Harvard Catalyst Profiles

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Karyn Austin, M.D.

Title
Institution
Department
Address

Biography
Mount Holyoke College, South Hadley, MABA2004Biochemistry
Tufts University, Boston, MAMD/PhD2015Medicine/Genetics
Boston Children's Hospital, Boston, MAResidency2018Pediatrics
Boston Children's Hospital, Boston, MAFellowship2021Pediatric Cardiology

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. PMID: 31028357.
    Citations:    
  2. Shearer AM, Rana R, Austin K, Baleja JD, Nguyen N, Bohm A, Covic L, Kuliopulos A. Targeting Liver Fibrosis with a Cell-penetrating Protease-activated Receptor-2 (PAR2) Pepducin. J Biol Chem. 2016 10 28; 291(44):23188-23198. PMID: 27613872.
    Citations:    
  3. Austin KM, Nguyen N, Javid G, Covic L, Kuliopulos A. Noncanonical matrix metalloprotease-1-protease-activated receptor-1 signaling triggers vascular smooth muscle cell dedifferentiation and arterial stenosis. J Biol Chem. 2013 Aug 09; 288(32):23105-15. PMID: 23814055.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  4. Austin KM, Covic L, Kuliopulos A. Matrix metalloproteases and PAR1 activation. Blood. 2013 Jan 17; 121(3):431-9. PMID: 23086754.
    Citations:    
  5. Sevigny LM, Austin KM, Zhang P, Kasuda S, Koukos G, Sharifi S, Covic L, Kuliopulos A. Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia. Arterioscler Thromb Vasc Biol. 2011 Dec; 31(12):e100-6. PMID: 21940952.
    Citations: 22     Fields:    Translation:Animals
  6. Tressel SL, Kaneider NC, Kasuda S, Foley C, Koukos G, Austin K, Agarwal A, Covic L, Opal SM, Kuliopulos A. A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis. EMBO Mol Med. 2011 Jul; 3(7):370-84. PMID: 21591259.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  7. Swift S, Xu J, Trivedi V, Austin KM, Tressel SL, Zhang L, Covic L, Kuliopulos A. A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. J Biol Chem. 2010 Apr 09; 285(15):11402-10. PMID: 20164183.
    Citations:    
  8. Tulpule A, Lensch MW, Miller JD, Austin K, D'Andrea A, Schlaeger TM, Shimamura A, Daley GQ. Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood. 2010 Apr 29; 115(17):3453-62. PMID: 20089964.
    Citations: 31     Fields:    Translation:HumansCells
  9. Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. J Clin Invest. 2008 Apr; 118(4):1511-8. PMID: 18324336.
    Citations: 30     Fields:    Translation:HumansCells
  10. Chander M, Austin KM, Aye-Han NN, Sircar P, Hsu LM. An alternate mechanism of abortive release marked by the formation of very long abortive transcripts. Biochemistry. 2007 Nov 06; 46(44):12687-99. PMID: 17929835.
    Citations:    
  11. Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura A. The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA. Blood. 2007 Sep 01; 110(5):1458-65. PMID: 17475909.
    Citations: 49     Fields:    Translation:HumansCellsCTClinical Trials
  12. Austin KM, Leary RJ, Shimamura A. The Shwachman-Diamond SBDS protein localizes to the nucleolus. Blood. 2005 Aug 15; 106(4):1253-8. PMID: 15860664.
    Citations: 34     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.