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Kevin Struhl, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35GM131801 (STRUHL, KEVIN) Jul 1, 2019 - Jun 30, 2024
    Mechanism of yeast gene regulation
    Role: Principal Investigator
  2. R01CA107486 (STRUHL, KEVIN) May 25, 2004 - Apr 30, 2021
    Genomic targets of oncoproteins and tumor suppressors
    Role: Principal Investigator
  3. R13CA078317 (STRUHL, KEVIN) Jul 1, 1998 - Jun 30, 1999
    Role: Principal Investigator
  4. R01GM053720 (STRUHL, KEVIN) Sep 30, 1995 - Dec 31, 2009
    Molecular Mechanisms of Global Represion in Yeast
    Role: Principal Investigator
  5. R01CA065965 (STRUHL, KEVIN) Sep 7, 1995 - Jun 30, 2001
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Petrenko N, Struhl K. Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species. Elife. 2021 09 13; 10. PMID: 34515029.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. He L, Pratt H, Gao M, Wei F, Weng Z, Struhl K. YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation. Elife. 2021 08 31; 10. PMID: 34463254.
    Citations: 1     Fields:    Translation:HumansCells
  3. Song R, Struhl K. S100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation. Sci Adv. 2021 Jan; 7(1). PMID: 33523865.
    Citations: 4     Fields:    
  4. Darwiche R, Struhl K. Pheno-RNA, a method to associate genes with a specific phenotype, identifies genes linked to cellular transformation. Proc Natl Acad Sci U S A. 2020 11 17; 117(46):28925-28929. PMID: 33144504.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Geisberg JV, Moqtaderi Z, Struhl K. The transcriptional elongation rate regulates alternative polyadenylation in yeast. Elife. 2020 08 26; 9. PMID: 32845240.
    Citations: 4     Fields:    Translation:AnimalsCells
  6. Hasegawa Y, Struhl K. Promoter-specific dynamics of TATA-binding protein association with the human genome. Genome Res. 2019 12; 29(12):1939-1950. PMID: 31732535.
    Citations: 6     Fields:    Translation:HumansCells
  7. Ji Z, He L, Regev A, Struhl K. Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9453-9462. PMID: 30910960.
    Citations: 41     Fields:    Translation:HumansCells
  8. Petrenko N, Jin Y, Dong L, Wong KH, Struhl K. Requirements for RNA polymerase II preinitiation complex formation in vivo. Elife. 2019 01 25; 8. PMID: 30681409.
    Citations: 15     Fields:    Translation:AnimalsCells
  9. Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez AB, Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernández-Zapico ME, Iliopoulos D. Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. Gut. 2019 07; 68(7):1271-1286. PMID: 30337373.
    Citations: 14     Fields:    Translation:HumansAnimals
  10. Moqtaderi Z, Geisberg JV, Struhl K. Extensive Structural Differences of Closely Related 3' mRNA Isoforms: Links to Pab1 Binding and mRNA Stability. Mol Cell. 2018 12 06; 72(5):849-861.e6. PMID: 30318446.
    Citations: 11     Fields:    Translation:AnimalsCells
  11. Li BB, Qian C, Gameiro PA, Liu CC, Jiang T, Roberts TM, Struhl K, Zhao JJ. Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9325-E9332. PMID: 30224479.
    Citations: 8     Fields:    Translation:HumansCells
  12. Gameiro PA, Struhl K. Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis. Cell Rep. 2018 08 07; 24(6):1415-1424. PMID: 30089253.
    Citations: 11     Fields:    Translation:HumansCells
  13. Ji Z, He L, Rotem A, Janzer A, Cheng CS, Regev A, Struhl K. Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation. Nat Commun. 2018 05 25; 9(1):2068. PMID: 29802342.
    Citations: 11     Fields:    Translation:HumansCells
  14. Petrenko N, Jin Y, Wong KH, Struhl K. Correction: Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo. Elife. 2017 09 18; 6. PMID: 28920856.
    Citations: 1     Fields:    
  15. Jin Y, Eser U, Struhl K, Churchman LS. The Ground State and Evolution of Promoter Region Directionality. Cell. 2017 Aug 24; 170(5):889-898.e10. PMID: 28803729.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  16. Petrenko N, Jin Y, Wong KH, Struhl K. Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo. Elife. 2017 07 12; 6. PMID: 28699889.
    Citations: 13     Fields:    Translation:AnimalsCells
  17. Henry WS, Hendrickson DG, Beca F, Glass B, Lindahl-Allen M, He L, Ji Z, Struhl K, Beck AH, Rinn JL, Toker A. LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. Oncotarget. 2016 Dec 13; 7(50):81981-81994. PMID: 27626181.
    Citations: 18     Fields:    Translation:HumansCells
  18. Petrenko N, Jin Y, Wong KH, Struhl K. Mediator Undergoes a Compositional Change during Transcriptional Activation. Mol Cell. 2016 11 03; 64(3):443-454. PMID: 27773675.
    Citations: 43     Fields:    Translation:AnimalsCells
  19. Miotto B, Ji Z, Struhl K. Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4810-9. PMID: 27436900.
    Citations: 62     Fields:    Translation:HumansCells
  20. Ji Z, Song R, Huang H, Regev A, Struhl K. Transcriptome-scale RNase-footprinting of RNA-protein complexes. Nat Biotechnol. 2016 Apr; 34(4):410-3. PMID: 26900662.
    Citations: 23     Fields:    Translation:HumansCells
  21. Ji Z, Song R, Regev A, Struhl K. Many lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins. Elife. 2015 Dec 19; 4:e08890. PMID: 26687005.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  22. Rotem A, Janzer A, Izar B, Ji Z, Doench JG, Garraway LA, Struhl K. Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation. Proc Natl Acad Sci U S A. 2015 May 05; 112(18):5708-13. PMID: 25902495.
    Citations: 31     Fields:    Translation:HumansCells
  23. Jin Y, Geisberg JV, Moqtaderi Z, Ji Z, Hoque M, Tian B, Struhl K. Mapping 3' mRNA isoforms on a genomic scale. Curr Protoc Mol Biol. 2015 Apr 01; 110:4.23.1-4.23.17. PMID: 25827089.
    Citations: 5     Fields:    
  24. Fleming JD, Giresi PG, Lindahl-Allen M, Krall EB, Lieb JD, Struhl K. STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer. Epigenetics Chromatin. 2015; 8:7. PMID: 25784959.
    Citations: 16     Fields:    
  25. Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10574-9. PMID: 25002509.
    Citations: 118     Fields:    Translation:HumansCells
  26. Wong KH, Jin Y, Struhl K. TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape. Mol Cell. 2014 May 22; 54(4):601-12. PMID: 24746699.
    Citations: 66     Fields:    Translation:AnimalsCells
  27. Moqtaderi Z, Geisberg JV, Struhl K. Secondary structures involving the poly(A) tail and other 3' sequences are major determinants of mRNA isoform stability in yeast. Microb Cell. 2014 Apr; 1(4):137-139. PMID: 25279376.
    Citations: 2     
  28. Struhl K. Is DNA methylation of tumour suppressor genes epigenetic? Elife. 2014 Mar 12; 3:e02475. PMID: 24623307.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  29. Geisberg JV, Moqtaderi Z, Fan X, Ozsolak F, Struhl K. Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast. Cell. 2014 Feb 13; 156(4):812-24. PMID: 24529382.
    Citations: 97     Fields:    Translation:AnimalsCells
  30. Moqtaderi Z, Geisberg JV, Jin Y, Fan X, Struhl K. Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11073-8. PMID: 23776204.
    Citations: 25     Fields:    Translation:AnimalsCells
  31. Fleming JD, Pavesi G, Benatti P, Imbriano C, Mantovani R, Struhl K. NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors. Genome Res. 2013 Aug; 23(8):1195-209. PMID: 23595228.
    Citations: 69     Fields:    Translation:HumansCells
  32. Struhl K, Segal E. Determinants of nucleosome positioning. Nat Struct Mol Biol. 2013 Mar; 20(3):267-73. PMID: 23463311.
    Citations: 237     Fields:    Translation:AnimalsCells
  33. Hirsch HA, Iliopoulos D, Struhl K. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):972-7. PMID: 23277563.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  34. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Sep 06; 489(7414):57-74. PMID: 22955616.
    Citations: 6165     Fields:    Translation:HumansAnimalsCells
  35. Polytarchou C, Iliopoulos D, Struhl K. An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14470-5. PMID: 22908280.
    Citations: 63     Fields:    Translation:HumansCells
  36. Hughes AL, Jin Y, Rando OJ, Struhl K. A functional evolutionary approach to identify determinants of nucleosome positioning: a unifying model for establishing the genome-wide pattern. Mol Cell. 2012 Oct 12; 48(1):5-15. PMID: 22885008.
    Citations: 74     Fields:    Translation:AnimalsCells
  37. Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012 Jul 05; 487(7405):114-8. PMID: 22722849.
    Citations: 201     Fields:    Translation:HumansAnimalsCells
  38. Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MA. Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes. Cell Rep. 2012 Feb 23; 1(2):83-90. PMID: 22720264.
    Citations: 29     Fields:    Translation:AnimalsCells
  39. Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. An HNF4a-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 09; 147(6):1233-47. PMID: 22153071.
    Citations: 218     Fields:    Translation:HumansAnimalsCells
  40. Wong KH, Struhl K. The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein. Genes Dev. 2011 Dec 01; 25(23):2525-39. PMID: 22156212.
    Citations: 66     Fields:    Translation:AnimalsCells
  41. Lee JJ, Drakaki A, Iliopoulos D, Struhl K. MiR-27b targets PPAR? to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells. Oncogene. 2012 Aug 16; 31(33):3818-25. PMID: 22120719.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  42. Krebs AR, Karmodiya K, Lindahl-Allen M, Struhl K, Tora L. SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers. Mol Cell. 2011 Nov 04; 44(3):410-423. PMID: 22055187.
    Citations: 70     Fields:    Translation:HumansCells
  43. Miotto B, Struhl K. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol Cell. 2011 Oct 07; 44(1):62-71. PMID: 21856198.
    Citations: 25     Fields:    Translation:HumansCells
  44. Tirosh I, Wong KH, Barkai N, Struhl K. Extensive divergence of yeast stress responses through transitions between induced and constitutive activation. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16693-8. PMID: 21930916.
    Citations: 17     Fields:    Translation:AnimalsCells
  45. Iliopoulos D, Rotem A, Struhl K. Inhibition of miR-193a expression by Max and RXRa activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res. 2011 Aug 01; 71(15):5144-53. PMID: 21670079.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  46. Esberg A, Moqtaderi Z, Fan X, Lu J, Struhl K, Byström A. Iwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae. PLoS One. 2011; 6(6):e20829. PMID: 21695216.
    Citations: 10     Fields:    Translation:AnimalsCells
  47. Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PN. Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res. 2011 Jul 01; 71(13):4720-31. PMID: 21555366.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  48. Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 2011 May 01; 71(9):3196-201. PMID: 21415163.
    Citations: 181     Fields:    Translation:HumansAnimalsCells
  49. Iliopoulos D, Hirsch HA, Wang G, Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1397-402. PMID: 21220315.
    Citations: 271     Fields:    Translation:HumansAnimalsCells
  50. Katan-Khaykovich Y, Struhl K. Splitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1296-301. PMID: 21220302.
    Citations: 37     Fields:    Translation:AnimalsCells
  51. Locke G, Tolkunov D, Moqtaderi Z, Struhl K, Morozov AV. High-throughput sequencing reveals a simple model of nucleosome energetics. Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):20998-1003. PMID: 21084631.
    Citations: 40     Fields:    Translation:HumansCells
  52. Fan X, Moqtaderi Z, Jin Y, Zhang Y, Liu XS, Struhl K. Nucleosome depletion at yeast terminators is not intrinsic and can occur by a transcriptional mechanism linked to 3'-end formation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):17945-50. PMID: 20921369.
    Citations: 47     Fields:    Translation:Cells
  53. Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell. 2010 Sep 10; 39(5):761-72. PMID: 20832727.
    Citations: 198     Fields:    Translation:HumansAnimalsCells
  54. Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell. 2010 Aug 27; 39(4):493-506. PMID: 20797623.
    Citations: 382     Fields:    Translation:HumansAnimalsCells
  55. Zhang Y, Moqtaderi Z, Rattner BP, Euskirchen G, Snyder M, Kadonaga JT, Liu XS, Struhl K. Evidence against a genomic code for nucleosome positioning. Reply to "Nucleosome sequence preferences influence in vivo nucleosome organization.". Nat Struct Mol Biol. 2010 Aug; 17(8):920-3. PMID: 20683474.
    Citations: 30     Fields:    Translation:HumansAnimalsCells