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Hee Yeon Im, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. You JS, Cho IA, Kang KR, Oh JS, Yu SJ, Lee GJ, Seo YS, Kim SG, Kim CS, Kim DK, Im HJ, Kim JS. Coumestrol Counteracts Interleukin-1ß-Induced Catabolic Effects by Suppressing Inflammation in Primary Rat Chondrocytes. Inflammation. 2017 Feb; 40(1):79-91. PMID: 27709316.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Chen D, Shen J, Zhao W, Wang T, Han L, Hamilton JL, Im HJ. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res. 2017; 5:16044. PMID: 28149655.
    Citations: 94     
  3. Riester SM, Denbeigh JM, Lin Y, Jones DL, de Mooij T, Lewallen EA, Nie H, Paradise CR, Radel DJ, Dudakovic A, Camilleri ET, Larson DR, Qu W, Krych AJ, Frick MA, Im HJ, Dietz AB, Smith J, van Wijnen AJ. Safety Studies for Use of Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells in a Rabbit Model for Osteoarthritis to Support a Phase I Clinical Trial. Stem Cells Transl Med. 2016 Oct 26. PMID: 27798372.
    Citations:    
  4. Lewallen EA, Bonin CA, Li X, Smith J, Karperien M, Larson AN, Lewallen DG, Cool SM, Westendorf JJ, Krych AJ, Leontovich AA, Im HJ, van Wijnen AJ. The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes. Gene. 2016 Oct 15; 591(2):456-64. PMID: 27378743.
    Citations: 7     Fields:    Translation:HumansCells
  5. Oh JS, Cho IA, Kang KR, You JS, Yu SJ, Lee GJ, Seo YS, Kim CS, Kim DK, Kim SG, Seo YW, Im HJ, Kim JS. Biochanin-A antagonizes the interleukin-1ß-induced catabolic inflammation through the modulation of NF?B cellular signaling in primary rat chondrocytes. Biochem Biophys Res Commun. 2016 09 02; 477(4):723-730. PMID: 27363337.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Kroin JS, Kc R, Li X, Hamilton JL, Das V, van Wijnen AJ, Dall OM, Shelly DA, Kenworth T, Im HJ. Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model. Gene. 2016 Oct 10; 591(1):1-5. PMID: 27356303.
    Citations: 1     Fields:    Translation:Animals
  7. Ellman MB, Kim J, An HS, Chen D, Kc R, Li X, Xiao G, Yan D, Suh J, van Wijnen AJ, Wang JH, Kim SG, Im HJ. Corrigendum to "Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells" [Gene. 2013 Jul. 25; 524(2):282-91]. Gene. 2017 02 20; 602:61. PMID: 27354310.
    Citations:    Fields:    
  8. Hamilton JL, Nagao M, Levine BR, Chen D, Olsen BR, Im HJ. Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain. J Bone Miner Res. 2016 05; 31(5):911-24. PMID: 27163679.
    Citations: 25     Fields:    Translation:HumansCells
  9. Lin Y, Lewallen EA, Camilleri ET, Bonin CA, Jones DL, Dudakovic A, Galeano-Garces C, Wang W, Karperien MJ, Larson AN, Dahm DL, Stuart MJ, Levy BA, Smith J, Ryssman DB, Westendorf JJ, Im HJ, van Wijnen AJ, Riester SM, Krych AJ. RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes. J Orthop Res. 2016 11; 34(11):1950-1959. PMID: 26909883.
    Citations: 12     Fields:    Translation:HumansCells
  10. Oh CD, Im HJ, Suh J, Chee A, An H, Chen D. Rho-Associated Kinase Inhibitor Immortalizes Rat Nucleus Pulposus and Annulus Fibrosus Cells: Establishment of Intervertebral Disc Cell Lines With Novel Approaches. Spine (Phila Pa 1976). 2016 Mar; 41(5):E255-61. PMID: 26693672.
    Citations: 9     Fields:    Translation:AnimalsCells
  11. Kc R, Li X, Kroin JS, Liu Z, Chen D, Xiao G, Levine B, Li J, Hamilton JL, van Wijnen AJ, Piel M, Shelly DA, Brass D, Kolb E, Im HJ. PKCd null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth. Ann Rheum Dis. 2016 Dec; 75(12):2133-2141. PMID: 26783110.
    Citations: 10     Fields:    Translation:AnimalsCells
  12. Dudek M, Gossan N, Yang N, Im HJ, Ruckshanthi JP, Yoshitane H, Li X, Jin D, Wang P, Boudiffa M, Bellantuono I, Fukada Y, Boot-Handford RP, Meng QJ. The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest. 2016 Jan; 126(1):365-76. PMID: 26657859.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  13. Kc R, Li X, Forsyth CB, Voigt RM, Summa KC, Vitaterna MH, Tryniszewska B, Keshavarzian A, Turek FW, Meng QJ, Im HJ. Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet. Sci Rep. 2015 Nov 20; 5:16896. PMID: 26584570.
    Citations: 5     Fields:    Translation:HumansAnimals
  14. Kim JS, Ahmadinia K, Li X, Hamilton JL, Andrews S, Haralampus CA, Xiao G, Sohn HM, You JW, Seo YS, Stein GS, Van Wijnen AJ, Kim SG, Im HJ. Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis. J Cell Physiol. 2015 Nov; 230(11):2837-47. PMID: 25858171.
    Citations: 13     Fields:    Translation:HumansAnimals
  15. Im HY, Zhong SH, Halberda J. Grouping by proximity and the visual impression of approximate number in random dot arrays. Vision Res. 2016 09; 126:291-307. PMID: 26386344.
    Citations: 3     Fields:    Translation:Humans
  16. Kc R, Li X, Voigt RM, Ellman MB, Summa KC, Vitaterna MH, Keshavarizian A, Turek FW, Meng QJ, Stein GS, van Wijnen AJ, Chen D, Forsyth CB, Im HJ. Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint. J Cell Physiol. 2015 Sep; 230(9):2174-2183. PMID: 25655021.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Wu C, Jiao H, Lai Y, Zheng W, Chen K, Qu H, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-ß signalling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 07; 6:7531. PMID: 26151572.
    Citations: 25     Fields:    Translation:AnimalsCells
  18. Kroin JS, Buvanendran A, Li J, Moric M, Im HJ, Tuman KJ, Shafikhani SH. Short-term glycemic control is effective in reducing surgical site infection in diabetic rats. Anesth Analg. 2015 Jun; 120(6):1289-96. PMID: 25695673.
    Citations: 6     Fields:    Translation:Animals
  19. Kc R, Voigt R, Li X, Forsyth CB, Ellman MB, Summa KC, Turek FW, Keshavarzian A, Kim JS, Im HJ. Induction of Osteoarthritis-like Pathologic Changes by Chronic Alcohol Consumption in an Experimental Mouse Model. Arthritis Rheumatol. 2015 Jun; 67(6):1678-80. PMID: 25708245.
    Citations: 5     Fields:    Translation:Animals
  20. Kim JS, Oh D, Yim MJ, Park JJ, Kang KR, Cho IA, Moon SM, Oh JS, You JS, Kim CS, Kim DK, Lee SY, Lee GJ, Im HJ, Kim SG. Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells. Oncol Rep. 2015 Apr; 33(4):1775-82. PMID: 25634589.
    Citations: 9     Fields:    Translation:HumansCells
  21. Park MR, Kim SG, Cho IA, Oh D, Kang KR, Lee SY, Moon SM, Cho SS, Yoon G, Kim CS, Oh JS, You JS, Kim DK, Seo YS, Im HJ, Kim JS. Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated TRAIL expression in head and neck squamous carcinoma FaDu cells. Food Chem Toxicol. 2015 Mar; 77:34-43. PMID: 25572524.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Piel MJ, Kroin JS, Im HJ. Assessment of knee joint pain in experimental rodent models of osteoarthritis. Methods Mol Biol. 2015; 1226:175-81. PMID: 25331050.
    Citations: 2     Fields:    Translation:HumansAnimals
  23. Lee GJ, Cho IA, Kang KR, Kim DK, Sohn HM, You JW, Oh JS, Seo YS, Yu SJ, You JS, Kim CS, Kim SG, Im HJ, Kim JS. Biological Effects of the Herbal Plant-Derived Phytoestrogen Bavachin in Primary Rat Chondrocytes. Biol Pharm Bull. 2015; 38(8):1199-207. PMID: 26235583.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Lu Y, Ding M, Li N, Wang Q, Li J, Li X, Gu J, Im HJ, Lei G, Zheng Q. Col10a1-Runx2 transgenic mice with delayed chondrocyte maturation are less susceptible to developing osteoarthritis. Am J Transl Res. 2014; 6(6):736-45. PMID: 25628784.
    Citations: 8     
  25. Gu SX, Li X, Hamilton JL, Chee A, Kc R, Chen D, An HS, Kim JS, Oh CD, Ma YZ, van Wijnen AJ, Im HJ. MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. Gene. 2015 Jan 25; 555(2):80-7. PMID: 25311550.
    Citations: 27     Fields:    Translation:AnimalsCells
  26. Dudakovic A, Camilleri E, Riester SM, Lewallen EA, Kvasha S, Chen X, Radel DJ, Anderson JM, Nair AA, Evans JM, Krych AJ, Smith J, Deyle DR, Stein JL, Stein GS, Im HJ, Cool SM, Westendorf JJ, Kakar S, Dietz AB, van Wijnen AJ. High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells. J Cell Biochem. 2014 Oct; 115(10):1816-28. PMID: 24905804.
    Citations: 53     Fields:    Translation:HumansCells
  27. Kim JS, Park MR, Lee SY, Kim DK, Moon SM, Kim CS, Cho SS, Yoon G, Im HJ, You JS, Oh JS, Kim SG. Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway. Oncol Rep. 2014 Feb; 31(2):755-62. PMID: 24337492.
    Citations: 7     Fields:    Translation:HumansCells
  28. Piel MJ, Kroin JS, van Wijnen AJ, Kc R, Im HJ. Pain assessment in animal models of osteoarthritis. Gene. 2014 Mar 10; 537(2):184-8. PMID: 24333346.
    Citations: 17     Fields:    Translation:Animals
  29. Li X, Kroin JS, Kc R, Gibson G, Chen D, Corbett GT, Pahan K, Fayyaz S, Kim JS, van Wijnen AJ, Suh J, Kim SG, Im HJ. Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints. J Bone Miner Res. 2013 Dec; 28(12):2512-22. PMID: 23744481.
    Citations: 30     Fields:    Translation:AnimalsCells
  30. Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D. Deletion of the transforming growth factor ß receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice. Arthritis Rheum. 2013 Dec; 65(12):3107-19. PMID: 23982761.
    Citations: 59     Fields:    Translation:AnimalsCells
  31. Ahmadinia K, Yan D, Ellman M, Im HJ. The anti-catabolic role of bovine lactoferricin in cartilage. Biomol Concepts. 2013 Oct; 4(5):495-500. PMID: 25436593.
    Citations:    Fields:    Translation:Animals
  32. Yan D, Kc R, Chen D, Xiao G, Im HJ. Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 01; 288(44):31655-69. PMID: 24036113.
    Citations: 3     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  33. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18; 288(42):30399-410. PMID: 24005670.
    Citations: 18     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  34. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res. 2013 Sep; 28(9):1870-1884. PMID: 23649506.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  35. Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Szabo G, Hoskin DW, Buechter DD, Van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep; 228(9):1884-96. PMID: 23460134.
    Citations: 20     Fields:    Translation:HumansAnimals
  36. Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ, Im HJ. A current review of molecular mechanisms regarding osteoarthritis and pain. Gene. 2013 Sep 25; 527(2):440-7. PMID: 23830938.
    Citations: 88     Fields:    Translation:Humans
  37. Zhang J, Middleton KK, Fu FH, Im HJ, Wang JH. HGF mediates the anti-inflammatory effects of PRP on injured tendons. PLoS One. 2013; 8(6):e67303. PMID: 23840657.
    Citations: 38     Fields:    Translation:AnimalsCells
  38. van Wijnen AJ, van de Peppel J, van Leeuwen JP, Lian JB, Stein GS, Westendorf JJ, Oursler MJ, Im HJ, Taipaleenmäki H, Hesse E, Riester S, Kakar S. MicroRNA functions in osteogenesis and dysfunctions in osteoporosis. Curr Osteoporos Rep. 2013 Jun; 11(2):72-82. PMID: 23605904.
    Citations: 59     Fields:    Translation:HumansCells
  39. Ellman MB, Kim J, An HS, Chen D, Kc R, Li X, Xiao G, Yan D, Suh J, van Wijnen AJ, Wang JH, Kim SG, Im HJ. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 07 25; 524(2):282-91. PMID: 23644135.
    Citations: 4     Fields:    Translation:AnimalsCells
  40. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. atf4 promotes ß-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-66. PMID: 23494915.
    Citations: 16     Fields:    Translation:AnimalsCells
  41. Yan D, Chen D, Shen J, Xiao G, van Wijnen AJ, Im HJ. Bovine lactoferricin is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb; 228(2):447-56. PMID: 22740381.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  42. Yan D, Chen D, Hawse JR, van Wijnen AJ, Im HJ. Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes. Gene. 2013 Mar 15; 517(1):12-8. PMID: 23313877.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  43. Wang M, Sampson ER, Jin H, Li J, Ke QH, Im HJ, Chen D. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther. 2013 Jan 08; 15(1):R5. PMID: 23298463.
    Citations: 96     Fields:    Translation:Animals
  44. Yu S, Sharma R, Nie D, Jiao H, Im HJ, Lai Y, Zhao Z, Zhu K, Fan J, Chen D, Wang Q, Xiao G. ADAR1 ablation decreases bone mass by impairing osteoblast function in mice. Gene. 2013 Jan 15; 513(1):101-10. PMID: 23123729.
    Citations: 10     Fields:    Translation:AnimalsCells
  45. Mi M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, Chen D. Chondrocyte BMP2 signaling plays an essential role in bone fracture healing. Gene. 2013 Jan 10; 512(2):211-8. PMID: 23107765.
    Citations: 22     Fields:    Translation:AnimalsCells
  46. Im HJ, Li X, Chen D, Yan D, Kim J, Ellman MB, Stein GS, Cole B, Kc R, Cs-Szabo G, van Wijnen AJ. Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells. J Cell Physiol. 2012 Oct; 227(10):3488-97. PMID: 22252971.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  47. Ding M, Lu Y, Abbassi S, Li F, Li X, Song Y, Geoffroy V, Im HJ, Zheng Q. Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. J Cell Physiol. 2012 Oct; 227(10):3446-56. PMID: 22223437.
    Citations: 22     Fields:    Translation:AnimalsCells
  48. Yan D, Chen D, Im HJ. Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCd pathway in human articular chondrocytes. J Cell Biochem. 2012 Sep; 113(9):2856-65. PMID: 22488450.
    Citations: 14     Fields:    Translation:HumansCells
  49. Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D. Conditional activation of ß-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum. 2012 Aug; 64(8):2611-23. PMID: 22422036.
    Citations: 41     Fields:    Translation:AnimalsCells
  50. Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Ranjan KC, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul; 113(7):2532-42. PMID: 22415882.
    Citations: 22     Fields:    Translation:HumansAnimals
  51. Henry JL, Yashpal K, Vernon H, Kim J, Im HJ. Lumbar facet joint compressive injury induces lasting changes in local structure, nociceptive scores, and inflammatory mediators in a novel rat model. Pain Res Treat. 2012; 2012:127636. PMID: 22966427.
    Citations: 7     
  52. Ellman MB, Kim JS, An HS, Chen D, KC R, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 01; 505(2):283-90. PMID: 22692007.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  53. Xiao G, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C. Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 Jun 15; 287(25):21450-60. PMID: 22556421.
    Citations: 28     Fields:    Translation:AnimalsCells
  54. Kim JS, Ellman MB, An HS, Yan D, van Wijnen AJ, Murphy G, Hoskin DW, Im HJ. Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc. J Cell Physiol. 2012 Apr; 227(4):1512-20. PMID: 21678402.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  55. Ellman MB, Kim JS, An HS, Kroin JS, Li X, Chen D, Yan D, Buechter DD, Nakayama K, Liu B, Morgan S, Im HJ. The pathophysiologic role of the protein kinase Cd pathway in the intervertebral discs of rabbits and mice: in vitro, ex vivo, and in vivo studies. Arthritis Rheum. 2012 Jun; 64(6):1950-9. PMID: 22161873.
    Citations: 15     Fields:    Translation:AnimalsCells
  56. Wang M, Shen J, Jin H, Im HJ, Sandy J, Chen D. Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci. 2011 Dec; 1240:61-9. PMID: 22172041.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  57. Kim JS, Kroin JS, Li X, An HS, Buvanendran A, Yan D, Tuman KJ, van Wijnen AJ, Chen D, Im HJ. The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain. Arthritis Res Ther. 2011; 13(5):R165. PMID: 21996269.
    Citations: 16     Fields:    Translation:Animals
  58. Kim JS, Kroin JS, Buvanendran A, Li X, van Wijnen AJ, Tuman KJ, Im HJ. Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis. Arthritis Rheum. 2011 Oct; 63(10):2966-73. PMID: 21953085.
    Citations: 13     Fields:    Translation:Animals
  59. Yan D, Chen D, Cool SM, van Wijnen AJ, Mikecz K, Murphy G, Im HJ. Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. Arthritis Res Ther. 2011 Aug 11; 13(4):R130. PMID: 21835001.
    Citations: 38     Fields:    Translation:HumansCells
  60. An HS, Masuda K, Cs-Szabo G, Zhang Y, Chee A, Andersson GB, Im HJ, Thonar EJ, Kwon YM. Biologic repair and regeneration of the intervertebral disk. J Am Acad Orthop Surg. 2011 Jul; 19(7):450-2. PMID: 21724924.
    Citations: 6     Fields:    Translation:Humans
  61. Zhang J, Pan T, Im HJ, Fu FH, Wang JH. Differential properties of human ACL and MCL stem cells may be responsible for their differential healing capacity. BMC Med. 2011 Jun 02; 9:68. PMID: 21635735.
    Citations: 18     Fields:    Translation:HumansCells
  62. Li X, Gibson G, Kim JS, Kroin J, Xu S, van Wijnen AJ, Im HJ. MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene. 2011 Jul 01; 480(1-2):34-41. PMID: 21397669.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  63. Li X, Kim JS, van Wijnen AJ, Im HJ. Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain. Mol Biol Rep. 2011 Nov; 38(8):5335-9. PMID: 21327824.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  64. Kim JS, Ellman MB, An HS, van Wijnen AJ, Borgia JA, Im HJ. Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells. Arthritis Rheum. 2010 Dec; 62(12):3706-15. PMID: 20812336.
    Citations: 18     Fields:    Translation:AnimalsCells
  65. Im HJ, Kim JS, Li X, Kotwal N, Sumner DR, van Wijnen AJ, Davis FJ, Yan D, Levine B, Henry JL, Desevré J, Kroin JS. Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model. Arthritis Rheum. 2010 Oct; 62(10):2995-3005. PMID: 20556813.
    Citations: 57     Fields:    Translation:AnimalsCells
  66. Yan D, Davis FJ, Sharrocks AD, Im HJ. Emerging roles of SUMO modification in arthritis. Gene. 2010 Oct 15; 466(1-2):1-15. PMID: 20627123.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  67. Takahashi N, Knudson CB, Thankamony S, Ariyoshi W, Mellor L, Im HJ, Knudson W. Induction of CD44 cleavage in articular chondrocytes. Arthritis Rheum. 2010 May; 62(5):1338-48. PMID: 20178130.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  68. Im HJ, Sharrocks AD, Lin X, Yan D, Kim J, van Wijnen AJ, Hipskind RA. Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes. Open Access Rheumatol. 2009; 1:151-161. PMID: 27789988.
    Citations: 3     
  69. Zhang Y, Markova D, Im HJ, Hu W, Thonar EJ, He TC, An HS, Phillips FM, Anderson DG. Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype. Am J Phys Med Rehabil. 2009 Jun; 88(6):455-63. PMID: 19454853.
    Citations: 2     Fields:    Translation:AnimalsCells
  70. Li X, Ellman M, Muddasani P, Wang JH, Cs-Szabo G, van Wijnen AJ, Im HJ. Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis. Arthritis Rheum. 2009 Feb; 60(2):513-23. PMID: 19180509.
    Citations: 43     Fields:    Translation:HumansCells
  71. Cravero JD, Carlson CS, Im HJ, Yammani RR, Long D, Loeser RF. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum. 2009 Feb; 60(2):492-500. PMID: 19180501.
    Citations: 26     Fields:    Translation:HumansCells
  72. Li X, Phillips FM, An HS, Ellman M, Thonar EJ, Wu W, Park D, Im HJ. The action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc. Spine (Phila Pa 1976). 2008 Nov 15; 33(24):2586-95. PMID: 19011540.
    Citations: 27     Fields:    Translation:AnimalsCells
  73. Ellman MB, An HS, Muddasani P, Im HJ. Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene. 2008 Aug 15; 420(1):82-9. PMID: 18565695.
    Citations: 52     Fields:    Translation:HumansCells
  74. Im HJ, Li X, Muddasani P, Kim GH, Davis F, Rangan J, Forsyth CB, Ellman M, Thonar EJ. Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes. J Cell Physiol. 2008 May; 215(2):452-63. PMID: 17960584.
    Citations: 33     Fields:    Translation:HumansCells
  75. Li X, An HS, Ellman M, Phillips F, Thonar EJ, Park DK, Udayakumar RK, Im HJ. Action of fibroblast growth factor-2 on the intervertebral disc. Arthritis Res Ther. 2008; 10(2):R48. PMID: 18435858.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  76. Muddasani P, Norman JC, Ellman M, van Wijnen AJ, Im HJ. Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. J Biol Chem. 2007 Oct 26; 282(43):31409-21. PMID: 17724016.
    Citations: 49     Fields:    Translation:HumansCells
  77. Im HJ, Muddasani P, Natarajan V, Schmid TM, Block JA, Davis F, van Wijnen AJ, Loeser RF. Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem. 2007 Apr 13; 282(15):11110-21. PMID: 17311929.
    Citations: 81     Fields:    Translation:HumansCells
  78. Wang JH, Thampatty BP, Lin JS, Im HJ. Mechanoregulation of gene expression in fibroblasts. Gene. 2007 Apr 15; 391(1-2):1-15. PMID: 17331678.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  79. Thampatty BP, Li H, Im HJ, Wang JH. EP4 receptor regulates collagen type-I, MMP-1, and MMP-3 gene expression in human tendon fibroblasts in response to IL-1 beta treatment. Gene. 2007 Jan 15; 386(1-2):154-61. PMID: 17046175.
    Citations: 21     Fields:    Translation:HumansCells
  80. Ohno S, Im HJ, Knudson CB, Knudson W. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. J Biol Chem. 2006 Jun 30; 281(26):17952-60. PMID: 16648633.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  81. Thampatty BP, Im HJ, Wang JH. Leukotriene B4 at low dosage negates the catabolic effect of prostaglandin E2 in human patellar tendon fibroblasts. Gene. 2006 May 10; 372:103-9. PMID: 16488093.
    Citations: 7     Fields:    Translation:HumansCells
  82. Oz HS, Im HJ, Chen TS, de Villiers WJ, McClain CJ. Glutathione-enhancing agents protect against steatohepatitis in a dietary model. J Biochem Mol Toxicol. 2006; 20(1):39-47. PMID: 16498637.
    Citations: 31     Fields:    Translation:Animals
  83. Loeser RF, Chubinskaya S, Pacione C, Im HJ. Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes. Arthritis Rheum. 2005 Dec; 52(12):3910-7. PMID: 16320338.
    Citations: 46     Fields:    Translation:HumansCells
  84. Yang G, Im HJ, Wang JH. Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Gene. 2005 Dec 19; 363:166-72. PMID: 16226404.
    Citations: 74     Fields:    Translation:HumansCells
  85. Forsyth CB, Cole A, Murphy G, Bienias JL, Im HJ, Loeser RF. Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli. J Gerontol A Biol Sci Med Sci. 2005 Sep; 60(9):1118-24. PMID: 16183949.
    Citations: 35     Fields:    Translation:HumansCells
  86. Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SD. Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum. 2005 Aug; 52(8):2376-85. PMID: 16052547.
    Citations: 70     Fields:    Translation:HumansCells
  87. Pulai JI, Chen H, Im HJ, Kumar S, Hanning C, Hegde PS, Loeser RF. NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol. 2005 May 01; 174(9):5781-8. PMID: 15843581.
    Citations: 69     Fields:    Translation:HumansCells
  88. Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY, Lian JB, Stein JL, Stein GS, van Wijnen AJ. The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem. 2005 May 27; 280(21):20274-85. PMID: 15781466.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  89. Ohno S, Im HJ, Knudson CB, Knudson W. Hyaluronan oligosaccharide-induced activation of transcription factors in bovine articular chondrocytes. Arthritis Rheum. 2005 Mar; 52(3):800-9. PMID: 15751080.
    Citations: 17     Fields:    Translation:AnimalsCells
  90. Kumar R, Lutz W, Frank E, Im HJ. Immediate early gene X-1 interacts with proteins that modulate apoptosis. Biochem Biophys Res Commun. 2004 Oct 29; 323(4):1293-8. PMID: 15451437.
    Citations: 12     Fields:    Translation:HumansCells
  91. Im HJ, Pacione C, Chubinskaya S, Van Wijnen AJ, Sun Y, Loeser RF. Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem. 2003 Jul 11; 278(28):25386-94. PMID: 12734180.
    Citations: 59     Fields:    Translation:HumansCells
  92. Loeser RF, Forsyth CB, Samarel AM, Im HJ. Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem. 2003 Jul 04; 278(27):24577-85. PMID: 12730223.
    Citations: 49     Fields:    Translation:HumansCells
  93. Kumar R, Pittelkow MR, Salisbury JL, Grande JP, Im HJ, Feldmann KA, Schilling D. A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis. Recent Results Cancer Res. 2003; 164:123-34. PMID: 12899517.
    Citations: 5     Fields:    Translation:HumansCells
  94. Im HJ, Craig TA, Pittelkow MR, Kumar R. Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression. Oncogene. 2002 May 23; 21(23):3706-14. PMID: 12032839.
    Citations: 3     Fields:    Translation:HumansCells
  95. Im HJ, Pittelkow MR, Kumar R. Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1. J Biol Chem. 2002 Apr 26; 277(17):14612-21. PMID: 11844788.
    Citations: 15     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.