:Humans
  27. Raigani S, De Silva GS, Criss CN, Novitsky YW, Rosen MJ. The impact of developing a comprehensive hernia center on the referral patterns and complexity of hernia care. Hernia. 2014 Oct; 18(5):625-30. PMID: 25038895.
    Citations: 3     Fields:    Translation:Humans
  28. Raigani S, Criss CN, Petro CC, Prabhu AS, Novitsky YW, Rosen MJ. Single-center experience with parastomal hernia repair using retromuscular mesh placement. J Gastrointest Surg. 2014 Sep; 18(9):1673-7. PMID: 24944155.
    Citations: 9     Fields:    Translation:Humans
  29. Raigani S, Hardacre JM, Kim J, Ammori JB. Trends in the surgical treatment of gastric adenocarcinoma. Ann Surg Oncol. 2014 Feb; 21(2):569-74. PMID: 24165900.
    Citations: 10     Fields:    Translation:Humans
  30. Raigani S, Agamanolis D, Soldes OS, Ponsky TA. Intra-abdominal (Type IV) sacrococcygeal teratoma presenting with buttock hemangioma. Pediatr Surg Int. 2013 Dec; 29(12):1341-4. PMID: 24057924.
    Citations:    Fields:    Translation:Humans
  31. Raigani S, Ammori J, Kim J, Hardacre JM. Trends in the treatment of resectable pancreatic adenocarcinoma. J Gastrointest Surg. 2014 Jan; 18(1):113-23. PMID: 24002769.
    Citations: 11     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.