Harvard Catalyst Profiles

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James Anthony Torchia, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. W81XWH-21-1-0080 (FREEMAN, GORDON JAMES) Jan 15, 2021 - Jan 14, 2022
    Department of Defense Peer Reviewed Medical Research Program
    Development of DF-COV for the Treatment and Prevention of COVID-19 and Associated Immunopathologic Respiratory Complications
    Role: Co-Investigator
  2. 2020YIA-3339402723 (TORCHIA, JAMES ANTHONY) Jul 1, 2020 - Jun 30, 2021
    American Society of Clinical Oncology
    Young Investigator Award
    Role: Principal Investigator
  3. F30CA186456 (TORCHIA, JAMES ANTHONY) Aug 14, 2014 - Jun 14, 2015
    Targeting lymphoma with modular anti-idiotype peptibodies
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Torchia JA, Tavares AH, Carstensen LS, Chen DY, Huang J, Xiao T, Mukherjee S, Reeves PM, Tu H, Sluder AE, Chen B, Kotton DN, Bowen RA, Saeed M, Poznansky MC, Freeman GJ. Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo. Sci Adv. 2022 12 09; 8(49):eabq6527. PMID: 36475798; PMCID: PMC9728973.
    Citations: 1     Fields:    Translation:HumansCells
  2. Pauken KE, Torchia JA, Chaudhri A, Sharpe AH, Freeman GJ. Emerging concepts in PD-1 checkpoint biology. Semin Immunol. 2021 02; 52:101480. PMID: 34006473; PMCID: PMC8545711.
    Citations: 12     Fields:    Translation:HumansCells
  3. Chu JN, Choi J, Ostvar S, Torchia JA, Reynolds KL, Tramontano A, Gainor JF, Chung DC, Clark JW, Hur C. Cost-effectiveness of immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer. Cancer. 2019 01 15; 125(2):278-289. PMID: 30343509.
    Citations: 8     Fields:    Translation:HumansCells
  4. Torchia J, Weiskopf K, Levy R. Targeting lymphoma with precision using semisynthetic anti-idiotype peptibodies. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5376-81. PMID: 27114517; PMCID: PMC4868466.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  5. Marabelle A, Kohrt H, Sagiv-Barfi I, Ajami B, Axtell RC, Zhou G, Rajapaksa R, Green MR, Torchia J, Brody J, Luong R, Rosenblum MD, Steinman L, Levitsky HI, Tse V, Levy R. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J Clin Invest. 2013 Jun; 123(6):2447-63. PMID: 23728179; PMCID: PMC3668834.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  6. Brody JD, Ai WZ, Czerwinski DK, Torchia JA, Levy M, Advani RH, Kim YH, Hoppe RT, Knox SJ, Shin LK, Wapnir I, Tibshirani RJ, Levy R. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol. 2010 Oct 01; 28(28):4324-32. PMID: 20697067.
    Citations: 211     Fields:    Translation:HumansCTClinical Trials
  7. Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MB. TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1. Sci Signal. 2010 May 18; 3(122):ra38. PMID: 20484116.
    Citations: 131     Fields:    Translation:AnimalsCells
  8. Houot R, Goldstein MJ, Kohrt HE, Myklebust JH, Alizadeh AA, Lin JT, Irish JM, Torchia JA, Kolstad A, Chen L, Levy R. Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Blood. 2009 Oct 15; 114(16):3431-8. PMID: 19641184; PMCID: PMC2765679.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  9. Wu Y, Torchia J, Yao W, Lane NE, Lanier LL, Nakamura MC, Humphrey MB. Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency. PLoS One. 2007 Jul 04; 2(7):e586. PMID: 17611621.
    Citations: 26     Fields:    Translation:AnimalsCells
  10. Miranda MB, Xu H, Torchia JA, Johnson DE. Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway. Leuk Res. 2005 Nov; 29(11):1293-306. PMID: 16164983.
    Citations: 22     Fields:    Translation:AnimalsCells
  11. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res. 2006 Feb; 21(2):237-45. PMID: 16418779.
    Citations: 68     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.