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Corneliu Sima, D.Sc., D.M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00DE024575 (SIMA, CORNELIU) Apr 1, 2018 - Mar 31, 2021
    NIH/NIDCR
    Regulation of Inflammation in T2D-Associated Periodontitis
    Role: Principal Investigator
  2. R01DE025255 (HAN, XIAOZHE) Jul 6, 2015 - May 31, 2020
    NIH/NIDCR
    Regulatory B cells in the amelioration of immune-mediated periodontal disease
    Role: Co-Principal Investigator
  3. K99DE024575 (SIMA, CORNELIU) Apr 1, 2015 - Mar 31, 2017
    NIH/NIDCR
    M1/M2 Regulation of Inflammation in T2D-Associated Periodontitis
    Role: Principal Investigator
  4. R44DE023714 (IFTIMIA, NICUSOR) Sep 1, 2013 - Mar 31, 2020
    NIH
    Optical probe for real-time assessment of periodontal health status
    Role: Principal Investigator (Consortium PI)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Van Dyke TE, Sima C. Understanding resolution of inflammation in periodontal diseases: Is chronic inflammatory periodontitis a failure to resolve? Periodontol 2000. 2020 02; 82(1):205-213. PMID: 31850636.
    Citations:    
  2. Choi SE, Sima C, Pandya A. Impact of Treating Oral Disease on Preventing Vascular Diseases: A Model-Based Cost-effectiveness Analysis of Periodontal Treatment Among Patients With Type 2 Diabetes. Diabetes Care. 2020 Mar; 43(3):563-571. PMID: 31882408.
    Citations:    
  3. Montero E, Herrera D, Sanz M, Dhir S, Van Dyke T, Sima C. Development and validation of a predictive model for periodontitis using NHANES 2011-2012 data. J Clin Periodontol. 2019 04; 46(4):420-429. PMID: 30891834.
    Citations:    
  4. Sima C, Viniegra A, Glogauer M. Macrophage immunomodulation in chronic osteolytic diseases-the case of periodontitis. J Leukoc Biol. 2019 03; 105(3):473-487. PMID: 30452781.
    Citations:    Fields:    
  5. Viniegra A, Goldberg H, Çil Ç, Fine N, Sheikh Z, Galli M, Freire M, Wang Y, Van Dyke TE, Glogauer M, Sima C. Resolving Macrophages Counter Osteolysis by Anabolic Actions on Bone Cells. J Dent Res. 2018 09; 97(10):1160-1169. PMID: 29993312.
    Citations: 1     Fields:    
  6. Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan CN, Van Dyke TE. Author Correction: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance. Sci Rep. 2018 Mar 02; 8(1):4143. PMID: 29500456.
    Citations:    Fields:    
  7. Sima C, Paster B, Van Dyke TE. Function of Pro-Resolving Lipid Mediator Resolvin E1 in Type 2 Diabetes. Crit Rev Immunol. 2018; 38(5):343-365. PMID: 30806214.
    Citations:    
  8. Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan CN, Van Dyke TE. ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance. Sci Rep. 2017 10 09; 7(1):12848. PMID: 28993702.
    Citations:    Fields:    
  9. Revelo XS, Ghazarian M, Chng MH, Luck H, Kim JH, Zeng K, Shi SY, Tsai S, Lei H, Kenkel J, Liu CL, Tangsombatvisit S, Tsui H, Sima C, Xiao C, Shen L, Li X, Jin T, Lewis GF, Woo M, Utz PJ, Glogauer M, Engleman E, Winer S, Winer DA. Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance. Cell Rep. 2016 07 19; 16(3):717-30. PMID: 27373163.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  10. Fine N, Hassanpour S, Borenstein A, Sima C, Oveisi M, Scholey J, Cherney D, Glogauer M. Distinct Oral Neutrophil Subsets Define Health and Periodontal Disease States. J Dent Res. 2016 07; 95(8):931-8. PMID: 27270666.
    Citations: 5     Fields:    Translation:HumansCells
  11. Sima C, Aboodi GM, Lakschevitz FS, Sun C, Goldberg MB, Glogauer M. Nuclear Factor Erythroid 2-Related Factor 2 Down-Regulation in Oral Neutrophils Is Associated with Periodontal Oxidative Damage and Severe Chronic Periodontitis. Am J Pathol. 2016 06; 186(6):1417-26. PMID: 27070823.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  12. Aboodi GM, Sima C, Moffa EB, Crosara KT, Xiao Y, Siqueira WL, Glogauer M. Salivary Cytoprotective Proteins in Inflammation and Resolution during Experimental Gingivitis--A Pilot Study. Front Cell Infect Microbiol. 2015; 5:92. PMID: 26779447.
    Citations: 1     Fields:    Translation:HumansCells
  13. Sima C, Van Dyke TE. Therapeutic Targets for Management of Periodontitis and Diabetes. Curr Pharm Des. 2016; 22(15):2216-37. PMID: 26881443.
    Citations: 2     Fields:    Translation:Humans
  14. Zamakhchari MF, Sima C, Sama K, Fine N, Glogauer M, Van Dyke TE, Gyurko R. Lack of p47(phox) in Akita Diabetic Mice Is Associated with Interstitial Pneumonia, Fibrosis, and Oral Inflammation. Am J Pathol. 2016 Mar; 186(3):659-70. PMID: 26747235.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Sima C, Cheng Q, Rautava J, Levesque C, Sherman P, Glogauer M. Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis. J Periodontal Res. 2016 Apr; 51(2):237-49. PMID: 26126603.
    Citations: 2     Fields:    Translation:Animals
  16. Sheikh Z, Sima C and Glogauer M. Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation. Materials. 2015; 6(8):2953-2993. View Publication.
  17. Cheng Q, Seltzer Z, Sima C, Lakschevitz FS, Glogauer M. Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. PLoS One. 2015; 10(5):e0124117. PMID: 25942439.
    Citations: 1     Fields:    Translation:Animals
  18. Jiang H, Wang Y, Viniegra A, Sima C, McCulloch CA, Glogauer M. Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss. FASEB J. 2015 Jun; 29(6):2281-91. PMID: 25681458.
    Citations: 3     Fields:    Translation:AnimalsCells
  19. Sima C and Glogauer M. Neutrophil Dysfunction and Host Susceptibility to Periodontal Inflammation: Current State of Knowledge. Current Oral Health Reports. 2014; 1(2):95-103. View Publication.
  20. Sima C, Gastfreund S, Sun C, Glogauer M. Rac-null leukocytes are associated with increased inflammation-mediated alveolar bone loss. Am J Pathol. 2014 Feb; 184(2):472-82. PMID: 24269593.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. Sima C, Glogauer M. Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone. Periodontol 2000. 2013 Oct; 63(1):80-101. PMID: 23931056.
    Citations: 8     Fields:    Translation:HumansCells
  22. Rajshankar D, Sima C, Wang Q, Goldberg SR, Kazembe M, Wang Y, Glogauer M, Downey GP, McCulloch CA. Role of PTPa in the destruction of periodontal connective tissues. PLoS One. 2013; 8(8):e70659. PMID: 23940616.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Sima C, Glogauer M. Diabetes mellitus and periodontal diseases. Curr Diab Rep. 2013 Jun; 13(3):445-52. PMID: 23430581.
    Citations: 7     Fields:    Translation:Humans
  24. Sima C, Rhourida K, Van Dyke TE, Gyurko R. Type 1 diabetes predisposes to enhanced gingival leukocyte margination and macromolecule extravasation in vivo. J Periodontal Res. 2010 Dec; 45(6):748-56. PMID: 20682016.
    Citations: 16     Fields:    Translation:AnimalsCells
  25. Osuchowski MF, Craciun FL, Schuller E, Sima C, Gyurko R, Remick DG. Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response. Shock. 2010 Oct; 34(4):369-76. PMID: 20610941.
    Citations: 11     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.