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Shasha Li, Ph.D., M.D.

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Sichuan University, Chengdu, Sichuan, ChinaM.D.06/2001Clinical Medicine
Sichuan University, Chengdu, Sichuan, ChinaMSc.06/2004Integrative Medicine
Sichuan University, Chengdu, Sichuan, ChinaPh.D.06/2010Physical Medicine & Rehabilitation
2010 - 2010
Outstanding Ph.D. Graduate Award
2012 - 2012
Outstanding Young Teacher Award
2012 - 2016
Outstanding Young Scientist Award
2017 - 2018
AHA: FDA Summer 2016 Postdoctoral Fellowship
2019 - 2024
K23: Mentored Patient-Oriented Research Career Development Award


Available: 11/30/22, Expires: 06/30/24

The human brain has a remarkable capacity to extract meaning from acoustical signals and relate this sensory input to articulatory motor representations to produce speech. Over half a century ago, the motor theory of speech perception (MTSP) argued that production circuits are necessary for speech perception. Transcranial magnetic stimulation (TMS) studies of the primary motor cortex (M1) suggest that the excitability of muscles controlling the tongue increases during listening to speech and during viewing speech-related movements. However, several critical arguments exist against the experimental evidence that supports MTSP. In this project, we aim to pinpoint areas of articulatory motor pathways at high resolution using 7 T fMRI, which provides better sensitivity and signal-to-noise ratio than traditional MRI field strengths. MD or Ph.D. candidates passionate about brain science integrated with cutting-edge neuroimage and neuromodulation are welcome to participate. The minimal time commitment is three-month and can be 12 months or longer with hands-on training in ultra-high-field fMRI data collection, fMRI-guided navigation TMS operation, or if with solid programming skills, can remotely work on fantastic data analysis.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23DC018022 (Shasha Li) Jul 1, 2019 - Jun 30, 2024
    Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain
    Role Description: The overall goal of this K23 award will develop a precise brain biomarker specific to auditory speech processing in healthy human subjects using a combination of advanced neuroimaging and noninvasive brain stimulation techniques. The knowledge gained from this project will serve as the basis for optimizing neuromodulation therapy and neurorehabilitation that will improve the quality of life for patients affected by a broad range of auditory communication disorders.
    Role: Principal Investigator
  2. 17POST32530004 (Shasha Li) Jan 1, 2017 - Dec 31, 2018
    American Heart Association
    Localizing Central Swallowing Functions by Combining Noninvasive Brain Stimulation with Neuroimaging
    Role Description: The aim of this study is to investigate how the brain controls the swallowing function in healthy volunteers by using noninvasive functional magnetic resonance imaging (fMRI) and navigated transcranial magnetic stimulation (nTMS). The results of this study could provide us with more information about how the brain processes swallowing, and thus allow for the development of more effective treatments for patients with swallowing dysfunctions.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lanlan Zhang, Chuang Tang, Min Zhang, Xia Tong, Yingying Xie, Ruitong Yan, Xiangjun Wang, Xin Zhang, Dan Liu, Shasha Li. Single cell meta-analysis of EndMT, EMT statue in COVID-19. Frontiers in Immunology. 2022; 5321.
  2. Jiang Zhang, Yuyan Liu, Xiaonan Guo, Jing Guo, Zhengcong Du, Muyuan He, Qihong Liu, Dundi Xu, Taiyuan Liu, Junran Zhang, Huijuan Yuan, Meiyun Wang, Shasha Li. Causal structural covariance network suggesting structural alterations progression in Type 2 diabetes patients. Frontiers in Human Neuroscience. 2022; (16):936943.
  3. Astrakas LG, Li S, Elbach S, Tzika AA. The Severity of Sensorimotor Tracts Degeneration May Predict Motor Performance in Chronic Stroke Patients, While Brain Structural Network Dysfunction May Not. Front Neurol. 2022; 13:813763. PMID: 35432180; PMCID: PMC9008887.
  4. Zhang L, Gui X, Zhang X, Dai Y, Wang X, Tong X, Li S. Endothelial Cell: Lactate Metabolic Player in Organ Regeneration. Front Cell Dev Biol. 2021; 9:701672. PMID: 34485288.
  5. Astrakas LG, Li S, Ottensmeyer MP, Pusatere C, Moskowitz MA, Tzika AA. Peak Activation Shifts in the Sensorimotor Cortex of Chronic Stroke Patients Following Robot-assisted Rehabilitation Therapy. Open Neuroimag J. 2021; 14:8-15. PMID: 34434290; PMCID: PMC8384467.
  6. Wang Y, Gao D, Cui B, Yu B, Fang J, Wang Z, Tang R, Cao Z, Song W, Song P, Li S. Increased grey matter volume and associated resting-state functional connectivity in chronic spontaneous urticaria: A structural and functional MRI study. J Neuroradiol. 2021 Jun; 48(4):236-242. PMID: 33549611.
    Citations: 2     Fields:    Translation:Humans
  7. Astrakas LG, De Novi G, Ottensmeyer MP, Pusatere C, Li S, Moskowitz MA, Tzika AA. Improving motor function after chronic stroke by interactive gaming with a redesigned MR-compatible hand training device. Exp Ther Med. 2021 Mar; 21(3):245. PMID: 33603853.
  8. Gu P, Tu W, Deng F, Ye L, Li S, Bai G, Jin X, Li S, Jiang S. Sequential neural activity in sensorimotor area and mirror neural system for graded mirror therapy with imagined hand movements. NeuroRehabilitation. 2021; 49(4):641-654. PMID: 34776425.
    Citations:    Fields:    Translation:Humans
  9. Qadri Z, Righi V, Li S, Tzika AA. Tracking of Labelled Stem Cells Using Molecular MR Imaging in a Mouse Burn Model in Vivo as an Approach to Regenerative Medicine. Adv J Mol Imaging. 2021 Jan; 11(1):1-15. PMID: 33996249.
  10. Zhang J, Liu Y, Luo R, Du Z, Lu F, Yuan Z, Zhou J, Li S. Classification of pure conduct disorder from healthy controls based on indices of brain networks during resting state. Med Biol Eng Comput. 2020 Sep; 58(9):2071-2082. PMID: 32648090.
    Citations:    Fields:    Translation:Humans
  11. Li S, Eshghi M, Khan S, Tian Q, Joutsa J, Ou Y, Wang QM, Kong J, Rosen BR, Ahveninen J, Nummenmaa A. Localizing central swallowing functions by combining non-invasive brain stimulation with neuroimaging. Brain Stimul. 2020 Sep - Oct; 13(5):1207-1210. PMID: 32504829; PMCID: PMC7494555.
    Citations:    Fields:    
  12. Meng Y, Michelena TM, Cai F, Lou X, Li S, Zhang R. Traditional Chinese Medicine in Emergency Treatment Mechanism and Application. Open Access Emerg Med. 2020; 12:111-119. PMID: 32431555; PMCID: PMC7198447.
    Citations: 2     
  13. Ottensmeyer MP, Li S, De Novi G, Tzika AA. Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits. J Vis Exp. 2019 11 23; (153). PMID: 31814610.
    Citations: 2     Fields:    Translation:Humans
  14. Shen W, Tu Y, Gollub RL, Ortiz A, Napadow V, Yu S, Wilson G, Park J, Lang C, Jung M, Gerber J, Mawla I, Chan ST, Wasan AD, Edwards RR, Kaptchuk T, Li S, Rosen B, Kong J. Visual network alterations in brain functional connectivity in chronic low back pain: A resting state functional connectivity and machine learning study. Neuroimage Clin. 2019; 22:101775. PMID: 30927604; PMCID: PMC6444301.
    Citations: 29     Fields:    Translation:Humans
  15. Li Y, Fan J, Yang J, He C, Li S. Effects of Repetitive Transcranial Magnetic Stimulation on Walking and Balance Function after Stroke: A Systematic Review and Meta-Analysis. Am J Phys Med Rehabil. 2018 11; 97(11):773-781. PMID: 29734235.
    Citations: 3     Fields:    Translation:Humans
  16. Wang Y, Fang J, Song P, Bao Y, Song W, Liu J, Lang C, Jorgenson K, Jung M, Shen D, Li S, Sun R, Ding X, Yang J, Meng X, Wang N, Yan Z, Yan Y, Kong Q, Dong Y, Cui F, Tu Y, Cui B, Kong J. The Dysfunction of the Cerebellum and Its Cerebellum-Reward-Sensorimotor Loops in Chronic Spontaneous Urticaria. Cerebellum. 2018 Oct; 17(5):507-516. PMID: 29574551.
    Citations: 3     Fields:    Translation:Humans
  17. Fan J, Li Y, Yang Y, Qu Y, Li S. Efficacy of Noninvasive Brain Stimulation on Unilateral Neglect After Stroke: A Systematic Review and Meta-analysis. Am J Phys Med Rehabil. 2018 04; 97(4):261-269. PMID: 28953034.
    Citations: 5     Fields:    Translation:Humans
  18. Li Y, Fan J, Yang J, He C, Li S. Effects of transcranial direct current stimulation on walking ability after stroke: A systematic review and meta-analysis. Restor Neurol Neurosci. 2018; 36(1):59-71. PMID: 29439362.
    Citations: 15     Fields:    Translation:Humans
  19. Ma X, Wei X, Li S. The Application of Functional Imaging in the Diagnosis of Tumors. Contrast Media Mol Imaging. 2017; 2017:3608912. PMID: 29379408.
    Citations:    Fields:    Translation:HumansAnimals
  20. Fan J, Li Y, Fu X, Li L, Hao X, Li S. Nonhuman primate models of focal cerebral ischemia. Neural Regen Res. 2017 Feb; 12(2):321-328. PMID: 28400817; PMCID: PMC5361519.
    Citations: 10     
  21. Yang Y, He C, Yang L, Gao Q, Li S, He J. Effects of cervical low-frequency electrical stimulation with various waveforms and densities on body mass, liver and kidney function, and death rate in ischemic stroke rats. Neural Regeneration Research. 2016; 4(6):304-308.
  22. Li S, Zaninotto AL, Neville IS, Paiva WS, Nunn D, Fregni F. Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence. Neuropsychiatr Dis Treat. 2015; 11:1573-86. PMID: 26170670; PMCID: PMC4494620.
    Citations: 29     
  23. Grecco LH, Li S, Michel S, Castillo-Saavedra L, Mourdoukoutas A, Bikson M, Fregni F. . Transcutaneous spinal stimulation as a therapeutic strategy for spinal cord injury: state of the art. Journal of Neurorestoratology. 2015; (3):73-82.
  24. Liu H, He H, Li S, Yang L, Wang P, Liu C, Wei X, Wu T, He C. Vitamin D receptor gene polymorphisms and risk of osteoarthritis: a meta-analysis. Exp Biol Med (Maywood). 2014 May; 239(5):559-67. PMID: 24603077.
    Citations: 5     Fields:    Translation:Humans
  25. Li S, Zhou M, Yu B, Ma Z, Chen S, Gong Q, He L, Huang X, Lui S, Wang X, Zhou D, He C. Altered default mode and affective network connectivity in stroke patients with and without dysphagia. J Rehabil Med. 2014 Feb; 46(2):126-31. PMID: 24213671.
    Citations: 7     Fields:    Translation:Humans
  26. Li S, Yu B, Zhou D, He C, Zhuo Q, Hulme JM. Electromagnetic fields for treating osteoarthritis. Cochrane Database Syst Rev. 2013 Dec 14; (12):CD003523. PMID: 24338431.
    Citations: 19     Fields:    Translation:Humans
  27. Li S, Ma Z, Tu S, Zhou M, Chen S, Guo Z, Gong Q, He L, Huang X, Yao D, Lui S, Yu B, Wang X, Zhou D, He C. Altered resting-state functional and white matter tract connectivity in stroke patients with dysphagia. Neurorehabil Neural Repair. 2014 Mar-Apr; 28(3):260-72. PMID: 24297761.
    Citations: 14     Fields:    Translation:HumansCells
  28. Li S, He C. Early rehabilitation prevents disability after earthquake: A letter to international rehabilitation colleagues. J Rehabil Med. 2013 Jun; 45(6):603. PMID: 23681118.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  29. He C, Wang S, Li S, Yang L, He H, Wu Y, Lan Q, Tang T. Study of the association between female obesity and osteoporosis. Journal of Back and Musculoskeletal Rehabilitation. 2012; (25):143-148.
  30. Zhang JL, He HC, Lin HD, Luo QL, Xia L, Li SS, He CQ. Motor function and activities of daily living capacity of patients with fractures sustained during the Wenchuan earthquake. Chin Med J (Engl). 2011 May; 124(10):1504-7. PMID: 21740806.
    Citations: 1     Fields:    Translation:Humans
  31. Li S, Yu B, Zhou D, He C, Kang L, Wang X, Jiang S, Chen X. Acupuncture for Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev. 2011 Apr 13; (4):CD007839. PMID: 21491402.
    Citations: 10     Fields:    Translation:Humans
  32. Li S, Luo Q, Huang L, Hu Y, Xia Q, He C. Effects of pulsed electromagnetic fields on cartilage apoptosis signalling pathways in ovariectomised rats. Int Orthop. 2011 Dec; 35(12):1875-82. PMID: 21404022.
    Citations: 8     Fields:    Translation:AnimalsCells
  33. Luo C, Li Q, Lai Y, Xia Y, Qin Y, Liao W, Li S, Zhou D, Yao D, Gong Q. Altered functional connectivity in default mode network in absence epilepsy: a resting-state fMRI study. Hum Brain Mapp. 2011 Mar; 32(3):438-49. PMID: 21319269.
    Citations: 112     Fields:    Translation:Humans
  34. Gao Q, Yang Y, Li S, He J, He C. Changes in plasma calcitonin gene-related peptide and serum neuron specific enolase in rats with acute cerebral ischemia after low-frequency electrical stimulation with different waveforms and intensities. Neural Regeneration Research. 2011; 28(6):2217-2221.
  35. Li S, Yu B, Lin Z, Jiang S, He J, Kang L, Li W, Chen X, Wang X. Randomized-controlled study of treating attention deficit hyperactivity disorder of preschool children with combined electro-acupuncture and behavior therapy. Complement Ther Med. 2010 Oct; 18(5):175-83. PMID: 21056840.
    Citations: 3     Fields:    Translation:Humans
  36. Li S, He H, Ding M, He C. The correlation of osteoporosis to clinical features: a study of 4382 female cases of a hospital cohort with musculoskeletal symptoms in southwest China. BMC Musculoskelet Disord. 2010 Aug 16; 11:183. PMID: 20712872; PMCID: PMC2929215.
    Citations: 6     Fields:    Translation:Humans
  37. Li S, Yang Y, Gao Q, He J, He C. Electrical stimulation upregulates angiopoietin-1/Tie-2 mRNA expression in a rat model of focal cerebral ischemia. Neural regeneration research. 2010; 19(5):1470-1474.
  38. Li S, Chen Q, Yu B, Xue K, Luo C, Xu Y, Gong Q, He C, Zhou D, He L, Yao D. Structural and functional changes mapped in the brains of amyotrophic lateral sclerosis patients with/without dysphagia: a pilot study. Amyotroph Lateral Scler. 2009 Oct-Dec; 10(5-6):280-7. PMID: 19922114.
    Citations: 11     Fields:    Translation:Humans
  39. Li S, Luo C, Yu B, Yan B, Gong Q, He C, He L, Huang X, Yao D, Lui S, Tang H, Chen Q, Zeng Y, Zhou D. Functional magnetic resonance imaging study on dysphagia after unilateral hemispheric stroke: a preliminary study. J Neurol Neurosurg Psychiatry. 2009 Dec; 80(12):1320-9. PMID: 19515639.
    Citations: 24     Fields:    Translation:Humans
  40. Yu B, Li S, Lin Z, Zhang N. Treatment of posthemorrhagic hydrocephalus in premature infants with subcutaneous reservoir drainage. Pediatr Neurosurg. 2009; 45(2):119-25. PMID: 19307746.
    Citations: 4     Fields:    Translation:Humans
  41. Li S, Luo C, He C, Gong Q, Zhou D. Central swallowing in normal adults using functional magnetic resonance imaging. Neural Regeneration Research. 2009; 4(4):258-264.
  42. Yu B, Li S, Yao Y, Lin Z. Changes in beta(1) integrin in renal tubular epithelial cells after intrauterine asphyxia of rabbit pups. J Perinat Med. 2009; 37(1):59-65. PMID: 18767988.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Luo Q, Li SS, He C, He H, Yang L, Deng L. Pulse electromagnetic fields effects on serum E2 levels, chondrocyte apoptosis, and matrix metalloproteinase-13 expression in ovariectomized rats. Rheumatol Int. 2009 Jun; 29(8):927-35. PMID: 19050895.
    Citations: 7     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.