Harvard Catalyst Profiles

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Quan Zhu, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI058804 (ZHU, QUAN KAREN) Apr 1, 2004 - Mar 31, 2008
    NIH/NIAID
    An AIDS Vaccine Strategy uding hCCR5-lgG Fusion Proteins
    Role: Principal Investigator
  2. R41HL057636 (ZHU, QUAN KAREN) Sep 30, 1997 - Sep 29, 2000
    NIH/NHLBI
    NON VIRAL GENE DELIVERY TO HEMATOPOIETIC STEM CELLS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Avnir Y, Tallarico AS, Zhu Q, Bennett AS, Connelly G, Sheehan J, Sui J, Fahmy A, Huang CY, Cadwell G, Bankston LA, McGuire AT, Stamatatos L, Wagner G, Liddington RC, Marasco WA. Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses. PLoS Pathog. 2014 May; 10(5):e1004103. PMID: 24788925.
    Citations: 26     Fields:    Translation:HumansCells
  2. Tang XC, Agnihothram SS, Jiao Y, Stanhope J, Graham RL, Peterson EC, Avnir Y, Tallarico AS, Sheehan J, Zhu Q, Baric RS, Marasco WA. Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):E2018-26. PMID: 24778221.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  3. Han T, Abdel-Motal UM, Chang DK, Sui J, Muvaffak A, Campbell J, Zhu Q, Kupper TS, Marasco WA. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma. PLoS One. 2012; 7(9):e44455. PMID: 22973452.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  4. Braun SE, Taube R, Zhu Q, Wong FE, Murakami A, Kamau E, Dwyer M, Qiu G, Daigle J, Carville A, Johnson RP, Marasco WA. In vivo selection of CD4(+) T cells transduced with a gamma-retroviral vector expressing a single-chain intrabody targeting HIV-1 tat. Hum Gene Ther. 2012 Sep; 23(9):917-31. PMID: 22734618.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  5. Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Mol Cancer Ther. 2012 Nov; 11(11):2451-61. PMID: 22869555.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  6. Biswas S, Chang H, Sarkis PT, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 2011 Dec; 134(4):419-33. PMID: 22044090.
    Citations: 29     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  7. Abdel-Motal UM, Sarkis PT, Han T, Pudney J, Anderson DJ, Zhu Q, Marasco WA. Anti-gp120 minibody gene transfer to female genital epithelial cells protects against HIV-1 virus challenge in vitro. PLoS One. 2011; 6(10):e26473. PMID: 22031835.
    Citations: 7     Fields:    Translation:HumansCells
  8. Han T, Sui J, Bennett AS, Liddington RC, Donis RO, Zhu Q, Marasco WA. Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display. Biochem Biophys Res Commun. 2011 Jun 03; 409(2):253-9. PMID: 21569761.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  9. Xu C, Lo A, Yammanuru A, Tallarico AS, Brady K, Murakami A, Barteneva N, Zhu Q, Marasco WA. Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PLoS One. 2010 Mar 10; 5(3):e9625. PMID: 20224781.
    Citations: 12     Fields:    Translation:HumansCells
  10. Nakase K, Cheng J, Zhu Q, Marasco WA. Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells. J Leukoc Biol. 2009 Jan; 85(1):165-74. PMID: 18948549.
    Citations: 10     Fields:    Translation:HumansCells
  11. Sui J, Aird DR, Tamin A, Murakami A, Yan M, Yammanuru A, Jing H, Kan B, Liu X, Zhu Q, Yuan QA, Adams GP, Bellini WJ, Xu J, Anderson LJ, Marasco WA. Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway. PLoS Pathog. 2008 Nov; 4(11):e1000197. PMID: 18989460.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  12. Taube R, Zhu Q, Xu C, Diaz-Griffero F, Sui J, Kamau E, Dwyer M, Aird D, Marasco WA. Lentivirus display: stable expression of human antibodies on the surface of human cells and virus particles. PLoS One. 2008 Sep 11; 3(9):e3181. PMID: 18784843.
    Citations: 5     Fields:    Translation:HumansCells
  13. Sui J, Zhu QK, Muvaffak A, Lo A, Marasco WA. Humanized Monoclonal Antibodies And Methods Of Use. 2008.
  14. Lo AS, Zhu Q, Marasco WA. Intracellular antibodies (intrabodies) and their therapeutic potential. Handb Exp Pharmacol. 2008; (181):343-73. PMID: 18071953.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  15. Taube R, Zhu Q, Xu C, Diaz-Griffero F, Sui J, Aird D, Dwyer MR and Marasco WA. . Lentivirus display: Stable expression of human antibodies on the surface of human cells and virus particles. (Under second review). Nature Biotech. 2008.
  16. Xu C, Sui J, Tao H, Zhu Q, Marasco WA. Human anti-CXCR4 antibodies undergo VH replacement, exhibit functional V-region sulfation, and define CXCR4 antigenic heterogeneity. J Immunol. 2007 Aug 15; 179(4):2408-18. PMID: 17675502.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  17. Cheng J, Kydd AR, Nakase K, Noonan KM, Murakami A, Tao H, Dwyer M, Xu C, Zhu Q, Marasco WA. Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein. Blood. 2007 Sep 15; 110(6):2110-20. PMID: 17540846.
    Citations: 9     Fields:    Translation:HumansCells
  18. Lo A, Zhu Q, Marasco WA. Intracellular antibodies (intrabodies) and their therapeutic potential. Eds. Y. Chernajovsky and A. Nissim. Handbook of Experimental Pharmacology: Therapeutic Antibodies. 2007; 181:333-63.
  19. Nakase K, Cheng J, Zhu Q, Marasco WA. . Transcriptional Regulation of the SHP-1, a candidate tumor suppressor gene in hematological malignancies. . The 48th Annual Meeting of American Society of Hematology. Orlando, FL. Published in Blood, American Society of Hematology 48th Annual Meeting. Orlando, FL. 2006. Abstract #4346 published in Blood, Volume 108, issue 11, November 16, 2006 . 2006; 108(11):Abstract #4346 .
  20. Zhu QK, Marasco WA. Vectors and Uses Thereof. 2004.
  21. Zhu Q, Maitra U, Johnston D, Lozano M, Dudley JP. The homeodomain protein CDP regulates mammary-specific gene transcription and tumorigenesis. Mol Cell Biol. 2004 Jun; 24(11):4810-23. PMID: 15143175.
    Citations: 12     Fields:    Translation:AnimalsCells
  22. Zhu Q, Ricardo RR, Zhang L, Ogueta S, Agrawal R, Dzau V, and Marasco WA. . Development of constitutive and inducible SIN lentiviral vectors and their application in cardiovascular gene transfer. Gene Ther Mol Biol. 2004; 8:91-102.
  23. Zhu Q, Marasco WA. Intracellular targeting of antibodies in mammalian cells. New Comprehensive Biochemistry: Gene Transfer and Expression in Mammalian Cells. Ed. Savvas C. Makrides. 2003; 38:573-87.
  24. Lecerf JM, Shirley TL, Zhu Q, Kazantsev A, Amersdorfer P, Housman DE, Messer A, Huston JS. Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4764-9. PMID: 11296304.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  25. Powell CM, Rudge TL, Zhu Q, Johnson LF, Hansen U. Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression. EMBO J. 2000 Sep 01; 19(17):4665-75. PMID: 10970859.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  26. Huston JS, Zhu QK, et al. Bioengineered vehicles for targeted nucleic acid delivery. 2000.
  27. Zhu Q, Zeng C, Huhalov A, Yao J, Turi TG, Danley D, Hynes T, Cong Y, DiMattia D, Kennedy S, Daumy G, Schaeffer E, Marasco WA and Huston JS. Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, Capase-7. J Immuno Meth. 1999; 231:207-22.
  28. Lecerf JM, Shirley TL, Zhu Q, Messer A, Huston JS. . Anti-huntingtin single-chain Fv intrabody blocks aggregation of co-transfected huntingtin protein. The 10th IBC International Conference on Antibody Engineering. La Jolla, CA. 1999.
  29. Volker JL, Rameh LE, Zhu Q, DeCaprio J, Hansen U. Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity. Genes Dev. 1997 Jun 01; 11(11):1435-46. PMID: 9192871.
    Citations: 26     Fields:    Translation:HumansCells
  30. Jones SD, Zhu Q, VanHaight C, Huhalov A. . Non-viral vectors used for delivery of genes encoding toxin molecules. Keystone Symposium. . 1997.
  31. Zhu Q, Courtney RJ. Chemical cross-linking of virion envelope and tegument proteins of herpes simplex virus type 1. Virology. 1994 Nov 01; 204(2):590-9. PMID: 7941326.
    Citations: 39     Fields:    Translation:HumansCells
  32. Shirra MK, Zhu Q, Huang HC, Pallas D, Hansen U. One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. Mol Cell Biol. 1994 Aug; 14(8):5076-87. PMID: 8035790.
    Citations: 23     Fields:    Translation:HumansCells
  33. Zhu, QK. Chemical cross-linking studies of herpes simplex virus type 1 glycoproteins. 1991.
  34. Zhu QL, Smith TF, Lathrop RH, Figge J. Acid helix-turn activator motif. Proteins. 1990; 8(2):156-63. PMID: 2172962.
    Citations: 4     Fields:    Translation:AnimalsCells
  35. Zhu Q, Courtney RJ. Chemical crosslinking of glycoproteins on the envelope of herpes simplex virus. Virology. 1988 Dec; 167(2):377-84. PMID: 2849232.
    Citations: 6     Fields:    Translation:Cells
  36. Zhu Q, Courtney RJ. Chemical cross-linking study of the herpes simplex virus glycoprotein oligomerization on the virion envelope. The 13th International Herpesvirus Workshop. Irvine CA. 1988.
  37. Zhu Q, Courtney RJ. . Chemical cross-linking of the HSV-specific glycoproteins on the envelope of HSV-1 virions. ASM South Central Branch and Louisiana Biochemistry Society joint meeting. Shreveport, LA. 1986.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.