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Youssef Jounaidi, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liao Y, Liu X, Jounaidi Y, Forman SA, Feng HJ. Etomidate Effects on Desensitization and Deactivation of a4ß3d GABAA Receptors Inducibly Expressed in HEK293 TetR Cells. J Pharmacol Exp Ther. 2019 Jan; 368(1):100-105. PMID: 30389723.
    Citations:    Fields:    
  2. Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. 2018 09; 129(3):459-476. PMID: 29894316.
    Citations:    Fields:    Translation:Animals
  3. Zhou X, Desai R, Zhang Y, Stec WJ, Miller KW, Jounaidi Y. High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing a4ß3d subunits. PLoS One. 2018; 13(1):e0191583. PMID: 29352320.
    Citations:    Fields:    Translation:HumansCells
  4. Jounaidi Y, Cotten JF, Miller KW, Forman SA. Tethering IL2 to Its Receptor IL2Rß Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells. Cancer Res. 2017 11 01; 77(21):5938-5951. PMID: 28916655.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. General Anesthetic Binding Sites in Human a4ß3d ?-Aminobutyric Acid Type A Receptors (GABAARs). J Biol Chem. 2016 Dec 16; 291(51):26529-26539. PMID: 27821594.
    Citations: 4     Fields:    Translation:HumansCells
  6. Liu K, Jounaidi Y, Forman SA, Feng HJ. Etomidate uniquely modulates the desensitization of recombinant a1ß3d GABA(A) receptors. Neuroscience. 2015 Aug 06; 300:307-13. PMID: 26028470; PMCID: PMC4484732.
    Citations: 3     Fields:    Translation:HumansCells
  7. Feng HJ, Jounaidi Y, Haburcak M, Yang X, Forman SA. Etomidate produces similar allosteric modulation in a1ß3d and a1ß3?2L GABA(A) receptors. Br J Pharmacol. 2014 Feb; 171(3):789-98. PMID: 24199598; PMCID: PMC3969089.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Mupparaju S, Hou H, Lariviere JP, Swartz H, Jounaidi Y, Khan N. Repeated tumor oximetry to identify therapeutic window during metronomic cyclophosphamide treatment of 9L gliomas. Oncol Rep. 2011 Jul; 26(1):281-6. PMID: 21503586; PMCID: PMC3146786.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Doloff JC, Jounaidi Y, Waxman DJ. Dual E1A oncolytic adenovirus: targeting tumor heterogeneity with two independent cancer-specific promoter elements, DF3/MUC1 and hTERT. Cancer Gene Ther. 2011 Mar; 18(3):153-66. PMID: 20865021; PMCID: PMC3010505.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  10. Doloff JC, Khan N, Ma J, Demidenko E, Swartz HM, Jounaidi Y. Increased tumor oxygenation and drug uptake during anti-angiogenic weekly low dose cyclophosphamide enhances the anti-tumor effect of weekly tirapazamine. Curr Cancer Drug Targets. 2009 Sep; 9(6):777-88. PMID: 19754361; PMCID: PMC2912211.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  11. Doloff JC, Waxman DJ, Jounaidi Y. Human telomerase reverse transcriptase promoter-driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions. Hum Gene Ther. 2008 Dec; 19(12):1383-400. PMID: 18771358; PMCID: PMC2715448.
    Citations: 12     Fields:    Translation:HumansCells
  12. Chen CS, Jounaidi Y, Su T, Waxman DJ. Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model. Cancer Gene Ther. 2007 Dec; 14(12):935-44. PMID: 17853921; PMCID: PMC2613860.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  13. Jounaidi Y, Doloff JC, Waxman DJ. Conditionally replicating adenoviruses for cancer treatment. Curr Cancer Drug Targets. 2007 May; 7(3):285-301. PMID: 17504125; PMCID: PMC3354698.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  14. Jounaidi Y, Chen CS, Veal GJ, Waxman DJ. Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11. Mol Cancer Ther. 2006 Mar; 5(3):541-55. PMID: 16546968.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  15. Riddick DS, Lee C, Ramji S, Chinje EC, Cowen RL, Williams KJ, Patterson AV, Stratford IJ, Morrow CS, Townsend AJ, Jounaidi Y, Chen CS, Su T, Lu H, Schwartz PS, Waxman DJ. Cancer chemotherapy and drug metabolism. Drug Metab Dispos. 2005 Aug; 33(8):1083-96. PMID: 16049130.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Chen CS, Jounaidi Y, Waxman DJ. Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. Drug Metab Dispos. 2005 Sep; 33(9):1261-7. PMID: 15919850.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Jounaidi Y, Waxman DJ. Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy. Cancer Res. 2004 Jan 01; 64(1):292-303. PMID: 14729637.
    Citations: 17     Fields:    Translation:HumansCells
  18. Baldwin A, Huang Z, Jounaidi Y, Waxman DJ. Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer. Arch Biochem Biophys. 2003 Jan 01; 409(1):197-206. PMID: 12464259.
    Citations: 3     Fields:    Translation:AnimalsCells
  19. Jounaidi Y. Cytochrome P450-based gene therapy for cancer treatment: from concept to the clinic. Curr Drug Metab. 2002 Dec; 3(6):609-22. PMID: 12369889.
    Citations: 5     Fields:    Translation:HumansAnimals
  20. Jounaidi Y, Waxman DJ. Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy. Cancer Res. 2001 Jun 01; 61(11):4437-44. PMID: 11389073.
    Citations: 14     Fields:    Translation:HumansAnimals
  21. Jounaidi Y, Waxman DJ. Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. Cancer Res. 2000 Jul 15; 60(14):3761-9. PMID: 10919648.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  22. Hecht JE, Jounaidi Y, Waxman DJ. Construction of p450-expressing tumor cell lines using retroviruses. Methods Mol Med. 2000; 35:85-94. PMID: 21390801.
    Citations:    Fields:    
  23. Pascussi JM, Jounaidi Y, Drocourt L, Domergue J, Balabaud C, Maurel P, Vilarem MJ. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. Biochem Biophys Res Commun. 1999 Jul 05; 260(2):377-81. PMID: 10403778.
    Citations: 13     Fields:    Translation:HumansCells
  24. Waxman DJ, Chen L, Hecht JE, Jounaidi Y. Cytochrome P450-based cancer gene therapy: recent advances and future prospects. Drug Metab Rev. 1999 May; 31(2):503-22. PMID: 10335450.
    Citations: 7     Fields:    Translation:Humans
  25. Jounaidi Y, Hecht JE, Waxman DJ. Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy. Cancer Res. 1998 Oct 01; 58(19):4391-401. PMID: 9766669.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  26. Gábelová A, Périn-Roussel O, Jounaidi Y, Périn F. DNA adduct formation in primary mouse embryo cells induced by 7H-dibenzo[c,g]carbazole and its organ-specific carcinogenic derivatives. Environ Mol Mutagen. 1997; 30(1):56-64. PMID: 9258330.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.